Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

1998 • 1,139 citations

A Pathogenetic Role for TNFα in the Syndrome of Cachexia, Arthritis, and Autoimmunity Resulting from Tristetraprolin (TTP) Deficiency

1996 • 742 citations

[35] Epitope tagging and protein surveillance

1991 • 526 citations

Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells

1995 • 493 citations

Modulation of the Fate of Cytoplasmic mRNA by AU-Rich Elements: Key Sequence Features Controlling mRNA Deadenylation and Decay

1997 • 352 citations

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.

1991 • 293 citations

Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein.

1990 • 247 citations

A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence.

1990 • 247 citations

[12] Systems for polyacrylamide gel electrophoresis

1984 • 208 citations

A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm.

1994 • 164 citations

The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat.

1991 • 162 citations

AU RNA-binding factors differ in their binding specificities and affinities.

1992 • 157 citations

Functional Characterization of a Non-AUUUA AU-Rich Element from the c-jun Proto-Oncogene mRNA: Evidence for a Novel Class of AU-Rich Elements

1996 • 154 citations

Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.

1992 • 150 citations

Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction.

1997 • 140 citations

Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate.

1989 • 135 citations

Phosphorylation of Tristetraprolin, a Potential Zinc Finger Transcription Factor, by Mitogen Stimulation in Intact Cells and by Mitogen-activated Protein Kinase in Vitro

1995 • 129 citations

Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones.

1988 • 113 citations

Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay.

1994 • 109 citations

An analysis of the rate of metallothionein mRNA POLY(A)-shortening using RNA blot hybridization

1985 • 108 citations

Metal binding properties and secondary structure of the zinc-binding domain of Nup475

1996 • 106 citations

Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor.

1996 • 104 citations

The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes

1991 • 91 citations

The nucleotide sequence of a cDNA encoding an EGF-inducible gene indicates the existence of a new family of mitogen-induced genes.

1990 • 78 citations

Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth

1996 • 77 citations

AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm

1994 • 75 citations

Promoter Analysis of Zfp-36 the Mitogen-inducible Gene Encoding the Zinc Finger Protein Tristetraprolin

1995 • 69 citations

A Human Putative Lymphocyte G₀/G₁Switch Gene Homologous to a Rodent Gene Encoding a Zinc-Binding Potential Transcription Factor

1993 • 63 citations

Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression

1999 • 60 citations

A corrected sequence for the predicted protein from the mitogen-inducible TIS11 primary response gene.

1991 • 51 citations

Role of AUUU sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells

1991 • 48 citations

Characteristics of the Intron Involvement in the Mitogen-induced Expression of Zfp-36

1998 • 48 citations

Two Distinct Regions in the 3′ Untranslated Region of Tumor Necrosis Factor Alpha mRNA Form Complexes with Macrophage Proteins

1996 • 47 citations

Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA.

1997 • 46 citations

Mapping of a Minimal AU-rich Sequence Required for Lipopolysaccharide-induced Binding of a 55-kDa Protein on Tumor Necrosis Factor-α mRNA

1998 • 41 citations

Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA

1998 • 41 citations

The Drosophila TIS11 homologue encodes a developmentally controlled gene.

1994 • 36 citations

The yeast homologue YTIS11, of the mammalian TIS11 gene family is a non-essential, glucose repressible gene.

1995 • 36 citations

ERF-2, the human homologue of the murine Tis11d early response gene

1995 • 35 citations

Association of AUUUA-binding Protein with A + U-rich mRNA during nucleo-cytoplasmic transport

1992 • 33 citations

Haematologic effects of TNF

1993 • 30 citations

Engagement of Tumor Necrosis Factor mRNA by an Endotoxin-Inducible Cytoplasmic Protein

1996 • 26 citations

Binding of a protein to an AU-rich domain of tumour necrosis factor α mRNA as a 35 kDa complex and its regulation in primary rat astrocytes

1996 • 9 citations