The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q

Chromosomal translocations in human cancer

1994 • 1,551 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

Chronic myelomonocytic leukemia in childhood. A retrospective analysis of 110 cases.

1997 • 398 citations

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993 • 392 citations

An SH3 Domain-Containing GTPase-Activating Protein for Rho and Cdc42 Associates with Focal Adhesion Kinase

1996 • 337 citations

The role of chromosome translocations in leukemogenesis.

1999 • 301 citations

The Ras superfamily of GTPases ¹

1996 • 269 citations

MLL rearrangements in haematological malignancies: lessons from clinical and biological studies

1999 • 266 citations

The 5q-syndrome

1994 • 256 citations

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

1997 • 252 citations

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.

1994 • 241 citations

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia

2000 • 223 citations

Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

1995 • 211 citations

The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo

1995 • 182 citations

Long PCR

1994 • 171 citations

Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1–1.5 Mb and preparation of a PAC-based physical map

1997 • 154 citations

Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

1994 • 149 citations

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

1993 • 139 citations

Ten novel 11q23 chromosomal partner sites

1998 • 131 citations

5q-, twenty-five years later: a Synopsis

1997 • 124 citations

Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth

1999 • 108 citations

Cytoskeletal changes induced by GRAF, the <u>G</u>TPase <u>r</u>egulator <u>a</u>ssociated with <u>f</u>ocal adhesion kinase, are mediated by Rho

1999 • 100 citations

Molecular Mapping of Uncharacteristically Small 5q Deletions in Two Patients with the 5q- Syndrome: Delineation of the Critical Region on 5q and Identification of a 5q- Breakpoint

1994 • 91 citations

Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis.

1995 • 85 citations

Tumour suppressor genes in disease and therapy

1995 • 63 citations

Activity and nature of p21 ^WAF1 complexes during the cell cycle

1998 • 61 citations

Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q- chromosome in some patients with the 5q- syndrome

1993 • 58 citations

Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases.

1996 • 56 citations

Chromosome 11q23 translocations in both infant and adult acute leukemias are detected by in situ hybridization with a yeast artificial chromosome

1992 • 47 citations

Checking on the cell cycle

1998 • 39 citations

Deletions of chromosome 5 in malignant myeloid disorders

1993 • 37 citations

Chromosome 11q23 translocations in both infant and adult acute leukemias are detected by in situ hybridization with a yeast artificial chromosome

1992 • 34 citations

Anatomy of the 5q- deletion: different sex ratios and deleted 5q bands in MDS and AML.

1996 • 33 citations

Cancer genes and hematopoiesis

1994 • 25 citations

Tumor suppressor genes

1995 • 24 citations

Novel Genes Mapping to the Critical Region of the 5q− Syndrome

1997 • 19 citations

5q-: pathogenetic importance of the common deleted region and clinical consequences of the entire deleted segment.

1993 • 15 citations

Acute myeloid leukemia with t(5;11): two case reports

1999 • 11 citations

A new fingerprint method for sequence analysis of chromosomal translocations at the genomic DNA level

1998 • 10 citations

Chimaeric oncoproteins resulting from chromosomal translocations in acute lymphoblastic leukaemia.

1993 • 9 citations

The isolation of a yeast artificial chromosome which spans the chromosome 11q23 region involved in a number of translocations in acute leukaemias.

1993 • 2 citations