‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

2001 • 2,167 citations

Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc

2001 • 945 citations

Viscoelastic properties of vimentin compared with other filamentous biopolymer networks.

1991 • 694 citations

Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis

1999 • 639 citations

Caspase Cleavage of Keratin 18 and Reorganization of Intermediate Filaments during Epithelial Cell Apoptosis

1997 • 596 citations

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells

1998 • 527 citations

Human keratin diseases: the increasing spectrum of disease and subtlety of the phenotype-genotype correlation

1999 • 393 citations

Are desmosomes more than tethers for intermediate filaments?

2000 • 388 citations

Intermediate filament interactions can be altered by HSP27 and αB-crystallin

1999 • 359 citations

Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice.

1994 • 304 citations

Genes for intermediate filament proteins and the draft sequence of the human genome

2001 • 285 citations

The Catalog of Human Hair Keratins

2001 • 270 citations

The Catalog of Human Hair Keratins

1999 • 270 citations

Keratin-Dependent, Epithelial Resistance to Tumor Necrosis Factor-Induced Apoptosis

2000 • 266 citations

The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14.

1995 • 263 citations

Mid-gestational lethality in mice lacking keratin 8.

1993 • 247 citations

Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation

2001 • 241 citations

Apoptosis Generates Stable Fragments of Human Type I Keratins

1997 • 230 citations

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

1998 • 218 citations

Lessons from Keratin 18 Knockout Mice: Formation of Novel Keratin Filaments, Secondary Loss of Keratin 7 and Accumulation of Liver-specific Keratin 8-Positive Aggregates

1998 • 205 citations

Mallory bodies revisited

2000 • 205 citations

Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes

1999 • 191 citations

The cytoskeleton of digestive epithelia in health and disease

1999 • 187 citations

Keratin modifications and solubility properties in epithelial cells and in vitro.

1998 • 179 citations

An autonomous folding unit mediates the assembly of two-stranded coiled coils

1998 • 177 citations

The Function of Plakophilin 1 in Desmosome Assembly and Actin Filament Organization

2000 • 174 citations

The ‘ins’ and ‘outs’ of intermediate filament organization

2000 • 173 citations

Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2

1998 • 172 citations

Modulation of Cell Proliferation by Cytokeratins K10 and K16

1999 • 170 citations

Keratin attenuates tumor necrosis factor–induced cytotoxicity through association with TRADD

2001 • 169 citations

Keratin 8 Mutations in Patients with Cryptogenic Liver Disease

2001 • 169 citations

Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality

2000 • 162 citations

Keratins Turn over by Ubiquitination in a Phosphorylation-Modulated Fashion

2000 • 162 citations

Bridging cytoskeletal intersections

2001 • 156 citations

Active Caspases and Cleaved Cytokeratins Are Sequestered into Cytoplasmic Inclusions in Trail-Induced Apoptosis

2000 • 156 citations

Insights into the Dynamic Properties of Keratin Intermediate Filaments in Living Epithelial Cells

2001 • 156 citations

Delayed Wound Healing in Keratin 6a Knockout Mice

2000 • 151 citations

A 'hot-spot' mutation alters the mechanical properties of keratin filament networks

2001 • 146 citations

The intermediate filament protein consensus motif of helix 2B: its atomic structure and contribution to assembly

2000 • 143 citations

Cytokeratin 8 Protects from Hepatotoxicity, and Its Ratio to Cytokeratin 18 Determines the Ability of Hepatocytes to Form Mallory Bodies

2000 • 143 citations

A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

1998 • 142 citations

Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix

2001 • 126 citations

Cytokeratins 8 and 19 in the Mouse Placental Development

2000 • 123 citations

Keratin 12-deficient mice have fragile corneal epithelia.

1996 • 122 citations

The wound repair-associated keratins 6, 16, and 17. Insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture.

1998 • 121 citations

Formation of a Normal Epidermis Supported by Increased Stability of Keratins 5 and 14 in Keratin 10 Null Mice

2001 • 119 citations

Divide-and-conquer crystallographic approach towards an atomic structure of intermediate filaments

2001 • 118 citations

Inhibition of Protein Kinase B (PKB) and PKCζ Mediates Keratin K10-Induced Cell Cycle Arrest

2001 • 117 citations

Specialized keratin expression pattern in human ridged skin as an adaptation to high physical stress

1998 • 116 citations

Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia

2001 • 115 citations

A distinct 14 residue site triggers coiled-coil formation in cortexillin I

1998 • 115 citations

Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia

2001 • 113 citations

A highly conserved lysine residue on the head domain of type II keratins is essential for the attachment of keratin intermediate filaments to the cornified cell envelope through isopeptide crosslinking by transglutaminases

1998 • 111 citations

Effects of Keratin 14 Ablation on the Clinical and Cellular Phenotype in a Kindred with Recessive Epidermolysis Bullosa Simplex

1996 • 108 citations

Complete Cytolysis and Neonatal Lethality in Keratin 5 Knockout Mice Reveal Its Fundamental Role in Skin Integrity and in Epidermolysis Bullosa Simplex

2001 • 107 citations

Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b

2001 • 103 citations

Introducing a Null Mutation in the Mouse K6α and K6β Genes Reveals Their Essential Structural Role in the Oral Mucosa

2000 • 102 citations

A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells

1998 • 102 citations

Mutation of a Major Keratin Phosphorylation Site Predisposes to Hepatotoxic Injury in Transgenic Mice

1998 • 100 citations

Functional Differences between Keratins of Stratified and Simple Epithelia

1998 • 94 citations

In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments

2000 • 93 citations

Identification of Mrj, a DnaJ/Hsp40 Family Protein, as a Keratin 8/18 Filament Regulatory Protein

2000 • 92 citations

Pairwise Assembly Determines the Intrinsic Potential for Self-Organization and Mechanical Properties of Keratin Filaments

2002 • 89 citations

Effect of Mutation and Phosphorylation of Type I Keratins on Their Caspase-mediated Degradation

2001 • 87 citations

Inflammatory Versus Proliferative Processes in Epidermis

2000 • 86 citations

Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype

2000 • 85 citations

Coiled-Coil Trigger Motifs in the 1B and 2B Rod Domain Segments Are Required for the Stability of Keratin Intermediate Filaments

2000 • 85 citations

Detection of cytokeratin dynamics by time-lapse fluorescence microscopy in living cells

1999 • 84 citations

The Two Functional Keratin 6 Genes of Mouse Are Differentially Regulated and Evolved Independently from Their Human Orthologs

1998 • 81 citations

An Alu Element from the K18 Gene Confers Position-independent Expression in Transgenic Mice

2000 • 75 citations

Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype

2000 • 74 citations

Focal Activation of a Mutant Allele Defines the Role of Stem Cells in Mosaic Skin Disorders

2001 • 73 citations

K15 Expression Implies Lateral Differentiation within Stratified Epithelial Basal Cells

2000 • 73 citations

The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro

2001 • 68 citations

Dose-dependent linkage, assembly inhibition and disassembly of vimentin and cytokeratin 5/14 filaments through plectin’s intermediate filament-binding domain

2000 • 66 citations

Increased Levels of Keratin 16 Alter Epithelialization Potential of Mouse Skin Keratinocytes In Vivo and Ex Vivo

2001 • 65 citations

Mouse Keratin 4 Is Necessary for Internal Epithelial Integrity

1998 • 63 citations

Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells

2001 • 61 citations

Identification of 12-Lipoxygenase Interaction with Cellular Proteins by Yeast Two-Hybrid Screening

2000 • 60 citations

A Novel Keratin 5 Mutation (K5V186L) in a Family with EBS-K: a Conservative Substitution Can Lead to Development of Different Disease Phenotypes

2001 • 54 citations

The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

1999 • 53 citations

A keratin 14 ‘knockout’ mutation in recessive epidermolysis bullosa simplex resulting in less severe disease

2000 • 51 citations

Forced Expression of Keratin 16 Alters the Adhesion, Differentiation, and Migration of Mouse Skin Keratinocytes

2000 • 50 citations

Unraveling double stranded ?-helical coiled coils: An x-ray diffraction study on hard ?-keratin fibers

2001 • 48 citations

Simple epithelial keratins are dispensable for cytoprotection in two pancreatitis models

2000 • 45 citations

A Unique Type I Keratin Intermediate Filament Gene Family is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles

2001 • 41 citations

In vitro characteristics of early epidermal progenitors isolated from keratin 14 (K14)-deficient mice: Insights into the role of keratin 17 in mouse keratinocytes

1999 • 40 citations

Characterization of the Major Physiologic Phosphorylation Site of Human Keratin 19 and Its Role in Filament Organization

1999 • 37 citations

Apoptosis-induced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line

2001 • 33 citations

A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos

2001 • 32 citations

Early perturbations in keratin and actin gene expression and fibrillar organisation in griseofulvin-fed mouse liver

2000 • 32 citations

Dissection of Protein Linkage between Keratins and Pinin, a Protein with Dual Location at Desmosome-Intermediate Filament Complex and in the Nucleus

2000 • 31 citations

Effects of Keratin Filament Disruption on Exocrine Pancreas-Stimulated Secretion and Susceptibility to Injury

2000 • 30 citations

Novel insights into intermediate-filament function from studies of transgenic and knockout mice

2000 • 28 citations

Characterisation and tissue-specific expression of the two keratin subfamilies of intermediate filament proteins in the cephalochordate Branchiostoma

2000 • 26 citations

The epidermal intermediate filament proteins of tunicates are distant keratins; a polymerisation-competent hetero coiled coil of the Styela D protein and Xenopus keratin 8

2000 • 24 citations

Analysis of Mouse Keratin 6a Regulatory Sequences in Transgenic Mice Reveals Constitutive, Tissue-Specific Expression by a Keratin 6a Minigene

2000 • 16 citations

The RNA polymerase II core subunit 11 interacts with keratin 19, a component of the intermediate filament proteins

1999 • 10 citations