Modulation of Drug Transporters at the Blood-Brain Barrier

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Nanoparticulate systems for brain delivery of drugs

2012 • 949 citations

Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

2003 • 899 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

2003 • 653 citations

Brain drug delivery of small molecules using immunoliposomes

1996 • 640 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

2002 • 590 citations

Estimation of Blood-Brain Barrier Crossing of Drugs Using Molecular Size and Shape, and H-Bonding Descriptors

1998 • 546 citations

Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain

1999 • 486 citations

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1997 • 432 citations

Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene

2001 • 424 citations

Localisation of breast cancer resistance protein in microvessel endothelium of human brain

2002 • 405 citations

Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier.

2000 • 399 citations

Multidrug resistance transporters and modulation

2000 • 388 citations

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

2002 • 358 citations

New Advances in the Transport of Doxorubicin through the Blood-Brain Barrier by a Peptide Vector-Mediated Strategy

2000 • 339 citations

Xenobiotic Transport across Isolated Brain Microvessels Studied by Confocal Microscopy

2000 • 310 citations

Pluronic® block copolymers as modulators of drug efflux transporter activity in the blood–brain barrier

2003 • 308 citations

Localization of the Organic Anion Transporting Polypeptide 2 (Oatp2) in Capillary Endothelium and Choroid Plexus Epithelium of Rat Brain

1999 • 300 citations

P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

1997 • 249 citations

Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.

1997 • 241 citations

Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.

2003 • 238 citations

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

2000 • 233 citations

Multidrug Resistance Protein MRP2 Contributes to Blood-Brain Barrier Function and Restricts Antiepileptic Drug Activity

2003 • 232 citations

Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood–brain barrier

2003 • 229 citations

Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na⁺gradient

2003 • 218 citations

Role of blood–brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

2002 • 207 citations

P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

2001 • 201 citations

Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease.

2003 • 194 citations

In Vivo Evidence for P‐Glycoprotein–Mediated Transport of Phenytoin at the Blood–Brain Barrier of Rats

2001 • 185 citations

Expression polymorphism of the blood???brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease

2002 • 179 citations

Functional expression and localization of P‐glycoprotein at the blood brain barrier

2002 • 178 citations

Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.

2001 • 178 citations

MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin

2003 • 154 citations

A new multidrug resistance protein at the blood–brain barrier

2002 • 148 citations

Brain Microvascular and Astrocyte Localization of P‐Glycoprotein

1997 • 146 citations

Blood—Brain Barrier Is Involved in the Efflux Transport of a Neuroactive Steroid, Dehydroepiandrosterone Sulfate, via Organic Anion Transporting Polypeptide 2

2000 • 141 citations

Polymorphisms in the ABC drug transporter gene MDR1

2001 • 136 citations

Evidence for P‐glycoprotein‐modulated penetration of morphine‐6‐glucuronide into brain capillary endothelium

1996 • 125 citations

By-passing of P-glycoprotein Using Immunoliposomes

2002 • 123 citations

Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies.

2000 • 120 citations

Contribution of Organic Anion Transporter 3 (Slc22a8) to the Elimination of p-Aminohippuric Acid and Benzylpenicillin across the Blood-Brain Barrier

2003 • 113 citations

High levels of P-glycoprotein detected in isolated brain capillaries

1993 • 109 citations

Uptake of Cationized Albumin Coupled Liposomes by Cultured Porcine Brain Microvessel Endothelial Cells and Intact Brain Capillaries

2002 • 104 citations

Endocytosis and Transcytosis of an Immunoliposome-Based Brain Drug Delivery System

2000 • 103 citations

Specialized Localization of P‐Glycoprotein Recognized by MRK 16 Monoclonal Antibody in Endothelial Cells of the Brain and the Spinal Cord

1990 • 97 citations

Xenobiotic efflux pumps in isolated fish brain capillaries

2002 • 92 citations

Distribution of valproate across the interface between blood and cerebrospinal fluid

1978 • 86 citations

Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system.

1997 • 75 citations

Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain.

2000 • 73 citations

Uptake and efflux of the peptidic delta-opioid receptor agonist [D-penicillamine2,5]-enkephalin at the murine blood–brain barrier by in situ perfusion

2001 • 64 citations

Morphological and cytochemical aspects of capillary permeability

2002 • 54 citations

BIRICODAR (VX-710; Incel™): an effective chemosensitizer in neuroblastoma

1999 • 53 citations

Permeability of porcine blood brain barrier to somatostatin analogues

2002 • 52 citations

Aluminum citrate is transported from brain into blood via the monocar☐ylic acid transporter located at the blood-brain barrier

1997 • 40 citations

Pluronic P85 Block Copolymer Enhances Opioid Peptide Analgesia

2002 • 30 citations

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

2002 • 30 citations