The Crossbridge Theory

Muscle Structure and Theories of Contraction

1957 • 3,392 citations

The variation in isometric tension with sarcomere length in vertebrate muscle fibres

1966 • 3,052 citations

Proposed Mechanism of Force Generation in Striated Muscle

1971 • 2,256 citations

ATPase Activity of Myosin Correlated with Speed of Muscle Shortening

1967 • 1,969 citations

Changes in the Cross-Striations of Muscle during Contraction and Stretch and their Structural Interpretation

1954 • 1,655 citations

Structural Changes in Muscle During Contraction: Interference Microscopy of Living Muscle Fibres

1954 • 1,532 citations

Electron microscope studies on the structure of natural and synthetic protein filaments from striated muscle

1963 • 1,452 citations

Mechanism of adenosine triphosphate hydrolysis by actomyosin

1971 • 1,289 citations

The low-angle X-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigor

1967 • 1,089 citations

Substructure of the myosin molecule

1971 • 1,062 citations

Tension responses to sudden length change in stimulated frog muscle fibres near slack length

1977 • 853 citations

THE CHEMISTRY OF MUSCULAR CONTRACTION

1922 • 666 citations

THE DOUBLE ARRAY OF FILAMENTS IN CROSS-STRIATED MUSCLE

1957 • 627 citations

Molecular control mechanisms in muscle contraction.

1973 • 565 citations

The structure of F-actin and of actin filaments isolated from muscle

1963 • 560 citations

Three-dimensional reconstruction of F-actin, thin filaments and decorated thin filaments

1970 • 552 citations

Induced Changes in Orientation of the Cross-Bridges of Glycerinated Insect Flight Muscle

1965 • 471 citations

Theoretical formalism for the sliding filament model of contraction of striated muscle Part I

1974 • 410 citations

The characterization of myosin–product complexes and of product-release steps during the magnesium ion-dependent adenosine triphosphatase reaction

1974 • 364 citations

FILAMENT LENGTHS IN STRIATED MUSCLE

1963 • 334 citations

Shape and flexibility of the myosin molecule

1978 • 329 citations

The mechanical properties of relaxing muscle

1960 • 326 citations

A cross-bridge model of muscle contraction

1979 • 317 citations

X-ray evidence for radial cross-bridge movement and for the sliding filament model in actively contracting skeletal muscle

1973 • 293 citations

X-ray evidence for conformational changes in the myosin filaments of vertebrate striated muscle

1975 • 283 citations

Comparison of the myosin and actomyosin ATPase mechanisms of the four types of vertebrate muscles

1980 • 250 citations

The reversibility of adenosine triphosphate cleavage by myosin

1973 • 249 citations

Transient state phosphate production in the hydrolysis of nucleoside triphosphates by myosin

1970 • 241 citations

Segmental flexibility of the S-1 moiety of myosin

1973 • 233 citations

Chemistry of Muscle Contraction

1972 • 231 citations

Fluorescence studies on heavy meromyosin-substrate interaction

1972 • 222 citations

Proteins of Contractile Systems

1976 • 197 citations

Intermediate states of subfragment 1 and actosubfragment 1 ATPase: reevaluation of the mechanism

1978 • 188 citations

Contraction kinetics of striated muscle fibres following quick changes in load

1966 • 169 citations

The relation between intrinsic speed of shortening and duration of the active state of muscle.

1965 • 163 citations

Chemical machines, Maxwell's demon and living organisms

1971 • 160 citations

Myosin content and filament structure in smooth and striated muscle

1973 • 142 citations

Structure of insect fibrillar flight muscle in the presence and absence of ATP

1972 • 136 citations

Muscle Filament Structure and Muscle Contraction

1975 • 124 citations

Motion of subfragment-1 in myosin and its supramolecular complexes: saturation transfer electron paramagnetic resonance.

1975 • 122 citations

ULTRASTRUCTURE OF THE RESTING AND CONTRACTED STRIATED MUSCLE FIBER AT DIFFERENT DEGREES OF STRETCH

1961 • 119 citations

Changes in muscle crossbridges when β,γ-imido-ATP binds to myosin

1976 • 109 citations

Temperature and amplitude dependence of tension transients in glycerinated skeletal and insect fibrillar muscle.

1977 • 100 citations

Dissociation constant of the actin-heavy meromyosin subfragment-1 complex

1975 • 99 citations

Coupling between the enzymatic site of myosin and the mechanical output of muscle

1979 • 90 citations

Actin Activation of Heavy Meromyosin Adenosine Triphosphatase

1970 • 86 citations

The kinetics of muscle contraction

1975 • 85 citations

Cross-bridge conformation as revealed by x-ray diffraction studies on insect flight muscles with ATP analogues

1975 • 82 citations

Diversity of cross-bridge configurations in invertebrate muscles

1975 • 81 citations

Evidence for a Refractory State of Heavy Meromyosin and Subfragment-1 Unable to Bind to Actin in the Presence of ATP

1973 • 80 citations

Evidence for a Complex between Myosin and ADP in Relaxed Muscle Fibres

1972 • 77 citations

Heat Production and chemical change in muscle

1971 • 76 citations

The Binding Constant of ATP to Myosin S1 Fragment

1977 • 76 citations

Muscle Crossbridges: Absence of Direct Effect of Calcium on Movement Away from the Thick Filaments

1976 • 68 citations

A Type of Contraction Hypothesis applicable to all Muscles

1970 • 63 citations

Pre-steady-state kinetic evidence for a cyclic interaction of myosin subfragment one with actin during the hydrolysis of adenosine 5'-triphosphate

1976 • 61 citations

A “molecular energy” muscle model

1972 • 60 citations

Actin mediated release of ATP from a myosin ATP complex

1978 • 57 citations

Heavy meromyosin binds actin with negative cooperativity

1978 • 41 citations

A Hypothesis of Contraction in Striated Muscle

1960 • 40 citations

Return of Myosin Heads to Thick Filaments After Muscle Contraction

1977 • 35 citations

Effect of activation by calcium on the X-ray diffraction pattern from insect flight muscle

1975 • 26 citations

Molecular mechanisms of contraction.

1977 • 19 citations

Comments on the Mechanism of Force Generation in Striated Muscles

1972 • 10 citations