“It Takes Two to Tango”: understanding how centrosome duplication is regulated throughout the cell cycle

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1999 • 1,521 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts

1996 • 978 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Reconstructions of centriole formation and ciliogenesis in mammalian lungs

1968 • 788 citations

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

2000 • 704 citations

Deregulated cyclin E induces chromosome instability

1999 • 692 citations

Whose end is destruction: cell division and the anaphase-promoting complex

1999 • 679 citations

Nucleophosmin/B23 Is a Target of CDK2/Cyclin E in Centrosome Duplication

2000 • 671 citations

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

2000 • 634 citations

Centrosome defects and genetic instability in malignant tumors.

1998 • 583 citations

Microtubule motors in mitosis

2000 • 580 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

1998 • 515 citations

Dynamic Association of Proteasomal Machinery with the Centrosome

1999 • 515 citations

Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts

1999 • 505 citations

Centrosome-independent mitotic spindle formation in vertebrates

2000 • 502 citations

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

1999 • 476 citations

The Respective Contributions of the Mother and Daughter Centrioles to Centrosome Activity and Behavior in Vertebrate Cells

2000 • 462 citations

Absence of centrioles in the first and second meiotic spindles of mouse oocytes

1972 • 454 citations

C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2

1998 • 438 citations

Polo-like kinases: a team that plays throughout mitosis

1998 • 424 citations

Cyclin-dependent kinase control of centrosome duplication

1999 • 423 citations

Lactacystin, Proteasome Function, and Cell Fate

1998 • 420 citations

The cell in development and inheritance

1906 • 418 citations

The pericentriolar material in Chinese hamster ovary cells nucleates microtubule formation

1977 • 416 citations

Managing the centrosome numbers game: from chaos to stability in cancer cell division

2001 • 402 citations

Centrosome-Dependent Exit of Cytokinesis in Animal Cells

2001 • 396 citations

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

1999 • 388 citations

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

1995 • 369 citations

Centrioles in the cell cycle. I. Epithelial cells.

1982 • 362 citations

Centriole Disassembly In Vivo and Its Effect on Centrosome Structure and Function in Vertebrate Cells

1998 • 361 citations

EXPRESSION OF PRIMARY CILIA IN MAMMALIAN CELLS

1996 • 359 citations

Origin and Continuity of Cell Organelles

1971 • 355 citations

Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells

1979 • 354 citations

Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase

1990 • 344 citations

Centrosomes Enhance the Fidelity of Cytokinesis in Vertebrates and Are Required for Cell Cycle Progression

2001 • 340 citations

Requirement of a Centrosomal Activity for Cell Cycle Progression Through G ₁ into S Phase

2001 • 336 citations

Centrin, centrosomes, and mitotic spindle poles

1995 • 335 citations

Spindle Assembly in Xenopus Egg Extracts: Respective Roles of Centrosomes and Microtubule Self-Organization

1997 • 335 citations

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

1999 • 329 citations

Cdk inhibitors: on the threshold of checkpoints and development

1994 • 326 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS

1968 • 316 citations

A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue

1996 • 304 citations

Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells.

1995 • 301 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Structural and chemical characterization of isolated centrosomes

1987 • 292 citations

Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression

1999 • 284 citations

Spindle Assembly in Animal Cells

2000 • 281 citations

The development of basal bodies in paramecium.

1968 • 280 citations

Centriole cycle in Chinese hamster ovary cells as determined by whole-mount electron microscopy.

1981 • 271 citations

A constitutive nucleolar protein identified as a member of the nucleoplasmin family.

1987 • 267 citations

The Chromosome Cycle and the Centrosome Cycle in the Mitotic Cycle

1987 • 263 citations

The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion

2000 • 232 citations

The centriole, a central enigma of cell biology

1982 • 227 citations

Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin.

1988 • 222 citations

Mitotic Spindle Poles are Organized by Structural and Motor Proteins in Addition to Centrosomes

1997 • 220 citations

Structural polarity of kinetochore microtubules in PtK1 cells.

1981 • 218 citations

The Multiplicity of the Mitotic Centers and the Time-Course of Their Duplication and Separation

1960 • 210 citations

Direct Interaction of Pericentrin with Cytoplasmic Dynein Light Intermediate Chain Contributes to Mitotic Spindle Organization

1999 • 203 citations

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

1999 • 201 citations

The tubulin fraternity: alpha to eta

2001 • 199 citations

Early events in DNA replication require cyclin E and are blocked by p21CIP1.

1995 • 197 citations

Mode of centriole duplication and distribution.

1990 • 197 citations

Cdc53p Acts in Concert with Cdc4p and Cdc34p To Control the G₁-to-S-Phase Transition and Identifies a Conserved Family of Proteins

1996 • 195 citations

Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells

1991 • 195 citations

Centrosome duplication continues in cycloheximide-treated Xenopus blastulae in the absence of a detectable cell cycle.

1990 • 176 citations

The Centrosome and Its Role in the Organization of Microtubules

1987 • 166 citations

Centriole number and the reproductive capacity of spindle poles.

1985 • 162 citations

Mitosis in a cell with multiple centrioles.

1982 • 158 citations

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

2000 • 145 citations

Functional autonomy of monopolar spindle and evidence for oscillatory movement in mitosis.

1982 • 145 citations

Maternal Xenopus Cdk2-Cyclin E Complexes Function during Meiotic and Early Embryonic Cell Cycles That Lack a G1 Phase

1995 • 142 citations

Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts

1996 • 142 citations

BASAL BODIES, BUT NOT CENTRIOLES, IN NAEGLERIA

1971 • 139 citations

Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E

1999 • 137 citations

Amorphous no longer: the centrosome comes into focus

1999 • 128 citations

Centriole and basal body formation during ciliogenesis revisited

1991 • 128 citations

The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry

1997 • 121 citations

Phosphorylation of Centrin during the Cell Cycle and Its Role in Centriole Separation Preceding Centrosome Duplication

2001 • 121 citations

Spindle formation and cleavage in Xenopus eggs injected with centriole-containing fractions from sperm

1976 • 109 citations

The reproduction of centrosomes: nuclear versus cytoplasmic controls.

1986 • 109 citations

Protein synthesis and the cell cycle: centrosome reproduction in sea urchin eggs is not under translational control.

1990 • 108 citations

The basal bodies of Chlamydomonas reinhardtii. Formation from probasal bodies, isolation, and partial characterization.

1975 • 107 citations

γ-Tubulin complexes and their interaction with microtubule-organizing centers

1999 • 105 citations

Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1.

1995 • 103 citations

The blepharoplast of Marsilea: its De Novo formation and spindle association

1976 • 96 citations

The cell in development and inheritance

1896 • 94 citations

Centrioles

1971 • 93 citations

Aster-free spindle poles in insect spermatocytes: evidence for chromosome-induced spindle formation?

1986 • 91 citations

The Coordination of Centrosome Reproduction with Nuclear Events of the Cell Cycle in the Sea Urchin Zygote

1998 • 90 citations

The SCF ubiquitin ligase protein Slimb regulates centrosome duplication in Drosophila

2000 • 88 citations

Culprits in the degradation of cyclin E apprehended

1999 • 81 citations

The ultrastructure of primary cilia in quiescent 3T3 cells

1980 • 79 citations

Reproductive capacity of sea urchin centrosomes without centrioles

1989 • 79 citations

The nucleolar phosphoprotein B23 redistributes in part to the spindle poles during mitosis

1999 • 77 citations

Genomic Convergence and Suppression of Centrosome Hyperamplification in Primary p53−/− Cells in Prolonged Culture

2000 • 65 citations

The centrosome-associated aurora/Ipl-like kinase family

1999 • 65 citations

A Role for Cyclin E/Cdk2 in the Timing of the Midblastula Transition inXenopusEmbryos

1997 • 65 citations

Basal bodies and centrioles: Their function and structure

1999 • 63 citations

Formation of the astral mitotic spindle: Ultrastructural basis for the centrosome-kinetochore interaction

1990 • 63 citations

Relationship between nuclear DNA synthesis and centrosome reproduction in sea urchin eggs

1987 • 60 citations

Role for microtubules in centrosome doubling in chinese hamster ovary cells

1999 • 58 citations

A Proteasome Cap Subunit Required for Spindle Pole Body Duplication in Yeast

1997 • 57 citations

Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle

1999 • 51 citations

Association of Human SCFSKP2Subunit p19SKP1with Interphase Centrosomes and Mitotic Spindle Poles

1999 • 50 citations

Variations in the distribution and migration of centriole duplexes in mitotic ptk2 cells studied by immunofluorescence microscopy

1980 • 50 citations

Experimental analysis of the reproduction of spindle poles

1985 • 50 citations

Cytology and nucleic acid synthesis of parthenogenetically activated sea urchin eggs

1972 • 48 citations

Two proteins isolated from sea urchin sperm flagella: structural components common to the stable microtubules of axonemes and centrioles

1998 • 46 citations

Dependence of centriole formation on protein synthesis.

1976 • 46 citations

Are there nucleic acids in the centrosome?

1999 • 46 citations

An investigation of the centriole cycle using 3t3 and cho cells

1985 • 42 citations

Origin and maturation of centrioles in association with the nuclear envelope in hypertonic-stressed sea urchin eggs.

1982 • 41 citations

Identification and function of the centrosome centromatrix

1999 • 40 citations

Centrosomal components immunologically related to tektins from ciliary and flagellar microtubules

1994 • 38 citations

Cell cycle: Driving the centrosome cycle

1999 • 36 citations

Centriole duplication and maturation in animal cells

1999 • 29 citations

Kinetochores and microtubules in multipolar mitosis and chromosome orientation

1975 • 29 citations

Cell division: The renaissance of the centriole

1999 • 27 citations

Centrosome repositioning immediately following karyokinesis and prior to cytokinesis

1993 • 26 citations

The Apparent Linkage between Centriole Replication and the S Phase of the Cell Cycle

1998 • 19 citations

Identification and function of the centrosome centromatrix

1999 • 8 citations