Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains

Functional rafts in cell membranes

1997 • 9,471 citations

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

Lipid Rafts As a Membrane-Organizing Principle

2009 • 4,078 citations

Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains

2013 • 3,867 citations

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

Structure of lipid bilayers

2000 • 2,543 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

2000 • 2,321 citations

SINGLE-PARTICLE TRACKING:Applications to Membrane Dynamics

1997 • 1,768 citations

Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

2003 • 1,538 citations

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

2008 • 1,461 citations

Separation of Liquid Phases in Giant Vesicles of Ternary Mixtures of Phospholipids and Cholesterol

2003 • 1,408 citations

Membrane recognition by phospholipid-binding domains

2008 • 1,400 citations

Lipid Rafts Reconstituted in Model Membranes

2001 • 1,330 citations

A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains

2002 • 1,130 citations

Supported phospholipid bilayers

1985 • 1,130 citations

Membrane Organization and Lipid Rafts

2011 • 989 citations

Cholesterol, lipid rafts, and disease

2002 • 985 citations

Structure and Origin of Ordered Lipid Domains in Biological Membranes

1998 • 962 citations

Inside-outside transitions of phospholipids in vesicle membranes

1971 • 942 citations

Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry.

1976 • 927 citations

Theory of self-assembly of lipid bilayers and vesicles

1977 • 903 citations

Membranes are more mosaic than fluid

2005 • 873 citations

Lipid–protein interactions in biological membranes: a structural perspective

2003 • 843 citations

Characterization of lipid bilayer phases by confocal microscopy and fluorescence correlation spectroscopy

1999 • 841 citations

Static and dynamic lipid asymmetry in cell membranes

1991 • 796 citations

Allogeneic stimulation of cytotoxic T cells by supported planar membranes.

1984 • 785 citations

Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles

1983 • 781 citations

Phospholipid and Phospholipid-Protein Monolayers at the Air/Water Interface

1990 • 688 citations

CD95 Signaling via Ceramide-rich Membrane Rafts

2001 • 630 citations

Area per Lipid and Acyl Length Distributions in Fluid Phosphatidylcholines Determined by 2H NMR Spectroscopy

2000 • 625 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Lecithin bilayers. Density measurement and molecular interactions

1978 • 576 citations

Formation of supported planar bilayers by fusion of vesicles to supported phospholipid monolayers

1992 • 575 citations

Micropatterning Fluid Lipid Bilayers on Solid Supports

1997 • 565 citations

Miscibility Phase Diagrams of Giant Vesicles Containing Sphingomyelin

2005 • 544 citations

Regulation of transbilayer plasma membrane phospholipid asymmetry

2003 • 543 citations

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform [published erratum appears in J Cell Biol 1995 Jul;130(2):501]

1995 • 541 citations

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

2003 • 525 citations

Structure of an adsorbed dimyristoylphosphatidylcholine bilayer measured with specular reflection of neutrons

1991 • 495 citations

Probing Lipid Mobility of Raft-exhibiting Model Membranes by Fluorescence Correlation Spectroscopy

2003 • 494 citations

Tethered Polymer-Supported Planar Lipid Bilayers for Reconstitution of Integral Membrane Proteins: Silane-Polyethyleneglycol-Lipid as a Cushion and Covalent Linker

2000 • 492 citations

Detergent-resistant membranes should not be identified with membrane rafts

2005 • 483 citations

Geometric packing constraints in egg phosphatidylcholine vesicles.

1978 • 469 citations

Physical properties of single phospholipid bilayers adsorbed to micro glass beads. A new vesicular model system studied by 2H-nuclear magnetic resonance

1990 • 446 citations

Role of Mutant CFTR in Hypersusceptibility of Cystic Fibrosis Patients to Lung Infections

1996 • 428 citations

Compartmentalization of ceramide signaling: physical foundations and biological effects

2000 • 421 citations

Raft ceramide in molecular medicine

2003 • 408 citations

Direct Observation of Enzyme Activity with the Atomic Force Microscope

1994 • 400 citations

Neutron diffraction studies on selectively deuterated phospholipid bilayers

1978 • 396 citations

Lipids do influence protein function—the hydrophobic matching hypothesis revisited

2004 • 392 citations

Effect of Line Tension on the Lateral Organization of Lipid Membranes

2007 • 390 citations

Two Photon Fluorescence Microscopy of Coexisting Lipid Domains in Giant Unilamellar Vesicles of Binary Phospholipid Mixtures

2000 • 389 citations

Ceramide Enables Fas to Cap and Kill

2001 • 377 citations

Lipid phase transitions and phase diagrams I. Lipid phase transitions

1977 • 374 citations

Lipids as Targeting Signals: Lipid Rafts and Intracellular Trafficking

2004 • 361 citations

The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease

2009 • 361 citations

Line Tensions, Correlation Lengths, and Critical Exponents in Lipid Membranes Near Critical Points

2008 • 322 citations

Acidic Sphingomyelinase Mediates Entry of N. gonorrhoeae into Nonphagocytic Cells

1997 • 319 citations

Involvement of Cellular Caveolae in Bacterial Entry into Mast Cells

2000 • 317 citations

Protein modulation of lipids, and vice-versa, in membranes

2008 • 308 citations

Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic

1997 • 303 citations

Hierarchical mesoscale domain organization of the plasma membrane

2011 • 298 citations

Role of Cholesterol in the Formation and Nature of Lipid Rafts in Planar and Spherical Model Membranes

2004 • 293 citations

Lipid Rafts and the Regulation of Exocytosis

2004 • 291 citations

Quantitative Analysis of Phospholipids in Functionally Important Membrane Domains from RBL-2H3 Mast Cells Using Tandem High-Resolution Mass Spectrometry

1999 • 288 citations

Periodic structures in lipid monolayer phase transitions

1984 • 287 citations

Sphingomyelinase Induces Lipid Microdomain Formation in a Fluid Phosphatidylcholine/Sphingomyelin Membrane

1998 • 276 citations

Membrane binding and subcellular targeting of C2 domains

2006 • 271 citations

Ceramide-mediated clustering is required for CD95-DISC formation

2003 • 270 citations

Domains and Rafts in Lipid Membranes

2003 • 268 citations

Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria

2003 • 267 citations

Tuning lipid mixtures to induce or suppress domain formation across leaflets of unsupported asymmetric bilayers

2008 • 266 citations

Visualizing detergent resistant domains in model membranes with atomic force microscopy

2001 • 266 citations

Liquid-Liquid Immiscibility in Membranes

2003 • 261 citations

Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrPSc) into contiguous membranes

2002 • 261 citations

Structure of fully hydrated bilayer dispersions

1988 • 259 citations

Ceramide-Rich Membrane Rafts Mediate CD40 Clustering

2002 • 256 citations

Transmembrane Asymmetry and Lateral Domains in Biological Membranes

2004 • 255 citations

CD95/CD95 Ligand Interactions on Epithelial Cells in Host Defense to Pseudomonas aeruginosa

2000 • 251 citations

Effects of Membrane Lipids on Ion Channel Structure and Function

2003 • 250 citations

Transbilayer (flip‐flop) lipid motion and lipid scrambling in membranes

2009 • 244 citations

Neutron scattering in the plane of membranes: structure of alamethicin pores

1996 • 234 citations

Ceramides in Phospholipid Membranes: Effects on Bilayer Stability and Transition to Nonlamellar Phases

1999 • 231 citations

Phase studies of model biomembranes: Complex behavior of DSPC/DOPC/Cholesterol

2007 • 225 citations

A Correlation between Lipid Domain Shape and Binary Phospholipid Mixture Composition in Free Standing Bilayers: A Two-Photon Fluorescence Microscopy Study

2000 • 220 citations

An essential role for membrane rafts in the initiation of Fas/CD95‐triggered cell death in mouse thymocytes

2002 • 219 citations

Transbilayer Effects of Raft-Like Lipid Domains in Asymmetric Planar Bilayers Measured by Single Molecule Tracking

2006 • 215 citations

Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2.

1991 • 213 citations

Domain coupling in asymmetric lipid bilayers

2008 • 211 citations

Chemical control of phospholipid distribution across bilayer membranes

2002 • 206 citations

Lateral diffusion and percolation in two-phase, two-component lipid bilayers. Topology of the solid-phase domains in-plane and across the lipid bilayer

1992 • 199 citations

Closed-Loop Miscibility Gap and Quantitative Tie-Lines in Ternary Membranes Containing Diphytanoyl PC

2006 • 197 citations

Cholesterol Depletion of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus with β-Cyclodextrin Inactivates and Permeabilizes the Virions: Evidence for Virion-Associated Lipid Rafts

2003 • 196 citations

Bilayer thickness and lipid interface area in unilamellar extruded 1,2-diacylphosphatidylcholine liposomes: a small-angle neutron scattering study

2001 • 195 citations

Dynamics of raft molecules in the cell and artificial membranes: approaches by pulse EPR spin labeling and single molecule optical microscopy

2003 • 192 citations

Theoretical models of phospholipid phase transitions

1991 • 190 citations

Lipid Asymmetry in DLPC/DSPC-Supported Lipid Bilayers: A Combined AFM and Fluorescence Microscopy Study

2005 • 188 citations

All-optical measurements of the bending rigidity of lipid-vesicle membranes across structural phase transitions

2001 • 186 citations

Nonbilayer phases of membrane lipids

1991 • 186 citations

Dynamic Transbilayer Lipid Asymmetry

2011 • 184 citations

Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids

2010 • 183 citations

Measuring Distances in Supported Bilayers by Fluorescence Interference-Contrast Microscopy: Polymer Supports and SNARE Proteins

2003 • 179 citations

Submicron Structure in l-α-Dipalmitoylphosphatidylcholine Monolayers and Bilayers Probed with Confocal, Atomic Force, and Near-Field Microscopy

1998 • 177 citations

Depth-Controlled Grazing-Incidence Diffraction of Synchrotron X Radiation

1986 • 170 citations

Hierarchical organization of the plasma membrane: Investigations by single‐molecule tracking vs. fluorescence correlation spectroscopy

2010 • 168 citations

Secondary and Tertiary Structure Formation of the β-Barrel Membrane Protein OmpA is Synchronized and Depends on Membrane Thickness

2002 • 167 citations

Ceramide, membrane rafts and infections

2004 • 165 citations

Nonequilibrium Behavior in Supported Lipid Membranes Containing Cholesterol

2004 • 164 citations

Fluctuation analysis of tension-controlled undulation forces between giant vesicles and solid substrates

1995 • 161 citations

Progress in high resolution atomic force microscopy in biology

1995 • 154 citations

Molecular mechanisms of bacteria induced apoptosis.

2001 • 154 citations

How membrane chain melting properties are regulated by the polar surface of the lipid bilayer

1987 • 149 citations

Sindbis Virus Entry into Cells Triggers Apoptosis by Activating Sphingomyelinase, Leading to the Release of Ceramide

2000 • 147 citations

Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis

2001 • 147 citations

Nanoscopic Lipid Domain Dynamics Revealed by Atomic Force Microscopy

2003 • 145 citations

Cholesterol Does Not Induce Segregation of Liquid-Ordered Domains in Bilayers Modeling the Inner Leaflet of the Plasma Membrane

2001 • 144 citations

Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering

2003 • 144 citations

Asymmetric lipid fluidity in human erythrocyte membrane: new spin-label evidence

1984 • 143 citations

Measuring Lipid Asymmetry in Planar Supported Bilayers by Fluorescence Interference Contrast Microscopy

2005 • 142 citations

Phase studies of model biomembranes: Macroscopic coexistence of Lα+Lβ, with light-induced coexistence of Lα+Lo Phases

2007 • 142 citations

Lateral diffusion and fluorescence microscope studies on a monoclonal antibody specifically bound to supported phospholipid bilayers

1988 • 141 citations

Obstructed Diffusion in Phase-Separated Supported Lipid Bilayers: A Combined Atomic Force Microscopy and Fluorescence Recovery after Photobleaching Approach

2002 • 138 citations

Domain Registration in Raft-Mimicking Lipid Mixtures Studied Using Polymer-Tethered Lipid Bilayers

2006 • 128 citations

The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis

2002 • 128 citations

P4 ATPases: Flippases in Health and Disease

2013 • 119 citations

Transbilayer Movement of Phospholipids at the Main Phase Transition of Lipid Membranes: Implications for Rapid Flip-Flop in Biological Membranes

2002 • 118 citations

Pseudomonas aeruginosa–Induced Apoptosis Is Defective in Respiratory Epithelial Cells Expressing Mutant Cystic Fibrosis Transmembrane Conductance Regulator

2003 • 117 citations

Flicker Spectroscopy of Thermal Lipid Bilayer Domain Boundary Fluctuations

2007 • 116 citations

Small-angle neutron scattering study of lipid phase diagrams by the contrast variation method

1981 • 116 citations

Observation of Topical Catalysis by Sphingomyelinase Coupled To Microspheres

2002 • 113 citations

Amphiphile regulation of ion channel function by changes in the bilayer spring constant

2010 • 113 citations

Lipid Asymmetry of the Eukaryotic Plasma Membrane: Functions and Related Enzymes

2006 • 112 citations

Acid sphingomyelinase is involved in CEACAM receptor‐mediated phagocytosis of Neisseria gonorrhoeae

2000 • 112 citations

Phase equilibria and local structure in binary lipid bilayers

1993 • 107 citations

Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers

1996 • 105 citations

Studies on sickled erythrocytes provide evidence that the asymmetric distribution of phosphatidylserine in the red cell membrane is maintained by both ATP-dependent translocation and interaction with membrane skeletal proteins

1988 • 101 citations

Cell-surface attachment of pedestal-forming enteropathogenicE. coliinduces a clustering of raft components and a recruitment of annexin 2

2002 • 100 citations

Coupling of Cholesterol-Rich Lipid Phases in Asymmetric Bilayers

2008 • 99 citations

The N-terminal Region of the Prion Protein Ectodomain Contains a Lipid Raft Targeting Determinant

2003 • 98 citations

Atomic force microscopy of nanometric liposome adsorption and nanoscopic membrane domain formation

2003 • 96 citations

Phospholipid asymmetry in health and disease

1998 • 92 citations

The effect of increasing membrane curvature on the phase transition and mixing behavior of a dimyristoyl-sn-glycero-3-phosphatidylcholine/ distearoyl-sn-glycero-3-phosphatidylcholine lipid mixture as studied by Fourier transform infrared spectroscopy and differential scanning calorimetry

1996 • 92 citations

Determination of fluid and gel domain sizes in two-component, two-phase lipid bilayers. An electron spin resonance spin label study

1992 • 91 citations

Anisotropic Motion and Molecular Dynamics of Cholesterol, Lanosterol, and Ergosterol in Lecithin Bilayers Studied by Quasi-elastic Neutron Scattering

2002 • 90 citations

Composition and Asymmetry in Supported Membranes Formed by Vesicle Fusion

2011 • 83 citations

Nonequilibrium Phenomena in the Phase Separation of a Two-Component Lipid Bilayer

2002 • 81 citations

Dependence of lipid membrane phase transition temperature on the mismatch of protein and lipid hydrophobic thickness

1988 • 81 citations

Indirect evidence for lipid-domain formation in the transition region of phospholipid bilayers by two-probe fluorescence energy transfer

1996 • 76 citations

Plasmodium falciparum Phospholipase C Hydrolyzing Sphingomyelin and Lysocholinephospholipids Is a Possible Target for Malaria Chemotherapy

2001 • 75 citations

Direct Detection of Domains in Phospholipid Bilayers by Grazing Incidence Diffraction of Neutrons and Atomic Force Microscopy

1998 • 73 citations

Domain Growth, Shapes, and Topology in Cationic Lipid Bilayers on Mica by Fluorescence and Atomic Force Microscopy

2000 • 72 citations

<scp>STED</scp> microscopy of living cells – new frontiers in membrane and neurobiology

2013 • 72 citations

Lipid Rafts: Feeling is Believing

2004 • 69 citations

The transmembranous domain of CD40 determines CD40 partitioning into lipid rafts

2002 • 67 citations

IR spectroscopic determination of gel state miscibility in long-chain phosphatidylcholine mixtures

1995 • 66 citations

FCS in STED Microscopy

2012 • 65 citations

Ceramides Modulate Protein Kinase C Activity and Perturb the Structure of Phosphatidylcholine/Phosphatidylserine Bilayers

1999 • 64 citations

Glycosphingolipid (GSL) microdomains as attachment platforms for host pathogens and their toxins on intestinal epithelial cells: activation of signal transduction pathways and perturbations of intestinal absorption and secretion.

2000 • 63 citations

Flipping and flopping-lipids on the move

2011 • 62 citations

Plasma Membrane Phospholipid Asymmetry

2006 • 62 citations

CD95 Rapidly Clusters in Cells of Diverse Origins

2003 • 60 citations

Lateral order in binary lipid alloys and its coupling to membrane functions

1991 • 60 citations

Phospholipid transmembrane domains and lateral diffusion in fibroblasts.

1993 • 49 citations

Differences in the Modulation of Collective Membrane Motions by Ergosterol, Lanosterol, and Cholesterol: A Dynamic Light Scattering Study

2005 • 46 citations

Partitioning of Amphiphiles between Coexisting Ordered and Disordered Phases in Two-Phase Lipid Bilayer Membranes

2000 • 44 citations

AFM Imaging of Lipid Domains in Model Membranes

2003 • 44 citations

Modulation of gramicidin channel conformation and organization by hydrophobic mismatch in saturated phosphatidylcholine bilayers

2007 • 38 citations

The thermodynamic control of protein binding to lipid bilayers for protein chromatography

1996 • 38 citations

Fluorescence Microscopy to Study Domains in Supported Lipid Bilayers

2007 • 38 citations

From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy

2011 • 37 citations

Cooperative elastic stresses, the hydrophobic effect, and lipid tilt in membrane remodeling

2010 • 31 citations

Membrane Thickness Changes Ion-Selectivity of Channel-Proteins

2004 • 17 citations

Aggregation and diffusion in the mitochondrial electron-transfer chain: role in electron flow and energy transfer

1986 • 17 citations

The Plasma Membrane ‘Skeleton’ of Tumor and Lymphoid Cells: A Role in Cell Lysis?

1985 • 14 citations