P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.

1990 • 581 citations

Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study.

1991 • 312 citations

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1992 • 288 citations

Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteins

1993 • 279 citations

Developmental regulation of GLUT-1 (erythroid/Hep G2) and GLUT-4 (muscle/fat) glucose transporter expression in rat heart, skeletal muscle, and brown adipose tissue.

1992 • 210 citations

Multidrug Resistance

1991 • 207 citations

Multidrug resistance and the role of P-glycoprotein knockout mice

1995 • 199 citations

Multidrug-resistance phenotype in Chinese hamster ovary cells.

1983 • 194 citations

P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines

1992 • 157 citations

mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies.

1992 • 141 citations

Multidrug Resistance and Chemosensitization: Therapeutic Implications for Cancer Chemotherapy

1990 • 116 citations

Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

1992 • 114 citations

High levels of P-glycoprotein detected in isolated brain capillaries

1993 • 109 citations

Interaction of drugs with P-glycoprotein in brain capillaries

1995 • 100 citations

Specialized Localization of P‐Glycoprotein Recognized by MRK 16 Monoclonal Antibody in Endothelial Cells of the Brain and the Spinal Cord

1990 • 97 citations

P-glycoprotein expression in brain tumors

1992 • 83 citations

Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein

1994 • 78 citations

Isolation and partial characterization of the luminal plasmalemma of microvascular endothelium from rat lungs.

1992 • 69 citations

In vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT4 in heart anf various types of skeletal muscle from streptozotocin-diabetic rats

1994 • 66 citations

Purification and characterization of metabolically active capillaries of the blood-brain barrier

1991 • 65 citations

Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas

1994 • 53 citations

Detection of P-Glycoprotein With Four Monoclonal Antibodies in Normal and Tumor Tissues

1993 • 48 citations

Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein

1995 • 47 citations

Biosynthesis, processing and half-life of P-glycoprotein in a human multidrug-resistant KB cell

1989 • 42 citations

Palmitoylation of the glucose transporter in blood-brain barrier capillaries

1995 • 28 citations

P-glycoprotein of blood brain barrier: cross-reactivity of MAb C219 with a 190 kDa protein in bovine and rat isolated brain capillaries

1995 • 27 citations