Uptake and efflux of the peptidic delta-opioid receptor agonist [D-penicillamine2,5]-enkephalin at the murine blood–brain barrier by in situ perfusion
Data up to Jan 2025
Total Citations Per Year
Abstract
References (19)
P-Glycoprotein, a gatekeeper in the blood–brain barrier
1999 • 918 citations
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.
1999 • 585 citations
Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier.
2000 • 399 citations
Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
1997 • 396 citations
Localization of the Organic Anion Transporting Polypeptide 2 (Oatp2) in Capillary Endothelium and Choroid Plexus Epithelium of Rat Brain
1999 • 300 citations
Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.
1997 • 272 citations
Development of anIn SituMouse Brain Perfusion Model and its Application tomdr1aP-Glycoprotein-Deficient Mice
2000 • 196 citations
Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)
1999 • 88 citations
Kinetic Analysis of Leucine-Enkephalin Cellular Uptake at the Luminal Side of the Blood-Brain Barrier of an In Situ Perfused Guinea-Pig Brain
1989 • 86 citations
The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism.
1995 • 72 citations
Altered disposition and antinociception of [D-penicillamine(2,5)] enkephalin in mdr1a-gene-deficient mice.
1998 • 58 citations
Deltorphin transport across the blood–brain barrier
1997 • 48 citations
Enhanced antinociception of the model opioid peptide [D-penicillamine] enkephalin by P-glycoprotein modulation.
1999 • 44 citations
Assessment of Stereoselectivity of Trimethylphenylalanine Analogues of δ‐Opioid [D‐Pen2,D‐Pen5]‐Enkephalin
2000 • 41 citations
Peptide drug delivery into the central nervous system
1998 • 41 citations
The entry of [D-penicillamine2,5]enkephalin into the central nervous system: saturation kinetics and specificity.
1997 • 32 citations
Extensive biliary excretion of the model opioid peptide [D-PEN2,5] enkephalin in rats.
1997 • 30 citations
Transport of the δ-opioid receptor agonist [D-penicillamine2,5] enkephalin across the blood–brain barrier involves transcytosis1
1999 • 28 citations
Blood-brain disposition and antinociceptive effects of -D-penicillamine2,5-enkephalin in the mouse.
1997 • 23 citations