A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in Apc ^Min /+ mice

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

1990 • 1,793 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

Alleles of the APC gene: An attenuated form of familial polyposis

1993 • 621 citations

An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor

1990 • 577 citations

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1996 • 494 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 380 citations

Loss of Apc+ in intestinal adenomas from Min mice.

1994 • 373 citations

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

1997 • 327 citations

Differential expression of bcl-2 in intestinal epithelia correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia

1995 • 308 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

1992 • 303 citations

Hereditary Gastrointestinal Polyposis Syndromes

1986 • 268 citations

Genetic Analysis of an Inherited Predisposition to Colon Cancer in a Family with a Variable Number of Adenomatous Polyps

1990 • 254 citations

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

1998 • 154 citations

Studies of neoplasia in the Min mouse1C57BL/6J Min/+ mice are available worldwide from The Jackson Laboratory, Bar Harbor, ME 04609, USA.1

1997 • 151 citations

Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium.

1996 • 142 citations

Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis

1993 • 110 citations

APC EXPRESSION IN NORMAL HUMAN TISSUES

1997 • 103 citations

Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin.

1995 • 86 citations

N-ethyl-N-nitrosourea treatment of multiple intestinal neoplasia (Min) mice: age-related effects on the formation of intestinal adenomas, cystic crypts, and epidermoid cysts.

1995 • 77 citations

Mom1 is a Semi-Dominant Modifier of Intestinal Adenoma Size and Multiplicity in Min/+ Mice

1996 • 71 citations

Genetic Evaluation of Candidate Genes for the Mom1 Modifier of Intestinal Neoplasia in Mice

1996 • 63 citations

Somatic mutational mechanisms involved in intestinal tumor formation in Min mice.

1997 • 61 citations

The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions

1998 • 48 citations

Risk factors for colorectal cancer in subjects with family history of the disease

1997 • 37 citations

Somatic genetic events linked to the apc locus in intestinal adenomas of the min mouse

1996 • 35 citations