In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy

Two-Photon Laser Scanning Fluorescence Microscopy

1990 • 9,129 citations

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Tumor Induction of VEGF Promoter Activity in Stromal Cells

1998 • 964 citations

Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex

1998 • 807 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Long-term two-photon fluorescence imaging of mammalian embryos without compromising viability

1999 • 537 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Apoptosis: an early event in metastatic inefficiency.

2001 • 268 citations

Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis

1999 • 209 citations

Measurement of Molecular Diffusion in Solution by Multiphoton Fluorescence Photobleaching Recovery

1999 • 207 citations

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.

1997 • 168 citations

Tissue Perfusion Inhomogeneity During Early Tumor Growth in Rats<xref ref-type="fn" rid="fn2">2</xref>

1979 • 152 citations

High-speed, two-photon scanning microscope

1999 • 150 citations

Directin vivomeasurement of targeted binding in a human tumor xenograft

1997 • 143 citations

Heterogeneous Vascular Dependence of Tumor Cell Populations

2001 • 139 citations

Leukocyte-endothelial adhesion and angiogenesis in tumors

1996 • 105 citations

Perfusion of Single Tumor Microvessels: Application to Vascular Permeability Measurement

1996 • 66 citations

Transparent Window Models and Intravital Microscopy: Imaging Gene Expression, Physiological Function, and Drug Delivery in Tumors

2003 • 14 citations