CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

LAT Palmitoylation

1998 • 837 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

2000 • 457 citations

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

1989 • 425 citations

Relationship of Lipid Rafts to Transient Confinement Zones Detected by Single Particle Tracking

2002 • 418 citations

The structure and ligand interactions of CD2: implications for T-cell function

1996 • 397 citations

Structures of Src-family tyrosine kinases

1997 • 377 citations

S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

1997 • 364 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

The EGF receptor: a nexus for trafficking and signaling

2000 • 346 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.

1996 • 312 citations

A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.

1989 • 303 citations

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

1993 • 288 citations

The O-glycosylated Stalk Domain Is Required for Apical Sorting of Neurotrophin Receptors in Polarized MDCK Cells

1997 • 279 citations

Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

1998 • 268 citations

The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation.

1991 • 266 citations

Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

2002 • 263 citations

An Inactivating Point Mutation in the Inhibitory Wedge of CD45 Causes Lymphoproliferation and Autoimmunity

2000 • 249 citations

CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.

1993 • 243 citations

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

2002 • 225 citations

Leucocyte Antigen Facts Book

1997 • 193 citations

Positive and negative regulation of Src-family membrane kinases by CD45

1999 • 184 citations

Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton- insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes

1996 • 172 citations

Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.

1994 • 163 citations

O-linked glycans mediate apical sorting of human intestinal sucrase-isomaltase through association with lipid rafts

1999 • 158 citations

Distinct Patterns of Membrane Microdomain Partitioning in Th1 and Th2 Cells

2001 • 157 citations

Release from Tonic Inhibition of T Cell Activation through Transient Displacement of C-terminal Src Kinase (Csk) from Lipid Rafts

2001 • 155 citations

Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases

2002 • 147 citations

Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains

1999 • 143 citations

Regulation of TCR Signaling by CD45 Lacking Transmembrane and Extracellular Domains

1993 • 138 citations

Microdomain-dependent Regulation of Lck and Fyn Protein-Tyrosine Kinases in T Lymphocyte Plasma Membranes

1999 • 136 citations

Cutting Edge: The CD45 Tyrosine Phosphatase Is an Inhibitor of Lck Activity in Thymocytes

1999 • 135 citations

Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases

2002 • 130 citations

N-Terminal Protein Acylation Confers Localization to Cholesterol, Sphingolipid-enriched Membranes But Not to Lipid Rafts/Caveolae

2001 • 123 citations

Second Cysteine-rich Region of Epidermal Growth Factor Receptor Contains Targeting Information for Caveolae/Rafts

2002 • 120 citations

Rescue of Signaling by a Chimeric Protein Containing the Cytoplasmic Domain of CD45

1993 • 112 citations

CD28 affects the earliest signaling events generated by TCR engagement

1998 • 110 citations

Differential Association of CD45 Isoforms with CD4 and CD8 Regulates the Actions of Specific Pools of p56lck Tyrosine Kinase in T Cell Antigen Receptor Signal Transduction

2002 • 103 citations

Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

1997 • 102 citations

Both T cell receptor (TcR)‐CD3 complex and CD2 increase the tyrosine kinase activity of p56^lck. CD2 can mediate TcR‐CD3‐independent and CD45‐dependent activation of p56^lck

1992 • 91 citations

Evidence for monomeric and dimeric forms of CD45 associated with a 30-kDa phosphorylated protein.

1992 • 85 citations

Lipid rafts mediate biosynthetic transport to the T lymphocyte uropod subdomain and are necessary for uropod integrity and function

2002 • 83 citations

Dynamic Association of CD45 with Detergent-Insoluble Microdomains in T Lymphocytes

2002 • 76 citations

Biochemical Association of CD45 with the T Cell Receptor Complex

1999 • 70 citations

The mode of anchorage to the cell surface determines both the function and the membrane location of Thy-1 glycoprotein

1994 • 59 citations

Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1

2000 • 52 citations

Raft membrane domains and immunoreceptor functions

2001 • 37 citations

Structural study of the O‐linked sugar chains of human leukocyte tyrosine phosphatase CD45

1998 • 34 citations

Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling

2002 • 33 citations