Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1998 • 1,548 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

1997 • 1,201 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro

1999 • 914 citations

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

1997 • 908 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

1998 • 679 citations

The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

1999 • 650 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

A common human skin tumour is caused by activating mutations in β-catenin

1999 • 608 citations

An HMG-box-containing T-cell factor required for thymocyte differentiation

1995 • 518 citations

Molecular determinants of dysplasia in colorectal lesions.

1994 • 506 citations

Apoptosis and APC in colorectal tumorigenesis.

1996 • 491 citations

The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin

1999 • 432 citations

β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation

1999 • 385 citations

Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

1998 • 302 citations

TCF/LEF factors earn their wings

1997 • 288 citations

ApcMin: A mouse model for intestinal and mammary tumorigenesis

1995 • 281 citations

Critical Involvement of Tcf-1 in Expansion of Thymocytes

1998 • 238 citations

Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3β and β-Catenin and Inhibits Axis Formation ofXenopus Embryos

1998 • 205 citations

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.

1993 • 199 citations

Extensive Alternative Splicing and Dual Promoter Usage Generate Tcf-1 Protein Isoforms with Differential Transcription Control Properties

1996 • 193 citations

Restricted High Level Expression of Tcf-4 Protein in Intestinal and Mammary Gland Epithelium

1999 • 153 citations

The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes

1995 • 54 citations

The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.

1992 • 44 citations

Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells

1997 • 34 citations

Deleted Work

1955 • 0 citations