Pluronic® block copolymers as modulators of drug efflux transporter activity in the blood–brain barrier

A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

2000 • 1,723 citations

Artificial skin I. Preparation and properties of pluronic F‐127 gels for treatment of burns

1972 • 833 citations

Amphiphilic Block Copolymers: Self-Assembly and Applications

2000 • 826 citations

Long circulating microparticulate drug carriers

1995 • 699 citations

Pluronic® block copolymers for overcoming drug resistance in cancer

2002 • 603 citations

Micelle Formation and Solubilization of Fluorescent Probes in Poly(oxyethylene-b-oxypropylene-b-oxyethylene) Solutions

1995 • 444 citations

A review of block polymer surfactants

1977 • 438 citations

Pluronic? Block Copolymers in Drug Delivery: from Micellar Nanocontainers to Biological Response Modifiers

2002 • 431 citations

Poloxamers and poloxamines in nanoparticle engineering and experimental medicine

2000 • 384 citations

An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity

1986 • 318 citations

Hypersensitization of Multidrug Resistant Human Ovarian Carcinoma Cells by Pluronic P85 Block Copolymer

1996 • 303 citations

The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles

1989 • 294 citations

A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain

1992 • 290 citations

The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system.

1996 • 285 citations

Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells.

1999 • 284 citations

Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization.

2001 • 282 citations

Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials

1999 • 263 citations

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

2000 • 233 citations

Reversal of multidrug resistance by surfactants

1992 • 230 citations

Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells.

1996 • 227 citations

Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion

2001 • 223 citations

Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity

1996 • 222 citations

Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers.

1999 • 204 citations

Expression of Multidrug Resistance-Associated Protein (MRP) in Brain Microvessel Endothelial Cells

1998 • 202 citations

Targeting of colloids to lymph nodes: influence of lymphatic physiology and colloidal characteristics

1995 • 177 citations

Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies.

2001 • 177 citations

The adjuvant activity of nonionic block polymer surfactants. I. The role of hydrophile-lipophile balance.

1981 • 175 citations

Membrane fluidization by ether, other anesthetics, and certain agents abolishes P‐glycoprotein ATPase activity and modulates efflux from multidrug‐resistant cells

1999 • 168 citations

Reversal of the multidrug resistance phenotype with cremophor EL, a common vehicle for water-insoluble vitamins and drugs.

1990 • 168 citations

Interactions of Pluronic Block Copolymers with Brain Microvessel Endothelial Cells: Evidence of Two Potential Pathways for Drug Absorption

1997 • 162 citations

Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers.

1998 • 159 citations

Quality and functionality of excipients

1999 • 151 citations

Reversal of Multidrug-Resistance Phenotype by Surfactants: Relationship to Membrane Lipid Fluidity

1995 • 140 citations

Mechanistic Roles of Neutral Surfactants on Concurrent Polarized and Passive Membrane Transport of a Model Peptide in Caco-2 Cells

1997 • 139 citations

Effects of pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells.

1998 • 139 citations

Introduction to the blood-brain barrier : methodology, biology, and pathology

2006 • 128 citations

Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity

1987 • 126 citations

Inhibition of multidrug resistance-associated protein (MRP) functional activity with pluronic block copolymers.

1999 • 124 citations

The adjuvant activity of nonionic block polymer surfactants. II. Antibody formation and inflammation related to the structure of triblock and octablock copolymers.

1984 • 122 citations

Poloxamer 407-induced atherogenesis in the C57BL/6 mouse

1998 • 112 citations

Understanding drug release from poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) gels

2001 • 101 citations

The Adjuvant Activity of Nonionic Block Polymer Surfactants

1986 • 100 citations

Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers

1999 • 98 citations

Tissue-Engineered Nipple Reconstruction

1998 • 98 citations

Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice

1999 • 97 citations

Pluronic F‐127 gel preparation as an artificial skin in the treatment of third‐degree burns in pigs

1987 • 92 citations

Poloxamer 407-mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats.

1992 • 92 citations

Comparison of solutol HS 15, cremophor EL and novel ethoxylated fatty acid surfactants as multidrug resistance modification agents

1995 • 91 citations

Beneficial Effects of RheothRx Injection in Patients Receiving Thrombolytic Therapy for Acute Myocardial Infarction

1996 • 85 citations

Adjuvant activity of non-ionic block copolymers. IV. Effect of molecular weight and formulation on titre and isotype of antibody

1991 • 77 citations

Pluronic F-68: A promising new skin wound cleanser

1980 • 75 citations

Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology

1999 • 73 citations

Dose-dependent hyperlipidemia in rabbits following administration of poloxamer 407 gel

1999 • 73 citations

Physical Basis for Poloxamer Interactions

1994 • 68 citations

Effect of a Polymeric Surfactant on Electron Transport in HL-60 Cells

2000 • 63 citations

A new silver sulfadiazine water soluble gel

1997 • 55 citations

Adjuvant activity of non-ionic block copolymers. V. Modulation of antibody isotype by lipopolysaccharides, lipid A and precursors

1991 • 50 citations

Use of Nonionic Block Copolymers in Vaccines and Therapeutics

1998 • 46 citations

An amorphous hydrogel enhances epithelialisation of wounds

1998 • 43 citations

Mechanisms of action of nonionic block copolymer adjuvants.

1994 • 37 citations

Perfluorochemicals as Oxygen Transport Vehicles

1988 • 35 citations

Pharmacokinetics of a new skin wound cleanser

1976 • 33 citations

Adjuvant formulations and their mode of action.

1990 • 32 citations

Potential applications of polymers in the delivery of drugs to the central nervous system

1999 • 30 citations

The effect of RheothRx Injection on the hemorheological parameters in patients with acute myocardial infarction.

1997 • 30 citations

Micelles of poly(oxyethylene)-poly(oxypropylene) block copolymer (pluronic) as a tool for low-molecular compound delivery into a cell: phosphorylation of intracellular proteins with micelle incorporated [gamma-32P]ATP.

1992 • 29 citations

Effect of adjuvant formulations on the selection of B-cell epitopes expressed by a malaria peptide vaccine

1992 • 27 citations

Block copolymers in pharmaceutics

2000 • 26 citations

The influence of pluronics and their conjugates with proteins on the rate of oxygen consumption by liver mitochondria and thymus lymphocytes.

1993 • 24 citations

The adjuvant activity of fatty acid esters. The role of acyl chain length and degree of saturation.

1981 • 22 citations

The influence of pluronics and their conjugates with proteins on the rate of oxygen consumption by liver mitochondria and thymus lymphocytes

1993 • 19 citations

Role of Poloxamer 188 During Recovery from Ischemic Spinal Cord Injury: A Preliminary Study

1996 • 19 citations

Nonionic Triblock Copolymers Facilitate Delivery of Exogenous Proteins into the MHC Class I and Class II Processing Pathways

1997 • 17 citations