Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis

1978 • 1,954 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Interleukin-10

1993 • 1,820 citations

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

1992 • 1,259 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Two populations of Ia-like molecules on a human B cell line.

1980 • 1,112 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.

1992 • 641 citations

Recombinant interferon-gamma increases HLA-DR synthesis and expression.

1983 • 577 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.

1991 • 514 citations

IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.

1995 • 420 citations

IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.

1992 • 417 citations

Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes

1994 • 396 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples

1992 • 384 citations

IL-10, a novel growth cofactor for mature and immature T cells.

1990 • 371 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

Expression cloning and characterization of a human IL-10 receptor.

1994 • 327 citations

Article

1995 • 325 citations

Assembly and maturation of HLA-A and HLA-B antigens in vivo

1979 • 278 citations

Antigen presentation mediated by recycling of surface HLA-DR molecules

1995 • 271 citations

Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins.

1992 • 263 citations

Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments

1990 • 254 citations

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

1994 • 244 citations

IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10.

1992 • 220 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Downregulation of TAP1 in B Lymphocytes by Cellular and Epstein-Barr Virus–Encoded Interleukin-10

1997 • 186 citations

Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains

1982 • 183 citations

How MHC class II molecules reach the endocytic pathway.

1995 • 173 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Interleukin‐10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells

1994 • 151 citations

Related Leucine-based Cytoplasmic Targeting Signals in Invariant Chain and Major Histocompatibility Complex Class II Molecules Control Endocytic Presentation of Distinct Determinants in a Single Protein

1997 • 135 citations

Chloroquine affects biosynthesis of Ia molecules by inhibiting dissociation of invariant (gamma) chains from alpha-beta dimers in B cells.

1985 • 123 citations

Specificity of monoclonal antibodies directed against human and murine class II histocompatibility antigens as analyzed by binding to HLA-deletion mutant cell lines

1985 • 106 citations

Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10.

1997 • 92 citations

Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complex.

1984 • 90 citations

Dissociation of IL-1 beta synthesis and secretion in human blood monocytes stimulated with bacterial cell wall products.

1993 • 84 citations

Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartments.

1996 • 83 citations

Cytokine mRNA expression during an in vitro response of human B lymphocytes: kinetics of B cell tumor necrosis factor alpha, interleukin (IL)6, IL-10, and transforming growth factor beta 1 mRNAs.

1993 • 67 citations

Increase of surface Ia-like antigen expression on human monocytes independent of antigenic stimuli.

1981 • 58 citations

Macrophage-colony-stimulating factor expression by anti-CD45 stimulated human monocytes is transcriptionally up-regulated by IL-1 beta and inhibited by IL-4 and IL-10.

1994 • 55 citations

FcR cross-linking on monocytes results in impaired T cell stimulatory capacity

1995 • 53 citations

Distribution of antigenic determinants recognized by three monoclonal antibodies (Q2/70, Q5/6 and Q5/13) on human Ia-like alloantigens and on their subunits

1981 • 41 citations

Introduction of T cell receptor (TCR)-alpha cDNA has differential effects on TCR-gamma delta/CD3 expression by PEER and Lyon-1 cells.

1989 • 22 citations

Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain.

1990 • 18 citations