The centrosome cycle

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1995 • 940 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 796 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

Nucleophosmin/B23 Is a Target of CDK2/Cyclin E in Centrosome Duplication

2000 • 671 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Centrosome defects and genetic instability in malignant tumors.

1998 • 583 citations

Centrosome amplification drives chromosomal instability in breast tumor development

2002 • 564 citations

Centrosome composition and microtubule anchoring mechanisms

2002 • 557 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

1998 • 515 citations

Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts

1999 • 505 citations

Centrosome-independent mitotic spindle formation in vertebrates

2000 • 502 citations

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

1999 • 476 citations

The Respective Contributions of the Mother and Daughter Centrioles to Centrosome Activity and Behavior in Vertebrate Cells

2000 • 462 citations

C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2

1998 • 438 citations

Cyclin-dependent kinase control of centrosome duplication

1999 • 423 citations

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators

1998 • 419 citations

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

2001 • 417 citations

Managing the centrosome numbers game: from chaos to stability in cancer cell division

2001 • 402 citations

Centrosome-Dependent Exit of Cytokinesis in Animal Cells

2001 • 396 citations

Re-evaluating centrosome function

2001 • 392 citations

Centrosomes Enhance the Fidelity of Cytokinesis in Vertebrates and Are Required for Cell Cycle Progression

2001 • 340 citations

The Sudden Recruitment of γ-Tubulin to the Centrosome at the Onset of Mitosis and Its Dynamic Exchange Throughout the Cell Cycle, Do Not Require Microtubules

1999 • 339 citations

Requirement of a Centrosomal Activity for Cell Cycle Progression Through G ₁ into S Phase

2001 • 336 citations

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

1999 • 329 citations

The C. elegans zyg-1 Gene Encodes a Regulator of Centrosome Duplication with Distinct Maternal and Paternal Roles in the Embryo

2001 • 309 citations

Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression

1999 • 284 citations

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

2000 • 274 citations

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle.

1995 • 269 citations

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

2002 • 251 citations

The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion

2000 • 232 citations

The centrosome in vertebrates: more than a microtubule-organizing center

2001 • 232 citations

The Mouse Mps1p-like Kinase Regulates Centrosome Duplication

2001 • 221 citations

The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5

1999 • 218 citations

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

1999 • 201 citations

Mode of centriole duplication and distribution.

1990 • 197 citations

Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype.

2001 • 197 citations

A molecular marker for centriole maturation in the mammalian cell cycle.

1995 • 197 citations

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

2002 • 194 citations

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1

2000 • 183 citations

Centrosome cohesion is regulated by a balance of kinase and phosphatase activities

2001 • 182 citations

Outer Dense Fiber 2 Is a Widespread Centrosome Scaffold Component Preferentially Associated with Mother Centrioles: Its Identification from Isolated Centrosomes

2001 • 176 citations

γ-Tubulin complexes and microtubule nucleation

2001 • 162 citations

The Drosophila Protein Asp Is Involved in Microtubule Organization during Spindle Formation and Cytokinesis

2001 • 149 citations

Centrosome maturation

1999 • 145 citations

Phosphorylation by p34cdc2 Protein Kinase Regulates Binding of the Kinesin-related Motor HsEg5 to the Dynactin Subunit p150Glued

1997 • 145 citations

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1

2000 • 144 citations

The spindle cycle in budding yeast

2001 • 134 citations

Centrosome abnormalities in pancreatic ductal carcinoma.

1999 • 129 citations

Reconstruction of the Centrosome Cycle from Cryoelectron Micrographs

1997 • 125 citations

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes

2001 • 124 citations

Phosphorylation of Centrin during the Cell Cycle and Its Role in Centriole Separation Preceding Centrosome Duplication

2001 • 121 citations

Spindle pole body duplication: a model for centrosome duplication?

2000 • 117 citations

Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos

1998 • 115 citations

Calcium, Calmodulin, and CaMKII Requirement for Initiation of Centrosome Duplication in Xenopus Egg Extracts

2002 • 101 citations

The role of the yeast spindle pole body and the mammalian centrosome in regulating late mitotic events

2001 • 99 citations

Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis inC. elegans

2002 • 96 citations

A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis inDrosophila

2002 • 91 citations

The SCF ubiquitin ligase protein Slimb regulates centrosome duplication in Drosophila

2000 • 88 citations

Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos

2000 • 86 citations

Centrosome Duplication

2001 • 85 citations

The role of the centrosome in the development of malignant tumors

1999 • 84 citations

Protein kinases in control of the centrosome cycle

1999 • 77 citations

The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in Xenopus laevis

2000 • 62 citations

Association of Human SCFSKP2Subunit p19SKP1with Interphase Centrosomes and Mitotic Spindle Poles

1999 • 50 citations

Overexpression of cyclin A in human HeLa cells induces detachment of kinetochores and spindle pole/centrosome overproduction

2001 • 38 citations

Centrosome duplication: Three kinases come up a winner!

2001 • 35 citations

Centrosomes: Central no more?

2001 • 32 citations