Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

1992 • 648 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

1994 • 458 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

1989 • 406 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative RhoRac guanine nucleotide exchange factor

1994 • 297 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

Oncogene ect2 is related to regulators of small GTP-binding proteins

1993 • 281 citations

Isolation of a new human oncogene from a diffuse B-cell lymphoma

1985 • 210 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle.

1993 • 186 citations

A familial syndrome of short stature associated with facial dysplasia and genital anomalies

1970 • 177 citations

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

1995 • 162 citations

Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function

1995 • 156 citations

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.

1994 • 134 citations

Direct Stimulation of Vav Guanine Nucleotide Exchange Activity for Ras by Phorbol Esters and Diglycerides

1994 • 132 citations

Signal transduction in T lymphocytes using a conditional allele of Sos.

1995 • 131 citations

A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.

1991 • 129 citations

ADP-ribosylation of the proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells

1990 • 126 citations

Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.

1995 • 124 citations

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.

1994 • 119 citations

Signalling properties of lysophosphatidic acid

1993 • 112 citations

The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

1995 • 111 citations

Vav Is Necessary for Prolactin-stimulated Proliferation and Is Translocated into the Nucleus of a T-cell Line

1995 • 111 citations

Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products.

1994 • 108 citations

Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor.

1994 • 90 citations

The Dbl Oncogene Product as a GDP/GTP Exchange Protein for the Rho Family: Its Properties in Comparison with Those of Smg GDS

1994 • 81 citations

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.

1994 • 78 citations

Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor.

1995 • 77 citations

Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain

1993 • 70 citations

The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins.

1993 • 69 citations

Inhibition of hematopoietic development from embryonic stem cells by antisense vav RNA.

1993 • 60 citations

Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells.

1994 • 57 citations

Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins.

1994 • 56 citations

Examination of human tumors for rhoA mutations.

1994 • 50 citations

Hematopoietic development of vav-/- mouse embryonic stem cells.

1994 • 49 citations

Alteration of the genomes of tumor cells

1983 • 28 citations

Reflectance in situ hybridization (RISH): detection, by confocal reflectance laser microscopy, of gold‐labelled riboprobes in breast cancer cell lines and histological specimens

1994 • 24 citations

Independently activated dbl oncogenes exhibit similar yet distinct structural alterations.

1987 • 21 citations

Expression of the dbl proto-oncogene in Ewing's sarcomas.

1989 • 15 citations

Dominant dysplasia of the lens in transgenic mice expressing the dbl oncogene.

1991 • 13 citations

DBL Expression Driven by the Neuron Specific Enolase Promoter Induces Tumor Formation in Transgenic Mice with a P53(±) Genetic Background

1995 • 12 citations

Effects of herbimycin A and its derivatives on growth and differentiation of Ph1-positive acute lymphoid leukemia cell lines

1994 • 11 citations

Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin.

1991 • 11 citations

Co-regulated expression of dbl and poly(ADP-ribose) polymerase in Ewing's sarcoma cells and dbl-transformed NIH3T3 fibroblasts.

1995 • 3 citations

Preferential expression of the dbl proto-oncogene in some neuroectodermal tumors.

1990 • 2 citations