Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

Solvent content of protein crystals

1968 • 7,954 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units

1968 • 1,497 citations

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

Hydrophobic bonding and accessible surface area in proteins

1974 • 887 citations

Structure of crystalline α-chymotrypsin

1972 • 675 citations

Real-space refinement of the structure of hen egg-white lysozyme

1974 • 516 citations

The Three-Dimensional Structure of Ribonuclease-S

1970 • 510 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1973 • 449 citations

Structure of crystalline α-chymotrypsin

1969 • 374 citations

Structure of crystalline α-chymotrypsin

1970 • 344 citations

The matching of physical models to three-dimensional electron-density maps: A simple optical device

1968 • 313 citations

Computing methods and the phase problem in X-ray crystal analysis

1953 • 300 citations

Three-dimensional Structure of Tosyl-elastase

1970 • 299 citations

The Basic Trypsin Inhibitor of Bovine Pancreas

1963 • 289 citations

The structure of bovine trypsin : Electron density maps of the inhibited enzyme at 5 Å and at 2·7 Å resolution

1974 • 279 citations

The Reactive Site of Trypsin Inhibitors

1966 • 276 citations

Determination of the amino acid sequence of porcine trypsin by sequenator analysis

1973 • 259 citations

A real-space refinement procedure for proteins

1971 • 233 citations

The distribution of phase angles for structures containing heavy atoms. II. A modification of the normal heavy-atom method for non-centrosymmetrical structures

1959 • 231 citations

Structure and specific binding of trypsin: Comparison of inhibited derivatives and a model for substrate binding

1974 • 199 citations

Studies on Soybean Trypsin Inhibitors

1973 • 199 citations

X-Ray Diffraction Studies of Enzymes

1970 • 194 citations

11 Protein Proteinase Inhibitors—Molecular Aspects

1971 • 194 citations

Crystallographic fast Fourier transforms

1973 • 193 citations

Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin

1973 • 191 citations

A mathematical model-building procedure for proteins

1966 • 183 citations

Substrate binding site in bovine chymotrypsin A_γ. Crystallographic study using peptide chloromethyl ketones as site-specific inhibitors

1971 • 181 citations

Representation of phase probability distributions for simplified combination of independent phase information

1970 • 178 citations

Three-dimensional Fourier Synthesis of Tosyl-elastase at 3.5 Å Resolution

1970 • 144 citations

Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. Stereochemical interpretation

1973 • 125 citations

Mode of action of soybean trypsin inhibitor (Kunitz) as a model for specific protein–protein interactions

1974 • 112 citations

The Formation of Anhydrochymotrypsin by Removing the Elements of Water from the Serine at the Active Site¹

1966 • 109 citations

A model for the association of bovine pancreatic trypsin inhibitor with chymotrypsin and trypsin

1972 • 107 citations

The accurate determination of the position and shape of heavy-atom replacement groups in proteins

1960 • 101 citations

Mechanism of action of naturally occurring proteinase inhibitors. Anhydrotrypsin and anhydrochymotrypsin purified by affinity chromatography

1974 • 94 citations

The Cotton Effects in the Optical Rotatory Dispersion of Proteins as New Criteria of Conformation

1965 • 88 citations

Resynthesis by Trypsin of the Cleaved Peptide Bond in Modified Soybean Trypsin Inhibitor

1967 • 86 citations

6 The Structure of Chymotrypsin

1971 • 84 citations

Kinetic investigation of the crystallographically deduced binding subsites of bovine chymotrypsin Aγ

1972 • 66 citations

Nuclear magnetic resonance studies of trypsin inhibitors. Histidines of virgin and modified soybean trypsin inhibitor (Kunitz)

1973 • 64 citations

Peptide-bond hydrolysis equilibria in native proteins. Conversion of virgin into modified soybean trypsin inhibitor

1969 • 63 citations

On the mechanism of enzyme action

1961 • 57 citations

Changes in the tertiary structure of .alpha.-chymotrypsin with change in pH. The pH 4.2-6.7

1973 • 54 citations

Soybean Trypsin Inhibitor

1969 • 54 citations

Calorimetry of Some Trypsin-Trypsin Inhibitor Reactions

1972 • 49 citations

Circular Dichroism and Optical Rotatory Dispersion of Trypsin Inhibitors*

1968 • 42 citations

Changes in Physical Properties Accompanying the Interaction of Trypsin with Protein Inhibitors

1965 • 38 citations

pH dependence of the equilibrium constant for the hydrolysis of the Arg⁶³-Ile reactive-site peptide bond in soybean trypsin inhibitor (Kunitz)

1973 • 36 citations

Parameter refinement in the multiple isomorphous-replacement method

1973 • 36 citations

Ionization Behavior of the Histidine Residue in the Catalytic Triad of Serine Proteases

1973 • 35 citations

The refinement of structures partially determined by the isomorphous replacement method

1961 • 34 citations

THE HYDROLYSIS OF N-BENZOYL-l-ARGININAMIDE BY CRYSTALLINE TRYPSIN

1949 • 33 citations

The reaction of tyrosyl residues of bovine trypsin and trypsinogen with tetranitromethane

1968 • 30 citations

Formation from Trypsin and Modified Soybean Trypsin Inhibitor of a Complex Which upon Kinetic Control Dissociation Yields Trypsin and Virgin Inhibitor

1970 • 27 citations

Location of reactive tyrosine residues in trypsin

1969 • 21 citations

The Involvement of Tyrosyl and Amino Groups in the Interaction of Trypsin and a Soybean Trypsin Inhibitor

1970 • 11 citations

The involvement of an arginine residue of trypsin in its interaction with the kunitz soybean trypsin inhibitor

1973 • 5 citations