The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

p-Nitrophenyl-p′-guanidinobenzoate HCl: A new active site titrant for trypsin

1967 • 848 citations

Structure of crystalline α-chymotrypsin

1972 • 675 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1974 • 548 citations

Crystallographic refinement of the structure of bovine pancreatic trypsin inhibitor at l.5 Å resolution

1975 • 544 citations

Real-space refinement of the structure of hen egg-white lysozyme

1974 • 516 citations

The refined crystal structure of bovine β-trypsin at 1·8 Å resolution

1975 • 462 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1973 • 449 citations

Structure of crystalline α-chymotrypsin

1968 • 435 citations

Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes

1969 • 433 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

Subtilisin. Stereochemical mechanism involving transition-state stabilization

1972 • 376 citations

Amino-Acid Sequence of Bovine Chymotrypsinogen-A

1964 • 373 citations

Basic Mechanisms in Blood Coagulation

1975 • 366 citations

Chymotrypsinogen: 2,5-Å crystal structure, comparison with α-chymotrypsin, and implications for zymogen activation

1970 • 345 citations

Structure of crystalline α-chymotrypsin

1970 • 344 citations

Chromatography of Trypsin and Its Derivatives

1968 • 281 citations

The structure of bovine trypsin : Electron density maps of the inhibited enzyme at 5 Å and at 2·7 Å resolution

1974 • 279 citations

Trypsin-pancreatic trypsin inhibitor association. Dynamics of the interaction and role of disulfide bridges

1972 • 251 citations

Structure of RNA and RNA binding site in tobacco mosaic virus from 4-Å map calculated from X-ray fibre diagrams

1977 • 243 citations

Crystal structure of bovine trypsinogen at 1·8 Å resolution

1977 • 242 citations

A real-space refinement procedure for proteins

1971 • 233 citations

Purification and Specificity of Porcine Enterokinase

1971 • 224 citations

Amino-acid Sequence of Porcine Pancreatic Elastase and its Homologies with other Serine Proteinases

1970 • 219 citations

Implication of an Ionizing Group in the Control of Conformation and Activity of Chymotrypsin

1966 • 193 citations

Structure of bovine trypsinogen at 1.9 Å resolution

1977 • 174 citations

ACYLATION OF THE ENZYMATIC SITE OF δ-CHYMOTRYPSIN BY ESTERS, ACID ANHYDRIDES, AND ACID CHLORIDES

1957 • 155 citations

The phylogeny of trypsin-related serine proteases and their zymogens. New methods for the investigation of distant evolutionary relationships

1975 • 152 citations

Equilibrium and rate constants for the interconversion of two conformations of α-chymotrypsin

1971 • 150 citations

Primary Structure of the B‐Chain of Human Plasmin

1977 • 148 citations

Induction of the bovine trypsinogen—trypsin transition by peptides sequentially similar to the N‐terminus of trypsin

1976 • 137 citations

Stability and specificity of protein-protein interactions: The case of the trypsin-trypsin inhibitor complexes

1976 • 113 citations

The single calcium‐binding site of crystalline bovine β‐trypsin

1975 • 112 citations

Structure of Chymotrypsinogen B compared with Chymotrypsinogen A and Trypsinogen

1968 • 105 citations

Crystal structure of bovine trypsinogen at 1.8 Å resolution. I. Data collection, application of Patterson search techniques and preliminary structural interpretation

1976 • 98 citations

The specificity of enzymic reactions aminoacyl-soluble RNA ligases

1966 • 91 citations

Proteolysis and Physiological Regulation

1976 • 89 citations

The binding of Ca2 to trypsinogen and its relation to the mechanism of activation

1967 • 80 citations

The Interaction between α‐Chymotrypsin and Pancreatic Trypsin Inhibitor (Kunitz Inhibitor)

1973 • 74 citations

Kinetics Of The Interaction Of Bovine Pancreatic Trypsin Inhibitor (Kunitz) With α-Chymotrypsin

1974 • 74 citations

Difference Fourier refinement of the structure of DIP-trypsin at 1.5 Å with a minicomputer technique

1977 • 74 citations

Refinement of setting angles in screenless film methods

1975 • 72 citations

NH2-Terminal Sequences of Mammalian Plasminogens and Plasmin S-Carboxymethyl Heavy (A) and Light (B) Chain Derivatives

1973 • 64 citations

Pre‐existence of the active site in zymogens, the interaction of trypsinogen with the basic pancreatic trypsin inhibitor (Kunitz)

1976 • 57 citations

Replacement of Lysine by Arginine, Phenylalanine and Tryptophan in the Reactive Site of the Bovine Trypsin‐Kallikrein Inhibitor (Kunitz) and Change of the Inhibitory Properties

1976 • 56 citations

Active site topography of isoleucyl transfer ribonucleic acid synthetase of Escherichia coli B

1973 • 54 citations

Specificity of the Valyl Ribonucleic Acid Synthetase from Escherichia coli in the Binding of Valine Analogues

1970 • 46 citations

A simple empirical absorption-correction method for X-ray intensity data films

1973 • 42 citations

Binding interactions between two ligands and a monomeric protein

1970 • 40 citations

Catalysis by serine proteases and their zymogens. Study of acyl intermediates by circular dichroism

1975 • 40 citations

Fluorescence energy-transfer measurements between the calcium binding site and the specificity pocket of bovine trypsin using lanthanide probes

1976 • 38 citations

Bovine factor IX (christmas factor). Further evidence of homology with factor X (Stuart factor) and prothrombin

1974 • 38 citations

Location of the calcium ion binding site in bovine α-trypsin and β-trypsin using lanthanide ion probes

1975 • 37 citations

The NH2-terminal sequences of a subunit of the first component of human complement, Cls, and its activated form, C?

1975 • 36 citations

On the structural and functional role of carboxylates in chymotrypsinogen A a comparison with chymotrypsin, trypsinogen and trypsin

1969 • 33 citations

A comparison of deacylation rates of para-substituted benzoyl-trypsins and chymotrypsins

1972 • 32 citations

Activation peptide of human trypsinogen 2

1976 • 31 citations

The reactions of sultones with chymotrypsin. The pH dependence of sulfonylation and desulfonylation

1968 • 28 citations

The hydrolysis of catalyzed by trypsin and acetyltrypsin. Dependence on pH

1971 • 25 citations

Thermodynamic Studies on the Specificity of <scp>l</scp>‐Isoleucine · tRNA Ligase of Escherichia coli MRE 600

1976 • 25 citations

Interaction of basic pancreatic trypsin inhibitor with trypsinogen

1969 • 25 citations

Influence of Side‐Chain Structure of Aliphatic Amino Acids on Binding to Isoleucyl‐tRNA Synthetase from Escherichia coli MRE 600

1976 • 17 citations

A STUDY OF THE ACTIVE CENTER OF TRYPSINOGEN BY COMPARATIVE AFFINITY CHROMATOGRAPHY OF TRYPSINOGEN, α‐, β‐, ψ‐TRYPSINS, DIP‐TRYPSIN, CHYMOTRYPSINOGEN, α‐CHYMOTRYPSIN AND ELASTASE

1974 • 15 citations

Change in the conformation of δ‐chymotrypsin upon binding a specific substrate at high pH

1975 • 2 citations