Lipid Rafts As a Membrane-Organizing Principle

Functional rafts in cell membranes

1997 • 9,471 citations

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

Membrane lipids: where they are and how they behave

2008 • 6,294 citations

High-Resolution Crystal Structure of an Engineered Human β ₂ -Adrenergic G Protein–Coupled Receptor

2007 • 3,186 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Model Systems, Lipid Rafts, and Cell Membranes

2004 • 1,625 citations

Lipid Rafts

2003 • 1,485 citations

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

2008 • 1,461 citations

Pathways of clathrin-independent endocytosis

2007 • 1,422 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains

2002 • 1,130 citations

Lipid rafts: at a crossroad between cell biology and physics

2007 • 1,072 citations

Phase equilibria in the phosphatidylcholine-cholesterol system

1987 • 1,024 citations

Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains

1996 • 1,006 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

Membranes are more mosaic than fluid

2005 • 873 citations

Lipid–protein interactions in biological membranes: a structural perspective

2003 • 843 citations

Cholesterol and the Golgi Apparatus

1993 • 819 citations

Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles

2007 • 778 citations

Lipid rafts: contentious only from simplistic standpoints

2006 • 769 citations

Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.

1994 • 688 citations

A Microscopic Interaction Model of Maximum Solubility of Cholesterol in Lipid Bilayers

1999 • 585 citations

Shiga toxin induces tubular membrane invaginations for its uptake into cells

2007 • 569 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

Miscibility Phase Diagrams of Giant Vesicles Containing Sphingomyelin

2005 • 544 citations

What's so special about cholesterol?

2004 • 497 citations

Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork

2006 • 468 citations

Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol

2004 • 434 citations

Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity

2008 • 434 citations

Order of lipid phases in model and plasma membranes

2009 • 427 citations

GM1 structure determines SV40-induced membrane invagination and infection

2009 • 406 citations

Effect of Line Tension on the Lateral Organization of Lipid Membranes

2007 • 390 citations

Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network

2009 • 387 citations

Plasma membranes are poised for activation of raft phase coalescence at physiological temperature

2008 • 367 citations

Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories

2007 • 364 citations

Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes

2005 • 314 citations

Combined influence of cholesterol and synthetic amphiphillic peptides upon bilayer thickness in model membranes

1992 • 309 citations

Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation

2008 • 298 citations

GPI-anchored receptor clusters transiently recruit Lyn and Gα for temporary cluster immobilization and Lyn activation: single-molecule tracking study 1

2007 • 296 citations

Lipids as Modulators of Proteolytic Activity of BACE

2005 • 275 citations

Models of Lipid-Protein Interactions in Membranes

1993 • 273 citations

Detergent resistance as a tool in membrane research

2007 • 265 citations

Phase diagrams and lipid domains in multicomponent lipid bilayer mixtures

2008 • 262 citations

Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling

2009 • 262 citations

Liquid-Liquid Immiscibility in Membranes

2003 • 261 citations

Structure, dynamics and composition of the lipid-protein interface. Perspectives from spin-labelling

1998 • 255 citations

Intracellular sterol dynamics

2009 • 233 citations

Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion

2009 • 231 citations

Evidence for Segregation of Sphingomyelin and Cholesterol during Formation of Copi-Coated Vesicles

2000 • 227 citations

Cholesterol-phosphatidylcholine interactions in multilamellar vesicles

1980 • 211 citations

Structural determinants for partitioning of lipids and proteins between coexisting fluid phases in giant plasma membrane vesicles

2007 • 209 citations

Informatics and computational strategies for the study of lipids

2007 • 207 citations

Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins

2007 • 178 citations

Why do worms need cholesterol?

2003 • 178 citations

Palmitoylation is required for efficient Fas cell death signaling

2006 • 178 citations

Phase coexistence and connectivity in the apical membrane of polarized epithelial cells

2006 • 162 citations

Membrane heterogeneities in the formation of B cell receptor–Lyn kinase microclusters and the immune synapse

2008 • 145 citations

Coexisting Domains in the Plasma Membranes of Live Cells Characterized by Spin-Label ESR Spectroscopy

2006 • 137 citations

Influence of Chain Length and Unsaturation on Sphingomyelin Bilayers

2005 • 116 citations

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells

2009 • 106 citations

The functional purification of P-glycoprotein is dependent on maintenance of a lipid–protein interface

1997 • 101 citations

Polyakov loop extended Nambu–Jona-Lasinio model with imaginary chemical potential

2008 • 92 citations

How sphingolipids bind and shape proteins: molecular basis of lipid-protein interactions in lipid shells, rafts and related biomembrane domains

2003 • 92 citations

Mechanism of homophilic cadherin adhesion

2000 • 87 citations

Ordered and Disordered Phases Coexist in Plasma Membrane Vesicles of RBL-2H3 Mast Cells. An ESR Study

2003 • 81 citations

The inner side of T cell lipid rafts

2004 • 59 citations

Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement

2007 • 42 citations