Raft ceramide in molecular medicine

Functional rafts in cell membranes

1997 • 9,471 citations

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration

2003 • 1,598 citations

Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

2003 • 1,538 citations

Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

2001 • 1,245 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Structure and Origin of Ordered Lipid Domains in Biological Membranes

1998 • 962 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

CD95 Signaling via Ceramide-rich Membrane Rafts

2001 • 630 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

2003 • 525 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I

2001 • 409 citations

Ceramide Enables Fas to Cap and Kill

2001 • 377 citations

Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells

1996 • 347 citations

Acidic Sphingomyelinase Mediates Entry of N. gonorrhoeae into Nonphagocytic Cells

1997 • 319 citations

Ceramide glycosylation potentiates cellular multidrug resistance

2001 • 303 citations

SPTLC1 is mutated in hereditary sensory neuropathy, type 1

2001 • 287 citations

Sphingomyelinase Induces Lipid Microdomain Formation in a Fluid Phosphatidylcholine/Sphingomyelin Membrane

1998 • 276 citations

Ceramide-Rich Membrane Rafts Mediate CD40 Clustering

2002 • 256 citations

Ceramides in Phospholipid Membranes: Effects on Bilayer Stability and Transition to Nonlamellar Phases

1999 • 231 citations

Defective TNF-α–mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

2003 • 222 citations

An essential role for membrane rafts in the initiation of Fas/CD95‐triggered cell death in mouse thymocytes

2002 • 219 citations

Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism

2000 • 219 citations

Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs

1991 • 210 citations

Pivotal Role for Acidic Sphingomyelinase in Cerebral Ischemia-Induced Ceramide and Cytokine Production, and Neuronal Apoptosis

2000 • 208 citations

Molecular mechanisms of bacteria induced apoptosis.

2001 • 154 citations

Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis

2001 • 147 citations

Sindbis Virus Entry into Cells Triggers Apoptosis by Activating Sphingomyelinase, Leading to the Release of Ceramide

2000 • 147 citations

Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering

2003 • 144 citations

Contribution of Fas ligand to T cell-mediated hepatic injury in mice

1997 • 139 citations

1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action.

1987 • 124 citations

Natural Ceramide Reverses Fas Resistance of Acid Sphingomyelinase −− Hepatocytes

2001 • 122 citations

Observation of Topical Catalysis by Sphingomyelinase Coupled To Microspheres

2002 • 113 citations

CD95-mediated Apoptosis in Vivo Involves Acid Sphingomyelinase

2000 • 112 citations

Acid sphingomyelinase is involved in CEACAM receptor‐mediated phagocytosis of Neisseria gonorrhoeae

2000 • 112 citations

Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers

1996 • 105 citations

CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo

1994 • 98 citations

Plasmodium falciparum Phospholipase C Hydrolyzing Sphingomyelin and Lysocholinephospholipids Is a Possible Target for Malaria Chemotherapy

2001 • 75 citations

Ceramides Modulate Protein Kinase C Activity and Perturb the Structure of Phosphatidylcholine/Phosphatidylserine Bilayers

1999 • 64 citations

Ceramide-Coated Balloon Catheters Limit Neointimal Hyperplasia After Stretch Injury in Carotid Arteries

2000 • 61 citations

CD95 Rapidly Clusters in Cells of Diverse Origins

2003 • 60 citations

Apoptosis induced by N-hexanoylsphingosine in CHP-100 cells associates with accumulation of endogenous ceramide and is potentiated by inhibition of glucocerebroside synthesis

1998 • 44 citations

Role of sphingomyelin-MAPKs pathway in heat-induced apoptosis

2003 • 29 citations