Structural and Functional Aspects of Domain Motions in Proteins

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Small-Angle X-Ray Scattering

2016 • 3,861 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

Conformation of Polypeptides and Proteins

1968 • 2,929 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

Atlas of Protein Sequence and Structure, 1972.

1973 • 2,408 citations

Fluorescence Energy Transfer as a Spectroscopic Ruler

1978 • 2,370 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

Stability of Proteins Small Globular Proteins

1979 • 2,139 citations

Dynamics of folded proteins

1977 • 1,929 citations

The Mechanism of Muscular Contraction

1969 • 1,928 citations

Fluorescence quenching studies with proteins

1981 • 1,700 citations

Dynamics of ligand binding to myoglobin

1975 • 1,616 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Proteases and biological control

1976 • 1,380 citations

Carp Muscle Calcium-binding Protein

1973 • 1,359 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

4 Lactate Dehydrogenase

1975 • 1,272 citations

Temperature-dependent X-ray diffraction as a probe of protein structural dynamics

1979 • 1,136 citations

Hydrogen Exchange in Proteins

1966 • 1,115 citations

Stability of proteins. Proteins which do not present a single cooperative system.

1982 • 1,041 citations

THE PLASMA PROTEINS

1960 • 934 citations

X-Rays in Theory and Experiment

1935 • 905 citations

Heat capacity and entropy changes in processes involving proteins.

1977 • 846 citations

Quenching of protein fluorescence by oxygen. Detection of structural fluctuations in proteins on the nanosecond time scale

1973 • 774 citations

Protein crystallography

1977 • 713 citations

3 Alcohol Dehydrogenases

1975 • 706 citations

Three-Dimensional Structure of Immunoglobulins

1979 • 692 citations

Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolution

1976 • 691 citations

Structure of myoglobin refined at 2·0 Å resolution

1977 • 676 citations

Structure of crystalline α-chymotrypsin

1972 • 675 citations

Structural basis of the activation and action of trypsin

1978 • 669 citations

Tomato bushy stunt virus at 2.9 Å resolution

1978 • 668 citations

Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix

1981 • 666 citations

Regulation of Oxygen Affinity of Hemoglobin: Influence of Structure of the Globin on the Heme Iron

1979 • 662 citations

Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA

1981 • 651 citations

Structure and refinement of oxymyoglobin at 1·6 Å resolution

1980 • 641 citations

Aminoacyl-tRNA Synthetases: General Features and Recognition of Transfer RNAs

1979 • 636 citations

Thermal vibrations in crystallography

1975 • 625 citations

Complement

1975 • 594 citations

Blood Coagulation

1980 • 562 citations

Assembly and Stability of the Tobacco Mosaic Virus Particle

1964 • 549 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1974 • 548 citations

Structure of the cro repressor from bacteriophage λ and its interaction with DNA

1981 • 545 citations

The operator-binding domain of λ repressor: structure and DNA recognition

1982 • 528 citations

Electron microscopy of an antibody-hapten complex

1967 • 505 citations

The Internal Dynamics of Globular Protein

1981 • 505 citations

Crystallographic refinement and atomic models of two different forms of citrate synthase at 2·7 and 1·7 Å resolution

1982 • 495 citations

Glyceraldehyde 3-phosphate dehydrogenases

1965 • 475 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Segmental flexibility in an antibody molecule

1970 • 465 citations

The refined crystal structure of bovine β-trypsin at 1·8 Å resolution

1975 • 462 citations

Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution

1980 • 455 citations

Sequence, structure and activity of phosphoglycerate kinase: a possible hinge-bending enzyme

1979 • 452 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1973 • 449 citations

Dynamics of ligand binding to heme proteins

1979 • 440 citations

Studies on Liver Alcohol Dehydrogenase. II. The Kinetics of the Compound of Horse Liver Alcohol Dehydrogenase and Reduced Diphosphopyridine Nucleotide.

1951 • 435 citations

Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.

1975 • 435 citations

The molecular structure and stability of the eye lens: X-ray analysis of γ-crystallin II

1981 • 432 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

Structure of bovine pancreatic phospholipase A2 at 1.7 Å resolution

1981 • 429 citations

Hydrogen Exchange

1972 • 423 citations

Mechanism of Actomyosin Atpase and the Problem of Muscle Contractio

1979 • 407 citations

Structure and refinement of penicillopepsin at 1.8 Å resolution

1983 • 405 citations

Thermodynamic fluctuations in protein molecules.

1976 • 376 citations

Three-dimensional structure of an intact human immunoglobulin.

1977 • 373 citations

Amino-Acid Sequence of Bovine Chymotrypsinogen-A

1964 • 373 citations

Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 Å resolution

1981 • 373 citations

Sequence and structure of yeast phosphoglycerate kinase.

1982 • 364 citations

Thermal Vibrations in Crystallography

1975 • 362 citations

Structure of a λ-type Bence-Jones protein at 3.5-Å resolution

1973 • 356 citations

X-rays in theory and experiment

1935 • 349 citations

The Antibody Problem

1969 • 347 citations

Chymotrypsinogen: 2,5-Å crystal structure, comparison with α-chymotrypsin, and implications for zymogen activation

1970 • 345 citations

Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin

1982 • 341 citations

NMR in Molecular Biology

1981 • 336 citations

Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase.

1975 • 330 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

A cross-bridge model of muscle contraction

1979 • 317 citations

Protein A Isolated from Staphylococcus aureus after Digestion with Lysostaphin

1972 • 307 citations

Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus

1977 • 307 citations

Glucose-induced conformational change in yeast hexokinase.

1978 • 305 citations

Substrate positions and induced-fit in crystalline adenylate kinase

1977 • 304 citations

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding

1978 • 301 citations

An X-ray study of azide methaemoglobin

1966 • 294 citations

Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

1978 • 293 citations

TRYPSINOGEN AND CHYMOTRYPSINOGEN AS HOMOLOGOUS PROTEINS

1964 • 292 citations

[17] Time-resolved fluorescence measurements

1979 • 283 citations

Structural domains in proteins and their role in the dynamics of protein function

1983 • 283 citations

Motions in Proteins

1979 • 281 citations

Chromatography of Trypsin and Its Derivatives

1968 • 281 citations

Space-Filling Models of Kinase Clefts and Conformation Changes

1979 • 280 citations

Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase

1975 • 267 citations

Dynamics of the aromatic amino acid residues in the globular conformation of the basic pancreatic trypsin inhibitor (BPTI)

1976 • 260 citations

Activation of the Complement System by Antibody-Antigen Complexes: The Classical Pathway

1979 • 258 citations

Three-dimensional structure of adenyl kinase

1974 • 258 citations

Binding of substrate in a ternary complex of horse liver alcohol dehydrogenase.

1982 • 255 citations

Trypsin-pancreatic trypsin inhibitor association. Dynamics of the interaction and role of disulfide bridges

1972 • 251 citations

The Three-Dimensional Structure at 6 A Resolution of a Human γG1 Immunoglobulin Molecule

1971 • 249 citations

Conformational substates in a protein: structure and dynamics of metmyoglobin at 80 K.

1982 • 247 citations

Structure of RNA and RNA binding site in tobacco mosaic virus from 4-Å map calculated from X-ray fibre diagrams

1977 • 243 citations

Calorimetric study of thermally induced conformational transitions of ribonuclease A and certain of its derivatives

1970 • 242 citations

Three-dimensional structure of a pyridoxal-phosphate-dependent enzyme, mitochondrial aspartate aminotransferase.

1980 • 242 citations

Crystal structure of bovine trypsinogen at 1·8 Å resolution

1977 • 242 citations

The lambda repressor contains two domains.

1979 • 238 citations

A real-space refinement procedure for proteins

1971 • 233 citations

Structure of a complex between yeast hexokinase A and glucose

1980 • 233 citations

Structure of catabolite gene activator protein at 2.9-A resolution. Incorporation of amino acid sequence and interactions with cyclic AMP.

1982 • 229 citations

Dynamics of metmyoglobin crystals investigated by nuclear gamma resonance absorption

1981 • 227 citations

Space-Filling Models of Kinase Clefts and Conformation Changes: Comparison of the surface structures of kinase enzymes implicates closing clefts in their mechanism.

1979 • 223 citations

Structure of Yeast Phosphoglycerate Kinase

1974 • 222 citations

Covalent structure of a human γG-immunoglobulin. XI. Functional implications

1970 • 221 citations

Enzyme Dynamics: The Statistical Physics Approach

1979 • 220 citations

Three-Dimensional Structure of Immunoglobulins

1975 • 218 citations

Rotational allomerism and divergent evolution of domains in immunoglobulin light chains

1975 • 217 citations

Some Physicochemical Properties of Protein A from Staphylococcus aureus

1972 • 217 citations

On the three-dimensional structure and catalytic mechanism of triose phosphate isomerase

1981 • 216 citations

Sidechain torsional potentials and motion of amino acids in porteins: bovine pancreatic trypsin inhibitor.

1975 • 215 citations

The Three-Dimensional Structure of the Fab′ Fragment of a Human Myeloma Immunoglobulin at 2.0-Å Resolution

1974 • 213 citations

Fluorotyrosine alkaline phosphatase: Internal mobility of individual tyrosines and the role of chemical shift anisotropy as a 19F nuclear spin relaxation mechanism in proteins

1975 • 213 citations

Hydrogen Exchange Kinetics and Internal Motions in Proteins and Nucleic Acids

1979 • 213 citations

Gross Conformation of Rabbit 7 S γ-Immunoglobulin and Its Papain-cleaved Fragments

1965 • 212 citations

Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7 Å resolution

1981 • 209 citations

Repetitive Sequences in Protein A from Staphylococcus aureus

1977 • 207 citations

Structure and function of the constant regions of immunoglobulins

1976 • 206 citations

Protein Folding

1981 • 206 citations

On the disordered activation domain in trypsinogen: chemical labelling and low-temperature crystallography

1982 • 204 citations

Crystallographic and NMR Studies of the Serine Proteases

1982 • 199 citations

The Structures and Related Functions of Phosphorylase a

1980 • 197 citations

A structural model of human erythrocyte spectrin. Alignment of chemical and functional domains.

1982 • 196 citations

The structure of the protein disk of tobacco mosaic virus to 5 Å resolution

1976 • 195 citations

Statistical Time Events in Enzymes: A Physical Assessmen

1975 • 194 citations

Functional significance of flexibility in proteins

1983 • 190 citations

Neutron Diffraction Analysis of Myoglobin: Structure of the Carbon Monoxide Derivative

1975 • 189 citations

A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes

1976 • 189 citations

Structure of horse muscle phosphoglycerate kinase

1974 • 189 citations

Structure of bovine liver rhodanese

1978 • 187 citations

Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 Å resolution

1982 • 186 citations

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding

1979 • 184 citations

Phosphofructokinase: structure and control

1981 • 183 citations

Effect of Antigen Binding on the Properties of Antibody

1974 • 182 citations

Crystallization, Crystal Structure Analysis and Atomic Model of the Complex Formed by a Human Fc Fragment and Fragment B of Protein A fromStaphylococcus aureus

1978 • 176 citations

The role of protein fluctuations in enzyme action: A review

1982 • 175 citations

Structure of bovine trypsinogen at 1.9 Å resolution

1977 • 174 citations

Substrate binding closes the cleft between the domains of yeast phosphoglycerate kinase.

1979 • 173 citations

Laser Raman Scattering as a Probe of Protein Structure

1977 • 172 citations

Structure and control of phosphofructokinase from Bacillus stearothermophilus

1979 • 172 citations

The Mechanism of Activation of Trypsinogen. The Role of the Four N-Terminal Aspartyl Residues

1969 • 163 citations

Kinetic Studies of Liver Alcohol Dehydrogenase and pH Effects with Coenzyme Preparations of High Purity

1963 • 158 citations

Structure of the expanded state of tomato bushy stunt virus

1982 • 158 citations

The use of synchrotron radiation in time-resolved X-ray diffraction studies of myosin layer-line reflections during muscle contraction

1980 • 157 citations

Crystallographic studies on the activity of glycogen phosphorylase b

1978 • 156 citations

The phylogeny of trypsin-related serine proteases and their zymogens. New methods for the investigation of distant evolutionary relationships

1975 • 152 citations

Tyrosyl-tRNA synthetase forms a mononucleotide-binding fold

1982 • 149 citations

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.

1982 • 148 citations

Structure of the human antibody molecule kol (immunoglobulin G1): An electron density map at 5 Å resolution

1976 • 148 citations

Protein A from Staphylococcus aureus

1975 • 147 citations

Two conformations of crystalline adenylate kinase

1977 • 146 citations

Site‐Specific Substituted Cobalt(II) Horse Liver Alcohol Dehydrogenases

1979 • 145 citations

Thermodynamic Characterization of Conformational States of Biological Macromolecules using Differential Scanning Calorimetry

1978 • 145 citations

Packing defects, cavities, volume fluctuations, and access to the interior of proteins. Including some general comments on surface area and protein structure

1979 • 143 citations

Crystallographic refinement of Japanese quail ovomucoid, a Kazal-type inhibitor, and model building studies of complexes with serine proteases

1982 • 142 citations

The Effect of Antigen on Antibodies: Recent Studies

1978 • 142 citations

Protein structural fluctuations during a period of 100 ps

1979 • 142 citations

Determination of the Rate of Hexokinase-Glucose Dissociation by the Isotope-trapping Method

1974 • 142 citations

15 α-Glucan Phosphorylases–Chemical and Physical Basis of Catalysis and Regulation

1972 • 142 citations

Crystal structure and molecular interactions of tropomyosin

1979 • 141 citations

Use of chromium-adenosine triphosphate and lyxose to elucidate the kinetic mechanism and coordination state of the nucleotide substrate for yeast hexokinase

1975 • 141 citations

Induction of the bovine trypsinogen—trypsin transition by peptides sequentially similar to the N‐terminus of trypsin

1976 • 137 citations

Subunit conformation of yeast alcohol dehydrogenase.

1978 • 137 citations

Simulation of Protein Dynamics

1980 • 132 citations

Sequencing a protein by X-ray crystallography

1978 • 131 citations

The crystal structure of wheat germ agglutinin at 2·2 Å resolution

1977 • 130 citations

Electron Mircroscopy of the Immunoglobulins

1969 • 130 citations

A refined model of the sugar binding site of yeast hexokinase B

1978 • 130 citations

Molecular Size and Conformation of Immunoglobulins

1970 • 129 citations

Yeast hexokinase in solution exhibits a large conformational change upon binding glucose or glucose 6-phosphate

1979 • 129 citations

Proton magnetic resonance studies of the tyrosine residues of hen lysozyme-assignment and detection of conformational mobility

1975 • 129 citations

Millisecond time-resolved changes in x-ray reflections from contracting muscle during rapid mechanical transients, recorded using synchrotron radiation.

1981 • 128 citations

Internal motion in globular proteins

1978 • 125 citations

Induced Fit in Yeast Hexokinase

1970 • 125 citations

Crystallographic Structural Studies of a Human Fc Fragment. II. A Complete Model Based on a Fourier Map at 3.5 Å Resolution

1976 • 123 citations

Rotational jumps of the tyrosine side chain in crystalline enkephalin. Hydrogen-2 NMR line shapes for aromatic ring motions in solids

1981 • 122 citations

High resolution X-ray structure of yeast hexokinase, an allosteric protein exhibiting a non-symmetric arrangement of subunits

1976 • 121 citations

[11] Small-angle x-ray scattering

1979 • 121 citations

Structural interpretation of the amide proton exchange in the basic pancreatic trypsin inhibitor and related proteins

1979 • 120 citations

The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies.

1978 • 119 citations

Kinetics of the exchange of individual amide protons in the basic pancreatic trypsin inhibitor

1979 • 115 citations

Mechanism of acid protease catalysis based on the crystal structure of penicillopepsin

1977 • 115 citations

Segmental flexibility of immunoglobulin G antibody molecules in solution: a new interpretation

1981 • 114 citations

The structure of glycogen phosphorylase a at 2.5 Å resolution

1979 • 113 citations

[2] The isotope trapping method: Desorption rates of productive E·S complexes

1980 • 113 citations

Principles of Mössbauer Spectroscopy

1976 • 112 citations

The radius of gyration of L-arabinose-binding protein decreases upon binding of ligand.

1981 • 111 citations

Untersuchung des Schwingungsanteils und des Kristallgitterfehleranteils des Temperaturfaktors in Myoglobin durch Vergleich von Mössbauer-absorptionsmessungen mit Röntgenstrukturdaten

1971 • 110 citations

GENETICS OF YEAST HEXOKINASE

1977 • 110 citations

Differences between Alcohol Dehydeogenases

1977 • 110 citations

The crystal structure of tyrosyl-transfer RNA synthetase at 2.7 Å resolution

1976 • 109 citations

Structure of a complex between yeast hexokinase A and glucose

1980 • 108 citations

The Hexokinases: Kinetic, Physical, and Regulatory Properties

1973 • 107 citations

Structure and activity of phosphoglycerate mutase

1981 • 107 citations

Protein Conformation, Dynamics, and Folding by Computer Simulation

1982 • 105 citations

Conformational Adaptability in Enzymes

1973 • 105 citations

The Conformation of Adenosine Diphosphoribose and 8-Bromoadenosine Diphosphoribose when Bound to Liver Alcohol Dehydrogenase

1975 • 104 citations

Structure of the l-arabinose-binding protein from Escherichia coli at 2.4 Å resolution

1981 • 104 citations

High resolution crystal structures of yeast hexokinase complexes with substrates, activators, and inhibitors. Evidence for an allosteric control site.

1977 • 103 citations

Crystallographic Studies of a Human Immunoglobulin

1968 • 101 citations

Immunologically Active and Structurally Similar Fragments of Protein A from Staphylococcus aureus

1975 • 101 citations

Expression of biological effector functions by immunoglobulin G molecules lacking the hinge region.

1981 • 100 citations

Structure of glycogen phosphorylase a at 3.0 A resolution and its ligand binding sites at 6 A.

1976 • 99 citations

Spectrin: Present status of a putative cyto-skeletal protein of the red cell membrane

1979 • 98 citations

Crystal structure of bovine trypsinogen at 1.8 Å resolution. I. Data collection, application of Patterson search techniques and preliminary structural interpretation

1976 • 98 citations

Recent Developments in Solution X-Ray Scattering

1980 • 97 citations

The theory of the method of isomorphous replacement for protein crystals. I

1956 • 96 citations

Raman Spectroscopy: A Conformational Probe in Biochemistr

1977 • 96 citations

Probes of Mechanism and Transition-State Structure in the Alcohol Dehydrogenase Reactio

1981 • 94 citations

[18] Low frequency vibrations and the dynamics of proteins and polypeptides

1979 • 93 citations

Acquisition and Interpretation of Hydrogen Exchange Data from Peptides, Polymers, and Proteins

1982 • 93 citations

Crystal structure determinations of coenzyme analog and substrate complexes of liver alcohol dehydrogenase: binding of 1,4,5,6-tetrahydronicotinamide adenine dinucleotide and trans-4-(N,N-dimethylamino)cinnamaldehyde to the enzyme

1982 • 92 citations

Differential mobility of the N-terminal headpiece in the lac-repressor protein

1979 • 92 citations

I. Serine proteinases. The structure of α-chymotrypsin

1970 • 92 citations

Conformational flexibility and its functional significance in some protein molecules

1979 • 90 citations

Unusual segmental flexibility in a region of tobacco mosaic virus coat protein

1978 • 90 citations

Phosphoglycerate kinase

1981 • 90 citations

Adenosine Triphosphatase Activity of Yeast Hexokinase and Its Relation to the Mechanism of the Hexokinase Reaction

1965 • 89 citations

Methionyl-tRNA synthetase from Escherichia coli. Primary structure of the active crystallised tryptic fragment.

1982 • 89 citations

X-ray crystallographic and kinetic studies of oligosaccharide binding to phosphorylase

1978 • 88 citations

6 The Structure of Chymotrypsin

1971 • 84 citations

The refined crystal structure of bovine β-trypsin at 1·8 Å resolution

1975 • 83 citations

Saturation Transfer Spectroscopy

1976 • 83 citations

Pyrazole binding in crystalline binary and ternary complexes with liver alcohol dehydrogenase

1982 • 81 citations

Shape, conformation and stability of fibronectin fragments determined by electron microscopy, circular dichroism and ultracentrifugation

1982 • 81 citations

Structure of pyruvate kinase and similarities with other enzymes: possible implications for protein taxonomy and evolution

1978 • 81 citations

The structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution.

1975 • 80 citations

Crystallography of liver alcohol dehydrogenase complexed with substrates

1978 • 80 citations

Hinge-regIon deletion localized in the IgG1-globulin Mcg

1973 • 78 citations

Dynamics of the aromatic amino acid residues in the globular conformation of the basic pancreatic trypsin inhibitor (BPTI)

1976 • 78 citations

Allosteric transitions of phosphorylase a and the regulation of glycogen metabolism.

1978 • 78 citations

Structural differences between apo- and holoenzyme of horse liver alcohol dehydrogenase.

1979 • 77 citations

Chemistry and subunit structure of yeast hexokinase isoenzymes

1973 • 76 citations

Carboxypeptidase A mechanisms.

1980 • 76 citations

Crystallization, crystal structure analysis and molecular model of the third domain of Japanese quail ovomucoid, a Kazal type inhibitor

1981 • 75 citations

The three-dimensional structure of antibodies

1982 • 74 citations

Difference Fourier refinement of the structure of DIP-trypsin at 1.5 Å with a minicomputer technique

1977 • 74 citations

Low-resolution structure of the glycogen phosphorylase a monomer and comparison with phosphorylase b

1976 • 74 citations

Crystallisation of trypsin‐modified methionyl‐tRNA synthetase from Escherichia coli

1971 • 73 citations

Protein interfaces and intersubunit bonding. The case of tomato bushy stunt virus

1980 • 72 citations

The crystal structure of phosphorylase b at 6 Å resolution

1974 • 72 citations

Structure of lobster apo-d-glyceraldehyde-3-phosphate dehydrogenase at 3.0 Å resolution

1980 • 71 citations

Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey.

1982 • 71 citations

Structural dynamics of yeast hexokinase during catalysis

1981 • 70 citations

Substrate synergism and the kinetic mechanism of yeast hexokinase

1982 • 68 citations

X‐Ray Small‐Angle Scattering of Yeast Glyceraldehyde‐3‐phosphate Dehydrogenase as a Function of Saturation with Nicotinamide‐Adenine‐Dinucleotide

1971 • 68 citations

The Crystal Structure of Complexes between Horse Liver Alcohol Dehydrogenase and the Coenzyme Analogues 3‐Iodopyridine‐adenine Dinucleotide and Pyridine‐adenine Dinucleotide

1977 • 68 citations

Crystallographic studies and model building of ATP at the active site of hexokinase

1980 • 67 citations

Electron Microscopy of Proteins

1975 • 66 citations

Nuclear magnetic resonance of heme protein crystals. General aspects.

1981 • 66 citations

Methionyl-tRNA synthetase shows the nucleotide binding fold observed in dehydrogenases

1981 • 66 citations

Activity of glycogen phosphorylase in the crystalline state.

1976 • 65 citations

Comparison of the crystal structures of chymotrypsinogen-A and α-chymotrypsin

1973 • 64 citations

Sequencing a protein by X-ray crystallography

1978 • 64 citations

Interaction between serine (pro)enzymes, and kazal and kunitz inhibitors

1983 • 64 citations

X-Ray Structure of Proteins

1977 • 63 citations

The subunit structure of methionyl‐tRNA synthetase from Escherichia coli

1974 • 63 citations

The Enzymology of the Formation and Breakdown of Citrate

1975 • 63 citations

Interactions of yeast valyl-tRNA synthetase with RNAs and conformational changes of the enzyme

1979 • 63 citations

Electron microscopic evidence for the axial rotation and inter-domain flexibility of the fab regions of immunoglobulin G

1983 • 62 citations

The Interchain Disulfide Bonds of a Human Pathological Immunoglobulin^*

1967 • 62 citations

The structure of mouse testicular lactate dehydrogenase isoenzyme C4 at 2.9 A resolution.

1979 • 61 citations

Structure of Immunoglobulins

1973 • 61 citations

L-Arabinose-binding protein-sugar complex at 2.4 A resolution. Stereochemistry and evidence for a structural change.

1981 • 60 citations

The role of the inter-heavy chain disulfide bond in modulating the flexibility of immunoglobulin G antibody

1977 • 60 citations

Fluorescence relaxation spectroscopy in the analysis of macromolecular structure and motion

1976 • 59 citations

Inelastic neutron scattering analysis of hexokinase dynamics and its modification on binding of glucose

1982 • 59 citations

Hydrogen exchange from identified regions of the S-protein component of ribonuclease as a function of temperature, pH, and the binding of S-peptide

1981 • 59 citations

Molecular structure and biological activity

1983 • 59 citations

Crystal structure of the human Fab fragment Kol and its comparison with the intact Kol molecule

1978 • 59 citations

The Enzymatic Significance of S-Acetylation and N-Acetylation of 3-Phosphoglyceraldehyde Dehydrogenase

1967 • 58 citations

Antico-operative binding of initiator transfer RNAMet to methionyl-transfer RNA synthetase from Escherichia coli: Neutron scattering studies

1978 • 58 citations

Crystallization of Horse Liver Alcohol Dehydrogenase Complexes from Alcohol Solutions.

1967 • 58 citations

QUASI-ELASTIC LIGHT SCATTERING APPLICATIONS IN BIOCHEMISTRY AND BIOLOGY

1981 • 57 citations

Crystallographic Structural Studies of a Human Fc-Fragment. I. An Electron-Density Map at 4 Å Resolution and a Partial Model

1976 • 57 citations

Antibody-induced conformational changes in proteins

1972 • 57 citations

Pre‐existence of the active site in zymogens, the interaction of trypsinogen with the basic pancreatic trypsin inhibitor (Kunitz)

1976 • 57 citations

Three-dimensional structure of the Mcg IgG1 immunoglobulin☆

1983 • 56 citations

Yeast 3-phosphoglycerate kinase: sulfate and substrate binding, their effect on the conformational state of the enzyme

1980 • 56 citations

Thermodynamics of the binding of D-glucose to yeast hexokinase

1981 • 55 citations

Saturation-Transfer Spectroscopy

1979 • 55 citations

Diffusion coefficients for segmentally flexible macromolecules: General formalism and application to rotational behavior of a body with two segments

1980 • 54 citations

Nucleotide binding to glycogen phosphorylase b in the crystal

1979 • 54 citations

Mobile Fc region in the Zie IgG2 cryoglobulin: comparison of crystals of the F(ab')₂ fragment and the intact immunoglobulin

1978 • 54 citations

Binding and properties of NAD+ in glyceraldehydephosphate dehydrogenase from lobster-tail muscle

1969 • 53 citations

Isotope trapping studies of yeast hexokinase during steady state catalysis. A combined rapid quench and isotope trapping technique.

1979 • 53 citations

Crystal structure analysis and refinement of two variants of trigonal trypsinogen

1978 • 53 citations

Structure of yeast hexokinase

1974 • 51 citations

Crystal properties as indicators of conformational changes during ligand binding or interconversion of Mcg light chain isomers

1978 • 50 citations

The Crossbridge Theory

1979 • 50 citations

Monoclonal antibodies as probes of domain structure of the spectrin alpha subunit.

1982 • 50 citations

Rotational dynamics of monoclonal anti-dansyl immunoglobulins

1982 • 50 citations

The structure of bovine pancreatic prophospholipase A2 at 3.0 Å resolution

1982 • 50 citations

Comparison of protein structure in the crystal and in solution. III. Tritium-hydrogen exchange of lysozyme and a lysozyme-saccharide complex

1968 • 50 citations

The structure of mouse testicular lactate dehydrogenase isoenzyme C4 at 2.9 A resolution.

1979 • 50 citations

Nanosecond fluorescence spectroscopy of pyrenebutyrate-anti-pyrene antibody complexes

1977 • 49 citations

Leucine, isoleucine, valine-binding protein from Escherichia coli. Structure at 3.0-A resolution and location of the binding site.

1983 • 49 citations

Nuclear magnetic resonance measurement of hydrogen exchange kinetics of single protons in basic pancreatic trypsin inhibitor

1978 • 48 citations

SYNTHESIS OF N-SUBSTITUTED GLUCOSAMINES AND THEIR EFFECT ON HEXOKINASE

1955 • 47 citations

The Kinetics of Yeast Hexokinase in the Light of the Induced Fit Involved in the Binding of its Sugar Substrate

1970 • 47 citations

A Crystallographic Investigation of a Human IgG Immunoglobulin

1970 • 47 citations

NMR studies of macromolecular dynamics

1981 • 46 citations

S-N Transfer and Dual Acetylation in the S-Acetylation and N-Acetylation of 3-Phosphoglyceraldehyde Dehydrogenase by Substrates

1966 • 46 citations

Conformational transition from trypsinogen to trypsin

1980 • 45 citations

pH-dependent conformational states of horse liver alcohol dehydrogenase.

1977 • 45 citations

Neutron Scattering

1972 • 44 citations

Catalytic activity in crystals of mitochondrial aspartate aminotransferase as detected by microspectrophotometry

1978 • 44 citations

The three-dimensional structure of mitochondrial aspartate aminotransferase at 4.5 Å resolution

1979 • 44 citations

Three-dimensional structure at 5 Å resolution of cytosolic aspartate transaminase from chicken heart

1978 • 42 citations

Crystal structure of galactan-binding mouse immunoglobulin J539 Fab at 4.5-A resolution.

1979 • 42 citations

Structure of horse liver alcohol dehydrogenase

1965 • 42 citations

The Use of Spin Labels for Studying the Structure and Function of Enzymes

1976 • 41 citations

Crystalline enzyme.substrate complexes of asparate aminotransferase

1978 • 41 citations

Optical Spectroscopy of Proteins

1982 • 40 citations

Phosphorylase: control and activity

1981 • 40 citations

Catalysis by serine proteases and their zymogens. Study of acyl intermediates by circular dichroism

1975 • 40 citations

Interconversion of conformational isomers of light chains in the Mcg immunoglobulins

1978 • 40 citations

Promotion of activation of bovine trypsinogen by specific modification of aspartyl residues

1969 • 40 citations

Three‐dimensional structure at 3.2 Å resolution of the complex of cytosolic aspartate aminotransferase from chicken heart with 2‐oxoglutarate

1982 • 39 citations

Microspectrophotometric measurements on single crystals of coenzyme containing complexes of horse liver alcohol dehydrogenase

1979 • 39 citations

Crystallizable human myeloma protein Dob has a hinge-region deletion

1979 • 39 citations

The free energy of angular position of the fab arms of IgG antibody

1980 • 39 citations

Three-dimensional structure of cat muscle pyruvate kinase at 6 Å resolution

1975 • 39 citations

Small-Angle X-Ray Studies of the Human Immunoglobulin Molecule Kol

1977 • 39 citations

Cooperative and Non-Cooperative Conformational Effects of the Coenzyme on Yeast Glyceraldehyde-3-Phosphate Dehydrogenase

2005 • 38 citations

Analysis of the surface topography of glycogen phosphorylase a: implications for metabolic interconversion and regulatory mechanisms

1979 • 38 citations

Gross quaternary changes in aspartate carbamoyltransferase are induced by the binding of N-(phosphonacetyl)-L-aspartate: A 3.5-A resolution study.

1982 • 38 citations

Active-Site-Specific Reconstituted Cobalt(II) Horse-Liver Alcohol Dehydrogenase. Changes of the Spectra of the Substrate trans-4-(N,N-Dimethylamino)-cinnamaldehyde and of the Catalytic Cobalt Ion upon Ternary Complex Formation with NADH and 1,4,5,6-Tetrahydronkotinamide-Adenine Dinucleotide

1979 • 37 citations

Dynamic Aspects of Antibody Function

1982 • 37 citations

Neutron scattering studies of biological macromolecules in solution

1977 • 37 citations

Small-Angle X-ray Scattering

1973 • 37 citations

A swivel‐jointed formalism for segmentally flexible macromolecules and its application to the rotational behavior of myosin

1982 • 37 citations

Intramolecular Reorientational Motion in Trypsinogen Studied by Perturbed Angular Correlation of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Hg</mml:mi></mml:mrow><mml:mprescripts /><mml:mrow /><mml:mrow><mml:mn>1</mml:mn><mml:mn>9</mml:mn><mml:mn>9</mml:mn><mml:mi>m</mml:mi></mml:mrow><mml:mrow /><mml:mrow /></mml:mmultiscripts></mml:mrow></mml:math>Labels

1982 • 37 citations

Thermodynamics of binding of oxidized and reduced nicotinamide adenine dinucleotides, adenosine-5'-diphosphoribose, and 5'-iodosalicylate to dehydrogenases

1978 • 37 citations

Die r�umliche Struktur der Immunglobulin-Molek�le

1980 • 35 citations

Structure and mechanism of action of riboflavin-binding protein: Small-angle X-ray scattering, sedimentation, and circular dichroism studies on the holo- and apoproteins

1982 • 34 citations

Effect of heavy water and nicotinamide adenine dinucleotide on the sedimentation properties and structure of glyceraldehyde phosphate dehydrogenase

1973 • 34 citations

On the structural and functional role of carboxylates in chymotrypsinogen A a comparison with chymotrypsin, trypsinogen and trypsin

1969 • 33 citations

Fluorescence-quenching study of glucose binding by yeast hexokinase isoenzymes

1978 • 33 citations

A comparison of X-ray small-angle scattering results to crystal structure analysis and other physical techniques in the field of biological macromolecules

1978 • 33 citations

Site of cleavage of γ-globulins by papain

1962 • 33 citations

Slow structural changes shown by the 3-nitrotyrosine-237 residue in pig heart [Tyr(3NO2)237] lactate dehydrogenase

1982 • 33 citations

Relaxation of rotational and internal modes of macromolecules determined by dynamic scattering

1976 • 33 citations

Evidence that Citrate Synthase Operates by an Ordered Ternary‐Complex Mechanism

1974 • 32 citations

Fluorescence polarization analysis of various immunoglobulins Dependence of rotational relaxation time on protein concentration and on ability to precipitate with antigen

1978 • 32 citations

Glyceraldehyde-3-phosphate dehydrogenase

1981 • 30 citations

Pressure relaxation studies of isomerisations of horse liver alcohol dehydrogenase linked to NAD⁺ binding

1977 • 30 citations

Marked structural differences of the Mcg Bence-Jones dimer in two crystal systems

1980 • 30 citations

The 6-hydroxymethyl group of a hexose is essential for the substrateinduced closure of the cleft in hexokinase

1982 • 30 citations

Subunit interactions and the allosteric response in phosphorylase

1980 • 29 citations

Thermodynamics of antibody-antigen reactions. 2. The binding of bivalent synthetic random coil antigens to antibodies having different antigen precipitating properties

1977 • 29 citations

Study of the Position of NAD and Its Effect on the Conformation of d-Glyceraldehyde-3-phosphate Dehydrogenase by Small-Angle X-Ray Scattering

1972 • 28 citations

Low-temperature protein crystallography. Effect on flexibility, temperature factor, mosaic spread, extinction and diffuse scattering in two examples: bovine trypsinogen and Fc fragment

1980 • 27 citations

Kinetics and mechanism for the conformational transition in p-guanidinobenzoate bovine trypsinogen induced by the isoleucine-valine dipeptide

1979 • 27 citations

Structure of the complex of active site metal-depleted horse liver alcohol dehydrogenase and NADH.

1983 • 27 citations

Neutron-scattering studies of the binding of initiator tRNAMet to Escherichia coli trypsin-modified methionyl-tRNA synthetase

1982 • 26 citations

Neutron scattering studies of Escherichia coli tyrosyl-tRNA synthetase and of its interaction with tRNATyr

1982 • 26 citations

The three-dimensional structure of a human IgGl immunoglobulin at 4 Å resolution: a computer fit of various structural domains on the electron density map

1982 • 26 citations

5-Methylnicotinamide-adenine Dinucleotide. Kinetic Investigation with Major and Minor Isoenzymes of Liver Alcohol Dehydrogenase and Structural Determination of Its Binary Complex with Alcohol Dehydrogenase

1981 • 26 citations

Substrate-inhibition by acetyl-CoA in the condensation reaction between oxaloacetate and acetyl-CoA catalyzed by citrate synthase from pig heart

1977 • 25 citations

Reactivity of crystalline ferrihemoglobin towards azide

1966 • 24 citations

Catalytic and regulatory properties of d-glyceraldehyde-3-phosphate dehydrogenase in the crystal

1977 • 24 citations

Proton NMR studies of the aromatic residues in the basic pancreatic trypsin inhibitor (BPTI)

1975 • 24 citations

Yeast Hexokinase

1976 • 23 citations

Enzymes immobilized as crystals. Hydrogen isotope exchange of crystalline lysozyme

1980 • 23 citations

Small‐Angle X‐Ray Studies of the Fab and Fc Fragments from the Human Immunoglobulin Molecule Kol

1976 • 21 citations

The conformation of subcomponent C1q of the first component of human complement

1980 • 21 citations

A tetragonal crystal form of phosphorylase b

1972 • 21 citations

Conformational Flexibility in Immunoglobulins

1978 • 21 citations

Structure and Mechanism of Liver Alcohol Dehydrogenase, Lactate Dehydrogenase and Glyceraldehyde-3-Phosphate Dehydrogenase

1980 • 20 citations

Solution conformation of lactate dehydrogenase as studied by saturation transfer ESR spectroscopy

1979 • 20 citations

Immunoglobulins I. Structure

1977 • 19 citations

A density-modification method for the improvement of poorly resolved protein electron-density maps

1982 • 19 citations

Energy transfer and dynamical structure

1976 • 19 citations

Small angle X-ray scattering of dimeric yeast hexokinase in solution.

1979 • 18 citations

Nuclear magnetic resonance studies of alcohol dehydrogenases. Binding of inhibitors to the yeast and liver enzymes

1973 • 18 citations

General Shape and Hapten‐Induced Conformational Changes of Pig Antibody against Dinitrophenyl

1981 • 18 citations

Hydrodynamics in Biophysical Chemistry

1977 • 18 citations

Preliminary X-ray data from well-ordered crystals of a human immunoglobulin G molecule

1974 • 18 citations

Coenzyme Binding and Co-operativity in <scp>d</scp>-Glyceraldehyde 3-Phosphate Dehydrogenase

1977 • 17 citations

Ligand‐Induced Conformational Changes in Proteins

1983 • 17 citations

Crystallization of binary and ternary complexes of horse liver alcohol dehydrogenase with DPNH and with DPNH and isobutyramide

1963 • 16 citations

The Study of Biological Macromolecules Using Perturbed Angular Correlations of Gamma Radiation

1972 • 16 citations

Crystallographic symmetry and coenzyme binding properties of D-glyceraldehyde-3-phosphate dehydrogenase from the tail muscle of Palinurus vulgaris.

1979 • 15 citations

The combination of independent phase information obtained from separate protein structure determinations of yeast hexokinase

1976 • 14 citations

Sequential conformational changes with the binding of NAD+ to rabbit muscle glyceraldehyde-3-phosphate dehydrogenase

1972 • 14 citations

On proteins. CVI. Covalent structure of bovine trypsinogen

1967 • 13 citations

Molecular Structure Determination by High Resolution Electron Microscopy

1979 • 13 citations

Modification of isoleucine-16 acetylated delta-chymotrypsin.

1975 • 12 citations

Glucose exchange and catalysis by two crystalline hexokinase x glucose complexes. Evidence for an obligatory ATP-dependent conformational change in catalysis.

1980 • 12 citations

Tryptophan distribution in yeast hexokinase isoenzyme B

1978 • 12 citations

Detection of Ligand‐Induced and Syncatalytic Conformational Changes of Enzymes by Differential Chemical Modification

1982 • 11 citations

Myosin Flexibility

1982 • 10 citations

Overall and localized fluctuation in the structure of a protein molecule.

1979 • 10 citations

Effects of glucose and magnesium ion on the quenching of yeast hexokinase fluorescence by acrylamide

1980 • 10 citations

Small-angle neutron scattering study of Bence-Jones protein Mcg: comparison of structures in solution and in crystal

1982 • 10 citations

Study of crystalline hexokinase-glucose complexes by isotope trapping.

1981 • 10 citations

EPR Crystallography of Metalloproteins and Spin-Labeled Enzymes

1981 • 10 citations

The binding of glucose to yeast hexokinase monomers is independent of ionic strength

1982 • 9 citations

Conformational fluctuation and change in biological macromolecules.

1980 • 9 citations

Symmetry and NAD+ -Dependent Structural Changes in D-Glyceraldehyde- 3-Phosphate Dehydrogenase

1977 • 9 citations

Conformational properties of human immunoglobulin G subclasses analysis by temperature-perturbation and solvent-perturbation spectroscopy

1983 • 9 citations

Über die physikalisch-chemische Charakterisierung und nachfolgende Kristallisation von Immunglobulinen und deren Fragmenten: Ein Beitrag zur dreidimensionalen Strukturaufklärung der Antikörper, IV. Das Fab-Fragment und das Fc-Fragment des humanen Immunglobulins Kol; Isolierung und Kristallisation

1976 • 8 citations

Dynamic aspects of enzyme specificity

1975 • 8 citations

Mapping functional sites on biological macromolecules

1982 • 7 citations

The trouble with kinase crystals

1978 • 7 citations

Effects of activators on chemically modified yeast hexokinase

1976 • 7 citations

Interaction of a Coenzyme Analog with Aspartate Aminotransferase Isoenzymes in the Crystal

1983 • 7 citations

¹H NMR studies of TYR‐237 of lactate dehydrogenase

1981 • 6 citations

Solution X‐ray scattering study of pig heart cytosolic aspartate aminotransferase

1983 • 4 citations

Fluorescent-Probe Studies of Contractile Proteins

1982 • 4 citations

Possible distortion of antibody binding site of the Mcg bence-jones protein by lattice forces

1980 • 3 citations