The three-dimensional structure of antibodies

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Three-Dimensional Structure of Immunoglobulins

1979 • 692 citations

Complement

1975 • 594 citations

Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution

1980 • 455 citations

Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

1978 • 293 citations

Studies of the mechanism of tunicamycin in hibition of IgA and IgE secretion by plasma cells.

1977 • 277 citations

Molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-Å resolution

1975 • 266 citations

Activation of the Complement System by Antibody-Antigen Complexes: The Classical Pathway

1979 • 258 citations

Crystal and Molecular Structure of a Dimer Composed of the Variable Portions of the Bence-Jones Protein REI

1974 • 231 citations

Rotational allomerism and divergent evolution of domains in immunoglobulin light chains

1975 • 217 citations

Separation and Isolation of Fractions of Rabbit Gamma-Globulin containing the Antibody and Antigenic Combining Sites

1958 • 210 citations

Crystallization, Crystal Structure Analysis and Atomic Model of the Complex Formed by a Human Fc Fragment and Fragment B of Protein A fromStaphylococcus aureus

1978 • 176 citations

The structure and function of immunoglobulin domains. IV. The distribution of some effector functions among the Cgamma2 and Cgamma3 homology regions of human immunoglobulin G1.

1976 • 165 citations

Structure of the human antibody molecule kol (immunoglobulin G1): An electron density map at 5 Å resolution

1976 • 148 citations

The Effect of Antigen on Antibodies: Recent Studies

1978 • 142 citations

Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.

1977 • 136 citations

Structural Studies on the Four Repetitive Fc-Binding Regions in Protein A from Staphylococcus aureus

1977 • 129 citations

Crystallographic Structural Studies of a Human Fc Fragment. II. A Complete Model Based on a Fourier Map at 3.5 Å Resolution

1976 • 123 citations

Biosynthesis, intracellular transport, and secretion of immunoglobulins. Effect of 2-deoxy-D-glucose in tumor plasma cells producing and secreting immunoglobulin G1

1973 • 108 citations

The Structure and Function of Immunoglobulin Domains

1976 • 107 citations

Progress in Immunology III

1980 • 95 citations

A new enzymic fragment (Facb) of rabbit immunoglobulin G

1971 • 90 citations

Mouse myeloma mutants blocked in the assembly, glycosylation and secretion of immunoglobulin

1976 • 66 citations

Conformational changes induced in a homogeneous antitype III pneumococcal antibody by oligosaccharides of increasing size

1975 • 60 citations

Crystal structure of the human Fab fragment Kol and its comparison with the intact Kol molecule

1978 • 59 citations

The structure determination of the variable portion of the Bence-Jones protein Au

1975 • 56 citations

Mobile Fc region in the Zie IgG2 cryoglobulin: comparison of crystals of the F(ab')₂ fragment and the intact immunoglobulin

1978 • 54 citations

Die molekularen Grundlagen der Antik�rperbildung

1969 • 39 citations

Covalent structure of a human γG-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H₁-H₄

1970 • 36 citations

Marked structural differences of the Mcg Bence-Jones dimer in two crystal systems

1980 • 30 citations

Crystalline monoclonal Fab fragment with specificity towards an influenza virus neuraminidase

1981 • 26 citations

Conformational Flexibility in Immunoglobulins

1978 • 21 citations

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