Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

Functional rafts in cell membranes

1997 • 9,471 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

LAT

1998 • 1,251 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

Caveolins, Liquid-Ordered Domains, and Signal Transduction

1999 • 1,016 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Structure and Origin of Ordered Lipid Domains in Biological Membranes

1998 • 962 citations

Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry.

1976 • 927 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Characterization of lipid bilayer phases by confocal microscopy and fluorescence correlation spectroscopy

1999 • 841 citations

LAT Palmitoylation

1998 • 837 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

On the Origin of Sphingolipid/Cholesterol-Rich Detergent-Insoluble Cell Membranes: Physiological Concentrations of Cholesterol and Sphingolipid Induce Formation of a Detergent-Insoluble, Liquid-Ordered Lipid Phase in Model Membranes

1997 • 661 citations

Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain

1997 • 644 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

Membrane microdomains and caveolae

1999 • 580 citations

Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

2000 • 572 citations

Electrospray Ionization Tandem Mass Spectrometry (Esi-Ms/Ms) Analysis of the Lipid Molecular Species Composition of Yeast Subcellular Membranes Reveals Acyl Chain-Based Sorting/Remodeling of Distinct Molecular Species En Route to the Plasma Membrane

1999 • 482 citations

A Role for Lipid Rafts in B Cell Antigen Receptor Signaling and Antigen Targeting

1999 • 473 citations

Lipid-dependent Targeting of G Proteins into Rafts

2000 • 428 citations

High-Resolution FRET Microscopy of Cholera Toxin B-Subunit and GPI-anchored Proteins in Cell Plasma Membranes

2000 • 427 citations

Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains

1998 • 415 citations

Looking at lipid rafts?

1999 • 406 citations

Two Photon Fluorescence Microscopy of Coexisting Lipid Domains in Giant Unilamellar Vesicles of Binary Phospholipid Mixtures

2000 • 389 citations

Endocytic Sorting of Lipid Analogues Differing Solely in the Chemistry of Their Hydrophobic Tails

1999 • 378 citations

DIVERGENT ROLES FOR F<scp>c</scp>RECEPTORS AND COMPLEMENT IN VIVO

1998 • 376 citations

Cholesterol Depletion of Caveolae Causes Hyperactivation of Extracellular Signal-related Kinase (ERK)

1998 • 375 citations

Cholesterol Depletion Delocalizes Phosphatidylinositol Bisphosphate and Inhibits Hormone-stimulated Phosphatidylinositol Turnover

1998 • 371 citations

Compartmentalized Activation of the High Affinity Immunoglobulin E Receptor within Membrane Domains

1997 • 353 citations

EphrinB Ligands Recruit GRIP Family PDZ Adaptor Proteins into Raft Membrane Microdomains

1999 • 345 citations

Critical Role for Cholesterol in Lyn-mediated Tyrosine Phosphorylation of FcεRI and Their Association with Detergent-resistant Membranes

1999 • 327 citations

Membrane raft microdomains mediate front–rear polarity in migrating cells

1999 • 316 citations

Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells : accumulation of actin regulated by local tyrosine phosphorylation

1999 • 316 citations

Quantitative Analysis of Phospholipids in Functionally Important Membrane Domains from RBL-2H3 Mast Cells Using Tandem High-Resolution Mass Spectrometry

1999 • 288 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

Differential Targeting of Shaker-like Potassium Channels to Lipid Rafts

2000 • 249 citations

N-Glycans Mediate the Apical Sorting of a Gpi-Anchored, Raft-Associated Protein in Madin-Darby Canine Kidney Cells

1999 • 247 citations

Cholesterol at Different Bilayer Concentrations Can Promote or Antagonize Lateral Segregation of Phospholipids of Differing Acyl Chain Length

1996 • 224 citations

Integrin Leukocyte Function-associated Antigen-1-mediated Cell Binding Can Be Activated by Clustering of Membrane Rafts

1999 • 178 citations

Role of Cholesterol in Formation and Function of a Signaling Complex Involving αvβ3, Integrin-Associated Protein (Cd47), and Heterotrimeric G Proteins

1999 • 174 citations

Glycans in post-Golgi apical targeting: sorting signals or structural props?

1999 • 166 citations

Localization of LAT in Glycolipid-enriched Microdomains Is Required for T cell Activation

1999 • 166 citations

Transmembrane Orientation of Hydrophobic α-Helices Is Regulated Both by the Relationship of Helix Length to Bilayer Thickness and by the Cholesterol Concentration

1997 • 163 citations

Glycosphingolipids Are Not Essential for Formation of Detergent-resistant Membrane Rafts in Melanoma Cells

1999 • 159 citations

Association of GAP-43 with Detergent-resistant Membranes Requires Two Palmitoylated Cysteine Residues

1998 • 144 citations

Liquid-crystalline phases of cholesterol/lipid bilayers as revealed by the fluorescence of trans-parinaric acid

1995 • 143 citations

Microdomains in lymphocyte signalling: beyond GPI-anchored proteins

2000 • 135 citations

A Balance between Positive and Negative Signals in Cytotoxic Lymphocytes Regulates the Polarization of Lipid Rafts during the Development of Cell-Mediated Killing

2000 • 134 citations

Multiple Domains in Caveolin-1 Control Its Intracellular Traffic

2000 • 122 citations

Membrane compartmentation and the response to antigen

1999 • 118 citations

Apical targeting in polarized epithelial cells: There's more afloat than rafts

1997 • 118 citations

Electron Spin Resonance Characterization of Liquid Ordered Phase of Detergent-Resistant Membranes from RBL-2H3 Cells

1999 • 116 citations

Identification of a Cytoplasmic Region of CD20 Required for Its Redistribution to a Detergent-Insoluble Membrane Compartment

1998 • 110 citations

Control of the Transmembrane Orientation and Interhelical Interactions within Membranes by Hydrophobic Helix Length

1999 • 109 citations

Structural Aspects of the Association of FcεRI with Detergent-resistant Membranes

1999 • 105 citations

Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts

1995 • 102 citations

Monolayer coupling in sphingomyelin bilayer systems

1978 • 92 citations

Convergence of Fcγ Receptor IIA and Fcγ Receptor IIIB Signaling Pathways in Human Neutrophils

2000 • 91 citations

Detergent extraction of cholera toxin and gangliosides from cultured cells and isolated membranes

1982 • 57 citations

Gamma-chain dependent recruitment of tyrosine kinases to membrane rafts by the human IgA receptor Fc alpha R.

1999 • 53 citations

Role for a Glycan Phosphoinositol Anchor in Fcγ Receptor Synergy

1997 • 52 citations

γ-Chain Dependent Recruitment of Tyrosine Kinases to Membrane Rafts by the Human IgA Receptor FcαR

1999 • 42 citations

A Short Peptide Motif at the Carboxyl Terminus Is Required for Incorporation of the Integral Membrane MAL Protein to Glycolipid-enriched Membranes

1998 • 30 citations