Cholesterol Does Not Induce Segregation of Liquid-Ordered Domains in Bilayers Modeling the Inner Leaflet of the Plasma Membrane

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Small-volume extrusion apparatus for preparation of large, unilamellar vesicles

1991 • 1,461 citations

Lipid Rafts Reconstituted in Model Membranes

2001 • 1,330 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

Structure and Origin of Ordered Lipid Domains in Biological Membranes

1998 • 962 citations

Polyamines: Mysterious Modulators of Cellular Functions

2000 • 858 citations

Characterization of lipid bilayer phases by confocal microscopy and fluorescence correlation spectroscopy

1999 • 841 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. III. Complete structure

1992 • 688 citations

Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.

1994 • 688 citations

Insolubility of lipids in Triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts)

2000 • 677 citations

Parallax method for direct measurement of membrane penetration depth utilizing fluorescence quenching by spin-labeled phospholipids

1987 • 671 citations

On the Origin of Sphingolipid/Cholesterol-Rich Detergent-Insoluble Cell Membranes: Physiological Concentrations of Cholesterol and Sphingolipid Induce Formation of a Detergent-Insoluble, Liquid-Ordered Lipid Phase in Model Membranes

1997 • 661 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

Membrane microdomains and caveolae

1999 • 580 citations

The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography

1977 • 566 citations

The differential miscibility of lipids as the basis for the formation of functional membrane rafts

1998 • 512 citations

Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?

1997 • 512 citations

Sphingolipid organization in biomembranes: what physical studies of model membranes reveal

1998 • 484 citations

Electrospray Ionization Tandem Mass Spectrometry (Esi-Ms/Ms) Analysis of the Lipid Molecular Species Composition of Yeast Subcellular Membranes Reveals Acyl Chain-Based Sorting/Remodeling of Distinct Molecular Species En Route to the Plasma Membrane

1999 • 482 citations

Lipid Traffic in Animal Cells

1989 • 468 citations

Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains

1998 • 415 citations

Analysis of Cd44-Containing Lipid Rafts

1999 • 399 citations

Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.

1994 • 389 citations

The preferential interactions of cholesterol with different classes of phospholipids

1977 • 374 citations

The preference of cholesterol for phosphatidylcholine in mixed phosphatidylcholine-phosphatidylethanolamine bilayers

1976 • 338 citations

Critical Role for Cholesterol in Lyn-mediated Tyrosine Phosphorylation of FcεRI and Their Association with Detergent-resistant Membranes

1999 • 327 citations

Phospholipid class and fatty acid composition of Golgi apparatus isolated from rat liver and comparison with other cell fractions

1970 • 292 citations

Quantitative Analysis of Phospholipids in Functionally Important Membrane Domains from RBL-2H3 Mast Cells Using Tandem High-Resolution Mass Spectrometry

1999 • 288 citations

Influence of Docosahexaenoic Acid and Cholesterol on Lateral Lipid Organization in Phospholipid Mixtures

1998 • 274 citations

Phosphatidylcholine

1992 • 273 citations

Myristoylation and Differential Palmitoylation of the HCK Protein-Tyrosine Kinases Govern Their Attachment to Membranes and Association with Caveolae

1995 • 237 citations

Interactions between FcεRI and lipid raft components are regulated by the actin cytoskeleton

2000 • 225 citations

Cholesterol at Different Bilayer Concentrations Can Promote or Antagonize Lateral Segregation of Phospholipids of Differing Acyl Chain Length

1996 • 224 citations

A method for the synthesis of isomerically pure saturated mixed-chain phosphatidylcholines

1981 • 164 citations

Sterol partitioning among intracellular membranes. Testing a model for cellular sterol distribution.

1983 • 163 citations

Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association.

1997 • 160 citations

A simple, sensitive method for lipid phosphorus

1974 • 148 citations

Association of GAP-43 with Detergent-resistant Membranes Requires Two Palmitoylated Cysteine Residues

1998 • 144 citations

Liquid-crystalline phases of cholesterol/lipid bilayers as revealed by the fluorescence of trans-parinaric acid

1995 • 143 citations

Red Blood Cell Lipids Form Immiscible Liquids

1998 • 141 citations

Effect of Cholesterol on Molecular Order and Dynamics in Highly Polyunsaturated Phospholipid Bilayers

1998 • 140 citations

Different Sphingolipids Show Differential Partitioning into Sphingolipid/Cholesterol-Rich Domains in Lipid Bilayers

2000 • 136 citations

Fluorescence quenching in model membranes. 1. Characterization of quenching caused by a spin-labeled phospholipid

1981 • 134 citations

Negatively charged phospholipids and their position in the cholesterol affinity sequence

1979 • 131 citations

Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. I. Scaling of neutron data and the distributions of double bonds and water

1991 • 127 citations

Factors contributing to the distribution of cholesterol among phospholipid vesicles.

1986 • 122 citations

The affinity of cholesterol for phosphatidylcholine and sphingomyelin

1979 • 100 citations

Fluorescence-Based Evaluation of the Partitioning of Lipids and Lipidated Peptides into Liquid-Ordered Lipid Microdomains: A Model for Molecular Partitioning into “Lipid Rafts”

2000 • 99 citations

Fluorescence Quenching in Model Membranes

1982 • 99 citations

Monolayer coupling in sphingomyelin bilayer systems

1978 • 92 citations

Differential Scanning Calorimetric and Fourier Transform Infrared Spectroscopic Studies of the Effects of Cholesterol on the Thermotropic Phase Behavior and Organization of a Homologous Series of Linear Saturated Phosphatidylserine Bilayer Membranes

2000 • 88 citations

Transfer of cholesterol between liposomal membranes

1979 • 80 citations

Differential Scanning Calorimetric Studies of the Interaction of Cholesterol with Distearoyl and Dielaidoyl Molecular Species of Phosphatidylcholine, Phosphatidylethanolamine, and Phosphatidylserine

1997 • 77 citations

Transbilayer distribution of bromine in fluid bilayers containing a specifically brominated analog of dioleoylphosphatidylcholine

1991 • 69 citations

Intracellular free magnesium in frog skeletal muscle fibres measured with ion‐selective micro‐electrodes.

1986 • 69 citations

Fluorescence quenching in model membranes An analysis of the local phospholipid environments of diphenylhexatriene and gramicidin A′

1981 • 69 citations

Cholesterol modulation of lipid intermixing in phospholipid and glycosphingolipid mixtures. Evaluation using fluorescent lipid probes and brominated lipid quenchers

1992 • 68 citations

Cholesterol Crystalline Polymorphism and the Solubility of Cholesterol in Phosphatidylserine

2000 • 64 citations

The effect of side-chain analogues of cholesterol on the thermotropic phase behavior of 1-stearoyl-2-oleoylphosphatidylcholine bilayers: a differential scanning calorimetric study

1996 • 60 citations

Cholesterol does not remove the gel-liquid crystalline phase transition of phosphatidylcholines containing two polyenoic acyl chains

1991 • 59 citations

Glycosphingolipid fatty acid arrangement in phospholipid bilayers: cholesterol effects

1995 • 58 citations

Transbilayer movement and distribution of spin-labelled phospholipids in the inner mitochondrial membrane

1999 • 42 citations

Phosphatidylcholine-cholesterol interactions: bilayers of heteroacid lipids containing linoleate lose calorimetric transitions at low cholesterol concentration

1989 • 38 citations

Effect of fluorophore linkage position of n-(9-anthroyloxy) fatty acids on probe distribution between coexisting gel and fluid phospholipid phases

1988 • 37 citations

Intracellular free magnesium in neurones of Helix aspersa measured with ion‐selective micro‐electrodes.

1984 • 36 citations

A long chain spin label for glycosphingolipid studies: transbilayer fatty acid interdigitation of lactosyl ceramide

1987 • 33 citations

Glycosphingolipid acyl chain orientational order in unsaturated phosphatidylcholine bilayers

1993 • 26 citations

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