Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain.

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.

1990 • 581 citations

MDR1 Gene Expression in Brain of Patients with Medically Intractable Epilepsy

1995 • 525 citations

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1988 • 417 citations

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

1979 • 368 citations

Functional involvement of P-glycoprotein in blood-brain barrier.

1992 • 352 citations

Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo.

1991 • 323 citations

Peptide Drug Delivery to the Brain

1992 • 309 citations

Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate.

1995 • 305 citations

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1992 • 288 citations

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

1996 • 278 citations

Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response.

1968 • 171 citations

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein

1993 • 157 citations

A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures.

1993 • 148 citations

Brain Microvascular and Astrocyte Localization of P‐Glycoprotein

1997 • 146 citations

In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier

1994 • 141 citations

Clinical trials of modulation of multidrug resistance pharmacokinetic and pharmacodynamic considerations

1993 • 139 citations

Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers

1996 • 135 citations

Evidence for P‐glycoprotein‐modulated penetration of morphine‐6‐glucuronide into brain capillary endothelium

1996 • 125 citations

Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody.

1993 • 125 citations

High levels of P-glycoprotein detected in isolated brain capillaries

1993 • 109 citations

Quantitative assessment of blood-brain barrier damage during microdialysis.

1996 • 101 citations

Restrictive Transport of a Lipid‐Soluble Peptide (Cyclosporin) Through the Blood–Brain Barrier

1985 • 100 citations

Interaction of drugs with P-glycoprotein in brain capillaries

1995 • 100 citations

Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.

1992 • 99 citations

Specialized Localization of P‐Glycoprotein Recognized by MRK 16 Monoclonal Antibody in Endothelial Cells of the Brain and the Spinal Cord

1990 • 97 citations

Effect of the P-Glycoprotein Inhibitor, Cyclosporine A, on the Distribution of Rhodamine-123 to the Brain: An in Vivo Microdialysis Study in Freely Moving Rats

1995 • 83 citations

Comparisons of P‐glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta

1995 • 80 citations

Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood‐brain barrier development

1995 • 76 citations

Microvessels Isolated from Rat Brain: Localization of Astrocyte Processes by Immunohistochemical Techniques

1981 • 75 citations

Cellular localization of P-glycoprotein in brain versus gonadal capillaries.

1996 • 73 citations

The multidrug-resistance gene MDR1 is expressed in human glial tumors

1991 • 71 citations

Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats.

1994 • 63 citations

Modulation of drug sensitivity by dipyridamole in multidrug resistant tumor cells in vitro.

1990 • 52 citations

Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein

1995 • 47 citations

Microvessels Isolated from Brain: Localization of Muscarinic Sites by Radioligand Binding and Immunofluorescent Techniques

1995 • 30 citations

P-glycoprotein of blood brain barrier: cross-reactivity of MAb C219 with a 190 kDa protein in bovine and rat isolated brain capillaries

1995 • 27 citations

P-Glycoprotein is Strongly Expressed in Brain Capillaries

1993 • 18 citations

P-glycoprotein expression in brain capillary endothelial cells after focal ischaemia in the rat

1994 • 18 citations

Glial-Vascular Relations

1997 • 7 citations