Growing up on the streets: why B-cell development differs from T-cell development

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization.

1982 • 665 citations

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

1975 • 623 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

1994 • 541 citations

Cellular Mechanisms of Immunologic Tolerance

1983 • 521 citations

Selective Events in T Cell Development

1994 • 486 citations

Most peripheral B cells in mice are ligand selected.

1991 • 424 citations

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

1994 • 340 citations

Differentiation of lymphocytes in mouse bone marrow

1974 • 305 citations

Evolution of Class-I MHC Genes and Proteins: From Natural Selection to Thymic Selection

1990 • 286 citations

Distinct short‐lived and long‐lived antibody‐producing cell populations

1986 • 276 citations

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

1995 • 274 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions.

1993 • 250 citations

Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics.

1992 • 246 citations

Expression and functional significance of the J11d marker on mouse thymocytes.

1987 • 218 citations

Immune Response(Ir)Genes of the Murine Major Histocompatibility Complex

1986 • 217 citations

Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.

1990 • 203 citations

Thymic selection: a matter of life and death

1992 • 184 citations

Regulation of Anti–double-stranded DNA B Cells in Nonautoimmune Mice: Localization to the T–B Interface of the Splenic Follicle

1997 • 176 citations

Differentiation potential of subsets of CD4−8− thymocytes

1987 • 169 citations

Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response.

1983 • 135 citations

Unresponsiveness to a foreign antigen can be caused by self-tolerance

1988 • 134 citations

The turnover of B-cell populations

1993 • 115 citations

Influence of the Major Histocompatibility Complex on Positive Thymic Selection of V_β17a⁺T Cells

1989 • 110 citations

Anatomy of autoantibody production: Dominant localization of antibody-producing cells to T cell zones in fas-deficient mice

1995 • 108 citations

Polyreactive antigen-binding B cells are the predominant cell type in the newborn B cell repertoire

1998 • 87 citations

Simultaneous induction of rheumatoid factor- and antigen-specific antibody-secreting cells during the secondary immune response in man.

1985 • 81 citations

Newly produced virgin B cells migrate to secondary lymphoid organs but their capacity to enter follicles is restricted

1987 • 75 citations

Outer Periarteriolar Lymphoid Sheath Arrest and Subsequent Differentiation of Both Naive and Tolerant Immunoglobulin Transgenic B Cells Is Determined by B Cell Receptor Occupancy

1997 • 74 citations

Characterization of the murine heat‐stable antigen: An hematolymphoid differentiation antigen defined by the J11d, M1/69 and B2A2 antibodies

1990 • 66 citations

Sites of B Lymphocyte Selection, Activation, and Tolerance in Spleen

1997 • 61 citations

Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus

1990 • 51 citations

The dynamic relationship between B-cell populations in adults

1993 • 50 citations

Spontaneous Follicular Exclusion of SHP1-deficient B Cells Is Conditional on the Presence of Competitor Wild-type B Cells

1998 • 33 citations

Unique site of IgG2a and rheumatoid factor production in MRL/lpr mice

1997 • 22 citations

Autoreactive B cells in normal humans. Autoantibody production upon lymphocyte stimulation with autoantigen-xenoantigen conjugates.

1988 • 6 citations