Motions in Proteins

Principles that Govern the Folding of Protein Chains

1973 • 6,771 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Catalysis in chemistry and enzymology

1969 • 3,236 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery

1970 • 2,874 citations

Hemoglobin and myoglobin in their reactions with ligands

1971 • 2,698 citations

Quenching of fluorescence by oxygen. Probe for structural fluctuations in macromolecules

1973 • 2,653 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

Proteins, amino acids and peptides

1943 • 2,189 citations

Dynamics of folded proteins

1977 • 1,929 citations

Solute perturbation of protein fluorescence. Quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion

1971 • 1,730 citations

Superoxide Dismutases

1975 • 1,673 citations

Dynamics of ligand binding to myoglobin

1975 • 1,616 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Structure and stability of biological macromolecules

1969 • 1,313 citations

Structure of Myoglobin: A Three-Dimensional Fourier Synthesis at 2 Å. Resolution

1960 • 1,313 citations

Calculation of Nuclear Magnetic Resonance Spectra of Aromatic Hydrocarbons

1958 • 1,200 citations

Enthalpy–entropy compensation phenomena in water solutions of proteins and small molecules: A ubiquitous properly of water

1970 • 1,173 citations

Temperature-dependent X-ray diffraction as a probe of protein structural dynamics

1979 • 1,136 citations

Hydrogen Exchange in Proteins

1966 • 1,115 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Exposure of tryptophanyl residues in proteins. Quantitative determination by fluorescence quenching studies

1976 • 1,020 citations

The α-helix dipole and the properties of proteins

1978 • 985 citations

Experimental and Theoretical Aspects of Protein Folding

1975 • 965 citations

The interpretation of protein structures: Total volume, group volume distributions and packing density

1974 • 906 citations

Structural invariants in protein folding

1975 • 865 citations

Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by

1972 • 831 citations

Theory of Protein Titration Curves. I. General Equations for Impenetrable Spheres

1957 • 798 citations

Quenching of protein fluorescence by oxygen. Detection of structural fluctuations in proteins on the nanosecond time scale

1973 • 774 citations

Fluorescence Spectroscopy of Proteins

1968 • 699 citations

Proteins at Interfaces

1978 • 677 citations

Structure of myoglobin refined at 2·0 Å resolution

1977 • 676 citations

Crystallographic studies of the activity of hen egg-white lysozyme

1967 • 649 citations

Protein-folding dynamics

1976 • 626 citations

Chemistry and Biology of Peptides

1972 • 616 citations

Protein-Protein Interactions

1954 • 574 citations

Crystallographic refinement of the structure of bovine pancreatic trypsin inhibitor at l.5 Å resolution

1975 • 544 citations

Energetics of Ligand Binding to Proteins

1975 • 519 citations

Time‐dependent fluorescence depolarization and Brownian rotational diffusion coefficients of macromolecules

1969 • 493 citations

Metabolism and Physiological Significance of Lipids

1963 • 482 citations

Segmental flexibility in an antibody molecule

1970 • 465 citations

Primary structure effects on peptide group hydrogen exchange

1972 • 463 citations

Theory of Nuclear Overhauser Enhancement and C13–1H Dipolar Relaxation in Proton-Decoupled Carbon-13 NMR Spectra of Macromolecules

1972 • 450 citations

Crystallographic studies of the dynamic properties of lysozyme

1979 • 437 citations

Refinement of the structure of carp muscle calcium-binding parvalbumin by model building and difference fourier analysis

1975 • 433 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

Hydrogen Exchange

1972 • 423 citations

Thermodynamic fluctuations in protein molecules.

1976 • 376 citations

The hinge-bending mode in lysozyme

1976 • 370 citations

Packing of α-helices: Geometrical constraints and contact areas

1978 • 366 citations

Nature of Haem–Haem Interaction

1972 • 360 citations

A crystallographic model for azurin at 3 Å resolution

1978 • 352 citations

Theory of NMR relaxation in macromolecules: Restricted diffusion and jump models for multiple internal rotations in amino acid side chains

1978 • 347 citations

Effect of Internal Rotation on Angular Correlation Functions

1967 • 343 citations

Picosecond dynamics of tyrosine side chains in proteins

1979 • 336 citations

Subnanosecond motions of tryptophan residues in proteins

1979 • 325 citations

An X-ray study of azide methaemoglobin

1966 • 294 citations

The Basic Trypsin Inhibitor of Bovine Pancreas

1963 • 289 citations

Empirical Correlation Between Hydrophobic Free Energy and Aqueous Cavity Surface Area

1974 • 284 citations

X-ray analysis of glucagon and its relationship to receptor binding

1975 • 279 citations

Chemical Rate Processes and Magnetic Resonance

1965 • 265 citations

Tunneling in Biological Systems

1979 • 264 citations

Slow hydrogen-deuterium exchange in a non-.alpha.-helical polyamide

1967 • 261 citations

Dynamics of the aromatic amino acid residues in the globular conformation of the basic pancreatic trypsin inhibitor (BPTI)

1976 • 260 citations

Intermediates in Protein Folding Reactions and the Mechanism of Protein Folding

1975 • 257 citations

Reversible Conformational Changes of Myoglobin and Apomyoglobin

1965 • 255 citations

Acquisition of Three-Dimensional Structure of Proteins

1973 • 248 citations

The mode of attachment of the azide ion to sperm whale metmyoglobin

1964 • 245 citations

Forces between Protein Molecules in Solution Arising from Fluctuations in Proton Charge and Configuration

1952 • 244 citations

Carbon nuclear magnetic resonance studies of the histidine residue in α-lytic protease. Implications for the catalytic mechanism of serine proteases

1973 • 239 citations

Binding of Xenon to Sperm Whale Myoglobin

1965 • 235 citations

Exchange of hydrogen atoms in insulin with deuterium atoms in aqueous solutions

1954 • 231 citations

Nuclear Magnetic Resonance Study of the Protolysis and Ionization of N-Methylacetamide¹

1959 • 228 citations

ON THE ENZYMIC ACTIVITY OF SUBTILISIN-MODIFIED RIBONUCLEASE

1958 • 227 citations

The Influence of Dipole Moment Fluctuations on the Dielectric Increment of Proteins in Solution

1952 • 226 citations

Sidechain torsional potentials and motion of amino acids in porteins: bovine pancreatic trypsin inhibitor.

1975 • 215 citations

Fluorotyrosine alkaline phosphatase: Internal mobility of individual tyrosines and the role of chemical shift anisotropy as a 19F nuclear spin relaxation mechanism in proteins

1975 • 213 citations

Mechanism of tertiary structural change in hemoglobin.

1977 • 212 citations

Electrostatic effects in myoglobin. Hydrogen ion equilibriums in sperm whale ferrimyoglobin

1974 • 211 citations

Tuna cytochrome c at 2.0 A resolution. I.Ferricytochrome structure analysis.

1977 • 201 citations

Room Temperature Phosphorescence and the Dynamic Aspects of Protein Structure

1974 • 198 citations

Statistical Time Events in Enzymes: A Physical Assessmen

1975 • 194 citations

A Hydrogen Exchange Method Using Tritium and Sephadex: Its Application to Ribonuclease^*

1963 • 191 citations

The conversion of serine at the active site of subtilisin to cysteine: a "chemical mutation".

1966 • 190 citations

Relative Conformations of Sperm Whale Metmyoglobin and Apomyoglobin in Solution

1965 • 190 citations

Carbon-13-NMR of peptides and proteins

1978 • 189 citations

Neutron Diffraction Analysis of Myoglobin: Structure of the Carbon Monoxide Derivative

1975 • 189 citations

Changes in the Intrinsic Viscosity and Optical Rotation of Bovine Plasma Albumin Associated with Acid Binding¹

1954 • 183 citations

Coordination complexes and catalytic properties of proteins and related substances. 104. Electrostatic effects in hemoglobin: hydrogen ion equilibriums in human deoxy- and oxyhemoglobin A

1979 • 181 citations

Conformation and segmental motion of native and denatured ribonuclease A in solution. Application of natural-abundance carbon-13 partially relaxed Fourier transform nuclear magnetic resonance

1971 • 175 citations

Allergic encephalomyelitis: the physico-chemical properties of the basic protein encephalitogen from bovine spinal cord

1969 • 173 citations

The influence of long-range interactions on the structure of myoglobin

1968 • 169 citations

Theory of differential phase fluorometry: Detection of anisotropic molecular rotations

1977 • 164 citations

D-Glyceraldehyde-3-Phosphate Dehydrogenase: Three-Dimensional Structure and Evolutionary Significance

1973 • 162 citations

Complete tyrosine assignments in the high field proton nuclear magnetic resonance spectrum of the bovine pancreatic trypsin inhibitor

1975 • 156 citations

Binding of carbon monoxide to isolated hemoglobin chains

1978 • 155 citations

Dynamics of a protein matrix revealed by fluorescence quenching.

1975 • 154 citations

Dynamic information from protein crystallography

1979 • 152 citations

On the nature of the protein interior

1971 • 149 citations

Studies of individual carbon sites of proteins in solution by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. Relaxation behavior

1975 • 145 citations

Protein structural fluctuations during a period of 100 ps

1979 • 142 citations

Allosteric regulation of aspartate transcarbamoylase. Analysis of the structural and functional behavior in terms of a two-state model

1977 • 139 citations

Temperature dependent molecular motion of a tyrosine residue of ferrocytochrome C

1976 • 138 citations

Calculation of dipolar nuclear magnetic relaxation times in molecules with multiple internal rotations. II. Theoretical results for anisotropic over-all motion of the molecule, and comparison with 13C relaxation times in n -alkanes and n -alkyl bromides

1974 • 137 citations

Volume occupation, environment and accessibility in proteins. The problem of the protein surface

1975 • 134 citations

Spread Monolayers of Protein

1947 • 133 citations

Allosteric regulation of aspartate transcarbamoylase. Changes in the sedimentation coefficient promoted by the bisubstrate analog N-(phosphonacetyl)-L-aspartate

1977 • 131 citations

Proton magnetic resonance studies of the tyrosine residues of hen lysozyme-assignment and detection of conformational mobility

1975 • 129 citations

Physical Principles and Techniques of Protein Chemistry

1969 • 129 citations

Internal motion in globular proteins

1978 • 125 citations

Tuna cytochrome c at 2.0 A resolution. II. Ferrocytochrome structure analysis.

1977 • 120 citations

Studies of individual carbon sites of proteins in solution by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. Strategies for assignments

1975 • 118 citations

Nuclease-T: an active derivative of staphylococcal nuclease composed of two noncovalently bonded peptide fragments.

1967 • 117 citations

Dynamics of carbon monoxide binding to protoheme

1976 • 116 citations

Nanosecond Time-resolved Fluorescence Spectra of a Protein-Dye Complex

1971 • 116 citations

X-ray Crystallographic Studies of Proteins

1976 • 114 citations

Calculation of dipolar nuclear magnetic relaxation times in molecules with multiple internal rotations

1973 • 114 citations

Electrostatic potentials of proteins. 1. Carboxypeptidase A

1976 • 108 citations

A new and highly effective aldol synthesis

1977 • 107 citations

The Influence of a Single Salt Bridge on Static and Dynamic Features of the Globular Solution Conformation of the Basic Pancreatic Trypsin Inhibitor. 1H and 13C Nuclear-Magnetic-Resonance Studies of the Native and the Transaminated Inhibitor

1978 • 104 citations

Time-resolved nanosecond emission spectroscopy: spectral shift due to solvent-solute relaxation

1968 • 104 citations

Dynamic model of globular protein conformations based on NMR studies in solution

1978 • 103 citations

Proton magnetic resonance investigation of the conformational properties of the basic pancreatic trypsin inhibitor

1973 • 103 citations

Nuclear magnetic resonance study of bovine pancreatic trypsin inhibitor. Tyrosine titrations and backbone NH groups

1973 • 102 citations

Calculation of carbon-13 relaxation times and nuclear Overhauser enhancements in a hydrocarbon chain undergoing gauche-trans isomerism

1977 • 101 citations

The Structural Basis for Antibody Complementary

1978 • 99 citations

The interpretation of carbon-13 spin-lattice relaxation resulting from ring puckering in proline

1978 • 98 citations

Conformational States of Bovine Pancreatic Ribonuclease A Observed by Normal and Partially Relaxed Carbon 13 Nuclear Magnetic Resonance

1972 • 97 citations

MEASUREMENT OF STRUCTURAL AND FREE ENERGY CHANGES IN HEMOGLOBIN BY HYDROGEN EXCHANGE METHODS

1975 • 96 citations

The organization and function of water in protein crystals

1977 • 96 citations

Electrostatic stabilization in myoglobin. The pH dependence of summed electrostatic contributions

1979 • 94 citations

Carbon 13 Nuclear Magnetic Resonance of Pentapeptides of Glycine Containing Central Residues of Serine, Threonine, Aspartic and Glutamic Acids, Asparagine, and Glutamine

1973 • 92 citations

The Conformational Properties of the Basic Pancreatic Trypsin-Inhibitor

1971 • 91 citations

Water and proteins. I. The significance and structure of water; its interaction with electrolytes and non-electrolytes.

1978 • 89 citations

Nuclear magnetic resonance studies of sperm whale myoglobin specifically enriched with 13C in the methionine methyl groups.

1976 • 88 citations

Fast relaxation processes in a protein revealed by the decay kinetics of tryptophan fluorescence

1974 • 87 citations

Carboxymethylation of Sperm Whale Metmyoglobin

1963 • 87 citations

Catalysis of Hydrogen-Deuterium Exchange in Polypeptides^*

1966 • 87 citations

Pancreatic Trypsin Inhibitor (Kunitz): Part I: Structure and function

1972 • 86 citations

Variability in the tertiary structure of α-chymotrypsin at 2.8-Å resolution

1973 • 84 citations

Conformational flexibility of angiotensin II. Carbon-13 spin-lattice relaxation study

1975 • 82 citations

Molecular mobility of polypeptides containing proline as determined by ¹³C magnetic resonance

1974 • 81 citations

Studies of proteins in solution by natural-abundance carbon-13 nuclear magnetic resonance. Spectral resolution and relaxation behavior at high magnetic field strengths

1977 • 81 citations

A ¹H Nuclear‐Magnetic‐Resonance Study of the Conformation and the Molecular Dynamics of the Glycoprotein Cow‐Colostrum Trypsin Inhibitor

1978 • 79 citations

Fluorotyrosine alkaline phosphatase. Fluorine-19 nuclear magnetic resonance relaxation times and molecular motion of the individual fluorotyrosines

1974 • 79 citations

Dynamics of the aromatic amino acid residues in the globular conformation of the basic pancreatic trypsin inhibitor (BPTI)

1976 • 78 citations

Coordination complexes and catalytic properties of proteins and related substances. 105. Electrostatic effects in hemoglobin: Bohr effect and ionic strength dependence of individual groups

1979 • 77 citations

Measurement of the free and the H-bonded amides of myoglobin

1969 • 77 citations

Determination of rotational mobilities of backbone and side-chain carbons of poly(γ-benzyl L-glutamate) in the helical and random-coil states from measurements of carbon-13 relaxation times and nuclear Overhauser enhancements

1973 • 74 citations

Concentration-dependent hydrogen exchange kinetics of 3H-labeled S-peptide in ribonuclease S

1976 • 74 citations

Studies of macromolecular structure by carbon-13 nuclear magnetic resonance. II. Specific labeling approach to the study of histidine residues in proteins

1973 • 73 citations

Carbon 13 Nuclear Magnetic Resonance of Pentapeptides of Glycine Containing Central Residues of Aliphatic Amino Acids

1973 • 71 citations

Oxygen binding to iron porphyrins

1975 • 69 citations

Discrete charge calculations of potentiometric titrations for globular proteins: Sperm whale myoglobin, hemoglobin alpha chain, cytochrome c

1978 • 68 citations

Conformational Changes in Human Serum Albumin as Revealed by Hydrogen-Deuterium Exchange Studies

1972 • 68 citations

Electrostatic potentials of proteins. 2. Role of electrostatics in a possible catalytic mechanism for carboxypeptidase A

1976 • 67 citations

High-field carbon-13 nuclear magnetic resonance studies at 90.5 MHz of the basic pancreatic trypsin inhibitor

1978 • 67 citations

Studies of Hydrogen Exchange in Proteins

1971 • 66 citations

Individual assignments of the methyl resonances in the proton nuclear magnetic resonance spectrum of the basic pancreatic trypsin inhibitor

1978 • 64 citations

Carbon-13 nuclear magnetic resonance study of molecular motions and conformational transitions in muscle calcium binding parvalbumins

1976 • 64 citations

REACTIONS OF OXYGEN WITH HEMOGLOBIN, CYTOCHROME C OXIDASE AND OTHER HEMEPROTEINS*

1975 • 63 citations

13C magnetic resonance evidence for anisotropic molecular motion in collagen fibrils

1976 • 63 citations

Carbon 13 Nuclear Magnetic Resonance of Pentapeptides of Glycine Containing Central Residues of Methionine, Proline, Arginine, and Lysine

1974 • 63 citations

Hydrogen-deuterium exchange of cytochrome c. I. Effect of oxidation state

1968 • 62 citations

¹ H nuclear magnetic resonance studies of the tyrosine residues of selectively deuterated Lactobacillus casei dihydrofolate reductase

1977 • 62 citations

Conformational changes of luciferase during catalyses tritium-hydrogen exchange and optical rotation studies

1967 • 61 citations

Heme proteins. II. Preparation and thermodynamic properties of sperm whale myoglobin

1971 • 61 citations

Proton nuclear magnetic resonance study of histidine ionizations in myoglobins of various species. Comparison of observed and computed pK values

1978 • 61 citations

Allosteric regulation of aspartate transcarbamoylase. Effect of active site ligands on the reactivity of sulfhydryl groups of the regulatory subunits

1977 • 60 citations

A survey of amino acid side-chain interactions in 21 proteins

1978 • 60 citations

Quantitative determination of carbamino adducts of alpha and beta chains in human adult hemoglobin in presence and absence of carbon monoxide and 2,3-diphosphoglycerate.

1977 • 59 citations

Fluctuations of an α‐helix

1976 • 59 citations

Proton‐Nuclear‐Magnetic‐Resonance Study of the Conformation of Neurotoxin II from Middle‐Asian Cobra (Naja naja oxiana) Venom

1976 • 57 citations

Conformational flexibility of luteinizing hormone-releasing hormone in aqueous solution. Carbon-13 spin-lattice relaxation time study

1975 • 55 citations

Binding of Cyclopropane to Sperm Whale Myoglobin

1967 • 55 citations

Determination of rotational correlation times of proteins in solution from carbon-13 spin-lattice relaxation measurements. Effect of magnetic field strength and anisotropic rotation

1976 • 54 citations

Changes in the tertiary structure of .alpha.-chymotrypsin with change in pH. The pH 4.2-6.7

1973 • 54 citations

Studies of exchangeable hydrogens in lysozyme by means of Fourier transform proton magnetic resonance

1975 • 53 citations

Nuclear Magnetic Resonance Studies Of Hemoglobin: Functional State Correlations And Isotopic Enrichment Strategie

1975 • 53 citations

Molecular dynamics and structure of the random coil and helical states of the collagen peptide, α1-CB2, as determined by ¹³C magnetic resonance

1975 • 53 citations

Electrostatic effects in myoglobin. Application of the modified Tanford-Kirkwood theory to myoglobins from horse, California grey whale, harbor seal, and California sea lion

1975 • 52 citations

Electrostatic effects in myoglobin. pH and ionic strength variations of ionization equilibria for individual groups in sperm whale ferrimyoglobin

1974 • 52 citations

Studies of Hydrogen Exchange in Proteins

1968 • 52 citations

Kinetics and thermodynamics of the α helix ⇄ β transconformation of poly(L-lysine) and L-leucine copolymers. Compensation phenomenon

1973 • 52 citations

Hydrogen Exchange Studies of Respiratory Proteins

1972 • 51 citations

Carbon-13 nuclear magnetic resonance studies of polyamino acids: The helix-coil transition of poly-l-lysine

1973 • 50 citations

Electrophoretic and Hydrogen Ion Binding Behavior of Bovine Plasma Albumin in the Presence of 0.02 M Thiocyanate Ion

1957 • 50 citations

Reaction of N-acetylglucosamine oligosaccharides with lysozyme. Temperature, pH, and solvent deuterium isotope effects; equilbrium, steady state, and pre-steady state measurements*

1975 • 49 citations

Dépolarisation de fluorescence pour un colorant engagé sur une macromolécule flexible

1969 • 48 citations

Nuclear magnetic resonance measurement of hydrogen exchange kinetics of single protons in basic pancreatic trypsin inhibitor

1978 • 48 citations

Simulation du mouvement brownien d’une chaine macromoléculaire par la méthode de Monte-Carlo.

1969 • 48 citations

¹³C Nuclear magnetic resonance spectroscopy of polypropylene, 2. ¹³C spin‐lattice relaxation study in solution

1973 • 48 citations

Structure of alkaline metmyoglobin-xenon complex

1969 • 48 citations

Studies of hydrogen exchange in proteins. VI. Urea effects on ribonuclease exchange kinetics leading to a general model for hydrogen exchange from folded proteins.

1971 • 48 citations

Mechanism of Action of Bovine Pancreatic Ribonuclease

1966 • 48 citations

Long‐time orientation relaxation for an internal bond of a chain

1975 • 48 citations

Kinetics of Oxygen Binding to Human Hemoglobin

1974 • 47 citations

A survey of atomic interactions in 21 proteins

1978 • 47 citations

Structural Homology of Cytochromes c

1978 • 47 citations

Depolarized light scattering and carbon nuclear resonance measurements of the isotropic rotational correlation time of muscle calcium binding protein

1975 • 46 citations

Nuclear magnetic resonance studies on bacterial dihydrofolate reductase containing [methyl-¹³C]methionine

1978 • 46 citations

Proton nuclear magnetic resonance study of histidine ionizations in myoglobins of various species. Specific assignment of individual resonances

1978 • 46 citations

Solvent accessibility in folded proteins. Studies of hydrogen exchange in trypsin

1975 • 45 citations

A discussion of pressure-volume effects in aqueous protein solutions

1975 • 45 citations

Proton nuclear magnetic resonance relaxation of water on lysozyme powders

1977 • 45 citations

Nuclear Magnetic Resonance of Rotational Mobility of Mouse Hemoglobin Labeled with [2- ¹³ C]Histidine

1975 • 45 citations

Structural changes and fluctuations of proteins

1977 • 44 citations

13C–{1H} nuclear Overhauser enhancement and 13C spin lattice relaxation in molecules undergoing multiple internal rotations

1976 • 44 citations

Hydrogen Exchange Studies of Respiratory Proteins

1973 • 44 citations

Specific enrichment with carbon-13 of the methionine methyl groups of sperm whale myoglobin

1975 • 43 citations

Aliphatic groups of sperm whale myoglobin: 13C NMR study.

1979 • 43 citations

Studies of individual carbon sites of hemoglobins in solution by natural abundance carbon 13 nuclear magnetic resonance spectroscopy

1975 • 43 citations

OXIDIZED RNASE AS A PROTEIN MODEL HAVING NO CONTRIBUTION TO THE HYDROGEN EXCHANGE RATE FROM CONFORMATIONAL RESTRICTIONS

1970 • 42 citations

Rotational motions in myoglobin assessed by carbon 13 relaxation measurements at two magnetic field strengths.

1975 • 41 citations

Comparison of the three basic scattering functions of myoglobin in solution with those from the known structure in crystalline state

1973 • 41 citations

Productive and unproductive lysozyme-chitosaccharide complexes. Equilibrium measurements

1975 • 40 citations

Asymmetrical changes in the tertiary structure of α-chymotrypsin with change in pH

1974 • 39 citations

Internal rotations of side chains and backbone in luteinizing hormone-releasing hormone (LH-RH). Analysis of carbon-13 spin-lattice relaxation times

1976 • 39 citations

Volume effects in aqueous solutions of macromolecules containing non‐polar groups

1972 • 39 citations

Subanosecond solvent relaxation studies by oxygen quenching of fluorescence

1973 • 39 citations

Studies of Hydrogen Exchange in Proteins

1971 • 39 citations

Carboxymethylation of Sperm Whale Myoglobin in the Crystalline State

1970 • 39 citations

Carbon magnetic resonance study of the conformational changes in carp muscle calcium binding parvalbumin

1974 • 39 citations

Titration behavior and tautomeric states of individual histidine residues of myoglobins. Application of natural abundance carbon 13 nuclear magnetic resonance spectroscopy.

1977 • 39 citations

Effect of Coenzymes on the Hydrogen-Deuterium Exchange of Chicken Heart Lactic Dehydrogenase as Measured by Infrared Spectrophotometry^*

1965 • 38 citations

Conformation of Cyclolinopeptide A Observed by Nuclear Magnetic Resonance Spectroscopy

1971 • 38 citations

Conformational mobility within the structure of muscular parvalbumins. An NMR study of the aromatic resonances of phenylalanine residues

1976 • 37 citations

Hydrogen-exchange study of lysozyme conformation changes induced by inhibitor binding

1974 • 37 citations

The physical aspects of enzyme functioning

1976 • 37 citations

Hydrogen-tritium exchange kinetics of soybean trypsin inhibitor (Kunitz). Solvent acessibility in the folded conformation

1975 • 37 citations

220 MHz proton NMR studies of hemoproteins High-spin-low-spin equilibrium in ferric myoglobin and hemoglobin derivatives

1974 • 36 citations

Titration behavior of individual tyrosine residues of myoglobins from sperm whale, horse, and red kangaroo.

1976 • 36 citations

Carboxymethylation of Sperm Whale Myoglobin in the Dissolved State

1970 • 35 citations

Ionization Behavior of the Histidine Residue in the Catalytic Triad of Serine Proteases

1973 • 35 citations

Binding of mercuri-iodide and related ions to crystals of sperm whale metmyoglobin

1968 • 35 citations

Anisotropic rotations in 1-naphthylamine. Existence of a red-edge transition moment normal to the ring plane

1977 • 35 citations

Calorimetric study of the binding of carbon monoxide to myoglobin

1972 • 35 citations

On Intermolecular and Intramolecular Interactions between Independent Pairs of Binding Sites in Proteins and Other Molecules

1956 • 35 citations

Productive and unproductive lysozyme-chitosaccharide complexes. Kinetic investigations

1975 • 34 citations

Transient analyzer with logarithmic time base

1976 • 34 citations

Crystal Spectra of a Heme and Some Heme-Protein Complexes^*

1967 • 34 citations

A Re-examination of the Acid Titration Behavior of Human Mercaptalbumin

1962 • 33 citations

Nuclear magnetic resonance studies of hemoproteins. Unusual temperature dependence of hyperfine shifts and spin equilibrium in ferric myoglobin and hemoglobin derivatives

1974 • 33 citations

Effects of ligand binding on the rates of hydrogen exchange in myoglobin and hemoglobin

1973 • 32 citations

Complete tyrosine assignments in the high-field proton nuclear magnetic resonance spectrum of bovine pancreatic trypsin inhibitor selectively reduced and carboxamidomethylated at cystine 14-38

1976 • 32 citations

Carboxymethylation of Sperm Whale Metmyoglobin

1964 • 31 citations

Thermodynamic basis of induced fit. Specific alkane binding to proteins

1969 • 31 citations

Review Lecture Energy states of proteins, enzymes and membranes

1978 • 30 citations

Anisotropic rotational diffusion and intramolecular motion in cyclic amino acids and peptides. An interpretation of carbon-13 spin-lattice relaxation data

1976 • 29 citations

Nuclear magnetic resonance studies of slowly exchanging peptide protons in cytochrome c in aqueous solution.

1976 • 29 citations

Semisynthesis of a specific NH2-terminal [l-13C] Glycine adduct to sperm whale myoglobin: Intermediate protection of ɛ-amino groups with methyl acetimidate

1975 • 28 citations

Carbon 13 Nuclear Magnetic Resonance Spectroscopy of Myoglobins Carboxymethylated with Enriched [2-13C]Bromoacetate

1973 • 28 citations

Solvent accessibility calculations for sperm whale ferrimyoglobin based on refined crystallographic data

1978 • 27 citations

Coordination complexes and catalytic properties of proteins and related substances. 98. Physical characterization of S-methylglucagon and quantitation of carbamino adduct formation

1978 • 27 citations

Observation of individual carboxyl groups in hen egg-white lysozyme by use of high field 13C-nuclear magnetic resonance.

1976 • 27 citations

Comparison of Carboxymethylation Patterns of Harbor Seal and Sperm Whale Myoglobins

1973 • 27 citations

Suppression of hydrogen exchange in staphylococcal nuclease by ligands.

1968 • 26 citations

Antibody-hapten interactions: Circular and linear polarization of the fluorescence of dansyl bound to anti-dansyl antibodies

1974 • 26 citations

Multioscillator fluorescence depolarization. Anisotropy of dye binding

1970 • 25 citations

Mechanism of serine protease action. Ionization behavior of tetrahedral adduct between α‐lytic protease and tripeptide aldehyde studied by carbon‐13 magnetic resonance

1975 • 25 citations

Microenvironment of histidine 12 in ribonuclease-S as detected by carbon-13 nuclear magnetic resonance

1974 • 24 citations

Dynamic solvent accessibility in the soybean trypsin inhibitor-trypsin complex

1977 • 24 citations

Extensions of the allosteric model for hemoglobin. II. Consequences of functional nonequivalence of the α and β chains

1974 • 23 citations

Kinetics and mechanisms. The influence of fluctuations in protein charge and charge configuration on the rates of enzymatic reactions

1955 • 22 citations

The solvent dependence of hydrogen exchange kinetics of folded proteins

1975 • 22 citations

Selectively enriched [γ-13C]-histidine as a nuclear magnetic resonance probe of enzyme structure and function. Synthesis and incorporation into E.coli alkaline phosphatase

1976 • 21 citations

Spinach plastocyanin: Comparison of reduced and oxidized forms by natural abundance carbon-13 nuclear magnetic resonance spectroscopy

1977 • 19 citations

A study of the dynamic state of histidine residues in tryptophan synthetase α subunit by 13C nuclear magnetic resonance

1973 • 19 citations

Natural Abundance Carbon 13 Nuclear Magnetic Resonance of Cyanoferrimyoglobins and of Some Carboxymethyl Derivatives

1973 • 19 citations

Solvation of crystalline proteins: Theory and its application to available data

1975 • 19 citations

High field ¹³C NMR studies at 90.5 MHz of the methyl groups in the basic pancreatic trypsin inhibitor

1977 • 18 citations

A 13C nuclear magnetic resonance study of the interaction of ligands with arginine residues in dihydrofolate reductase

1977 • 17 citations

1H NMR studies at 360 MHz of the aromatic amino acid residues in ferrocytochrome c-552 from euglena gracilis

1977 • 17 citations

Proton magnetic resonance observations of hydrogen exchange rates and secondary structure in algal ferredoxin

1974 • 16 citations

Effect of metals on hydrogen-tritium exchange of proteins

1969 • 16 citations

Crystal Spectra of Some Ferric Hemoproteins^*

1967 • 16 citations

Hydrogen exchange kinetics changes upon formation of the soybean trypsin inhibitor-trypsin complex

1975 • 16 citations

Analysis of the 13C T 1 relaxation times in n-alkanes

1973 • 16 citations

¹³C spin relaxation studies of the basic pancreatic trypsin inhibitor

1976 • 16 citations

A carbon-13 spin lattice relaxation study of alumichrome at 25.1 MHz and 90.5 MHz

1977 • 15 citations

Natural abundance carbon-13 nuclear magnetic resonance study of gelatin

1973 • 15 citations

Jac. Berzelius: His Life and Work

1972 • 14 citations

Carbon-13 magnetic resonance spectra of aortic α-elastin in solution, coacervate and fibrous states

1976 • 14 citations

Specific interactions in proteins due to proton fluctuations

1966 • 14 citations

Deuterium nuclear magnetic resonance of deuterium-labeled diacetyldeuterohemin incorporated into sperm whale myoglobin.

1975 • 14 citations

A hydrogen-deuterium exchange study of the conformation of bovine liver glutamate dehydrogenase

1970 • 13 citations

Carbon-13 Spin-lattice relaxation studies of intramolecular motion in lysine and a series of oligolysines

1974 • 13 citations

Physical aspects of non-mechanistic biological theory

1962 • 13 citations

Protein Model Refinement Based on X-Ray Data

1974 • 11 citations

Myoglobin semisynthesis: removal of the amino-terminal valine of sperm whale myoglobin and its subsequent reincorporation

1979 • 10 citations

Observation of deuterium-labeled diacetyldeuteroporphyrin incorporated in cyanoferrimyoglobin by deuterium nuclear magnetic resonance

1975 • 10 citations

Carboxymethylation of crystalline ribonuclease

1969 • 9 citations

Proton NMR studies on soya bean lipoxygenase-1

1978 • 9 citations

Nuclear magnetic resonance studies of hemoproteins IV. Hindered rotation of heme side methyl group as a probe for studying van der waals contacts in the heme side environments of myoglobin derivatives

1975 • 9 citations

Nuclear magnetic resonance relaxation in lysozyme crystals

1974 • 7 citations