Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection

Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

1989 • 332 citations

Current views on the relationships between amoebae, legionellae and man.

1986 • 298 citations

Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages.

1992 • 272 citations

A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection

1989 • 254 citations

Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene

1994 • 248 citations

Legionnaires disease: historical perspective

1988 • 238 citations

DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity

1989 • 212 citations

Absence of siderophore activity in Legionella species grown in iron-deficient media

1983 • 196 citations

The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophages

1994 • 182 citations

Characterization of the micro‐environment of Salmonella typhimurium–containing vacuoles within MDCK epithelial cells

1992 • 167 citations

Development of a chemically defined liquid medium for growth of Legionella pneumophila

1979 • 166 citations

Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes.

1990 • 157 citations

Intracellular multiplication ofLegionella pneumophila in amoebae isolated from hospital hot water tanks

1989 • 154 citations

Comparative study of selective media for isolation of Legionella pneumophila from potable water

1982 • 139 citations

ENTEROBACTERIAL CHELATORS OF IRON: THEIR OCCURRENCE, DETECTION, AND RELATION TO PATHOGENICITY

1975 • 134 citations

Growth of Legionella pneumophila in a human macrophage-like (U937) cell line

1988 • 126 citations

Virulence factors of the family Legionellaceae

1992 • 124 citations

Cellular Regulation of Iron Assimilation

1989 • 114 citations

Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma-activated human monocytes depending upon its degree of iron saturation. Iron-lactoferrin and nonphysiologic iron chelates reverse monocyte activation against Legionella pneumophila.

1991 • 114 citations

Hemin utilization is related to virulence of Streptococcus pneumoniae

1993 • 104 citations

Chemically defined medium for Legionella pneumophila growth

1981 • 93 citations

Effects of cytochalasin D and methylamine on intracellular growth of Legionella pneumophila in amoebae and human monocyte-like cells

1991 • 91 citations

Exogenous induction of the iron dicitrate transport system of Escherichia coli K-12

1984 • 87 citations

Cloning and expression of Legionella pneumophila antigens in Escherichia coli

1984 • 86 citations

An iron- and fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetases

1997 • 80 citations

Iron enhances the bactericidal action of streptonigrin

1982 • 71 citations

Genetics and molecular pathogenesis of Legionella pneumophila, an intracellular parasite of macrophages.

1989 • 71 citations

Cloning and sequencing of the Legionella pneumophila fur gene

1994 • 70 citations

Cloning and nucleotide sequence of a gene (ompS) encoding the major outer membrane protein of Legionella pneumophila

1992 • 68 citations

Acquisition of iron by Legionella pneumophila: role of iron reductase

1991 • 67 citations

Isolation by streptonigrin enrichment and characterization of a transferrin-specific iron uptake mutant of Neisseria meningitidis

1987 • 61 citations

Bactericidal effect of lactoferrin on Legionella pneumophila: effect of the physiological state of the organism

1989 • 57 citations

The major iron-containing protein of Legionella pneumophila is an aconitase homologous with the human iron-responsive element-binding protein

1993 • 57 citations

Macrophage permissiveness for Legionella pneumophila growth modulated by iron

1994 • 52 citations

A Legionella pneumophila gene that promotes hemin binding

1996 • 51 citations

Cytotoxicity of extracellular Legionella pneumophila

1994 • 51 citations

Iron-vibriobactin transport system is not required for virulence of Vibrio cholerae

1985 • 50 citations

Ferric reductases of Legionella pneumophila

1993 • 50 citations

Characterization of a Legionella micdadei mip mutant

1995 • 43 citations

Opsonin-independent adherence and intracellular development of Legionella pneumophila within U-937 cells

1993 • 41 citations

Interactions Between Macrophages and Legionella pneumophila

1992 • 40 citations

Chromosome-mediated 2,3-dihydroxybenzoic acid is a precursor in the biosynthesis of the plasmid-mediated siderophore anguibactin in Vibrio anguillarum

1994 • 40 citations

Role of extracellular iron in the action of the quinone antibiotic streptonigrin: mechanisms of killing and resistance of Neisseria gonorrhoeae

1987 • 38 citations

Isolation and characterization of a mutant of Neisseria gonorrhoeae that is defective in the uptake of iron from transferrin and haemoglobin and is avirulent in mouse subcutaneous chambers

1991 • 38 citations

Site-specific mutagenesis inLegionella pneumophilaby allelic exchange using counterselectable ColE1 vectors

1988 • 35 citations

Metabolic pathways and nitrogen metabolism inLegionella pneumophila

1984 • 35 citations

DNA interaction and nucleotide sequence cleavage of copper-streptonigrin

1984 • 30 citations

Random mutagenesis ofLegionella pneumophilawith mini-Tn10

1994 • 27 citations

Killing ofLegionella pneumophila by human serum and iron-binding agents

1988 • 25 citations

Growth of Legionella spp. under conditions of iron restriction

1991 • 22 citations

Tn5 insertion mutants of Pseudomonas aeruginosa deficient in surface expression of ferripyochelin-binding protein

1987 • 21 citations

Shuttle mutagenesis of Legionella pneumophila: identification of a gene associated with host cell cytopathicity

1994 • 21 citations

Absence of siderophore-like activity in Legionella pneumophila supernatants

1996 • 17 citations

Genetic approaches to studyLegionella pneumophilapathogenicity

1994 • 11 citations

Chelating Tendencies of N,N′-Ethylenebis-[2-(o-Hydroxyphenyl)] Glycine

1957 • 6 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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