Selective Accumulation of Raft-Associated Membrane Protein Lat in T Cell Receptor Signaling Assemblies

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

LAT

1998 • 1,251 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

LAT Palmitoylation

1998 • 837 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?

1997 • 512 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

The role of lipid rafts in T cell antigen receptor (TCR) signalling

2000 • 453 citations

Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.

1994 • 389 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

1997 • 364 citations

Interaction of Shc with the ζ Chain of the T Cell Receptor Upon T Cell Activation

1993 • 343 citations

Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes

2000 • 338 citations

Critical Role for Cholesterol in Lyn-mediated Tyrosine Phosphorylation of FcεRI and Their Association with Detergent-resistant Membranes

1999 • 327 citations

Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells : accumulation of actin regulated by local tyrosine phosphorylation

1999 • 316 citations

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

2000 • 295 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

GPI-microdomains: a role in signalling via immunoreceptors

1999 • 270 citations

The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers

2000 • 254 citations

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

1999 • 252 citations

Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent Mechanism

1998 • 247 citations

T cell antigen-receptor signal transduction

1999 • 240 citations

Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction.

1994 • 240 citations

A Pore-forming Toxin Interacts with a GPI-anchored Protein and Causes Vacuolation of the Endoplasmic Reticulum

1998 • 221 citations

Regulation of antigen receptor signal transduction by protein tyrosine kinases

1996 • 179 citations

Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

2000 • 178 citations

Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton- insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes

1996 • 172 citations

Localization of LAT in Glycolipid-enriched Microdomains Is Required for T cell Activation

1999 • 166 citations

T-cell signaling: The importance of receptor clustering

1997 • 155 citations

Large-scale co-aggregation of fluorescent lipid probes with cell surface proteins.

1994 • 146 citations

Membrane organization in immunoglobulin E receptor signaling

1999 • 135 citations

Microdomains in lymphocyte signalling: beyond GPI-anchored proteins

2000 • 135 citations

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.

1996 • 130 citations

Membrane compartmentation and the response to antigen

1999 • 118 citations

Noncovalent associations of T lymphocyte surface proteins

1996 • 111 citations

The role of membrane-associated adaptors in T cell receptor signalling

2000 • 111 citations

Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction

1999 • 110 citations

Dual Fatty Acylation of p59Fyn Is Required for Association with the T Cell Receptor ζ Chain through Phosphotyrosine–Src Homology Domain-2 Interactions

1999 • 105 citations

Quantitative Contribution of CD4 and CD8 to T Cell Antigen Receptor Serial Triggering

1997 • 94 citations

Signals Determining Protein Tyrosine Kinase and Glycosyl-Phosphatidylinositol-Anchored Protein Targeting to a Glycolipid-Enriched Membrane Fraction

1994 • 88 citations

CD4 segregates into specific detergent‐resistant T‐cell membrane microdomains

1999 • 56 citations

Thy-1/CD3 coengagement promotes TCR signaling and enhances particularly tyrosine phosphorylation of the raft molecule LAT

1999 • 32 citations

Sustained T cell receptor-mediated Ca2+ responses rely on dynamic engagement of receptors.

1996 • 18 citations

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