Pathways for self-tolerance and the treatment of autoimmune diseases

The Fas Death Factor

1995 • 4,070 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Innate Immunity

2000 • 1,715 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms

1998 • 1,516 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

Consequences of Cell Death

2000 • 1,382 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

1999 • 973 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

Defective IL7R expression in T-B+NK+ severe combined immunodeficiency

1998 • 805 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

The Influence of Antigen Organization on B Cell Responsiveness

1993 • 701 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Cellular Mechanisms of Immunologic Tolerance

1983 • 521 citations

Regulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex

2000 • 513 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

CD95(APO-1/Fas)-Mediated Apoptosis: Live and Let Die

1998 • 405 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Costimulatory regulation of T cell function

1999 • 391 citations

DIVERGENT ROLES FOR F<scp>c</scp>RECEPTORS AND COMPLEMENT IN VIVO

1998 • 376 citations

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

1994 • 340 citations

Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts

1999 • 322 citations

POSITIVE VERSUS NEGATIVE SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1998 • 320 citations

Homeostasis of αβ TCR+ T cells

2000 • 251 citations

Endotoxin, Toll-like receptor 4, and the afferent limb of innate immunity

2000 • 238 citations

Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor κb Activation

2000 • 215 citations

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

2000 • 212 citations

Infectious tolerance

1998 • 198 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

Links between complement abnormalities and systemic lupus erythematosus

2000 • 156 citations

Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.

1994 • 156 citations

Role of pro-inflammatory cytokines in rheumatoid arthritis

1998 • 154 citations

From genome to aetiology in a multifactorial disease, type 1 diabetes

1999 • 143 citations

Regulation of autoimmunity by proinflammatory cytokines

1998 • 140 citations

Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA.

1982 • 131 citations

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

1994 • 89 citations

gp96—The immune system's Swiss army knife

2000 • 89 citations

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

2000 • 71 citations

Tumor necrosis factor-a and the progression of diabetes in non-obese diabetic mice

1999 • 70 citations

Self-reactive B Cells Are Not Eliminated or Inactivated by Autoantigen Expressed on Thyroid Epithelial Cells

1997 • 70 citations

T cells: A proliferation of costimulatory molecules

2000 • 57 citations

Immunologic privilege of the eye

1999 • 43 citations

MHC structure and autoimmune T cell repertoire development

1999 • 41 citations

The initiation of autoimmune diabetes

1999 • 38 citations

Growing up on the streets: why B-cell development differs from T-cell development

1999 • 38 citations