Conformational Adaptability in Enzymes

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

Conformation of Polypeptides and Proteins

1968 • 2,929 citations

Application of a Theory of Enzyme Specificity to Protein Synthesis

1958 • 2,272 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

The Mechanism of Muscular Contraction

1969 • 1,928 citations

Einfluss der Configuration auf die Wirkung der Enzyme

1894 • 1,695 citations

The interaction of a naphthalene dye with apomyoglobin and apohemoglobin

1965 • 1,486 citations

Hydrogen Exchange in Proteins

1966 • 1,115 citations

The Enzymology of Control by Feedback Inhibition

1962 • 1,003 citations

Adenosine Triphosphate Conservation in Metabolic Regulation

1967 • 878 citations

Conformation Changes of Proteins

1954 • 859 citations

Crystallographic studies of the activity of hen egg-white lysozyme

1967 • 649 citations

The Preparation of Subtilisin-modified Ribonuclease and the Separation of the Peptide and Protein Components

1959 • 632 citations

Kinetic Aspects of Regulation of Metabolic Processes

1970 • 616 citations

Regulation of Enzyme Activity

1966 • 612 citations

The Catalytic and Regulatory Properties of Enzymes

1968 • 603 citations

Studies on the Reduction and Re-formation of Protein Disulfide Bonds

1961 • 595 citations

Tertiary Structure of Ribonuclease

1967 • 573 citations

Fragmentation of Bovine Serum Albumin by Pepsin

1964 • 514 citations

Electron microscopy of an antibody-hapten complex

1967 • 505 citations

Flexibility of an Active Center in Sodium-Plus-Potassium Adenosine Triphosphatase

1969 • 476 citations

Water-Insoluble Derivatives of Enzymes, Antigens, and Antibodies

1966 • 475 citations

Fluorescent Probes for Conformational States of Proteins. I. Mechanism of Fluorescence of 2-p-Toluidinylnaphthalene-6-sulfonate, a Hydrophobic Probe^*

1966 • 475 citations

Segmental flexibility in an antibody molecule

1970 • 465 citations

Negative cooperativity in enzyme action. Binding of diphosphopyridine nucleotide to glyceraldehyde-3-phosphate dehydrogenase

1968 • 456 citations

Acceleration of Reactivation of Reduced Bovine Pancreatic Ribonuclease by a Microsomal System from Rat Liver

1963 • 439 citations

ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES

1967 • 439 citations

Studies on Liver Alcohol Dehydrogenase. II. The Kinetics of the Compound of Horse Liver Alcohol Dehydrogenase and Reduced Diphosphopyridine Nucleotide.

1951 • 435 citations

[124] “Malic”-enzyme

1955 • 425 citations

Evidence for a Negative-Feedback Mechanism in the Biosynthesis of Isoleucine

1956 • 423 citations

The molecular basis of antibody formation: a paradox.

1965 • 394 citations

Kinetics of Regulatory Enzymes

1965 • 390 citations

CRYSTALLINE d-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM RABBIT MUSCLE

1948 • 375 citations

Structure of crystalline α-chymotrypsin

1969 • 374 citations

Specific labeling and partial purification of the M protein, a component of the beta-galactoside transport system of Escherichia coli.

1965 • 374 citations

Glutamic Aspartic Transaminase

1959 • 368 citations

The Structure of Ribonuclease-S at 3.5 A Resolution

1967 • 351 citations

The Antibody Problem

1969 • 347 citations

The Mechanism of Tricarboxylic Acid Cycle Regulation of Fatty Acid Synthesis

1962 • 333 citations

Glutamic Dehydrogenase

1959 • 333 citations

Studies on the Mechanism of Activation of Acetyl Coenzyme A Carboxylase by Citrate

1963 • 333 citations

Functional Tyrosyl Residues in the Active Center of Bovine Pancreatic Carboxypeptidase A^*

1963 • 302 citations

The Genetic Control of Tertiary Protein Structure: Studies With Model Systems

1963 • 301 citations

Membrane Transport Proteins

1968 • 297 citations

Heterogeneity of the Binding Sites of Bovine Serum Albumin¹

1950 • 297 citations

INTERMOLECULAR CROSS LINKING OF A PROTEIN IN THE CRYSTALLINE STATE: CARBOXYPEPTIDASE-A

1964 • 287 citations

The mechanism of the reaction catalysed by adenosine triphosphate-creatine phosphotransferase

1965 • 286 citations

Studies on liver alcohol dehydrogenase complexes

1964 • 281 citations

lac repressor—Operator interaction

1970 • 279 citations

Reductive Cleavage of Disulfide Bridges in Ribonuclease

1957 • 278 citations

Kinetic and Magnetic Resonance Studies of the Pyruvate Kinase Reaction

1966 • 277 citations

Glutamate Dehydrogenase

1963 • 269 citations

The photochemical formation of a quickly reacting form of haemoglobin

1959 • 269 citations

Mechanism of Action of Reagents that uncouple Oxidative Phosphorylation

1969 • 258 citations

Lactic Dehydrogenase

1959 • 258 citations

Half-of-the-sites reactivity and conformational states of cytidine triphosphate synthetase

1971 • 256 citations

Glutamic Dehydrogenase

1959 • 243 citations

Structure of Some Crystalline Lysozyme-Inhibitor Complexes Determined by X-Ray Analysis At 6 Å Resolution

1965 • 240 citations

ADENOSINETRIPHOSPHATE-CREATINE TRANSPHOSPHORYLASE

1954 • 239 citations

Chemical Approaches to the Properties of Active Sites of Enzymes

1969 • 236 citations

Structure of Lactate Dehydrogenase at 2.8 Å Resolution

1970 • 234 citations

Treatment of Enzyme Kinetic Data

1964 • 233 citations

Exchange of hydrogen atoms in insulin with deuterium atoms in aqueous solutions

1954 • 231 citations

Fluorescent Probes of Biological Membranes

1970 • 228 citations

Side-chain Interactions Governing the Pairing of Half-cystine Residues in Ribonuclease

1962 • 227 citations

Crystallization and Properties of Rabbit Skeletal Muscle Phosphofructokinase

1966 • 225 citations

[87] Fluorescence measurements

1967 • 223 citations

Correlation of Structure and Function in Enzyme Action

1963 • 222 citations

Allosteric interactions in aspartate transcarbamylase. I. Binding of specific ligands to the native enzyme and its isolated subunits

1968 • 219 citations

Transport

1970 • 213 citations

Glutamic Dehydrogenase

1959 • 212 citations

The Enzymic Behavior of Carboxypeptidase-A in the Solid State^*

1966 • 210 citations

The Dissociation and Reconstitution of Aldolase^*

1962 • 210 citations

Pyruvate Carboxylase

1965 • 209 citations

Studies on the Mechanism of Glutamine Synthesis; Isolation and Properties of the Enzyme from Sheep Brain^*

1962 • 204 citations

Bromopyruvate Inactivation of 2-Keto-3-deoxy-6-phosphogluconic Aldolase. I. Kinetic Evidence for Active Site Specificity^*

1967 • 203 citations

A New Method of Preparation of D-Amino Acid Oxidase Apoprotein and a Conformational Change after Its Combination with Flavin Adenine Dinucleotide

1966 • 199 citations

Kinetic and Magnetic Resonance Studies of the Pyruvate Kinase Reaction

1965 • 199 citations

The interpretation of non-hyperbolic rate curves for two-substrate enzymes. A possible mechanism for phosphofructokinase

1966 • 196 citations

THE BINDING OF NICOTINAMIDE-ADENINE DINUCLEOTIDE TO YEAST D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE: TEMPERATURE-JUMP RELAXATION STUDIES ON THE MECHANISM OF AN ALLOSTERIC ENZYME

1966 • 196 citations

Purification and Properties of Isoleucyl Ribonucleic Acid Synthetase from Escherichia coli

1966 • 195 citations

X-Ray Diffraction Studies of Enzymes

1970 • 194 citations

Enzyme flexibility and enzyme action

1959 • 192 citations

A Hydrogen Exchange Method Using Tritium and Sephadex: Its Application to Ribonuclease^*

1963 • 191 citations

Environmentally Sensitive Tyrosyl Residues. Nitration with Tetranitromethane^*

1967 • 190 citations

Cell Membranes: Structure and Synthesis

1969 • 189 citations

The Acyl-enzyme Intermediate and the Kinetic Mechanism of the Glyceraldehyde 3-Phosphate Dehydrogenase Reaction

1965 • 187 citations

Selective chemical modification of proteins.

1970 • 187 citations

Studies on Adenosine Triphosphate Transphosphorylases

1962 • 186 citations

Molecular Mechanism of Formation of an Antigen–Antibody Complex

1965 • 184 citations

Comparative Aspects of Primary Structures of Proteins

1968 • 184 citations

Specific Chemical Modification of Proteins

1970 • 181 citations

Structure and activity of enzymes

1966 • 180 citations

The Anatomy of an Enzymatic Catalysis. α-Chymotrypsin

1964 • 179 citations

7 The Molecular Basis for Enzyme Regulation

1970 • 177 citations

Antibodies to biologically active molecules

1967 • 177 citations

Fluorescent Probes for Conformational States of Proteins. II. The Binding of 2-p-Toluidinylnaphthalene-6-sulfonate to α-Chymotrypsin^*

1967 • 176 citations

Complement

1969 • 175 citations

CRYSTALLINE HEXOKINASE (HETEROPHOSPHATESE)

1946 • 174 citations

Kinetics of Regulatory Enzymes

1965 • 174 citations

Molecular weight of the subunits, oligomeric and associated forms of bovine liver glutamate dehydrogenase

1968 • 171 citations

Nuclear magnetic resonance studies of the structure and binding sites of enzymes

1969 • 171 citations

From Enzymatic Adaptation to Allosteric Transitions

1966 • 167 citations

An Environmentally-Sensitive Reagent with Selectivity for the Tryptophan Residue in Proteins

1964 • 167 citations

Structure and biological properties of immunoglobulins

1967 • 166 citations

Kinetics of Escherichia coli B D-Lactate Dehydrogenase and Evidence for Pyruvate-controlled Change in Conformation

1968 • 166 citations

Kinetic Studies of Rabbit Muscle Lactate Dehydrogenase

1962 • 164 citations

Relaxation Spectrometry of Biological Systems

1968 • 163 citations

Comprehensive Biochemistry

1963 • 162 citations

On the excitability and cooperativity of the electroplax membrane.

1968 • 159 citations

Changes in Ultraviolet Absorption Produced by Alteration of Protein Conformation

1969 • 159 citations

Group-Specific Reagents in Protein Chemistry

1968 • 158 citations

The enzymic reactivation of reduced ribonuclease

1963 • 158 citations

Kinetic aspects of conformational changes in proteins. I. Rate of regain of enzyme activity from denatured proteins

1971 • 156 citations

Hemoglobin

1970 • 155 citations

Spectrophotometric Identification of an Active Site-specific Acyl Glyceraldehyde 3-Phosphate Dehydrogenase

1968 • 153 citations

DISULFIDE INTERCHANGE AND THE THREE-DIMENSIONAL STRUCTURE OF PROTEINS

1965 • 152 citations

STUDIES ON SUCCINIC DEHYDROGENASE

1957 • 152 citations

Structure of Hæmoglobin : An X-ray Examination of Reduced Horse Hæmoglobin

1964 • 149 citations

Chemical Characterization of D-Lactate Dehydrogenase from Escherichia coli B

1968 • 148 citations

LACTIC DEHYDROGENASE

1956 • 146 citations

Allosteric Interactions in Aspartate Transcarbamylase. III. Interpretation of Experimental Data in Terms of the Model of Monod, Wyman, and Changeux

1968 • 143 citations

Equilibrium and kinetics of the unfolding of lysozyme (muramidase) by guanidine hydrochloride

1966 • 141 citations

The relationship between molecular conformation and the binding of flavin-adenine dinucleotide in glucose oxidase

1969 • 141 citations

The Role of Flexibility in Enzyme Action

1963 • 140 citations

The Tyrosyl Residues at the Active Site of Staphylococcal Nuclease

1968 • 140 citations

On the interaction of the active site of α-chymotrypsin with chromophores: Proflavin binding and enzyme conformation during catalysis

1966 • 139 citations

Der physiologische erschlaffungsfaktor und die muskelgrana

1960 • 138 citations

THE MECHANISM OF ACTION OF RIBONUCLEASE

1969 • 137 citations

Co-operative Effects in Enzyme Catalysis: A Possible Kinetic Model Based on Substrate-Induced Conformation Isomerization

1967 • 136 citations

Sulfhydryl Groups Involved in the Active Site of Myosin A Adenosine Triphosphatase*

1966 • 135 citations

Positive and negative cooperativity in yeast glyceraldehyde 3-phosphate dehydrogenase

1970 • 135 citations

The inhibition of erythrocyte cholinesterase by tri-esters of phosphoric acid. 3

1954 • 134 citations

Enzymatically active conformers of mitochondrial malate dehydrogenase.

1966 • 133 citations

Reversible Dissociation of Aldolase into Unfolded Subunits^*

1963 • 133 citations

The Activity of an Enzyme in the Crystalline State: Ribonuclease S

1963 • 131 citations

Effect of Modification of a Methionyl Residue on the Kinetic and Molecular Properties of Isocitrate Dehydrogenase

1968 • 131 citations

The Catalytic Environment and its Biological Implications

1964 • 131 citations

Cross-Linking of Bovine Pancreatic Ribonuclease A with Dimethyl Adipimidate^*

1967 • 129 citations

Low resolution study of crystalline l-lactate dehydrogenase

1969 • 128 citations

THE STRUCTURE OF CARBOXYPEPTIDASE A, VI. SOME RESULTS AT 2.0-Å RESOLUTION, AND THE COMPLEX WITH GLYCYL-TYROSINE AT 2.8-Å RESOLUTION

1967 • 126 citations

Drug Receptors and their Function

1971 • 125 citations

Induced Fit in Yeast Hexokinase

1970 • 125 citations

STUDIES ON THE MECHANISM OF THE ALDOLASE REACTION

1958 • 125 citations

RECOVERY OF ANTIGENIC SPECIFICITY AFTER DENATURATION AND COMPLETE REDUCTION OF DISULFIDES IN A PAPAIN FRAGMENT OF ANTIBODY

1964 • 124 citations

9 Enzymes as Control Elements in Metabolic Regulation

1970 • 122 citations

GENETIC CONTROL OF THE MEMBRANE PROTEIN COMPONENT OF THE LACTOSE TRANSPORT SYSTEM OF Escherichia coli

1967 • 122 citations

Cytidine triphosphate synthetase. Covalent intermediates and mechanisms of action

1971 • 122 citations

An introduction to the study of enzymes

1965 • 121 citations

Citrate-condensing Enzyme-Oxalacetate Binary Complex

1966 • 121 citations

The Preparation and Properties of the Isolated α and β Subunits of Hemoglobin A^*

1966 • 121 citations

Specific Anion Binding to Fructose Diphosphate Aldolase from Rabbit Muscle^*

1966 • 119 citations

The Relation of Function and Structure in Lipoyl Dehydrogenase

1962 • 118 citations

Magnetic Resonance Investigations of Ternary Complexes of Enzyme–Metal–Substrate

1962 • 118 citations

The kinetics of the reaction of nitrophenyl phosphates with alkaline phosphatase from Escherichia coli

1968 • 118 citations

Relationships between the Conformation of Ribonuclease and Its Reactivity toward Iodoacetate

1961 • 118 citations

Acetylcholine Receptor: Covalent Attachment of Depolarizing Groups at the Active Site

1969 • 118 citations

The stabilization of <scp>d</scp>-amino-acid oxidase by flavin-adenine dinucleotide, substrates and competitive inhibitors

1951 • 118 citations

Conformation of Proteins

1967 • 116 citations

1 X-Ray Crystallography and Enzyme Structure

1970 • 116 citations

Adenosine Triphosphate Conservation in Biosynthetic Regulation

1967 • 115 citations

Models for Cooperative Effects in Proteins Containing Subunits

1967 • 115 citations

Studies on the tryptic digestion of myosin

1959 • 114 citations

The kinetics of the reversible inhibition of heart lactate dehydrogenase through the formation of the enzyme–oxidized nicotinamide–adenine dinucleotide–pyruvate compound

1968 • 114 citations

Kinetics of carboxypeptidase A. I. Hydrolysis of carbobenzoxyglycyl-L-phenylalanine, benzoylglycyl-L-phenylalanine, and hippuryl-DL-.beta.-phenyllactic acid by metal-substituted and acetylated carboxypeptidases

1968 • 113 citations

Structure and Function of Carbamoylphosphate Synthase

1968 • 111 citations

Reversible Inactivation of Dehydrogenases

1966 • 109 citations

Transients in the reactions of liver alcohol dehydrogenase

1970 • 109 citations

Kinetic aspects of conformational changes in proteins. II. Structural changes in renaturation of denatured proteins

1971 • 108 citations

Stability and ligand sensitivity of [3H]ouabain binding to (Na+ + K+)-ATPase

1970 • 108 citations

Rotatory Dispersion and Circular Dichroism

1968 • 108 citations

Antibody-mediated activation of a defective beta-D-galactosidase extracted from an Escherichia coli mutant.

1968 • 107 citations

Reversible inactivation of rabbit muscle aldolase by o-phenanthroline

1967 • 107 citations

Regulation of enzyme activity and allosteric interactions

1968 • 107 citations

The Reactivity toward N-Bromosuccinimide of Tryptophan in Enzymes, Zymogens, and Inhibited Enzymes^*

1966 • 106 citations

Synthetic Lipid Bilayer Membranes

1969 • 104 citations

An Exploration of the Active Site of Aldolase Using Structural Analogs of Fructose Diphosphate^*

1965 • 104 citations

Molecular Uniformity in Biological Catalyses

1967 • 104 citations

Reactions of Haemoglobin Dimers after Ligand Dissociation

1970 • 104 citations

Evidence for Conformation Changes Induced by Substrates of Phosphoglucomutase

1965 • 103 citations

Alternative to allosterism and cooperativity in the interpretation of enzyme kinetic data

1968 • 102 citations

The Interaction of 6-Diazo-5-oxo-l-norleucine with Phosphoribosyl Pyrophosphate Amidotransferase

1963 • 101 citations

Proteins in Excitable Membranes

1970 • 100 citations

Lactic Dehydrogenase

1959 • 100 citations

Evidence for a carrier conformational change associated with sugar transport in erythrocytes

1971 • 99 citations

Effects of Temperature, Substrate, and Activating Cations on the Conformations of Pyruvate Kinase in Aqueous Solutions

1965 • 99 citations

Application of Optical Rotatory Dispersion and Circular Dichroism to the Study of Biopolymers

1970 • 98 citations

Structural Studies of Ribonuclease. VII. Chymotryptic Hydrolysis of Ribonuclease A at Elevated Temperatures^*

1963 • 97 citations

Enzymic studies of the gelatin → collagen-fold transition

1959 • 96 citations

Investigations of the Chymotrypsin-catalyzed Hydrolysis of Specific Substrates

1967 • 95 citations

On Some Structural Analogies between Acetylcholinesterase and the Macromolecular Receptor of Acetylcholine

1969 • 95 citations

Studies on the Interaction of Substrate and Monovalent and Divalent Cations with Pyruvate Kinase^*

1966 • 94 citations

Thermostable Protease from Thermophilic Bacteria

1967 • 93 citations

Liver Alcohol Dehydrogenase. III. Kinetics in the Presence of Caprate, Isobutyramide and Imidazole.

1961 • 93 citations

INTRODUCTION: IMMUNOCHEMISTRY OF ENZYMES

1963 • 93 citations

Nuclear magnetic resonance determination of ligand-induced conformational changes in myoglobin

1970 • 92 citations

The Enzymatic Activity and Inhibition of Adenosine 5′-Triphosphate-Creatine Transphosphorylase

1960 • 92 citations

Multiplicity of Binding by Lactate Dehydrogenases^*

1965 • 91 citations

SPECIFICITY OF RECOMBINATION OF H AND L CHAINS FROM HUMAN γG-MYELOMA PROTEINS

1965 • 91 citations

Equilibrium and Net Reaction Rates in Relation to the Mechanism of Yeast Hexokinase

1964 • 90 citations

Bifunctional Reagents. Cross-Linking of Pancreatic Ribonuclease with a Diimido Ester¹

1966 • 90 citations

Adenosine Triphosphatase Activity of Yeast Hexokinase and Its Relation to the Mechanism of the Hexokinase Reaction

1965 • 89 citations

Structure of Proteins

1963 • 89 citations

Multiplicity of Binding. Range of Validity and Practical Test of Adair's Equation^*

1965 • 89 citations

Ribitol Dehydrogenase

1962 • 88 citations

AN APPROACH TO THE PROBLEM OF CONFORMATIONAL ISOZYMES

1968 • 88 citations

Interactions of Substrates, Inhibitors, and Coenzymes at the Active Site of Horse Liver Alcohol Dehydrogenase

1967 • 87 citations

Studies on the Interaction of Aldolase with Substrate Analogues

1969 • 87 citations

On the binding of chitin oligosaccharides to lysozyme.

1966 • 87 citations

Magnetic Resonance Investigations of the Metal Complexes Formed in the Manganese-activated Creatine Kinase Reaction

1966 • 86 citations

Lactic Dehydrogenase

1967 • 86 citations

Lactic Dehydrogenase

1959 • 86 citations

Coenzyme-induced Changes in the Optical Rotatory Dispersion Properties of Glyceraldehyde 3-Phosphate Dehydrogenase

1965 • 85 citations

Phosphoribosyl Pyrophosphate Amidotransferase

1963 • 85 citations

The Structure of Carboxypeptidase A

1967 • 85 citations

Requirement of sulfhydryl groups for the catalytic and tRNA recognition functions of isoleucyl-tRNA synthetase

1969 • 84 citations

Steric Course and Specificity of α-Chymotrypsin-catalyzed Reactions. II

1962 • 84 citations

Association Sites of Lysozyme in Solution

1969 • 84 citations

The Structure of Ribonuclease-S at 6 A Resolution

1967 • 84 citations

Regulation of Enzyme Activity

1971 • 83 citations

Synthesis of Citrulline with Animal and Bacterial Enzymes

1960 • 82 citations

Hemoglobin and its Reaction with Ligands

1967 • 82 citations

Purification and Kinetic Characteristics of Dogfish Liver Glutamate Dehydrogenase

1967 • 82 citations

Yeast phenylalanyl transfer ribonucleic acid synthetase. Purification, molecular weight, and subunit structure

1971 • 82 citations

A study of the ‘reactive’ sulphydryl groups of adenosine 5′-triphosphate-creatine phosphotransferase

1962 • 81 citations

Structure of Ribonuclease

1967 • 81 citations

Protein substrate conformation and proteolysis.

1965 • 81 citations

Mechanism of Enzyme Catalysis

1964 • 81 citations

Low Cyst(e)ine Content of Bacterial Extracellular Proteins: Its Possible Physiological Significance

1962 • 80 citations

RECOVERY OF SPECIFIC ACTIVITY AFTER COMPLETE UNFOLDING AND REDUCTION OF AN ANTIBODY FRAGMENT

1965 • 80 citations

Nature of urea effect on anion binding by macromolecules

1968 • 80 citations

Effect of temperature on the rate of hydrolysis of adenosine triphosphate and inosine triphosphate by myosin with and without modifiers. Evidence for a change in protein conformation

1962 • 80 citations

Implications of X-Ray Crystallographic Studies of Protein Structure

1968 • 80 citations

1-Anilinonaphthalene-8-sulphonate, a fluorescent conformational probe for glutamate dehydrogenase

1969 • 79 citations

An Allosteric Reduced Nicotinamide Adenine Dinucleotide Oxidase from Mycobacterium tuberculosis

1965 • 79 citations

The structure of the nicotinamide-adenine dinucleotide coenzyme when bound to lactate dehydrogenase

1970 • 78 citations

USE OF „REPORTER GROUPS” IN STRUCTURE-FUNCTION STUDIES OF PROTEINS

1964 • 78 citations

Nucleotide Specificity and Conformation of the Active Site of Creatine Kinase

1966 • 77 citations

Conformational changes in proteins as measured by difference sedimentation studies. I. Technique for measuring small changes in sedimentation coefficient

1971 • 77 citations

Peptide Bonds in Globular Proteins

1938 • 77 citations

On the ternary complex of liver alcohol dehydrogenase with reduced coenzyme and isobutyramide. Effect of p-chloromercuriphenyl sulfonate and stability of the complex

1962 • 77 citations

A substrate-induced conformation change in the reaction of alkaline phosphatase from Escherichia coli

1969 • 77 citations

Interaction of sugars with the membrane protein component of the lactose transport system of Escherichia coli.

1968 • 76 citations

Metabolic control and structure of glycolytic enzymes. IV. Nicotinamide adenine dinucleotide-dependent in vitro reversal of dissociation and possible in vivo control of yeast glyceraldehyde-3-phosphate dehydrogenase synthesis

1969 • 75 citations

Kinetics of Folding of Staphylococcal Nuclease

1970 • 75 citations

The Effect of Urea and Guanidine Hydrochloride on Activity and Optical Rotation of Penicillinase

1960 • 75 citations

Studies of the Enzyme Hexokinase. I. Steady State Kinetics at pH 8

1962 • 74 citations

ADENOSINE 5′-TRIPHOSPHATE-ARGININE PHOSPHOTRANSFERASE FROM LOBSTER MUSCLE: PURIFICATION AND PROPERTIES

1965 • 74 citations

The Denaturation of Lactic Dehydrogenases

1964 • 74 citations

Tryptophan Oxygenase of Pseudomonas acidovorans

1969 • 73 citations

Conformational Changes in Aspartate Transcarbamylase

1968 • 72 citations

Inactivation and Labeling of Triose Phosphate Isomerase and Enolase by Glycidol Phosphate

1969 • 72 citations

Conformational changes and the mechanism of resolution of glycogen phosphorylase

1969 • 72 citations

On the Prevalence of „Nonspecific” Binding at the Specific Binding Sites of Globular Proteins

1970 • 71 citations

Purification and properties of frog skeletal muscle phosphorylase

1968 • 71 citations

STIMULATING AND INHIBITING ANTIBODIES FOR BACTERIAL PENICILLINASE.

1964 • 71 citations

Properties of crystalline hexokinase from yeast II. Studies on ATP-enzyme interaction

1961 • 71 citations

Physical Chemical Studies on Proteins and Polypeptides

1966 • 71 citations

Structure-Function Relationships in Lysozyme by Circular Dichroism¹

1966 • 70 citations

The Quaternary Structure of Proteins Composed of Identical Subunits

1971 • 70 citations

Conformational changes and the regulation of glutamate-dehydrogenase activity

1966 • 70 citations

THE EXTRACELLULAR NUCLEASE OF Staphylococcus aureus : STRUCTURES OF THE NATIVE ENZYME AND AN ENZYME-INHIBITOR COMPLEX AT 4 Å RESOLUTION

1969 • 69 citations

Preparation and characterization of sheep brain glutamine synthetase

1969 • 69 citations

Modification of glycogen phosphorylase b by glutaraldehyde. Preparation and isolation of enzyme derivatives with enhanced stability

1969 • 69 citations

Glutamate Dehydrogenase

1963 • 69 citations

Fluorescent Probe Environment and the Structural and Charge Changes in Energy Coupling of Mitochondrial Membranes

1970 • 68 citations

The mechanism of activation of skeletal muscle phosphorylase A by glycogen.

1967 • 68 citations

Respiratory chain-linked nicotinamide adenine dinucleotide dehydrogenase. XVIII. Action of sulfhydryl inhibitors on different forms of the respiratory chain-linked reduced nicotinamide-adenine dinucleotide dehydrogenase

1970 • 68 citations

Oxygen equilibria of human hemoglobin valency hybrids

1969 • 68 citations

The inhibition of succinate dehydrogenase by oxaloacetate

1969 • 68 citations

Interaction of lactate dehydrogenase with its coenzyme, nicotinamide-adenine dinucleotide

1970 • 68 citations

X‐Ray Small‐Angle Scattering of Yeast Glyceraldehyde‐3‐phosphate Dehydrogenase as a Function of Saturation with Nicotinamide‐Adenine‐Dinucleotide

1971 • 68 citations

Reactivity and Function of Sulfhydryl Groups in Horse Liver Alcohol Dehydrogenase^*

1965 • 67 citations

The Reaction of Glutamate Dehydrogenase with 4‐Iodoacetamido Salicylic Acid

1970 • 67 citations

Secondary enzyme-substrate interactions and the specificity of pepsin

1970 • 67 citations

Fluorescence spectra of ternary complexes of dehydrogenases with reduced diphosphopyridine nucleotide and reduced substrates

1958 • 67 citations

XANTHINE OXIDASE

1958 • 66 citations

Specific Alkylation of the Sarcoplasmic Reticulum ATPase by N‐Ethyl‐[1‐¹⁴C]maleimide and Identification of the Labeled Protein in Acrylamide Gel‐Electrophoresis

1970 • 66 citations

Threonine Deaminase from Bacillus subtilis

1970 • 66 citations

Re-evaluation of the Kinetic Constants of Previously Investigated Specific Substrates of α-Chymotrypsin¹

1955 • 66 citations

The Mechanism of the Specificity of Trypsin Catalysis

1964 • 66 citations

Isolation and Some Properties of the Triphosphopyridine Nucleotide Isocitrate Dehydrogenase from Bacillus stearothermophilus

1970 • 65 citations

X-Ray Analysis, Structure and Function of Enzymes

1969 • 65 citations

Binding of adenosine 5'-monophosphate and substrate by rabbit liver fructose 1,6-diphosphatase

1969 • 65 citations

The Binding of N-Acetylglucosamine to Lysozyme: Studies on Circular Dichroism *

1969 • 65 citations

Lactic Dehydrogenase

1961 • 65 citations

The reaction of iodoacetamide with the active center of γ-glutamyl transpeptidase

1965 • 64 citations

Conformational properties of the isoenzymes of aspartate transaminase and the enzyme-substrate complexes

1970 • 64 citations

Magnetic resonance studies of enzymesubstrate complexes with paramagnetic probes as illustrated by creatine kinase

1970 • 64 citations

Preparation and Kinetic Properties of Intermediates in the Reaction of Hemoglobin with Ligands

1966 • 63 citations

Pyridoxal 5′-phosphate as a specific photosensitizer for histidine residue at the active site of 6-phosphogluconate dehydrogenase

1969 • 63 citations

Hydrogen-deuterium exchange of cytochrome c. I. Effect of oxidation state

1968 • 62 citations

Conformation of Polypeptide Chains

1969 • 62 citations

The Antigen Receptor Problem

1970 • 61 citations

Relaxation spectra of adenosine triphosphate-creatine phosphotransferase

1969 • 61 citations

Conformational changes of luciferase during catalyses tritium-hydrogen exchange and optical rotation studies

1967 • 61 citations

The Asparagine Synthetase of Escherichia coli

1969 • 60 citations

The Threonine‐Sensitive Homoserine Dehydrogenase and Aspartokinase Activities of Escherichia coli K 12

1969 • 60 citations

Cross-linking of Aminotyrosyl Residues in the Active Site of Staphylococcal Nuclease

1969 • 60 citations

Kinetic Study of Yeast Hexokinase. 1. Steady-State Kinetics

1968 • 60 citations

8 Mechanisms of Enzyme Regulation in Metabolism

1970 • 60 citations

Chemical Cleavage of Proteins

1968 • 60 citations

Effect of Adenylic Acid on the Regulatory Nicotinamide-Adenine Dinucleotide Specific Isocitrate Dehydrogenase^*

1966 • 59 citations

Complexes of Liver Alcohol Dehydrogenase. Further Studies on the Rate of Inactivation

1970 • 59 citations

Mechanism of Action of Carboxydismutase

1964 • 58 citations

Aspartate Transcarbamylase

1970 • 57 citations

Reaction kinetics of a crystalline hemoprotein: An effect of crystal structure on reactivity of ferrimyoglobin

1966 • 57 citations

Induction of Biological Activity by Limited Proteolysis

1967 • 57 citations

Spectroscopic Studies of α-Chymotrypsin Catalyzed Reactions. II. Spectral Changes at 290 mμ

1962 • 56 citations

The thiol groups of yeast alcohol dehydrogenase

1964 • 56 citations

Studies on liver alcohol dehydrogenase complexes

1964 • 56 citations

The Role of the Sulfhydryl Groups of Lactic Dehydrogenases^*

1963 • 56 citations

THE HARVEY LECTURES, SERIES 60

1967 • 56 citations

Physicochemical properties of Bence-Jones proteins in the form of L-chain dimers

1965 • 56 citations

Two antigenically different states of active penicillinase

1958 • 55 citations

Syncatalytic modification of a functional tyrosyl residue in aspartate aminotransferase

1970 • 55 citations

Factors affecting the reversible dissociation of dehydrogenases.

1965 • 55 citations

Crystallization of thermostable glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus

1966 • 54 citations

Relaxation spectrometry of enzymatic reactions

1968 • 54 citations

THE ACTION OF TRYPSIN ON NATIVE AND DENATURED PROTEINS

1945 • 54 citations

The Influence of Binding Domains on the Nature of Subunit Interactions in Oligomeric Proteins

1970 • 54 citations

Kinetic Evidence for a Tetrameric Functional Unit in Hemoglobin

1968 • 53 citations

Yeast Alcohol Dehydrogenase. III. Relation of Alcohol Structure to Activity¹

1957 • 53 citations

The Primary Specificity of α-Chymotrypsin. Acylated Amino Acid Esters with Normal Alkyl Side Chains¹

1965 • 53 citations

IMMUNOLOGICAL CHARACTERISTICS OF DEHYDROGENASES

1963 • 53 citations

Glutamate dehydrogenase from yeast and from animal tissues

1964 • 53 citations

The Molecular Weight of Avidin

1964 • 53 citations

Coenzyme binding, observed by fluorescence enhancement, apparently unrelated to the enzymic activity of glutamic dehydrogenase

1961 • 53 citations

Iodohistidine Formation in Ribonuclease A

1966 • 52 citations

The Mechanism of Refording of the Reduced Random Coil form of Lysozyme*

1968 • 52 citations

Proteins of Excitable Membranes

1969 • 52 citations

The reactivity of thiol groups and the subunit structure of aldolase

1970 • 52 citations

Fluorescence studies of the interaction of nucleotides with the active site of the nuclease of Staphylococcus aureus.

1967 • 51 citations

Ribulose-1,5-diphosphate carboxylase from Hydrogenomonas eutropha and Hydrogenomonas facilis. II. Molecular weight, subunits, composition, and sulfhydryl groups

1969 • 51 citations

Immunoglobulin E (Reagin) and Allergy

1971 • 51 citations

The l-amino acid oxidases of snake venom. III. Reversible inactivation of l-amino acid oxidases

1951 • 51 citations

Changes in absorption spectrum and crystal structure of triose phosphate isomerase brought about by 2-phosphoglycollate, a potential transition state analogue

1970 • 51 citations

Effect of allosteric effectors and adenosine triphosphate on the aggregation and rate of inhibition by N-ethylmaleimide of carbamyl phosphate synthetase of Escherichia coli

1970 • 51 citations

The Chemistry of a Reporter Group: 2-Hydroxy-5-nitrobenzyl Bromide

1970 • 50 citations

The conformational basis of energy transduction in membrane systems

1969 • 50 citations

Comparison of protein structure in the crystal and in solution. III. Tritium-hydrogen exchange of lysozyme and a lysozyme-saccharide complex

1968 • 50 citations

Inhibition of Parental and Mutant Xanthosine 5'-Phosphate Aminases by Psicofuranine

1963 • 50 citations

The effect of 5′adenylic acid upon the association between bromthymol blue and muscle phosphorylase b

1964 • 50 citations

The Interaction of Nucleotides with the Active Site of Staphylococcal Nuclease

1967 • 50 citations

A Kinetic Study of the Mechanism of Crystalline Carbamate Kinase

1966 • 50 citations

Structural changes induced by the blocking of protein SH groups

1961 • 49 citations

The unfolding and refolding of ribonuclease in urea solutions

1964 • 49 citations

Effect of ornithine, IMP, and UMP on carbamyl phosphate synthetase from Escherichiacoli

1968 • 49 citations

The Reaction of Nucleotide Substrate Analogues with Adenosine Triphosphate-Creatine Phosphotransferase

1966 • 49 citations

Nuclear magnetic resonance in the study of biopolymers and their interaction with ions and small molecules

1970 • 48 citations

Optical and chemical identification of kinetic steps in trypsin- and chymotrypsin-catalysed reactions

1966 • 48 citations

Local anesthetic induced changes of a membrane‐bound fluorochrome A link between ion uptake and membrane structure

1969 • 48 citations

Conformational isomers of alkaline phosphatase in the mechanism of hydrolysis

1971 • 48 citations

The Molecular Basis of Muscle Contraction

1969 • 48 citations

Effect of temperature and effectors on the conformations of yeast pyruvate kinase

1970 • 48 citations

Fructose Diphosphatase from Rabbit Liver. VII. Tyrosine Residues and Adenosine Monophosphate Inhibition^*

1966 • 47 citations

Detection of a conformational change in an antihapten-antibody system upon interaction with divalent hapten

1970 • 47 citations

The function of histidine residues in rabbit muscle aldolase.

1967 • 47 citations

Fluorescent Probes for Conformational States of Proteins. III. The Activation of Chymotrypsinogen^*

1967 • 47 citations

The Kinetics of Yeast Hexokinase in the Light of the Induced Fit Involved in the Binding of its Sugar Substrate

1970 • 47 citations

Acyltransferase Activity to 1-O-Alkyl-Glycero-3-phosphorylcholine in Sarcoplasmic Reticulum

1970 • 47 citations

The interaction of trypsin with neutral substrates and modifiers

1968 • 46 citations

Aldolase Reaction with Sugar Diphosphates

1967 • 46 citations

The Mechanism of 6-Deoxyhexose Synthesis

1969 • 46 citations

The Role of Sulfhydryl Groups in the Catalytic Function of Isocitrate Dehydrogenase

1970 • 46 citations

Structural and functional role of FAD in the NADH‐nitrate reducing system from Chlorella

1970 • 46 citations

A mechanism for the effects of dinitrophenol and temperature on the hydrolytic activity of myosin

1959 • 46 citations

Specificity of α-Chymotrypsin

1961 • 46 citations

PURIFIED MUSCLE PROTEINS AND THE WALKING RATE OF ANTS

1959 • 46 citations

The rate-limiting reaction in papain action as derived from the reaction of the enzyme with chloroacetic acid

1968 • 45 citations

Evidence for Conformational Changes in α-Chymotrypsin-catalyzed Reactions. VI. Changes in Optical Rotatory Dispersion Parameters

1963 • 45 citations

Immunoenzymology of acetylcholinesterase—I

1969 • 45 citations

Ligand-induced Resistance of Staphylococcal Nuclease and Nuclease-T to Proteolysis by Subtilisin, α-Chymotrypsin, and Thermolysin

1969 • 44 citations

Rates of binding of reduced nicotinamide adenine dinucleotide analogs to liver alcohol dehydrogenase

1969 • 44 citations

Role of the Coenzyme in the Stabilization of Glyceraldehyde-3-phosphate Dehydrogenase

1959 • 44 citations

Studies of the Enzyme Hexokinase. II. Kinetic Inhibition by Products

1962 • 44 citations

SPECIFICITY IN THE ASSEMBLY OF MULTISUBUNIT PROTEINS

1969 • 44 citations

The reactive lysine residue at the allosteric site of sheep kidney pyruvate carboxylase

1968 • 44 citations

Proteolytic Enzymes

1954 • 44 citations

The chemical reactivity of the thiol group in the active centre of ficin

1964 • 44 citations

Fluorescence Studies of Coenzyme-binding to Beef Heart Lactic Dehydrogenase

1959 • 44 citations

Environment of a reporter group at the active site of chymotrypsin

1967 • 44 citations

Effect of Antigen on the Structural Configuration of Homologous Antibody following Antigen-Antibody Combination

1966 • 44 citations

Mechanism of the Salicylate hydroxylase reaction'

1969 • 44 citations

Glutamine phosphoribosylpyrophosphate amidotransferase. Catalytic and conformation heterogeneity of the pigeon liver enzyme

1970 • 43 citations

Labeling of the active site of aldolase with glyceraldehyde 3-phosphate and erythrose 4-phosphate

1968 • 43 citations

Relation of protein subunit interactions to the molecular species observed during cooperative binding of ligands.

1967 • 43 citations

Relaxation spectra of aspartate transcarbamylase. I. Interaction of 5-bromocytidine triphosphate with native enzyme and regulatory subunit

1970 • 42 citations

Conformational Changes in Aspartate Transcarbamylase

1971 • 42 citations

Antibodies to Enzymes — A Tool in the Study of Antigenic Specificity Determinants

1971 • 42 citations

Nuclear Magnetic Resonance Studies of the Structure and Binding Sites of Enzymes, XII. A Conformational Equilibrium in Staphylococcal Nuclease Involving a Histidine Residue

1970 • 42 citations

Chemical modification of hemoglobins: a study of conformation restraint by internal bridging.

1966 • 42 citations

A PROPOSED COMMON ALLOSTERIC MECHANISM FOR ACTIVE TRANSPORT, MUSCLE CONTRACTION, AND RIBOSOMAL TRANSLOCATION

1969 • 42 citations

The interaction of penicillinase with penicillins I. Effect of substrates and of a competitive inhibitor on native and urea-treated enzyme

1962 • 42 citations

Inactivation of lysozyme by iodine oxidation of a single tryptophan

1964 • 42 citations

Effect of alkyl guanidines and alkyl amines on trypsin catalysis

1968 • 42 citations

Selective carboxymethylation of functional sulfhydryl groups at the active center of horse liver alcohol dehydrogenase

1963 • 42 citations

Structure of horse liver alcohol dehydrogenase

1965 • 42 citations

Specific Inactivation of Yeast Hexokinase Induced by Xylose in the Presence of a Phosphoryl Donor Substrate

1970 • 41 citations

The Oxidation by Iodine of Tryptophan 108 in Lysozyme

1967 • 41 citations

Proteolytic enzymes as probes of the secondary structure of fibrous proteins

1959 • 41 citations

Conformation of myosin Effects of substrate and modifiers

1969 • 41 citations

A Soluble Ribonucleic Acid-induced Increase in the Specificity of Escherichia coli Isoleucine-activating Enzyme

1965 • 41 citations

Anti-Nucleic Acid Specificities of Mouse Myeloma Immunoglobulins

1970 • 41 citations

Some Aspects of Antibody-Antigen Reactions and Theoretical Considerations of the Immunologic Response

1963 • 41 citations

Cooperative Effects of Substrates and Substrate Analogs on the Conformation of Creatine Phosphokinase^*

1966 • 41 citations

Conformational Aspects of Enzyme Regulation

1969 • 41 citations

Metabolic control and structure of glycolytic enzymes. VII. Destabilization and inactivation of yeast glyceraldehyde 3-phosphate dehydrogenase by adenosine phosphates and chymotrypsin

1969 • 41 citations

Environmental sensitivity of azo chromophores in arsanilazocarboxypeptidase

1969 • 41 citations

Conformational changes induced in Na+, K+-ATPase by ouabain through a K+-sensitive reaction: Kinetic and spectroscopic studies

1970 • 41 citations

The interaction of penicillinase with penicillins IV. Structural aspects of catalytic and non-catalytic interactions

1965 • 40 citations

Nuclear magnetic resonance studies of the structure and binding sites of enzymes

1970 • 40 citations

POLARIZATION OF FLUORESCENCE AS A MEASURE OF ANTIGEN-ANTIBODY INTERACTION

1962 • 40 citations

Conformational changes accompanying the formation of chymotrypsin-substrate complexes. Evidence for the involvement of an N-terminal α-amino group in the activity and the conformation of the enzyme

1964 • 40 citations

Folic acid coenzymes and one-carbon metabolism. XXV. Effect of N-bromosuccinimide on dihydrofolate reductase

1969 • 40 citations

Stabilization of Mutant Catalase by Complex Formation with Antibody to Normal Catalase

1971 • 40 citations

Binding interactions between two ligands and a monomeric protein

1970 • 40 citations

The role of thiol groups in the structure and mechanism of action of arginine kinase

1966 • 39 citations

Conformational change accompanying modification of myosin ATPase

1966 • 39 citations

Properties of crystalline hexokinase from yeast. III. Studies on glucose-enzyme interaction

1961 • 39 citations

Protein conformation: Autoplastic and alloplastic effects

1966 • 39 citations

Rabbit Muscle Phosphofructokinase

1968 • 39 citations

Structure of the Antibody Combining Site. I. Hapten Stabilization of Antibody Conformation^*

1967 • 39 citations

Ligand-induced Conformational Changes in Ribonuclease

1968 • 39 citations

Substrate Control of Conformation Characteristics in Chymotrypsin

1963 • 39 citations

Properties and reaction with iodoacetamide of adenosine 5′-triphosphate–creatinine phosphotransferase from human skeletal muscle. Further evidence about the role of the essential thiol group in relation to the mechanism of action

1970 • 39 citations

Enzyme activation by antibody. I. Fractionation of immune sera in search for an enzyme activating antibody.

1969 • 39 citations

Studies on Dihydrofolic Reductase

1968 • 39 citations

Effect of Coenzymes on the Hydrogen-Deuterium Exchange of Chicken Heart Lactic Dehydrogenase as Measured by Infrared Spectrophotometry^*

1965 • 38 citations

Chemical modification of glutamate dehydrogenase by 2,4,6-trinitrobenzenesulphonic acid

1969 • 38 citations

The mechanism of antibody-antigen reaction

1956 • 38 citations

Effet du pH sur la fixation d'inhibiteurs compétitifs synthétiques par la trypsine

1967 • 38 citations

Cooperative and Non-Cooperative Conformational Effects of the Coenzyme on Yeast Glyceraldehyde-3-Phosphate Dehydrogenase

2005 • 38 citations

Changes in Physical Properties Accompanying the Interaction of Trypsin with Protein Inhibitors

1965 • 38 citations

The Threonine‐Sensitive Homoserine Dehydrogenase and Aspartokinase Activities of Escherichia coli K 12

1969 • 37 citations

Three Dimensional Structure of Haemoglobin Rainier

1971 • 37 citations

The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli

1966 • 37 citations

The rate of an allosteric process: inhibition of homoserine dehydrogenase I from E. coli by threonine.

1968 • 37 citations

Immunoenzymological Evidence Suggesting a Change in Conformation of Adenylic Acid Deaminase and Creatine Kinase during Substrate Combination

1961 • 37 citations

Purification and properties of the 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (phenylalanine sensitive) of Escherichia coli K12

1969 • 37 citations

Stereospecific requirements for carbonyl reagents in the resolution and reconstitution of phosphorylase b

1969 • 37 citations

An Optical Rotatory Dispersion Study of Aspartic Amino Transferase^*

1964 • 37 citations

Purification and properties of the synthase (phenylalanine sensitive) of Escherichia coli K12

1969 • 37 citations

The effect of modifiers on the hydrolysis of esters and peptides by carboxypeptidase A

1968 • 37 citations

Hapten stabilization of antibody conformation

1970 • 36 citations

Comments on the Kinetics and Mechanism of Yeast Hexokinase Action

1969 • 36 citations

The catalytic-centre activity and kinetic properties of bovine milk alkaline phosphatase

1966 • 36 citations

Studies of the Interaction of Substrate Analogues with Bacterial Liquefying α-Amylase* by Means of Spectrophotometry and Steady State Kinetics

1971 • 36 citations

The Specific Binding of Biebrich Scarlet to the Active Site of α-Chymotrypsin

1967 • 36 citations

Dye-sensitized Photooxidation As a Tool for Determining the Degree of Exposure of Amino Acid Residues in Proteins

1970 • 36 citations

Conformative response of xanthosine 5'-phosphate aminase

1969 • 36 citations

A Study of the Reaction of Glyceraldehyde with Glyceraldehyde 3-Phosphate Dehydrogenase

1966 • 35 citations

The Sulfhydryl Groups of Muscle Phosphorylase

1970 • 35 citations

The Effect of Magnesium on the Reactivity of the Essential Sulfhydryl Groups in Creatine Kinase-Substrate Complexes^*

1966 • 35 citations

Conformational change of tyrosyl-RNA synthetase induced by its specific transfer RNA

1967 • 35 citations

Substrate-dependent association of lactic dehydrogenase subunits to active tetramer.

1966 • 35 citations

Anomalous Rotatory Dispersion of Enzyme-Chelate Complexes

1961 • 34 citations

Reversible inactivation of papain by cyanate

1967 • 34 citations

Magnetic Resonance and Kinetic Studies Related to the Manganese Activation of the Adenylate Kinase Reaction

1968 • 34 citations

Investigations of the Chymotrypsin-catalyzed Hydrolysis of Specific Substrates

1967 • 34 citations

Bedeutung von SH-Gruppen für die enzymatische Aktivität. Studien an Milchsäuredehydrogenase aus Schweineherz

1959 • 34 citations

Optical Rotatory Dispersion of Ribonuclease and Ribonuclease-Nucleotide Complexes^*

1965 • 34 citations

Desensitization of glutamate dehydrogenase by reaction of tyrosine residues

1969 • 33 citations

Threonine dehydratase of Bacillus licheniformis

1968 • 33 citations

Iodocarboxypeptidase^*

1966 • 33 citations

A Separate Antibiotic-binding Site in Xanthosine-5'-phosphate Aminase: Inhibitor- and Substrate-binding Studies^*

1964 • 33 citations

The binding of substrates and modifiers to glucosamine synthetase

1971 • 33 citations

THE STRUCTURE OF CARBOXYPEPTIDASE A, IV. PRELIMINARY RESULTS AT 2.8 Å RESOLUTION, AND A SUBSTRATE COMPLEX AT 6 Å RESOLUTION

1967 • 33 citations

Effect of Substrate on the Conformation of Myosin

1969 • 33 citations

Effects of pH, ionic strength, and metabolic intermediates on the rates of heat inactivation of lactate dehydrogenase isozymes.

1966 • 33 citations

New aspects of acetylglutamate action. Cold inactivation of frog carbamyl phosphate synthetase

1961 • 33 citations

Mechanism of the salicylate hydroxylase reaction

1969 • 33 citations

Evidence for a substrate-mediated change in conformation of rabbit muscle aldolase

1968 • 33 citations

Evidence for Conformational Changes in α-Chymotrypsin Catalyzed Reactions. VII. Thermal Induced Reversible Changes of Conformation at pH 2.0

1963 • 32 citations

STUDIES ON CYTOCHROME C*

1960 • 32 citations

ANOMALOUS ROTATORY DISPERSION OF ENZYME COMPLEXES, II. THE ASYMMETRIC BINDING OF COENZYMES AND INHIBITORS TO LIVER ALCOHOL DEHYDROGENASE

1961 • 32 citations

p-Hydroxybenzoate hydroxylase: Conformational changes in crystals of holoenzyme vs holoenzyme-substrate complex

1969 • 32 citations

The binding of NADH to liver alcohol dehydrogenase: A two step reaction

1967 • 32 citations

Creatine kinase. Relations of trypsin susceptibility to substrate binding

1968 • 32 citations

Influences of pH and substrate analogs on ribonuclease T1 fluorescence

1970 • 32 citations

Flavin and thiol groups of yeast glutathione reductase

1961 • 32 citations

Nicotinamide Adenine Dinucleotide As an Active Site Director in Glyceraldehyde 3-Phosphate Dehydrogenase Modification

1970 • 31 citations

Fluorescence Detection of the Chemical Relaxation of the Reaction of Lactate Dehydrogenase with Reduced Nicotinamide Adenine Dinucleotide

1964 • 31 citations

The Reoxidation of Reduced Ribonuclease Derivatives

1964 • 31 citations

The Denaturation of Lactic Dehydrogenases

1965 • 31 citations

RATES OF GDP-INDUCED AND GTP-INDUCED DEPOLYMERIZATION AND ISOMERIZATION OF THE BOVINE LIVER GLUTAMATE DEHYDROGENASE-COENZYME COMPLEX: A POSSIBLE CONTROLLING FACTOR IN METABOLIC REGULATION

1969 • 31 citations

Effect of Glucose 6-Phosphate on the Nucleotide Site of Glycogen Phosphorylase b

1970 • 31 citations

The heterogeneity and molecular transformations of glucose-6-phosphate dehydrogenase of the rat

1970 • 31 citations

Reversible changes of ordered polypeptide structures in oxidized and reduced epimerase.

1968 • 31 citations

A COMPARISON OF THE ACTION OF CRYSTALLINE PAPAIN ON NATIVE AND UREA-DENATURED PROTEINS

1941 • 31 citations

CONFORMATION CHANGES IN ACETYLCHOLINESTERASE

1967 • 31 citations

Mechanism of Action of Yeast Alcohol Dehydrogenase

1962 • 31 citations

Biosynthesis and Utilization of Acetyl Phosphate, Formyl Phosphate, and Carbamyl Phosphate and their Relations to the Urea Cycle

1964 • 31 citations

Hydrogen Exchange in Proteins as a Measure of Solvent Exclusion due to Ligands

1969 • 31 citations

The resolution of some steps of the reactions of lactate dehydrogenase with its substrates

1968 • 31 citations

Immunological studies of aspartate transcarbamoylase. II. Effect of ligands on the conformation of the enzyme

1968 • 30 citations

The effect of proteases on the (Na+ + K+)-activated adenosine triphosphatase system of rat brain

1968 • 30 citations

Enzymatic Synthesis of Monofluorocitrate from β-Fluoro-oxaloacetate

1962 • 30 citations

Decrease in thermal stability of frog liver carbamyl phosphate synthetase by substrates and cofactors

1959 • 30 citations

The interaction of ‘soluble’ ribonucleic acid, magnesium ions and sulphydryl groups in the control of amino acid-dependent pyrophosphate-exchange reactions

1961 • 29 citations

Stereospecificity of the catalytic reaction of L-asparaginase

1972 • 29 citations

Factors controlling the Interconversion of Enzyme–Substrate Compounds of Pig Heart Lactate Dehydrogenase

1968 • 29 citations

The mechanism of binding of flavin-adenine dinucleotide to the apoenzyme of glucose oxidase and evidence for the involvement of multiple bonds

1969 • 29 citations

Spectrophotometric study of the enzyme-substrate complex of phosphorylase b

1968 • 29 citations

Binding of NAD+ to rabbit-muscle glyceraldehydephosphate dehydrogenase as studied by optical rotatory dispersion and circular dichroism

1969 • 29 citations

Chemical modification of the allosteric and catalytic sites of fructose 1,6-diphosphatase.

1966 • 29 citations

Modulation of heart muscle mitochondrial malate dehydrogenase activity. I. Activation and inhibition by p-mercuribenzoate

1970 • 29 citations

Allosteric enzyme models and their analysis by the theory of graphs

1966 • 29 citations

[32] Yeast hexokinase

1955 • 29 citations

STUDIES ON THE MECHANISM OF ACTION OF ADENOSINE 5′-TRIPHOSPHATE-CREATINE PHOSPHOTRANSFERASE. INHIBITION BY MANGANESE IONS AND BY P-NITROPHENYL ACETATE

1963 • 29 citations

The Role of Sulfhydryl Groups in the Catalytic Function of Isocitrate Dehydrogenase

1970 • 29 citations

Fluorescence enhancement of uridine diphosphogalactose 4-epimerase induced by specific sugars

1966 • 29 citations

DENATURATION AND INACTIVATION OF ENZYME PROTEINS: XI. INACTIVATION AND DENATURATION OF GLUTAMIC ACID DEHYDROGENASE BY UREA, AND THE EFFECT OF ITS COENZYME ON THESE PROCESSES

1959 • 29 citations

The essential thiol group of sheep kidney mitochondrial phosphoenolpyruvate carboxykinase

1968 • 28 citations

Spectral shift in heavy-meromyosin induced by substrate

1966 • 28 citations

Kinetic of the protection of lactate dehydrogenase by substrates against heat inactivation

1970 • 28 citations

Enzyme-activation by antibody. 3. The effect of antibody on activity-restoration in mixtures of S-peptide and S-protein.

1971 • 28 citations

Complex formation of apo-enzyme, coenzyme and substrate of d-amino acid oxidase IV. Changes in physico-chemical properties of the protein

1962 • 28 citations

Evidence for β-β interactions during the binding of oxygen to hemoglobin

1969 • 28 citations

Substrate-induced dissociation of rabbit muscle aldolase into active subunits

1967 • 28 citations

Low molecular RNA associated with chromatin Purification and characterization of RNA that stimulates RNA synthesis

1972 • 28 citations

Beef Heart Malic Dehydrogenases

1968 • 28 citations

Haloacetol phosphates. Potential active-site reagents for aldolase, triose phosphate isomerase, and glycerophosphate dehydrogenase. II. Inactivation of aldolase

1970 • 28 citations

Difference spectropolarimetry as a probe for small conformational changes

1968 • 27 citations

Sedimentation studies of fumarase

1957 • 27 citations

The regulation of aspartokinase inBacillus licheniformis

1969 • 27 citations

Enzyme Activation by Antibody

1969 • 27 citations

Measurement of Fast Biochemical Reactions

1970 • 27 citations

8-Anilino naphthalene sulfonate binding as a probe for conformational changes induced in glutamate dehydrogenase by regulatory reagents

1968 • 27 citations

CONFORMATIONAL CHANGES IN ENZYME CATALYSIS

1962 • 27 citations

Variations in heat stability of enzymes with substrates and cofactors

1959 • 27 citations

Ficin- and papain-catalyzed reactions. Changes in reactivity of the essential sulfhydryl group in the presence of substrates and competitive inhibitors

1969 • 27 citations

Fructose 1,6-Diphosphatase from Rabbit Liver. VI. Functional Tyrosyl Residues in the Active Center^*

1966 • 27 citations

Direct evidence for the conformational nature of the Na+, K+-ATPase system: Fluorescence and circular dichroism studies

1970 • 27 citations

Optical Activity and Conformation Studies of Pig Heart Lipoamide Dehydrogenase

1969 • 27 citations

Conformational changes in rabbit muscle aldolase. Ultraviolet spectroscopic studies

1971 • 27 citations

Conformational Changes Accompanying An Enzyme Catalyzed Reaction

1962 • 27 citations

Suppression of hydrogen exchange in staphylococcal nuclease by ligands.

1968 • 26 citations

The l-amino acid oxidases of snake venom. IV. The effect of anions on the reversible inactivation

1951 • 26 citations

Homoserine dehydrogenase-aspartokinase of Escherichia coli. Comparison of threonine saturation and enzyme conformation

1971 • 26 citations

Identification of a Cysteinyl Residue Involved in the Activity of Rabbit Muscle Aldolase

1970 • 26 citations

Bifunctional reagents and protein structure determination. The reaction of phenolic disulfonyl chlorides with lysozyme

1964 • 26 citations

Anomalous Rotatory Dispersion of Enzyme Complexes

1964 • 26 citations

The interaction of penicillinase with penicillins

1968 • 26 citations

Studies on I. Effects of PH and competitive inhibitors

1968 • 26 citations

Glutamate dehydrogenase from human liver III. Antibody-binding sites and properties of the antigen-antibody complex

1971 • 26 citations

Possible “Allosteric” effects controlling the kinetic behavior of amino acid-dependent pyrophosphate exchange reactions

1966 • 26 citations

THE DENATURATION OF PROTEINS AND ITS APPARENT REVERSAL

1942 • 26 citations

Enzyme-activation by antibody. II. The distribution of activating antibody in chromatographic fractions of ribonuclease antisera and their competition with inhibiting antibody for enzyme sites.

1970 • 26 citations

Magnetic Resonance and Kinetic Studies on the Manganese Activated Arginine Kinase Reaction

1969 • 26 citations

The Inactivation of Bacillus subtilis α-Amylase by N-Acetylimidazole and Tetranitromethane

1970 • 25 citations

Optical rotatory dispersion of liver alcohol dehydrogenase, and its complexes with coenzymes and inhibitors

1965 • 25 citations

Studies of the active site of yeast phosphoglycerate mutase

1971 • 25 citations

Change in Ultraviolet Absorption Spectrum of H-Meromyosin Induced by Its Binding with Substrate and Competitive Inhibitor*

1967 • 25 citations

The Role of the Tyrosyl Groups on the Mechanism of Action of Chicken Heart Lactic Dehydrogenase^*

1965 • 25 citations

Cytochrome (l-lactate déshydrogénase):équilibre et processus élémentaires de la réaction de combinaison substrat à l'enzyme

1967 • 25 citations

The Mechanism of Triosephosphate Dehydrogenase Inactivation by Reduced Diphosphopyridine Nucleotide

1962 • 25 citations

The effect of coenzyme on the S→N acyl migration in glyceraldehyde-3-phosphate dehydrogenase

1966 • 25 citations

Enzyme-Activation by Antibody

1971 • 25 citations

Substrate-induced Conformational Changes of Liver Fructose 1,6-Diphosphatase Studied with the Hydrophobic Probe, 1-Anilinonaphthalene-8-sulfonate

1970 • 25 citations

The interaction of penicillinase with penicillins

1968 • 25 citations

Effect of crystallization upon the reactivity of horse liver alcohol dehydrogenase

1966 • 24 citations

OPHIDIAN <scp>l</scp>-AMINO ACID OXIDASE. THE NATURE OF THE ENZYME-SUBSTRATE COMPLEXES

1965 • 24 citations

PH-dependent inactivation of nicotinamide-adenine dinucleotide glycohydrolase by its substrate, oxidized nicotinamide-adenine dinucleotide

1971 • 24 citations

Complex formation of apoenzyme, coenzyme and substrate of d-amino acid oxidase V. Change in conformation of the protein by forming a model of enzyme-substrate complex

1963 • 24 citations

Fluorescence quneching technique for the investigation of the configurations of binding sites for small molecules

1969 • 24 citations

Dissociation-produced loss of regulatory control of homoserine dehydrogenase of Rhodospirillum rubrum. I. Factors which affect the interconversion of the regulatable and nonregulatable states

1969 • 24 citations

Inactivation of Muscle Triosephosphate Dehydrogenase by Reduced Diphosphopyridine Nucleotide at Physiological Concentrations

1962 • 24 citations

Studies on Conformational Changes in Glyceraldehyde-3-Phosphate Dehydrogenase Accompanying its Catalytic Action.

1965 • 24 citations

Allosteric Interactions in (Na+ + K+)-ATPase

1970 • 24 citations

Sedimentation behaviour of phosphoribosyladenosine triphosphate synthetase effects of substrates and modifiers

1971 • 24 citations

Evidence for a change in the active site of penicillinase caused by a competitive inhibitor

1961 • 24 citations

Kinetic Studies on the Inhibition of a d(-)-Specific Lactate Dehydrogenase by Adenosine Triphosphate

1968 • 23 citations

Circular dichroic and optical rotatory dispersion spectra of the threonine-inhibited aspartokinase-homoserine dehydrogenase of Escherichia coli K 12. Effects of ligand binding and protein denaturation

1970 • 23 citations

Lysyl transfer ribonucleic acid synthetase from Escherichia coli

1969 • 23 citations

Studies on the Interaction between Regulatory Enzymes and Effectors

1967 • 23 citations

Glutamate-dehydrogenase inactivation by reduced nicotinamide-adenine dinucleotide phosphate

1962 • 23 citations

Studies of the chymotrypsinogen family. IV. The conversion of chymotrypsinogen A to alpha-chymotrypsin.

1965 • 23 citations

On the role of s-RNA in regulating the rates of amino acid-dependent pyrophosphate exchange reactions: A possible “allosteric control” phenomenon

1964 • 23 citations

The optical-rotatory dispersion of myosin A

1963 • 23 citations

The Nature of Resistance of A Penicillin to Hydrolysis by Penicillinase

1962 • 23 citations

Identification of the Most Rapidly Iodinating Tyrosine Residue in α-Chymotrypsin

1964 • 23 citations

The Alteration in the Reactivity of the Tyrosine and Tryptophan Groups of Trypsin upon Combination with Protein Inhibitors^*

1966 • 23 citations

Conformational basis of energy transduction in mitochondria

1969 • 22 citations

Studies on the histidine residues of rabbit muscle myokinase

1970 • 22 citations

The reaction of yeast alcohol dehydrogenase with iodoacetamide as determined with a silver-silver iodide electrode

1964 • 22 citations

PROTECTION OF LACTATE DEHYDROGENASE ISOZYMES FROM HEAT INACTIVATION AND ENZYMATIC DEGRADATION

1968 • 22 citations

Reaction of the sulphydryl groups of lobster-muscle glyceraldehyde-3-phosphate dehydrogenase with organic mercurials

1969 • 22 citations

Protection of the proline-and valine-activating enzymes by their amino acid substrates against thermal inactivation

1967 • 22 citations

Relation between conformations and activities of lipoamide dehydrogenase. IV. Apoenzyme structure and flavin binding aspects

1970 • 22 citations

Determination of the binding constant of a specific ester and a specific amide substrate to α-chymotrypsin

1966 • 22 citations

The effect of urea on the activity of penicillinase

1958 • 22 citations

The unfolding and refolding of ribonuclease in urea solutions

1964 • 22 citations

ON THE SITES OF ATTACHMENT AND REACTION OF ALDEHYDE DEHYDROGEN ASES

1960 • 22 citations

Stereospecific features of the conformative response of L-asparaginase

1972 • 22 citations

Thermal stability of horse liver alcohol dehydrogenase and its complexes

1971 • 22 citations

On the active site of myosin A-adenosine triphosphatase IV. Properties of binding of trinitrobenzenesulfonate and p-chloromercuribenzoate to myosin a

1963 • 21 citations

Étude cinétique de changements conformationnels de la <scp>l</scp>‐glutamate déshydrogénase provoqués par le couple effecteur GTP + NADH

1970 • 21 citations

Conformational studies on the interaction of chymotrypsin with substrates and inhibitors

1965 • 21 citations

Influence of Allosteric Effector Substances on the Structure and Catalytic Activity of Tryptophan Oxygenase

1969 • 21 citations

An Alteration in the Reactivity of Chymotrypsin and Trypsin towards Hydrogen Peroxide in the Presence of Specific Substrates

1963 • 21 citations

Effect of 2-oxoglutarate on the catalytic activity and stability of glutamate dehydrogenase

1968 • 21 citations

The Properties of Rabbit Muscle Glyceraldehyde 3-Phosphate Dehydrogenase Labeled with a "Reporter Group"

1970 • 21 citations

Binding of competitive inhibitors to the different pH-dependent forms of trypsin

1969 • 20 citations

Unified theory of enzyme catalysis and denaturation. I. Specificity considerations of prostatic acid phosphatase

1958 • 20 citations

The 5Åresolution structure of an abortive ternary complex of lactate dehydrogenase and its comparison with the apo-enzyme

1971 • 20 citations

The interaction of penicillinase with penicillins

1963 • 20 citations

Requirement of substrate for adenosine 5′-monophosphate binding to liver fructose 1,6-diphosphatase

1968 • 20 citations

Comparative studies on d-glyceraldehyde-3-phosphate dehydrogenase VII. Studies on the digestibility of the enzyme isolated from various mammals

1959 • 20 citations

Inhibition of yeast S-lactylglutathione lyase (glyoxalase I) by sulfhydryl reagents

1970 • 20 citations

Carboxymethylation of Yeast Enolase^*

1962 • 19 citations

1‐Anilino‐8‐naphthalene sulfonate binding as a probe for substrate mediated change in conformation of transaldolase

1970 • 19 citations

The fluorescence of α-chymotrysin in the presence of substrates and inhibitors

1962 • 19 citations

The regulation of penicillinase synthesis

1967 • 19 citations

Structural and Functional Roles of the Cysteine Residues in the α Subunit of the Escherichia coli Tryptophan Synthetase

1971 • 19 citations

Conformation changes in citrate-condensing enzyme

1965 • 19 citations

Reaction of cyanide with the transaldolase-dihydroxyacetone complex

1968 • 19 citations

Effect of oxidized nicotinamide-adenine dinucleotide on hydrogen-deuterium exchange of yeast alcohol dehydrogenase as measured by infrared spectrophotometry

1963 • 19 citations

Substrate-Induced Denaturation of Lipoyl Dehydrogenase in Urea

1960 • 19 citations

Substrate binding by non-activated papain

1966 • 18 citations

Reversal of the Adenosine Triphosphate and Adenosine Diphosphate Inactivation of Liver Fructose 1, 6-Diphosphatase by 3-Phosphoglycerate

1971 • 18 citations

Induced Activation of the Catalytic Site of Trypsin

1963 • 18 citations

The essential thiol group of propionyl-Coa carboxylase

1967 • 18 citations

Characterization of a Reversibly Formed Enzyme Complex in the Reaction of Chymotrypsin with Diisopropyl Fluorophosphate

1965 • 18 citations

Alteration of the conformative response and inhibition of xanthosine 5'-phosphate aminase by adenine glycosides

1970 • 18 citations

Evidence for the Involvement of a Tryptophan Residue in the Reaction of Diisopropylphosphorofluoridate with α-Chymotrypsin

1960 • 18 citations

Carboxamidomethylation and Inactivation of Rabbit Muscle Phosphoglucose Isomerase

1970 • 18 citations

Univalent fragments of antibody: A study by electron microscopy

1965 • 17 citations

Structure-function studies on glyceraldehyde-3-phosphate dehydrogenase. III. Dependency of proteolysis on NAD+ concentration

1970 • 17 citations

The chemistry of xanthine oxidase. Reaction with iodoacetamide

1966 • 17 citations

The reaction of diisopropylfluorophosphate with crystals of γ-chymotrypsin

1963 • 17 citations

Reversible, pH-dependent formation of a conformer of rabbit liver fructose 1,6-diphosphatase with low catalytic activity

1971 • 17 citations

The introduction of a “reporter” group at the active site of glyceraldehyde-3-phosphate dehydrogenase

1966 • 17 citations

The liberator

1967 • 17 citations

Ligand-induced association-dissociation as a means for enzyme purification

1970 • 17 citations

Alkylation Studies on a Reactive Histidine in Pig Heart Malate Dehydrogenase

1970 • 17 citations

Photosensitized Modification of Bovine Pancreatic Ribonuclease by a Colored Substrate Analogue, 4-Thiouridylic Acid*

1969 • 17 citations

Evidence for a slow transition leading to cooperative binding of 5′‐amp onto rabbit muscle phosphorylase b at 5°

1970 • 17 citations

Use of circular dichroism to study the interactions of carboxypeptidase A (Anson) and Aα+β with substrates and inhibitors

1971 • 17 citations

Actions of steroid hormones at cellular and molecular levels.

1969 • 17 citations

APPROACHES TO THE SELECTIVE CHEMICAL LABELING OF THE ACTIVE SITE OF CARBOXYPEPTIDASE A

1962 • 17 citations

Biological sciences: Allosteric Preconditioning: Role of Allosteric Ligands in Promoting the Maturation of Enzymes

1971 • 17 citations

Immunological Heterogeneity of Rabbit Antibody Fragments against Taka-amylase A

1963 • 17 citations

An effect of the substrate on ureamodified penicillinase.

1960 • 17 citations

Enzyme-Activation by Antibody

1970 • 16 citations

The Primary Specificity of Chymotrypsin. Further Evidence for “Wrong-Way” Binding^*

1966 • 16 citations

Fluorescent derivatives of nitrotyrosine. Model compounds for fluorescent reporter groups in proteins

1971 • 16 citations

The interaction of penicillinase with penicillins III. Comparison of exopenicillinase preparations of various origins

1964 • 16 citations

Substrate-specific inactivation of staphylococcal penicillinase

1967 • 16 citations

Substrate-induced dissociation of lysozyme dimers

1969 • 16 citations

ATP-Catalyzed Preconditioning of Phosphofructokinase

1971 • 16 citations

Formaldehyde-induced Cross-Linkages in the α Subunit of the Escherichia coli Tryptophan Synthetase

1971 • 16 citations

Conformational Model of Active Transport

1970 • 16 citations

Denaturation studies on prostatic acid phosphatase

1954 • 16 citations

Reversible inactivation of rat liver serine dehydratase by its substrates

1970 • 16 citations

The effect of acetylation on the activity of rabbit muscle fructose diphosphate aldolase

1967 • 16 citations

Crystallization of binary and ternary complexes of horse liver alcohol dehydrogenase with DPNH and with DPNH and isobutyramide

1963 • 16 citations

Modification of Regulatory Properties of Phosphofructokinase by Acetylation

1969 • 16 citations

Spectroscopic Studies of α-Chymotrypsin Catalyzed Reactions. I. Spectral Changes at 245 mμ

1961 • 16 citations

Inversion and enhancement of the circular dichroic spectrum of flavin adenine dinucleotide by the combination to D-amino acid oxidase

1966 • 16 citations

Optical rotatory dispersion and circular dichroism of d-amino acid oxidase

1966 • 16 citations

The effect of a competitive inhibitor on the acetylation of tyrosyl and lysyl residues of staphylococcal nuclease

1968 • 15 citations

A CHANGE IN OPTICAL ROTATION OF CREATINE-ATP TRANSPHOSPHORYLASE DURING ENZYME SUBSTRATE INTERACTION SUGGESTING AN ALTERATION IN CONFORMATION

1961 • 15 citations

Modified Substrate Specificity of Cell-bound Penicillinase

1963 • 15 citations

The Mechanism of 2-Keto-3-deoxy-6-phosphogluconate Aldolase

1971 • 15 citations

The interaction of penicillinase with penicillins V. Conformative response constants

1967 • 15 citations

Study of the thermal denaturation of ribonuclease A by differential thermal analysis and susceptibility to proteolysis

1970 • 15 citations

A time-dependent activation of threonine deaminase

1968 • 15 citations

Reversibility of the activation of succinate dehydrogenase

1963 • 15 citations

Structure and function of chloroplast proteins

1968 • 14 citations

Streptococcus faecalis aspartate transcarbamylase. I. Purification and general properties

1970 • 14 citations

Homoserine dehydrogenase of Rhodospirillium rubrum. Conformational changes in the presence of substrates and modifiers

1971 • 14 citations

Purification and properties of the γ-type β-lactamase of Bacillus cereus

1967 • 14 citations

Contribution of tryptophan to the biologic properties of anti-dinitrophenyl antibody

1967 • 14 citations

Structural specificity of coenzyme a for phosphotransacetylase

1970 • 14 citations

The probing of active sites by similar reporter groups. The preparation of 4-bromoacetamido-2-nitrophenol

1967 • 14 citations

Antibody-ligand interactions studied by fluorescence enhancement methods_I

1970 • 14 citations

FLUORESCENCE STUDIES OF COENZYME BINDING TO DEHYDROGENASES

1958 • 14 citations

Relationships between stability of threonine deaminase and its apparent kinetics

1969 • 14 citations

DENATURATION AND INACTIVATION OF ENZYME PROTEINS

1957 • 14 citations

Protection of Polynucleotide Phosphorylase by Substrates against Urea Inactivation

1967 • 14 citations

Relationship between stability and state of association in glutamate dehydrogenase

1969 • 13 citations

Antibody-ligand interactions studied by fluorescence enhancement methods—II

1970 • 13 citations

Untersuchungen zur Photooxydation von Schweineleberesterase

1969 • 13 citations

Analogs of isosteric and allosteric ligands of deoxycytidylate aminohydrolase

1970 • 13 citations

Trinitrophenylation of D-amino-acid oxidase

1966 • 13 citations

A hydrogen-deuterium exchange study of the conformation of bovine liver glutamate dehydrogenase

1970 • 13 citations

SPECIFICITY OF CRYSTALLINE BACTERIAL PROTEINASE

1956 • 13 citations

The optical rotatory dispersion of myosin a IV. Conformational changes in meromyosins

1963 • 13 citations

Inhibition of Yeast Alcohol Dehydrogenase by Alkylating Agents

1968 • 13 citations

Effect of Alkylguanidines on the Inactivation of Trypsin by Alkylation and Phosphorylation

1969 • 13 citations

Differences in the Thermal Inactivation Properties of Lysyl and Arginyl Transfer Ribonucleic Acid Synthetases of Bakers' Yeast

1970 • 13 citations

DENATURATION AND INACTIVATION OF ENZYME PROTEINS

1956 • 12 citations

Action of Urea on the Activity of Dehydrogenases and α-Glucosidase in Aerobacter aerogenes grown in Continuous Culture

1969 • 12 citations

Relations entre degré de dénaturation et sensibilité à la trypsine de la sérumalbumine. Influence de Ca++ et de Mn++ et rôle des ponts disulfure

1956 • 12 citations

High-Sensitivity Polarimetry and its Application to the Study of Small Conformational Changes in Proteins

1966 • 12 citations

AMP Nucleosidase from Azotobacter vinelandii

1970 • 12 citations

The Alkylation of the Active Site of Trypsin with Iodoacetamide in the Presence of Alkylguanidines

1965 • 12 citations

Determination of a constant for a specific conformational transition

1967 • 12 citations

The Thermal Inactivation of Acetoacetate Decarboxylase

1970 • 12 citations

The reaction mechanism of p-hydroxybenzoate hydroxylase and a role of the substrate as an effector

1969 • 12 citations

Substrate-induced changes in reactivity of sulfhydryl groups of carbamyl phosphate synthetase

1966 • 12 citations

Mercurial-Induced Transformation of Myosin Prevented by Adenosine Triphosphate and Pyrophosphate

1965 • 12 citations

Steady-state kinetics of one-substrate enzymic mechanisms involving two enzyme conformations I. Effects of modifiers on a mechanism postulating a single enzyme-substrate complex

1968 • 12 citations

Änderung der optischen Rotationsdispersion von Lactat-Dehydrogenase aus Schweineherzmuskel nach Zugabe von Harnstoff, Coenzym und SH-blockierenden Reagenzien

1969 • 12 citations

Thermal stabilization of prostatic acid phosphatase by fluoride

1955 • 12 citations

Effect of adenosine monophosphate on the reactivity of thiol groups of D-fructose 1,6-diphosphatase from rabbit liver

1969 • 12 citations

Restoration of Enzyme Activity of Heat-denatured Acetylcholinesterase by Antibodies to the Native Enzyme

1967 • 12 citations

Aminoacyl tRNAmet transformylase II

1967 • 11 citations

The Primary Specificity of α-Chymotrypsin. Interaction with Acylated Derivatives of D-Valine Methyl Ester and D-Norvaline Methyl Ester^*

1965 • 11 citations

The Structure and Function of RibonucleaseT1

1971 • 11 citations

On the Mechanism of Accelaration of Carboxypeptidase A Activity

1971 • 11 citations

Chemical evidence for the involvement of tryptophan in the interaction of trypsin with the inhibitor from beef pancereas

1965 • 11 citations

Conformational changes in glutamate dehydrogenase

1965 • 11 citations

Synthesis of Adenosine Triphosphate from Acetyl Phosphate by Carbamyl Phosphate Synthetase

1962 • 11 citations

The Action of Dipicolinic Acid and Its Chemical Analogues on the Heat Stability of Glucose Dehydrogenase of Bacillus subtilis Spores*

1967 • 11 citations

STUDIES ON THE AMPHOTERIC PROPERTIES OF TAKA-AMYLASE A

1960 • 11 citations

d-lacticodéshydrogénase de la levure anaérobie II. Étude de la protection vis-à-vis d'un chélateur par les substrats et inhibiteurs

1961 • 11 citations

Substrate Induced Changes in the Reactivity of the Sulfhydryl Groups of Aspartate Transaminase

1969 • 10 citations

Studies on proteolytic inhibitors

1968 • 10 citations

Function of tyrosine residues in rabbit muscle aldolase

1967 • 10 citations

Separation of antigens by immunological specificity. Studies on the desorption of homologous antigen from disulphide-linked antibody immunosorbents

1970 • 10 citations

X-ray investigations of horse liver alcohol dehydrogenase and its complexes

1965 • 10 citations

Immunobiological Studies on Crystalline Alcohol Dehydrogenases from Closely Related Yeast Species

1957 • 10 citations

Mode of interaction of purine nucleotides and amino acids with glutamate dehydrogenase

1966 • 10 citations

Possible interpretation and extrapolation of heating experiments with enzymes in the presence of substrates or cofactors

1960 • 9 citations

Selective reactivity of thiol groups in proteins

1970 • 9 citations

Glutamine synthetase of Neurospora crassa

1969 • 9 citations

Molecular aggregation of bovine pancreatic ribonuclease induced by substrate

1970 • 9 citations

Reactivity and Interrelationship of Intermediates in the Hydrolysis of p-Nitrophenyl Acetate Catalysed by Chymotrypsin

1959 • 9 citations

Studies on the Oxidative Fraction of Rabbit Muscle Glyceraldehyde‐3‐phosphate Dehydrogenase

1970 • 9 citations

Anomalous dissociation constants for penicillinase and competing substrates

1968 • 9 citations

Stereoselective Alkylation with Asymmetric Reagents

1968 • 9 citations

Iodine sensitivity of Bacillus cereus penicillinase

1970 • 8 citations

Steady-state kinetics of one-substrate enzymic mechanisms involving two enzyme conformations

1969 • 8 citations

The effects of substrates on the optical rotatory dispersion of carnitine acetyltransferase

1969 • 8 citations

Coenzyme binding to glyceraldehyde-3-phosphate dehydrogenase after modification by substrate and coenzyme

1965 • 8 citations

Effect of labelling with dansyl group on the renaturation of lysozyme

1971 • 8 citations

Interaction of rat liver alanine aminotransferase with L-proline

1968 • 8 citations

STUDIES ON CYTOCHROME C:IV. MODE OF EXISTENCE OF NATIVE AND MODIFIED CYTOCHROME C

1960 • 8 citations

Tryptophanyl‐tRNA synthétase de pancreas de bœuf

1970 • 8 citations

INTERPRETATION OF NMR RELAXATION MECHANISM OF WATER PROTONS IN SOLUTIONS OF ENZYME-MANGANESE-SUBSTRATE COMPLEXES FROM TEMPERATURE DEPENDENCE OF RELAXATION RATES

1967 • 8 citations

Effect of Diazonium Derivatives on Myosin A Adenosine Triphosphatase

1968 • 8 citations

The kinetics of inactivation of adenylosuccinate lyase: evidence for a substrate-induced conformational change

1969 • 7 citations

The Effect of Iodination upon the Catalytic and Regulatory Activities of Fructose 1,6-Diphosphatase^*

1967 • 7 citations

The mechanism of action of aldolases. XI. Activation by aromatic sulfhydryl reagents and beta-elimination of selected thiol groups.

1965 • 7 citations

Substrate Effect on Heat Inactivation of Taka-Amylase A

1965 • 7 citations

DENATURATION AND INACTIVATION OF ENZYME PROTEINS: XII. THERMAL INACTIVATION AND DENATURATION OF GLUTAMIC ACID DEHYDROGENASE AND THE EFFECT OF ITS COENZYME ON THESE PROCESSES*

1959 • 7 citations

Effect of temperature on the Ks for homoserine and the Ki for threonine of homoserine dehydrogenase from Chlamidomonas reinhardti

1968 • 7 citations

Heat and Photochemical Inactivations of Taka-Amylase A and Mechanisms of Protection by Substrate

1967 • 7 citations

The Optical Rotatory Dispersion of Myosin A

1966 • 7 citations

Thermodynamic properties of the allosteric transition of 7-phosphate synthase

1967 • 6 citations

Recent advances in the study of biological systems with rapid reaction techniques

1969 • 6 citations

Nicotinamide-Nucleotide Coenzymes or Nicotiniumamide-Nucleotide Coenzymes?

1963 • 6 citations

Factors affecting urea inactivation of NADP-specificβ-isocitrate dehydrogenase

1969 • 6 citations

On the reversibility of substrate-induced dissociation of lysozyme aggregates. Native and reacted lysozyme

1971 • 6 citations

Alkylation of bovine brain creatine kinase

1970 • 6 citations

Incorporation of penicillinase into reaggregated mycoplasma membranes

1971 • 6 citations

Persistance of the effects of regulatory reagents on conformation of catalytically inactive glutamate dehydrogenase

1967 • 5 citations

Correlations between thermal stability and circular dichroism of hemoglobin derivatives of different species

1971 • 5 citations

Differences between the active and the inhibited conformations of the allosteric N-acetylglutamate 5-phosphotransferase

1969 • 5 citations

The significance of anions in the protection by substrates of adenosine triphosphate-creatine phosphotransferase against inhibition by iodoacetamide

1970 • 5 citations

Production of Phenotypically Epimeraseless Yeast by <scp>l</scp> -Arabinose

1971 • 5 citations

Constraints in the Determination of Active-Centre Topography

1960 • 5 citations

Effect of Glucose on the Denaturation of Glucose Dehydrogenase by Urea

1966 • 5 citations

Conformational States of Rabbit Liver Fructose 1,6-Diphosphatase

1970 • 5 citations

The effect of substrates on the hydrogen-tritium exchange of the isoleucyl-tRNA synthetase from E. coli

1969 • 5 citations

Effect of Diazoniuxa Derivatives on Myosin A Adenosine Triphosphatase

1969 • 5 citations

The α-Chymotrypsin Catalyzed Hydrolysis of p-Nitrophenyl Acetate^1a

1960 • 5 citations

The binding of pyridoxamine 5-phosphate to alanine aminotransferase as measured by fluorescence spectroscopy

1969 • 5 citations

Alkylation and photooxidation of phosphorylase a

1965 • 5 citations

Effects of Substrate on Heat Inactivation of Taka-amylase A

1967 • 4 citations

Kinetic effects of urea on the activation of aged glycogen phosphorylase a by adenosine 5′-phosphate

1969 • 4 citations

EVIDENCE FOR A NEW INTERMEDIATE IN THE CHYMOTRYPSIN CATALYZED HYDROLYSIS OF p-NITROPHENYL ACETATE

1959 • 4 citations

Conformational Effects of NAD+ on Yeast Glyceraldehyde-3-Phosphate Dehydrogenase

1970 • 4 citations

Photoreduction of amino-acid oxidases in the presence of free flavin and the effect of urea

1968 • 4 citations

[109] Pyridoxal kinase from brewer's yeast

1955 • 4 citations

Some stability effects of ATP, Mg++, and dinitrophenol on actomyosin and myosin adenosinetriphosphatase

1960 • 4 citations

Studies on the inactivation of whale pancreatic ribonuclease W1 with iodoacetate

1970 • 4 citations

The effect of glucose, glucose monophosphates and inorganic phosphate on the tryptic digestion of phosphorylase b

1970 • 4 citations

A New Allosteric Effect in the Reaction Cycle of Liver Alcohol Dehydrogenase

1968 • 3 citations

Substrate effect on riboflavin-sensitized photoinactivation of Taka-amylase A

1966 • 3 citations

ÜBER PFLANZENPROTEASEN

1955 • 3 citations

PROMOTION OF THE AUTOLYSIS OF α-CHYMOTRYPSIN BY EVANS BLUE

1969 • 3 citations

Influence of substrate-induced enzymic inactivation on the sulfhydryl content of glyceraldehyde-3-phosphate dehydrogenase

1966 • 3 citations

The effects of some nucleosides and dithiothreitol on the stability and activity of liver phenylalanine hydroxylase

1971 • 3 citations

Conformation and displacement in muscle contraction.

1970 • 3 citations

Photooxidation of Ribonuclease T&lt;sub&gt;1&lt;/sub&gt; in the Presence of Substrate Analog

1970 • 3 citations

Binding of arginine transfer RNA to the arginine tRNA synthetase ofEscherichia coli

1969 • 3 citations

THE NATURE OF THE SPECTRAL CHANGES ACCOMPANYING THE DEACYLATION OF MONOACETYL-α-CHYMOTRYPSIN¹

1960 • 3 citations

Inhibition of aggregation of heat-denatured Taka-amylase a by substrate

1966 • 3 citations

Photo- and heat-inactivation of taka-amylase a and substrate effects

1967 • 2 citations

Effects of Ionic Strength, Substrate and pH on Inactivation of Heavy Meromyosin Caused by Low Concentrations of Urea

1967 • 2 citations

Heat inactivation of lysyl-transfer-ribonucleic acid synthetase and arginyl-transfer-ribonucleic acid synthetase from yeast: evidence for substrate-induced conformational changes

1970 • 1 citations

Instructions to Authors

1971 • 1 citations

Effect of Phosphate on the Digestion of Ribonuclease T&lt;sub&gt;1&lt;/sub&gt; with Proteases

1969 • 1 citations

Protective action of substrate from heat inactivation of Taka-Amylase A

1966 • 1 citations

Methyl octadecadienoates as protectors against inactivation of alkaline phosphatase by γ‐radiation

1969 • 1 citations

Kinetic probes for the stoicheiometry and reactivity of thiol groups in enzymes

1970 • 1 citations