Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

The Pezcoller lecture: cancer cell cycles revisited.

2000 • 1,208 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

1998 • 614 citations

Targeted disruption of the three Rb-related genes leads to loss of G₁ control and immortalization

2000 • 583 citations

Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts

1999 • 505 citations

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1998 • 498 citations

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

1999 • 476 citations

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

1993 • 471 citations

Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.

1996 • 470 citations

Cyclin-dependent kinase control of centrosome duplication

1999 • 423 citations

Ablation of the Retinoblastoma gene family deregulates G₁ control causing immortalization and increased cell turnover under growth-restricting conditions

2000 • 415 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

Centrosome-Dependent Exit of Cytokinesis in Animal Cells

2001 • 396 citations

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

1999 • 329 citations

A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue

1996 • 304 citations

Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells.

1995 • 301 citations

Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

1995 • 291 citations

Barrett's esophagus

1987 • 282 citations

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

1996 • 266 citations

Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy

2000 • 253 citations

Model for the genetic evolution of human solid tumors.

1989 • 251 citations

Pancreatic Neoplasia Induced by SV40 T-Antigen Expression in Acinar Cells of Transgenic Mice

1987 • 243 citations

Hydroxyurea

1975 • 234 citations

Progression to cancer in Barrett's esophagus is associated with genomic instability.

1989 • 225 citations

Genotoxicity of dental materials

1996 • 215 citations

Altered Centrosome Structure Is Associated with Abnormal Mitoses in Human Breast Tumors

1999 • 200 citations

Aneuploid colon cancer cells have a robust spindle checkpoint

2001 • 173 citations

p21^Waf1/Cip1 Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption

1999 • 171 citations

Mitosis in a cell with multiple centrioles.

1982 • 158 citations

Prognostic significance of dna measurements in 409 consecutive breast cancer patients

1988 • 148 citations

Role of pRb-Related Proteins in Simian Virus 40 Large-T-Antigen-Mediated Transformation

1995 • 139 citations

Flow cytometry of prostate cancer: relationship of DNA content to survival.

1987 • 133 citations

Retrospective analysis of the prognostic significance of DNA content and proliferative activity in large bowel carcinoma.

1987 • 116 citations

Chromosome markers and progression in bladder cancer.

1977 • 116 citations

Neither p21WAF1 nor 14-3-3sigma prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21WAF1 induces stable G1 arrest in resulting tetraploid cells.

2001 • 112 citations

A model of DNA aneuploidization and evolution in colorectal cancer.

1994 • 105 citations

Differential Taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells.

1996 • 96 citations

Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state

1996 • 94 citations

Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery.

1995 • 92 citations

Inhibition of cytokinesis and altered contractile ring morphology induced by cytochalasins in synchronized PtK2 cells

1981 • 51 citations

Independence of centriole formation and initiation of DNA synthesis in Chinese hamster ovary cells

1986 • 31 citations

Simian virus 40 large tumor antigen alone or two cooperating oncogenes convert REF52 cells to a state permissive for gene amplification.

1992 • 28 citations