LIME, a Novel Transmembrane Adaptor Protein, Associates with p56lck and Mediates T Cell Activation

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

LAT

1998 • 1,251 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

LAT Palmitoylation

1998 • 837 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

2000 • 457 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

Recognition and specificity in protein tyrosine kinase-mediated signalling

1995 • 367 citations

TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts

2002 • 330 citations

The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

1999 • 325 citations

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

1999 • 252 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Floating the Raft Hypothesis

2001 • 226 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

Non–T Cell Activation Linker (NTAL)

2002 • 203 citations

Dynamics of p56lck Translocation to the T Cell Immunological Synapse following Agonist and Antagonist Stimulation

2002 • 166 citations

LAB: A new membrane-associated adaptor molecule in B cell activation

2003 • 154 citations

Differential association of phosphatases with hematopoietic co‐receptors bearing immunoreceptor tyrosine‐based inhibition motifs

1997 • 143 citations

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

1998 • 131 citations

T Cell Receptor (TCR) Interacting Molecule (TRIM), A Novel Disulfide-linked Dimer Associated with the TCR–CD3–ζ Complex, Recruits Intracellular Signaling Proteins to the Plasma Membrane

1998 • 129 citations

In the Immune Synapse, ZAP-70 Controls T Cell Polarization and Recruitment of Signaling Proteins but Not Formation of the Synaptic Pattern

2002 • 125 citations

The role of membrane-associated adaptors in T cell receptor signalling

2000 • 111 citations

LAT, the Linker for Activation of T Cells: A Bridge Between T Cell-Specific and General Signaling Pathways

2000 • 111 citations

Superantigen-Induced T Cell:B Cell Conjugation Is Mediated by LFA-1 and Requires Signaling Through Lck, But Not ZAP-70

2001 • 104 citations

Molecular Cloning of SKAP55, a Novel Protein That Associates with the Protein Tyrosine Kinase p59 in Human T-lymphocytes

1997 • 102 citations

Ribp, a Novel Rlk/Txk- and Itk-Binding Adaptor Protein That Regulates T Cell Activation

1999 • 99 citations

Lad, an Adapter Protein Interacting with the SH2 Domain of p56lck, Is Required for T Cell Activation

1999 • 71 citations

SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation

1999 • 70 citations

The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production.

1997 • 57 citations

Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase.

1992 • 41 citations

Genetic Evidence of a Role for Lck in T-Cell Receptor Function Independent or Downstream of ZAP-70/Syk Protein Tyrosine Kinases

1998 • 29 citations

Non-receptor protein tyrosine kinases as immune targets of viruses

1997 • 25 citations

Adaptor Protein Lad Relays PDGF Signal to Grb2 in Lung Cells: A Tissue-Specific PDGF Signal Transduction

2001 • 21 citations

Tyrosine Phosphorylation-dependent Yeast Two-Hybrid System for the Identification of the SH2 Domain-binding Proteins

2001 • 9 citations