Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transition

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

Wnt signaling and cancer

2000 • 3,215 citations

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

2000 • 2,569 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

An Overview of Epithelio-Mesenchymal Transformation

1995 • 1,505 citations

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

1999 • 916 citations

The candidate Wilms' tumour gene is involved in genitourinary development

1990 • 884 citations

Regulation of Cadherin Adhesive Activity

2000 • 793 citations

Control of Cell Behavior During Vertebrate Development by Slug , a Zinc Finger Gene

1994 • 744 citations

Matrix metalloproteinases: multifunctional contributors to tumor progression

2000 • 639 citations

The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells.

1990 • 629 citations

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

1997 • 515 citations

Induction of the prospective neural crest of Xenopus

1995 • 451 citations

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

1998 • 421 citations

Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16.

1996 • 401 citations

The Catenin p120^ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor

1999 • 396 citations

Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation

1998 • 377 citations

PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1999 • 367 citations

ERM proteins in cell adhesion and membrane dynamics

1999 • 364 citations

Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

1998 • 363 citations

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

1994 • 347 citations

Desmoplakin Is Required Early in Development for Assembly of Desmosomes and Cytoskeletal Linkage

1998 • 336 citations

Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly

1998 • 330 citations

Effectors for the Rho GTPases

1999 • 327 citations

Structure and function of hepatocyte growth factor

1991 • 307 citations

Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell–Cell Adhesion

1998 • 254 citations

The slug gene is not essential for mesoderm or neural crest development in mice

1998 • 247 citations

Desmosomes: Intercellular Adhesive Junctions Specialized for Attachment of Intermediate Filaments

1998 • 234 citations

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

1994 • 223 citations

NH2-terminal Deletion of β-Catenin Results in Stable Colocalization of Mutant β-Catenin with Adenomatous Polyposis Coli Protein and Altered MDCK Cell Adhesion

1997 • 220 citations

Integrins and GTPases in tumour cell growth, motility and invasion

1998 • 219 citations

Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells.

1989 • 210 citations

SLUG, a ces-1-Related Zinc Finger Transcription Factor Gene with Antiapoptotic Activity, Is a Downstream Target of the E2A-HLF Oncoprotein

1999 • 207 citations

Epithelial Mesenchymal Transition by c-Fos Estrogen Receptor Activation Involves Nuclear Translocation of β-Catenin and Upregulation of β-Catenin/Lymphoid Enhancer Binding Factor-1 Transcriptional Activity

2000 • 207 citations

Regulation of cadherin-mediated cell–cell adhesion by the Rho family GTPases

1999 • 204 citations

Expression ofsnail2,a Second Member of the Zebrafish Snail Family, in Cephalic Mesendoderm and Presumptive Neural Crest of Wild-Type andspadetailMutant Embryos

1995 • 173 citations

The α Isoform of Protein Kinase C Is Involved in Signaling the Response of Desmosomes to Wounding in Cultured Epithelial Cells

2000 • 163 citations

The Nonreceptor Protein Tyrosine Phosphatase PTP1B Binds to the Cytoplasmic Domain of N-Cadherin and Regulates the Cadherin–Actin Linkage

1998 • 163 citations

RB and c-Myc Activate Expression of the E-Cadherin Gene in Epithelial Cells through Interaction with Transcription Factor AP-2

1998 • 161 citations

Activation of the Small GTPase Rac Is Sufficient to Disrupt Cadherin-dependent Cell-Cell Adhesion in Normal Human Keratinocytes

2000 • 158 citations

The Catalytic Activity of the Src Family Kinases Is Required to Disrupt Cadherin-dependent Cell–Cell Contacts

2000 • 156 citations

Cross Talk between Adhesion Molecules: Control of N-cadherin Activity by Intracellular Signals Elicited by β1 and β3 Integrins in Migrating Neural Crest Cells

1997 • 155 citations

Adhesive But Not Lateral E-cadherin Complexes Require Calcium and Catenins for Their Formation

1998 • 154 citations

Two-hybrid Analysis Reveals Fundamental Differences in Direct Interactions between Desmoplakin and Cell Type-specific Intermediate Filaments

1997 • 151 citations

Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development

1992 • 144 citations

Mechanisms Identified in the Transcriptional Control of Epithelial Gene Expression

1996 • 142 citations

Src and Ras are involved in separate pathways in epithelial cell scattering

1997 • 141 citations

Protein-tyrosine Phosphatase α Regulates Src Family Kinases and Alters Cell-Substratum Adhesion

1998 • 137 citations

Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells.

1994 • 135 citations

E-cadherin Is a WT1 Target Gene

2000 • 133 citations

Molecular mechanisms of hormone-mediated Müllerian duct regression: involvement of β-catenin

2000 • 132 citations

Plakophilin-3, a novel Armadillo-like protein present in nuclei and desmosomes of epithelial cells

1999 • 130 citations

Human Slug Is a Repressor That Localizes to Sites of Active Transcription

2000 • 129 citations

Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.

1994 • 124 citations

Regulation and function of the interaction between the APC tumour suppressor protein and EB1

2000 • 121 citations

The Nonreceptor Tyrosine Kinase Fer Mediates Cross-Talk between N-Cadherin and β1-Integrins

2000 • 120 citations

The Transition to Endoreduplication in Trophoblast Giant Cells Is Regulated by the mSNA Zinc Finger Transcription Factor

1998 • 115 citations

Desmosomal localization of β-catenin in the skin of plakoglobin null-mutant mice

1999 • 114 citations

Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: a coordinated Sisyphus cycle.

1995 • 109 citations

Transmembrane Signaling for Adhesive Regulation of Desmosomes and Hemidesmosomes, and for Cell-Cell Detachment Induced by Pemphigus IgG in Cultured Keratinocytes: Involvement of Protein Kinase C

1999 • 109 citations

α3β1 integrin regulates epithelial cytoskeletal organization

1999 • 100 citations

Potent Blockade of Hepatocyte Growth Factor-stimulated Cell Motility, Matrix Invasion and Branching Morphogenesis by Antagonists of Grb2 Src Homology 2 Domain Interactions

2001 • 97 citations

Protein Kinase C Activation Upregulates Intercellular Adhesion of α-Catenin–negative Human Colon Cancer Cell Variants via Induction of Desmosomes

1997 • 95 citations

Growth Factor-dependent Phosphorylation of the Actin-binding Protein Cortactin Is Mediated by the Cytoplasmic Tyrosine Kinase FER

1998 • 93 citations

Definition of the DNA-binding site repertoire for theDrosophilatranscription factor SNAIL

1993 • 93 citations

The epithelial cell default‐phenotype hypothesis and its implications for cancer

1997 • 93 citations

The Expression of Desmoglein Isoforms in Cultured Human Keratinocytes Is Regulated by Calcium, Serum, and Protein Kinase C

1998 • 86 citations

A novel Snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs

2000 • 83 citations

Differential signaling by alternative HGF isoforms through c-Met: activation of both MAP kinase and PI 3-kinase pathways is insufficient for mitogenesis

1999 • 80 citations

A Notl restriction map of the entire long arm of human chromosome 21

1993 • 72 citations

Modulations of the epithelial phenotype during embryogenesis and cancer progression

1994 • 70 citations

Slug, a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest, is also involved in chick limb development

1990 • 69 citations

Cell-Cell Dissociation upon Epithelial Cell Scattering Requires a Step Mediated by the Proteasome

1999 • 61 citations

Molecular Basis for Leukocyte Integrin αEβ7 Adhesion to Epithelial (E)-Cadherin

2000 • 57 citations

Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation

1998 • 52 citations

Genomics, the cytoskeleton and motility

2001 • 50 citations

Accumulation of a microtubule-binding protein, pp170, at desmosomal plaques

1992 • 49 citations

Mechanisms for de novo biogenesis of an apical membrane compartment in groups of simple epithelial cells surrounded by extracellular matrix

1997 • 48 citations

Development of desmosomal adhesion between MDCK cells following calcium switching

1990 • 48 citations

Slug mRNA is expressed by specific mesodermal derivatives during rodent organogenesis

1998 • 47 citations

Expression of the Cytoplasmic Domain of E-cadherin Induces Precocious Mammary Epithelial Alveolar Formation and Affects Cell Polarity and Cell–Matrix Integrity

1999 • 44 citations

Cell-extracellular matrix interactions and EGF are important regulators of the basal mammary epithelial cell phenotype

1999 • 41 citations

Cbl-transforming Variants Trigger a Cascade of Molecular Alterations That Lead to Epithelial Mesenchymal Conversion

2000 • 35 citations

All-trans retinoic acid compromises desmosome expression in human epidermis

1998 • 32 citations

Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids.

1997 • 28 citations

Activation of protein kinase C modulates cell-cell and cell-substratum adhesion of a human colorectal carcinoma cell line and restores ?normal? epithelial morphology

1999 • 23 citations