Probing the microenvironment of intracellular bacterial pathogens

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Common themes in microbial pathogenicity revisited

1997 • 1,370 citations

Cloning the Differences Between Two Complex Genomes

1993 • 1,301 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution

1997 • 1,123 citations

Mg2+ as an Extracellular Signal: Environmental Regulation of Salmonella Virulence

1996 • 817 citations

Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

1989 • 724 citations

Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.

1995 • 680 citations

Photonic detection of bacterial pathogens in living hosts

1995 • 655 citations

Fluorescence-Based Isolation of Bacterial Genes Expressed Within Host Cells

1997 • 593 citations

Pathogenicity Islands: Bacterial Evolution in Quantum Leaps

1996 • 566 citations

Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid‐inducible promoters by differential fluorescence induction

1996 • 466 citations

Induction of Salmonella Stress Proteins Upon Infection of Macrophages

1990 • 429 citations

Modulation of Virulence Factor Expression by Pathogen Target Cell Contact

1996 • 412 citations

Expression of Legionella pneumophila Virulence Traits in Response to Growth Conditions

1998 • 361 citations

Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis.

1996 • 357 citations

The Mycobacterium tuberculosis phagosome interacts with early endosomes and is accessible to exogenously administered transferrin.

1996 • 307 citations

Applications for green fluorescent protein (GFP) in the study of hostpathogen interactions

1996 • 284 citations

Invasion of Protozoa by Legionella pneumophila and Its Role in Bacterial Ecology and Pathogenesis

1998 • 245 citations

The expression of virulence genes in Listeria monocytogenes is thermoregulated

1992 • 236 citations

Bacterial infection as assessed by in vivo gene expression

1997 • 236 citations

Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host.

1995 • 235 citations

Genomic subtraction for cloning DNA corresponding to deletion mutations.

1990 • 203 citations

The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum

1996 • 200 citations

Borrelia burgdorferi genes selectively expressed in the infected host.

1995 • 175 citations

Phenotypic modulation by Legionella pneumophila upon infection of macrophages

1993 • 170 citations

Characterization of the micro‐environment of Salmonella typhimurium–containing vacuoles within MDCK epithelial cells

1992 • 167 citations

Analysis of proteins synthesized by Salmonella typhimurium during growth within a host macrophage

1993 • 156 citations

Identification of macrophage and stress-induced proteins of Mycobacterium tuberculosis.

1995 • 148 citations

Induction of Mycobacterium avium gene expression following phagocytosis by human macrophages

1994 • 136 citations

The use of differential display‐PCR to isolate and characterize a Legionella pneumophila locus induced during the intracellular infection of macrophages

1996 • 110 citations

Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells

1996 • 91 citations

Transcriptional regulation of the macrophage‐induced gene (gspA) of Legionella pneumophila and phenotypic characterization of a null mutant

1997 • 90 citations

Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlate with virulence

1996 • 88 citations

Activity of mycobacterial promoters during intracellular and extracellular growth

1995 • 84 citations

Fatal attraction of mammalian cells to Legionella pneumophila

1998 • 84 citations

[38] In vivo expression technology for selection of bacterial genes specifically induced in host Tissues

1994 • 84 citations

Identification and cloning of genes differentially expressed in the virulent strain of Mycobacterium tuberculosis

1993 • 75 citations

Induced Expression of the Legionella pneumophila Gene Encoding a 20-Kilodalton Protein during Intracellular Infection

1998 • 65 citations

Application for PCR technology to subtractive cDNA cloning: identification of genes expressed specifically in murine plasmacytoma cells

1990 • 63 citations

Cloning and molecular characterization of a Legionella pneumophila gene induced by intracellular infection and by various in vitro stress conditions

1994 • 62 citations

Identification of the Aspartate-β-Semialdehyde Dehydrogenase Gene of Legionella pneumophila and Characterization of a Null Mutant

1998 • 59 citations

Probing bacterial gene expression within host cells

1997 • 57 citations

Selection for bacterial genes that are specifically induced in host tissues: the hunt for virulence factors.

1993 • 47 citations

Cloning, sequencing, and expression of the mig gene of Mycobacterium avium, which codes for a secreted macrophage-induced protein

1997 • 40 citations

De novo synthesis of Legionella pneumophila antigens during intracellular growth in phagocytic cells

1996 • 38 citations

Invasion of mammalian and protozoan cells by Legionella pneumophila

1998 • 30 citations

Specific detection of Salmonella typhimurium proteins synthesized intracellularly

1997 • 27 citations

Miniaturization Puts Chemical Plants Where You Want Them

1998 • 22 citations

The Macrophage-Induced Gene mig as a Marker for Clinical Pathogenicity and In Vitro Virulence of Mycobacterium avium Complex Strains

1998 • 19 citations

In search of virulence factors of human bacterial disease

1997 • 16 citations

Methods for the Identification of Virulence Genes Expressed in Mycobacterium tuberculosis Strain H37Rc

1994 • 13 citations

Genomics in infectious diseases: approaching the pathogens

1998 • 6 citations