Lipid rafts in T cell receptor signalling (Review)

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Lipid Rafts

2003 • 1,485 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

LAT

1998 • 1,251 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

The Immunological Synapse

2001 • 987 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism

1999 • 850 citations

Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors

2003 • 839 citations

LAT Palmitoylation

1998 • 837 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

Single-Molecule Microscopy Reveals Plasma Membrane Microdomains Created by Protein-Protein Networks that Exclude or Trap Signaling Molecules in T Cells

2005 • 748 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Triton Promotes Domain Formation in Lipid Raft Mixtures

2002 • 547 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Sphingolipid organization in biomembranes: what physical studies of model membranes reveal

1998 • 484 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

2000 • 457 citations

The role of lipid rafts in T cell antigen receptor (TCR) signalling

2000 • 453 citations

Ultrafine Membrane Compartments for Molecular Diffusion as Revealed by Single Molecule Techniques

2004 • 429 citations

Structures of Src-family tyrosine kinases

1997 • 377 citations

S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

1997 • 364 citations

Staging and resetting T cell activation in SMACs

2002 • 343 citations

Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes

2000 • 338 citations

TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts

2002 • 330 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.

1993 • 318 citations

Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.

1996 • 312 citations

Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

2001 • 301 citations

CD45: new jobs for an old acquaintance

2001 • 286 citations

Positive and negative regulation of T-cell activation through kinases and phosphatases

2003 • 273 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

Lipid microdomains in cell surface membranes

1997 • 245 citations

Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction.

1994 • 240 citations

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

2002 • 225 citations

LIGAND RECOGNITION BY T CELL RECEPTORS

1998 • 207 citations

Lipid raft proteins have a random distribution during localized activation of the T-cell receptor

2004 • 200 citations

Proximal protein tyrosine kinases in immunoreceptor signaling

2001 • 189 citations

Phosphorylation-Dependent Regulation of T-Cell Activation by PAG/Cbp, a Lipid Raft-Associated Transmembrane Adaptor

2003 • 188 citations

Alterations in Lipid Raft Composition and Dynamics Contribute to Abnormal T Cell Responses in Systemic Lupus Erythematosus

2004 • 181 citations

Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).

1990 • 173 citations

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

2002 • 165 citations

Altered lipid raft–associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus

2004 • 165 citations

Altered lipid raft–associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus

2004 • 164 citations

Release from Tonic Inhibition of T Cell Activation through Transient Displacement of C-terminal Src Kinase (Csk) from Lipid Rafts

2001 • 155 citations

Selective Accumulation of Raft-Associated Membrane Protein Lat in T Cell Receptor Signaling Assemblies

2000 • 154 citations

Cutting Edge: The CD45 Tyrosine Phosphatase Is an Inhibitor of Lck Activity in Thymocytes

1999 • 135 citations

Lipid Raft Distribution of CD4 Depends on its Palmitoylation and Association with Lck, and Evidence for CD4-Induced Lipid Raft Aggregation as an Additional Mechanism to Enhance CD3 Signaling

2003 • 134 citations

Negative regulation of Lck by Cbl ubiquitin ligase

2002 • 128 citations

Mass spectrometric characterization of proteins extracted from Jurkat T cell detergent-resistant membrane domains

2001 • 122 citations

Cutting Edge: Fyn Is Essential for Tyrosine Phosphorylation of Csk-Binding Protein/Phosphoprotein Associated with Glycolipid-Enriched Microdomains in Lipid Rafts in Resting T Cells

2002 • 120 citations

Membrane compartmentation and the response to antigen

1999 • 118 citations

Recruitment of Slp-76 to the Membrane and Glycolipid-Enriched Membrane Microdomains Replaces the Requirement for Linker for Activation of T Cells in T Cell Receptor Signaling

2000 • 114 citations

Involvement of SHP-1 Tyrosine Phosphatase in TCR-Mediated Signaling Pathways in Lipid Rafts

2001 • 109 citations

LIME

2003 • 104 citations

T-cell receptor-CD4 physical association in a murine T-cell hybridoma: induction by antigen receptor ligation.

1989 • 103 citations

The amplification of TCR signaling by dynamic membrane microdomains

2001 • 100 citations

Regulation of T‐cell receptor signalling by membrane microdomains

2004 • 97 citations

The TCR Triggering Puzzle

2001 • 96 citations

LIME, a Novel Transmembrane Adaptor Protein, Associates with p56lck and Mediates T Cell Activation

2003 • 93 citations

Signals Determining Protein Tyrosine Kinase and Glycosyl-Phosphatidylinositol-Anchored Protein Targeting to a Glycolipid-Enriched Membrane Fraction

1994 • 88 citations

CD2ϵ and CD3ξ cytoplasmic domains can independently generate signals for T cell development and function

1995 • 85 citations

Dynamic Association of CD45 with Detergent-Insoluble Microdomains in T Lymphocytes

2002 • 76 citations

CD4 Raft Association and Signaling Regulate Molecular Clustering at the Immunological Synapse Site

2004 • 71 citations

Palmitylation of an Amino-Terminal Cysteine Motif of Protein Tyrosine Kinases p56^lckand p59^fynMediates Interaction With Glycosyl-Phosphatidylinositol-Anchored Proteins

1993 • 66 citations

Membrane Raft-Dependent Regulation of Phospholipase Cγ-1 Activation in T Lymphocytes

2001 • 64 citations

Mechanism of Lck Recruitment to the T‐Cell Receptor Cluster as Studied by Single‐Molecule‐Fluorescence Video Imaging

2003 • 64 citations

Human CD8⁺T cells do not require the polarization of lipid rafts for activation and proliferation

2002 • 56 citations

p56^Lckanchors CD4 to distinct microdomains on microvilli

2002 • 52 citations

Cutting Edge: Localization of Linker for Activation of T Cells to Lipid Rafts Is Not Essential in T Cell Activation and Development

2005 • 52 citations

Physiological T cell activation starts and propagates in lipid rafts

2003 • 45 citations

Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells

2003 • 42 citations

Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase.

1992 • 41 citations

The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling

2002 • 34 citations

T-lymphocyte signalling in systemic lupus erythematosus: a lipid raft perspective

2004 • 25 citations

Regulation of expression and function of Lck tyrosine kinase by high cell density

2005 • 1 citations

Cited By (0)

Loading...