Immunologic privilege of the eye

Immunobiology: the immune system in health and disease

1995 • 3,893 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Natural history of the major histo-compatibility complex

1987 • 1,274 citations

Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.

1948 • 1,042 citations

Immunologically Privileged Sites

1978 • 815 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Immunobiology: The immune system in health and disease

1995 • 475 citations

Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor.

1991 • 470 citations

Quantitative studies on tissue transplantation immunity. II. The origin, strength and duration of actively and adoptively acquired immunity

1954 • 426 citations

BOTH ALLOANTIGEN-DEPENDENT AND -INDEPENDENT FACTORS INFLUENCE CHRONIC ALLOGRAFT REJECTION

1995 • 378 citations

CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.

1997 • 375 citations

Indirect presentation of MHC antigens in transplantation

1994 • 362 citations

BOTH ALLOANTIGEN-DEPENDENT AND -INDEPENDENT FACTORS INFLUENCE CHRONIC ALLOGRAFT REJECTION

1995 • 340 citations

CELLS MEDIATING ALLOGRAFT REJECTION

1991 • 330 citations

Unraveling Immune Privilege

1995 • 302 citations

ORTHOTOPIC CORNEAL TRANSPLANTATION IN MICE—EVIDENCE THAT THE IMMUNOGENETIC RULES OF REJECTION DO NOT APPLY

1992 • 298 citations

A second study of the behaviour and fate of skin homografts in rabbits: A Report to the War Wounds Committee of the Medical Research Council.

1945 • 273 citations

Immune Privilege and Immune Regulation in the Eye

1990 • 265 citations

Studies on the induction of anterior chamber‐associated immune deviation (ACAID) III. Induction of ACAID depends upon intraocular transforming growth factor‐β

1992 • 250 citations

Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation.

1990 • 234 citations

Corneal allografts fail to express Ia antigens

1979 • 227 citations

Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor

1992 • 225 citations

The Influence of Donor-Recipient Sensitization on Corneal Grafts*

1951 • 223 citations

Immune regulation and the eye: a dangerous compromise

1987 • 217 citations

Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments

1993 • 216 citations

Immune response to immunization via the anterior chamber of the eye. I. F. lymphocyte-induced immune deviation.

1977 • 208 citations

Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor.

1994 • 207 citations

Transplantation and rejection of individual cell layers of the cornea.

1969 • 188 citations

Studies on the induction of anterior chamber-associated immune deviation (ACAID). 1. Evidence that an antigen-specific, ACAID-inducing, cell-associated signal exists in the peripheral blood.

1991 • 179 citations

Differential expression of the complement regulatory proteins in the human eye.

1993 • 175 citations

The distribution of HLA antigens on human corneal tissue.

1984 • 157 citations

Deviant immune responses to allogeneic tumors injected intracamerally and subcutaneously in mice.

1981 • 156 citations

Pathophysiology of the blood-brain barrier

1990 • 153 citations

ROLE OF FAS-FAS LIGAND INTERACTIONS IN THE IMMUNOREJECTION OF ALLOGENEIC MOUSE CORNEAL TRANSPLANTS1

1997 • 147 citations

Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID.

1991 • 144 citations

Calcitonin gene-related peptide in the eye: release by sensory nerve stimulation and effects associated with neurogenic inflammation

1986 • 140 citations

Systemic immune unresponsiveness induced in adult mice by anterior chamber presentation of minor histocompatibility antigens.

1980 • 139 citations

MIGRATION PATTERNS OF DENDRITIC LEUKOCYTES

1990 • 139 citations

Immune Response to Immunization Via the Anterior Chamber of the Eye

1977 • 139 citations

The Expression of HLA Antigens by Cells in the Human Cornea

1984 • 124 citations

Immunization with Skin Isografts Taken from Tolerant Mice

1967 • 123 citations

Organ-Resident, Nonlymphoid Cells Suppress Proliferation of Autoimmune T-Helper Lymphocytes

1987 • 118 citations

DIFFERENT INFLUENCES ON CORNEAL GRAFT SURVIVAL IN 539 TRANSPLANTS

1982 • 107 citations

The passenger cell concept in transplantation immunology

1971 • 107 citations

Immunosuppressive properties of tissues obtained from eyes with experimentally manipulated corneas.

1996 • 103 citations

Distinctive humoral immune responses following anterior chamber and intravenous administration of soluble antigen. Evidence for active suppression of IgG2-secreting B lymphocytes.

1990 • 97 citations

Inhibition of lymphocyte proliferation by aqueous humor.

1989 • 96 citations

Immunoregulatory properties of bone marrow-derived cells in the iris and ciliary body.

1989 • 95 citations

The collaborative corneal transplantation studies (CCTS). Effectiveness of histocompatibility matching in high-risk corneal transplantation. The Collaborative Corneal Transplantation Studies Research Group.

1992 • 95 citations

Immune response to immunization via the anterior chamber of the eye. II. An analysis of F1 lymphocyte-induced immune deviation.

1978 • 93 citations

T-cell mediated responses in a murine model of orthotopic corneal transplantation.

1995 • 91 citations

Suppression of experimental autoimmune uveitis in mice by induction of anterior chamber-associated immune deviation with interphotoreceptor retinoid-binding protein.

1992 • 90 citations

The distribution and ontogeny of MHC antigens in murine ocular tissue.

1987 • 77 citations

Interleukin-1 receptor antagonist suppresses Langerhans cell activity and promotes ocular immune privilege.

1998 • 76 citations

Transplantation immunology of the anterior chamber of the eye. II. Immune response to allogeneic cells.

1975 • 74 citations

Expression of HLA-A/B/C and -DR Locus Antigens on Epithelial, Stromal, and Endothelial Cells of the Human Cornea

1982 • 70 citations

Immunobiology of Langerhans cells on the ocular surface. I. Langerhans cells within the central cornea interfere with induction of anterior chamber associated immune deviation.

1987 • 70 citations

Migration patterns of dendritic leukocytes

1989 • 66 citations

Do immunologically privileged sites require a functioning spleen?

1974 • 65 citations

Murine orthotopic corneal transplantation in high-risk eyes. Rejection is dictated primarily by weak rather than strong alloantigens.

1997 • 63 citations

Immune Response to Immunization via the Anterior Chamber of the Eye

1978 • 63 citations

A small molecular weight factor in aqueous humor acts on C1q to prevent antibody-dependent complement activation.

1998 • 59 citations

The presence of biologically significant concentrations of glucocorticoids but little or no cortisol binding globulin within aqueous humor: relevance to immune privilege in the anterior chamber of the eye.

1994 • 58 citations

Corneal endothelial cells inhibit T cell proliferation by blocking IL-2 production.

1994 • 57 citations

Immunopathology of Uveitis.

1965 • 56 citations

Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice.

1989 • 56 citations

Placental immunoregulation.

1986 • 47 citations

SHORT COMMUNICATION: Induction of donor-specific ACAID can prolong orthotopic corneal allograft survival in "high-risk" eyes

1997 • 45 citations

Effect of mismatches for major histocompatibility complex and minor antigens on corneal graft rejection.

1991 • 45 citations

Penetrating Keratoplasty in the Rabbit

1968 • 42 citations

Functional studies of major histocompatibility class II-positive dendritic cells and resident tissue macrophages isolated from the rat iris.

1995 • 41 citations

Detection of transforming growth factor-alpha messenger RNA and protein in human corneal epithelial cells.

1992 • 40 citations

The immunogenic privilege of corneal allografts.

1989 • 33 citations

Transplantation immunology of the anterior chamber of the eye. I. An intra-ocular graft-vs-host reaction (immunogenic anterior uveitis).

1975 • 26 citations

Anterior chamber-associated immune deviation elicited via primate eyes.

1993 • 26 citations

A critical role for ACAID in the distinctive pattern of retinitis that follows anterior chamber inoculation of HSV-1

1987 • 26 citations

Effectiveness of histocompatibility matching in high-risk corneal transplantation: a summary of results from the Collaborative Corneal Transplantation Studies.

1994 • 24 citations

The effect of immunological and non-immunological factors on corneal graft survival: A single centre study

1984 • 23 citations

The Effect of Immunological and Non-immunological Factors on Corneal Graft Survival

1984 • 21 citations

Transplantation Immunology of the Anterior Chamber of the Eye

1975 • 21 citations

Immunocompetent cells in the anterior segment

1994 • 14 citations

The Collaborative Corneal Transplantation Studies-Reply

1992 • 12 citations

Immunosuppressive properties of tissues of the ocular anterior segment

1996 • 12 citations