From protozoa to mammalian cells: a new paradigm in the life cycle of intracellular bacterial pathogens

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

MICROBIAL BIOFILMS

1995 • 4,253 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Effects of cytochalasin and phalloidin on actin.

1987 • 1,989 citations

Legionnaires' Disease

1977 • 1,687 citations

Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae.

1980 • 979 citations

THINKING ABOUT BACTERIAL POPULATIONS AS MULTICELLULAR ORGANISMS

1998 • 870 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

Conjugative Transfer by the Virulence System of Legionella pneumophila

1998 • 709 citations

Ecological distribution of Legionella pneumophila

1981 • 560 citations

The molecular ecology of legionellae

1996 • 539 citations

Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome

1998 • 530 citations

High Rates of Conjugation in Bacterial Biofilms as Determined by Quantitative In Situ Analysis

1999 • 469 citations

Interaction of Mycobacterium avium with environmental amoebae enhances virulence

1997 • 442 citations

Ecology of Free-Living Amoebae

1994 • 425 citations

Classification of the Legionnaires' Disease Bacterium: Legionella pneumophila, genus novum, species nova, of the Family Legionellaceae, familia nova

1979 • 393 citations

Resuscitation of viable but nonculturable Legionella pneumophila Philadelphia JR32 by Acanthamoeba castellanii

1997 • 366 citations

Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion

1994 • 366 citations

Expression of Legionella pneumophila Virulence Traits in Response to Growth Conditions

1998 • 361 citations

Survival of coliforms and bacterial pathogens within protozoa during chlorination

1988 • 356 citations

Survival of Legionella pneumophila within cysts of Acanthamoeba polyphaga following chlorine exposure

1990 • 328 citations

Agrobacterium tumefaciens T-complex transport apparatus: a paradigm for a new family of multifunctional transporters in eubacteria

1997 • 322 citations

Phagocytosis of the legionnaires' disease bacterium (legionella pneumophila) occurs by a novel mechanism: Engulfment within a Pseudopod coil

1984 • 317 citations

Legionella pneumophila Utilizes the Same Genes To Multiply within Acanthamoeba castellanii and Human Macrophages

1999 • 299 citations

Current views on the relationships between amoebae, legionellae and man.

1986 • 298 citations

Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth

1999 • 281 citations

The Origin of Programmed Cell Death

1996 • 280 citations

Influence of temperature and plumbing material selection on biofilm formation and growth of Legionella pneumophila in a model potable water system containing complex microbial flora

1994 • 278 citations

Isolation of the galactose-binding lectin that mediates the in vitro adherence of Entamoeba histolytica.

1987 • 275 citations

Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages.

1992 • 272 citations

Mycobacterium aviumBacilli Grow Saprozoically in Coculture withAcanthamoeba polyphagaand Survive within Cyst Walls

1998 • 271 citations

Obligate intracellular bacterial parasites of acanthamoebae related to Chlamydia spp

1997 • 268 citations

A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection

1989 • 254 citations

Invasion of Protozoa by Legionella pneumophila and Its Role in Bacterial Ecology and Pathogenesis

1998 • 245 citations

Unexplored reservoirs of pathogenic bacteria: protozoa and biofilms

1999 • 243 citations

Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa

1997 • 236 citations

Surface-Associated Hsp60 Chaperonin of Legionella pneumophila Mediates Invasion in a HeLa Cell Model

1998 • 232 citations

Evidence for pore‐forming ability by Legionella pneumophila

1998 • 227 citations

Production of Respirable Vesicles Containing Live Legionella pneumophila Cells by Two Acanthamoeba spp

1998 • 220 citations

Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion

1996 • 205 citations

The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum

1996 • 200 citations

Expression of Multiple Pili by Legionella pneumophila : Identification and Characterization of a Type IV Pilin Gene and Its Role in Adherence to Mammalian and Protozoan Cells

1998 • 190 citations

Adaptation of a conjugal transfer system for the export of pathogenic macromolecules

1996 • 188 citations

Natural Competence for DNA Transformation by Legionella pneumophila and Its Association with Expression of Type IV Pili

1999 • 187 citations

Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila

1999 • 186 citations

The Legionella pneumophila rpoS Gene Is Required for Growth within Acanthamoeba castellanii

1999 • 183 citations

Mip protein of Legionella pneumophila exhibits peptidyl‐prolyl‐cis/trans isomerase (PPIase) activity

1992 • 182 citations

Relationship between Legionella pneumophila and Acanthamoeba polyphaga: physiological status and susceptibility to chemical inactivation

1992 • 177 citations

Phenotypic modulation by Legionella pneumophila upon infection of macrophages

1993 • 170 citations

Ingested Listeria monocytogenes survive and multiply in protozoa

1990 • 159 citations

Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes.

1990 • 157 citations

In Situ Detection of High Levels of Horizontal Plasmid Transfer in Marine Bacterial Communities

1998 • 151 citations

Interactions between Naegleria fowleri and Legionella pneumophila

1985 • 148 citations

Poly-3-Hydroxybutyrate in Legionella pneumophila , an Energy Source for Survival in Low-Nutrient Environments

1999 • 146 citations

Development of Cellular Dependence on Infective Organisms: Micrurgical Studies in Amoebas

1972 • 140 citations

Immunogold and fluorescein immunolabelling of Legionella pneumophila within an aquatic biofilm visualized by using episcopic differential interference contrast microscopy

1992 • 139 citations

Intracellular survival and saprophytic growth of isolates from the Burkholderia cepacia complex in free-living amoebae

1999 • 138 citations

Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components of IncQ plasmid RSF1010

1998 • 136 citations

Apoptosis in Macrophages and Alveolar Epithelial Cells during Early Stages of Infection byLegionella pneumophilaand Its Role in Cytopathogenicity

1999 • 132 citations

Infection of Acanthamoeba castellanii by Chlamydia pneumoniae

1997 • 132 citations

Detection of Legionella species in sewage and ocean water by polymerase chain reaction, direct fluorescent-antibody, and plate culture methods

1993 • 127 citations

Virulence factors of the family Legionellaceae

1992 • 124 citations

Influence of site specifically altered Mip proteins on intracellular survival of Legionella pneumophila in eukaryotic cells

1995 • 124 citations

Legionella-Like Amebal Pathogens––Phylogenetic Status and Possible Role in Respiratory Disease

1996 • 123 citations

The prepilin peptidase is required for protein secretion by and the virulence of the intracellular pathogen Legionella pneumophila

1999 • 119 citations

Interaction between Burkholderia pseudomallei and Acanthamoeba Species Results in Coiling Phagocytosis, Endamebic Bacterial Survival, and Escape

2000 • 117 citations

Legionella pneumophilaContains a Type II General Secretion Pathway Required for Growth in Amoebae as Well as for Secretion of the Msp Protease

1999 • 112 citations

Genetic Responses to Free Radicals: Homeostasis and Gene Control

2000 • 112 citations

Identification and Temperature Regulation of Legionella pneumophila Genes Involved in Type IV Pilus Biogenesis and Type II Protein Secretion

1998 • 111 citations

The use of differential display‐PCR to isolate and characterize a Legionella pneumophila locus induced during the intracellular infection of macrophages

1996 • 110 citations

The mechanism of killing and exiting the protozoan host Acanthamoeba polyphaga by Legionella pneumophila

2000 • 110 citations

Intracellular growth of Legionella pneumophila within Acanthamoeba castellanii Neff

1984 • 109 citations

Activation of Caspase 3 duringLegionella pneumophila-Induced Apoptosis

1999 • 109 citations

Molecular characterization of the vir regulon of Agrobacterium tumefaciens: Complete nucleotide sequence and gene organization of the 28.63-kbp regulon cloned as a single unit

1990 • 106 citations

The role of Legionella pneumophila-infected Hartmannella vermiformis as an infectious particle in a murine model of Legionnaire's disease

1997 • 105 citations

How is the intracellular fate of the Legionella pneumophila phagosome determined?

1998 • 101 citations

Identification of a Gal/GalNAc Lectin in the Protozoan Hartmannella vermiformis as a Potential Receptor for Attachment and Invasion by the Legionnaires' Disease Bacterium

1997 • 101 citations

Effects of an isogenic Zn‐metalloprotease‐deficien mutant of Legionella pneumophila in a guinea‐pig pneumonia model

1994 • 97 citations

Phylogenetic diversity of intra-amoebal legionellae as revealed by 16S rRNA gene sequence comparison

1996 • 96 citations

Field investigations of tularemia in Norway

1996 • 93 citations

Effects of cytochalasin D and methylamine on intracellular growth of Legionella pneumophila in amoebae and human monocyte-like cells

1991 • 91 citations

Identification of Macrophage-Specific Infectivity Loci ( mil ) of Legionella pneumophila That Are Not Required for Infectivity of Protozoa

1998 • 91 citations

Transcriptional regulation of the macrophage‐induced gene (gspA) of Legionella pneumophila and phenotypic characterization of a null mutant

1997 • 90 citations

Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlate with virulence

1996 • 88 citations

Fatal attraction of mammalian cells to Legionella pneumophila

1998 • 84 citations

Relationship between mycobacteria and amoebae: ecological and epidemiological concerns

2007 • 84 citations

Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection

1996 • 80 citations

Heterogeneity in the Attachment and Uptake Mechanisms of the Legionnaires’ Disease Bacterium, Legionella pneumophila , by Protozoan Hosts

1998 • 78 citations

Protein expression by the protozoan Hartmannella vermiformis upon contact with its bacterial parasite Legionella pneumophila

1994 • 74 citations

Infectivity of Legionella pneumophila mip mutant for alveolar epithelial cells

1995 • 71 citations

Molecular Aspects of the Cell Cycle and Encystment of Acanthamoeba

1991 • 70 citations

Free‐living amoebae: pathogenicity and immunity

1991 • 70 citations

Acute melioidosis outbreak in Western Australia

1999 • 69 citations

Induced Expression of the Legionella pneumophila Gene Encoding a 20-Kilodalton Protein during Intracellular Infection

1998 • 65 citations

Virulence factors of the family Legionellaceae.

1992 • 65 citations

Biofilms

1999 • 63 citations

Cloning and molecular characterization of a Legionella pneumophila gene induced by intracellular infection and by various in vitro stress conditions

1994 • 62 citations

Heterogeneity in intracellular replication and cytopathogenicity of Legionella pneumophila and Legionella micdadei in mammalian and protozoan cells

1999 • 60 citations

Different fates ofLegionella pneumophila pmiandmilmutants within macrophages and alveolar epithelial cells

1998 • 60 citations

Identification of the Aspartate-β-Semialdehyde Dehydrogenase Gene of Legionella pneumophila and Characterization of a Null Mutant

1998 • 59 citations

Legionella pneumophilakills human phagocytes but not protozoan host cells by inducing apoptotic cell death

1998 • 55 citations

Interspecies sequence differences in the Mip protein from the genus Legionella: implications for function and evolutionary relatedness

1997 • 50 citations

Bacterial endosymbionts of Acanthamoeba sp.

1985 • 49 citations

Comparative Analysis of Legionella pneumophila and Legionella micdadei Virulence Traits

1999 • 48 citations

Identification of Putative Cytoskeletal Protein Homologues in the Protozoan Host Hartmannella vermiformis as Substrates for Induced Tyrosine Phosphatase Activity upon Attachment to the Legionnaires' Disease Bacterium, Legionella pneumophila

1998 • 42 citations

Bacterial Endosymbionts of Acanthamoeba sp.

1985 • 42 citations

Role of the 25 kDa major outer membrane protein ofLegionella pneumophilain attachment to U‐937 cells and its potential as a virulence factor for chick embryos

1999 • 39 citations

Signal Transduction in the Protozoan Host Hartmannella vermiformis upon Attachment and Invasion by Legionella micdadei

1998 • 38 citations

The Legionella pneumophila prp locus; required during infection of macrophages and amoebae

1999 • 37 citations

Change of Cellular "Pathogens" into Required Cell Components

1987 • 33 citations

Invasion of mammalian and protozoan cells by Legionella pneumophila

1998 • 30 citations

Antagonistic Action of the Bacterium Bacillus Licheniformis M‐4 Toward the Amoeba Naegleria Fowleri

1993 • 27 citations

Exploring a novel perspective on pathogenic relationships

1999 • 26 citations

Phenotypic modulation by intracellular bacterial pathogens

1999 • 23 citations

Speculations on the influence of infecting phenotype on virulence and antibiotic susceptibility of Legionella pneumophila

1995 • 23 citations

Growth of legionella and other heterotrophic bacteria in a circulating cooling water system exposed to ultraviolet irradiation

1994 • 22 citations

Probing the microenvironment of intracellular bacterial pathogens

1999 • 21 citations

Transcription by RNA polymerase II during Acanthamoeba differentiation

1998 • 17 citations

Field investigations of tularemia in Norway

1996 • 11 citations