Ceramide Enables Fas to Cap and Kill

Functional rafts in cell membranes

1997 • 9,471 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Caveolins, Liquid-Ordered Domains, and Signal Transduction

1999 • 1,016 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

LAT Palmitoylation

1998 • 837 citations

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

1998 • 789 citations

Regulated internalization of caveolae.

1994 • 760 citations

Filipin-dependent Inhibition of Cholera Toxin: Evidence for Toxin Internalization and Activation through Caveolae-like Domains

1998 • 724 citations

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

2000 • 650 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

CD95 Signaling via Ceramide-rich Membrane Rafts

2001 • 630 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Triggering Cell Death

1999 • 425 citations

Compartmentalization of ceramide signaling: physical foundations and biological effects

2000 • 421 citations

Crystallographic structure studies of an IgG molecule and an Fc fragment

1976 • 416 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Localization of Platelet-derived Growth Factor-stimulated Phosphorylation Cascade to Caveolae

1996 • 378 citations

Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal

1998 • 366 citations

S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

1997 • 364 citations

Compartmentalized Activation of the High Affinity Immunoglobulin E Receptor within Membrane Domains

1997 • 353 citations

Compartmentalized Production of Ceramide at the Cell Surface

1995 • 352 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Caspase-independent Cell Killing by Fas-associated Protein with Death Domain

1998 • 317 citations

Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.

1996 • 312 citations

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x_L

1999 • 295 citations

Ceramides in Phospholipid Membranes: Effects on Bilayer Stability and Transition to Nonlamellar Phases

1999 • 231 citations

Capping and the Cytoskeleton

1984 • 215 citations

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

1998 • 209 citations

Caveolin 1-Mediated Regulation of Receptor Tyrosine Kinase-Associated Phosphatidylinositol 3-Kinase Activity by Ceramide

2000 • 194 citations

Association of p75 with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae

1997 • 169 citations

Caveolin Interacts with Trk A and p75NTR and Regulates Neurotrophin Signaling Pathways

1999 • 163 citations

Endocytosis of GPI-anchored proteins in human lymphocytes: role of glycolipid-based domains, actin cytoskeleton, and protein kinases.

1996 • 156 citations

Acidic Sphingomyelinase (ASM) Is Necessary for Fas-induced GD3 Ganglioside Accumulation and Efficient Apoptosis of Lymphoid Cells

1998 • 150 citations

Role of Acidic Sphingomyelinase in Fas/CD95-mediated Cell Death

2000 • 141 citations

Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis.

1998 • 140 citations

TNF-alpha-mediated apoptosis is initiated in caveolae-like domains.

1999 • 138 citations

CD95-mediated apoptosis in vivo requires acid sphingomyelinase

2000 • 131 citations

Fas/CD95/Apo-I activates the acidic sphingomyelinase via Caspases

1998 • 127 citations

Detection of circulating antigen-antibody complexes by their inhibitory effect on the agglutination of IgG-coated particles by rheumatioid factor of Clq.

1976 • 125 citations

Natural Ceramide Reverses Fas Resistance of Acid Sphingomyelinase −− Hepatocytes

2001 • 122 citations

Signal Transduction via Glycosyl Phosphatidylinositol-anchored Proteins in T Cells Is Inhibited by Lowering Cellular Cholesterol

1997 • 117 citations

Intracellular Phosphotyrosine Induction by Major Histocompatibility Complex Class II Requires Co-aggregation with Membrane Rafts

1999 • 113 citations

CD95-mediated Apoptosis in Vivo Involves Acid Sphingomyelinase

2000 • 112 citations

TNF-α-Mediated Apoptosis Is Initiated in Caveolae-Like Domains

1999 • 107 citations

Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers

1996 • 105 citations

CD95 (Fas/APO-1) Induces Ceramide Formation and Apoptosis in the Absence of a Functional Acid Sphingomyelinase

1998 • 102 citations

Radiation-Induced Apoptosis in Human Lymphocytes and Lymphoma Cells Critically Relies on the Up-Regulation of CD95/Fas/APO-1 Ligand

1998 • 92 citations

Differential Effects of Sphingomyelin Hydrolysis and Cholesterol Transport on Oxysterol-binding Protein Phosphorylation and Golgi Localization

1998 • 90 citations

CD95(Fas/APO-1) Signals Ceramide Generation Independent of the Effector Stage of Apoptosis

2000 • 85 citations

Co-capping of ras proteins with surface immunoglobulins in B lymphocytes

1990 • 81 citations

Neutral sphingomyelinase action stimulates signal transduction of tumor necrosis factor-alpha in the synthesis of cholesteryl esters in human fibroblasts.

1994 • 80 citations

Liposomes Containing Sphingomyelin and Cholesterol: Detergent Solubilisation and Infrared Spectroscopic Studies

1999 • 57 citations

THE 1999 MOYER AWARD Burn Injury Induces Skeletal Muscle Apoptosis and the Activation of Caspase Pathways in Rats

1999 • 51 citations

Ceramides perturb the structure of phosphatidylcholine bilayers and modulate the activity of phospholipase A 2

1998 • 48 citations

T cell receptor aggregation, but not dimerization, induces increased cytosolic calcium concentrations and reveals a lack of stable association between CD4 and the T cell receptor.

1992 • 42 citations

The CD95(APO-1/Fas)/CD95L system

1998 • 41 citations

Role of cholesterol in the capping of surface immunoglobulin receptors on murine lymphocytes.

1983 • 40 citations

TCR antagonist peptides induce formation of APC-T cell conjugates and activate a Rac signaling pathway

2000 • 30 citations

Lymphocyte activation and capping of hormone receptors

1988 • 30 citations

Intracellular mechanisms of ?-selectin induced capping

1999 • 28 citations

The role of the endothelium in ceramide-induced vasodilation

1998 • 15 citations

The role of cholesterol and sphigomyelin in tyrosine phosphorylation of proteins and capping of Fcgamma receptor II.

1999 • 13 citations