Tumor necrosis factor-a and the progression of diabetes in non-obese diabetic mice

Dendritic cells and the control of immunity

1998 • 14,345 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1994 • 777 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 • 581 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

T cell genetic background determines default T helper phenotype development in vitro.

1995 • 466 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice

1998 • 454 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors

1993 • 431 citations

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

1999 • 426 citations

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

1995 • 383 citations

Genetic Susceptibility to Leishmania : IL-12 Responsiveness in T _H 1 Cell Development

1996 • 367 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1996 • 349 citations

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

1996 • 340 citations

Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and β-Cell Destruction in NOD Mice

1994 • 331 citations

β cell apoptosis in T cell-mediated autoimmune diabetes

1997 • 330 citations

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

1997 • 320 citations

Contenders in FasL/TNF death signaling

1995 • 319 citations

Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.

1994 • 318 citations

Dendritic Cells Induce Autoimmune Diabetes and Maintain Disease via De Novo Formation of Local Lymphoid Tissue

1998 • 315 citations

Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice.

1996 • 311 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

1997 • 287 citations

Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

1995 • 267 citations

TRANCE, a Tumor Necrosis Factor Family Member Critical for CD40 Ligand–independent T Helper Cell Activation

1999 • 262 citations

B Lymphocytes Are Crucial Antigen-Presenting Cells in the Pathogenic Autoimmune Response to GAD65 Antigen in Nonobese Diabetic Mice

1998 • 259 citations

B-Cells Are Required for the Initiation of Insulitis and Sialitis in Nonobese Diabetic Mice

1997 • 254 citations

CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.

1997 • 244 citations

Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice

1997 • 232 citations

The role of CD8⁺ T cells in the initiation of insulin‐dependent diabetes mellitus

1996 • 225 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

A Mechanism for the Major Histocompatibility Complex–linked Resistance to Autoimmunity

1997 • 202 citations

Interferon-γ impacts at multiple points during the progression of autoimmune diabetes

1997 • 201 citations

Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice

1993 • 201 citations

Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet Antigens

1998 • 195 citations

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

1994 • 188 citations

Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse.

1998 • 182 citations

BETA-CELL APOPTOSIS IS RESPONSIBLE FOR THE DEVELOPMENT OF IDDM IN THE MULTIPLE LOW-DOSE STREPTOZOTOCIN MODEL

1996 • 181 citations

TGF-β1 Alters APC Preference, Polarizing Islet Antigen Responses toward a Th2 Phenotype

1998 • 180 citations

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

1998 • 179 citations

Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice

1997 • 178 citations

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

1993 • 169 citations

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.

1996 • 162 citations

Antigen-pulsed CD8α+ Dendritic Cells Generate an Immune Response after Subcutaneous Injection without Homing to the Draining Lymph Node

1999 • 161 citations

CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection

1996 • 154 citations

CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions.

1996 • 149 citations

Diverse strategies for tetracycline-regulated inducible gene expression.

1996 • 149 citations

Genetic Control of Diabetes Progression

1997 • 148 citations

Defective maturation and function of antigen-presenting cells in type 1 diabetes

1995 • 147 citations

Dendritic Cells and Macrophages Are the First and Major Producers of TNF-α in Pancreatic Islets in the Nonobese Diabetic Mouse

1998 • 146 citations

B Cells Directly Tolerize CD8+ T Cells

1998 • 142 citations

Impaired Yield, Phenotype, and Function of Monocyte-Derived Dendritic Cells in Humans at Risk for Insulin-Dependent Diabetes

1998 • 140 citations

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

1990 • 134 citations

Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.

1997 • 134 citations

Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells.

1995 • 129 citations

Dendritic Cells and Scavenger Macrophages in Pancreatic Islets of Prediabetic BB Rats

1989 • 105 citations

Costimulation and autoimmunity

1996 • 99 citations

Mice lacking the transcription factor CIITA--a second look.

1998 • 95 citations

Tetracycline-regulated cardiac gene expression in vivo.

1994 • 90 citations

Analysis of the Role of Variation of Major Histocompatibility Complex Class II Expression on Nonobese Diabetic (NOD) Peripheral T Cell Response

1998 • 76 citations

CIITA activates the expression of MHC class II genes in mouse T cells

1995 • 75 citations

Pancreatic Infiltration But Not Diabetes Occurs in the Relative Absence of MHC Class II-Restricted CD4 T Cells: Studies Using NOD/CIITA-Deficient Mice

1999 • 71 citations

Administration of IL-4 Prevents Autoimmune Diabetes but Enhances Pancreatic Insulitis in NOD Mice

1998 • 57 citations

IL-10 Impacts Autoimmune Diabetes Via a CD8+ T Cell Pathway Circumventing the Requirement for CD4+ T and B Lymphocytes

1998 • 56 citations

Immunological Tolerance to a Pancreatic Antigen as a Result of Local Expression of TNFα by Islet β Cells

1997 • 48 citations

Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development

1992 • 42 citations

Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats

1989 • 40 citations

Expression of murine VCAM-1 in vitro and in different models of inflammation in vivo: correlation with immigration of monocytes

1994 • 39 citations

IL-4 addition during differentiation of CD34 progenitors delays maturation of dendritic cells while promoting their survival

1998 • 26 citations

Dendritic Cells in the Autoimmune Insulitis in NOD Mouse Models of Diabetes

1997 • 23 citations

Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes.

1998 • 20 citations

Role of T-cell anergy and suppression in susceptibility to IDDM

1997 • 20 citations

Autoimmune diabetes: How many steps for one disease?

1997 • 16 citations

Autoimmunity Without Diabetes in Transgenic Mice Expressing β Cell-Specific CD86, But Not CD80: Parameters that Trigger Progression to Diabetes

1998 • 14 citations

Mechanisms underlying the loss of self tolerance in NOD mice

1997 • 11 citations