Phenotypic modulation by intracellular bacterial pathogens

Escherichia coli and Salmonella :cellular and molecular biology

1996 • 8,124 citations

Common themes in microbial pathogenicity revisited

1997 • 1,370 citations

Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

1986 • 1,116 citations

Mg2+ as an Extracellular Signal: Environmental Regulation of Salmonella Virulence

1996 • 817 citations

Environmental signals controlling expression of virulence determinants in bacteria

1992 • 803 citations

Common themes in microbial pathogenicity revisited.

1997 • 782 citations

The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes.

1983 • 704 citations

Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.

1995 • 680 citations

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

1994 • 676 citations

Selection of Bacterial Virulence Genes That Are Specifically Induced in Host Tissues

1993 • 671 citations

Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes.

1983 • 644 citations

Heat shock factor and the heat shock response

1991 • 615 citations

Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages

1998 • 596 citations

Induction of Salmonella Stress Proteins Upon Infection of Macrophages

1990 • 429 citations

Legionella pneumophila inhibits acidification of its phagosome in human monocytes.

1984 • 384 citations

Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

1998 • 360 citations

Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.

1994 • 358 citations

Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis.

1996 • 357 citations

Acidification of phagosomes containing Salmonella typhimurium in murine macrophages

1996 • 312 citations

Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors.

1987 • 287 citations

Molecular characterization of phagosomes.

1994 • 287 citations

Applications for green fluorescent protein (GFP) in the study of hostpathogen interactions

1996 • 284 citations

The role of a stress‐response protein in Salmonella typhimurium virulence

1991 • 281 citations

Targeting of Salmonella typhimurium to vesicles containing lysosomal membrane glycoproteins bypasses compartments with mannose 6-phosphate receptors.

1995 • 256 citations

Invasion of Protozoa by Legionella pneumophila and Its Role in Bacterial Ecology and Pathogenesis

1998 • 245 citations

A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurlum

1996 • 240 citations

Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa

1997 • 236 citations

The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton

1998 • 234 citations

SAFE HAVEN: The Cell Biology of Nonfusogenic Pathogen Vacuoles

1997 • 227 citations

Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion

1996 • 205 citations

The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum

1996 • 200 citations

Epithelial Cell Surfaces Induce Salmonella Proteins Required for Bacterial Adherence and Invasion

1989 • 196 citations

Fate of Listeria monocytogenes in murine macrophages: evidence for simultaneous killing and survival of intracellular bacteria

1994 • 180 citations

Mycobacterium avium- and Mycobacterium tuberculosis-containing vacuoles are dynamic, fusion-competent vesicles that are accessible to glycosphingolipids from the host cell plasmalemma.

1996 • 178 citations

Phenotypic modulation by Legionella pneumophila upon infection of macrophages

1993 • 170 citations

Characterization of the micro‐environment of Salmonella typhimurium–containing vacuoles within MDCK epithelial cells

1992 • 167 citations

Intraphagocytic growth induces an antibiotic-resistant phenotype of Legionella pneumophila

1995 • 157 citations

Analysis of proteins synthesized by Salmonella typhimurium during growth within a host macrophage

1993 • 156 citations

Secreted Effector Proteins of Salmonella dublin Act in Concert To Induce Enteritis

1998 • 150 citations

An overlap between osmotic and anaerobic stress responses: a potential role for DNA supercoiling in the coordinate regulation of gene expression

1989 • 149 citations

Identification of macrophage and stress-induced proteins of Mycobacterium tuberculosis.

1995 • 148 citations

Rapid and complete fusion of macrophage lysosomes with phagosomes containing Salmonella typhimurium

1996 • 139 citations

Characterization of the Mycobacterium tuberculosis phagosome

1996 • 135 citations

The varied lifestyles of intracellular pathogens within eukaryotic vacuolar compartments

1995 • 133 citations

Different fates of phagocytosed particles after delivery into macrophage lysosomes.

1996 • 131 citations

Membrane trafficking along the phagocytic pathway

1995 • 130 citations

Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages

1996 • 126 citations

The Chlamydia trachomatis parasitophorous vacuolar membrane is not passively permeable to low-molecular-weight compounds

1997 • 111 citations

The use of differential display‐PCR to isolate and characterize a Legionella pneumophila locus induced during the intracellular infection of macrophages

1996 • 110 citations

Identification of Macrophage-Specific Infectivity Loci ( mil ) of Legionella pneumophila That Are Not Required for Infectivity of Protozoa

1998 • 91 citations

Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells

1996 • 91 citations

Transcriptional regulation of the macrophage‐induced gene (gspA) of Legionella pneumophila and phenotypic characterization of a null mutant

1997 • 90 citations

Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlate with virulence

1996 • 88 citations

Participation of the molecular chaperone DnaK in intracellular growth of Brucella suis within U937‐derived phagocytes

1996 • 87 citations

Fatal attraction of mammalian cells to Legionella pneumophila

1998 • 84 citations

Identification and comparison of macrophage-induced proteins and proteins induced under various stress conditions in Brucella abortus

1996 • 79 citations

Listeria monocytogenes can grow in macrophages without the aid of proteins induced by environmental stresses

1995 • 70 citations

Induced Expression of the Legionella pneumophila Gene Encoding a 20-Kilodalton Protein during Intracellular Infection

1998 • 65 citations

Cloning and molecular characterization of a Legionella pneumophila gene induced by intracellular infection and by various in vitro stress conditions

1994 • 62 citations

Identification of the Aspartate-β-Semialdehyde Dehydrogenase Gene of Legionella pneumophila and Characterization of a Null Mutant

1998 • 59 citations

Adherence of Legionella pneumophila to guinea pig peritoneal macrophages, J774 mouse macrophages, and undifferentiated U937 human monocytes: role of Fc and complement receptors

1992 • 47 citations

Intracellular replication of Salmonella within epithelial cells is associated with filamentous structures containing lysosomal membrane glycoproteins.

1993 • 46 citations

Hypoexpression of major histocompatibility complex molecules on Legionella pneumophila phagosomes and phagolysosomes

1993 • 44 citations

Opsonin-independent adherence and intracellular development of Legionella pneumophila within U-937 cells

1993 • 41 citations

Induction ofYersinia enterocoliticaStress Proteins by Phagocytosis with Macrophage

1994 • 32 citations

The Legionella pneumophila hel locus encodes intracellularly induced homologs of heavy-metal ion transporters of Alcaligenes spp

1996 • 30 citations

Identification of Legionella pneumophila promoters regulated by the macrophage intracellular environment.

1993 • 29 citations

Specific detection of Salmonella typhimurium proteins synthesized intracellularly

1997 • 27 citations

Induction of mycobacterial proteins during phagocytosis and heat shock: a time interval analysis

1994 • 23 citations

Probing the microenvironment of intracellular bacterial pathogens

1999 • 21 citations

Salmonella typhidoes not inhibit phagosome-lysosome fusion in human monocyte-derived macrophages

1995 • 12 citations