Comparative Analysis of Legionella pneumophila and Legionella micdadei Virulence Traits

PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY

1974 • 3,882 citations

cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

1996 • 1,883 citations

Legionnaires' Disease

1977 • 1,687 citations

inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis

1994 • 1,348 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis

1990 • 1,231 citations

Legionnaires' Disease

1977 • 1,199 citations

Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae.

1980 • 979 citations

Conjugative Transfer by the Virulence System of Legionella pneumophila

1998 • 709 citations

The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes.

1983 • 704 citations

Legionnaires' Disease Bacterium (Legionella pneumophila) Multiplies Intracellularly in Human Monocytes

1980 • 648 citations

Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes.

1983 • 644 citations

Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila

1993 • 633 citations

Association of Legionella pneumophila with the macrophage endoplasmic reticulum

1995 • 556 citations

The molecular ecology of legionellae

1996 • 539 citations

A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12

1985 • 535 citations

Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells

1988 • 437 citations

The CTAB-DNA precipitation method: a common mini-scale preparation of template DNA from phagemids, phages or plasmids suitable for sequencing.

1989 • 414 citations

Surveillance for Legionnaires' disease. Risk factors for morbidity and mortality

1994 • 409 citations

Legionella pneumophila inhibits acidification of its phagosome in human monocytes.

1984 • 384 citations

Expression of Legionella pneumophila Virulence Traits in Response to Growth Conditions

1998 • 361 citations

Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

1998 • 360 citations

Identification of Legionella pneumophila genes required for growth within and killing of human macrophages

1993 • 357 citations

Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

1989 • 332 citations

Agrobacterium tumefaciens T-complex transport apparatus: a paradigm for a new family of multifunctional transporters in eubacteria

1997 • 322 citations

Phagocytosis of the legionnaires' disease bacterium (legionella pneumophila) occurs by a novel mechanism: Engulfment within a Pseudopod coil

1984 • 317 citations

Molecular characterization of an operon required for pertussis toxin secretion.

1993 • 307 citations

Legionella pneumophila Utilizes the Same Genes To Multiply within Acanthamoeba castellanii and Human Macrophages

1999 • 299 citations

Surveillance for Legionnaires' Disease

1994 • 296 citations

Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages.

1992 • 272 citations

Starvation-induced cross protection against osmotic challenge in Escherichia coli

1990 • 270 citations

A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection

1989 • 254 citations

Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene

1994 • 248 citations

Unexplored reservoirs of pathogenic bacteria: protozoa and biofilms

1999 • 243 citations

Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa

1997 • 236 citations

Evidence for pore‐forming ability by Legionella pneumophila

1998 • 227 citations

Identification of Linked Legionella pneumophila Genes Essential for Intracellular Growth and Evasion of the Endocytic Pathway

1998 • 201 citations

Nosocomial Legionnaires' Disease: A Continuing Common-Source Epidemic at Wadsworth Medical Center

1979 • 184 citations

Disease Due to the Legionellaceae (Other than Legionella pneumophila)

1989 • 182 citations

Legionella Pneumonia in the United States: The Distribution of Serogroups and Species Causing Human Illness

1984 • 176 citations

Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis

1995 • 166 citations

Characterization of a new region required for macrophage killing by Legionella pneumophila

1997 • 166 citations

Cell biology of Legionella pneumophila

1999 • 157 citations

Classification of the genus Legionella.

1998 • 149 citations

Opportunistic Lung Infection Due to “Pittsburgh Pneumonia Agent”

1979 • 146 citations

Risk factors for nosocomial Legionella pneumophila pneumonia.

1994 • 143 citations

Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components of IncQ plasmid RSF1010

1998 • 136 citations

The use of 16S ribosomal RNA analyses to investigate the phylogeny of the family Legionellaceae

1991 • 129 citations

Growth of Legionella pneumophila in a human macrophage-like (U937) cell line

1988 • 126 citations

Virulence factors of the family Legionellaceae

1992 • 124 citations

Topology of Legionella pneumophila DotA: an inner membrane protein required for replication in macrophages

1997 • 124 citations

Comparison of guinea pig and protozoan models for determining virulence of Legionella species

1986 • 123 citations

Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.

1995 • 122 citations

Identification of Legionella pneumophila mutants that have aberrant intracellular fates

1996 • 122 citations

The prepilin peptidase is required for protein secretion by and the virulence of the intracellular pathogen Legionella pneumophila

1999 • 119 citations

Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence

1994 • 101 citations

How is the intracellular fate of the Legionella pneumophila phagosome determined?

1998 • 101 citations

Membrane sorting during phagocytosis: selective exclusion of major histocompatibility complex molecules but not complement receptor CR3 during conventional and coiling phagocytosis.

1992 • 87 citations

Cloning and genetic characterization of the flagellum subunit gene (flaA) of Legionella pneumophila serogroup 1

1995 • 86 citations

Opportunistic Pneumonia

1979 • 85 citations

IN ESCHERICHIA COLI

1981 • 79 citations

Use of Salt to Isolate Legionella pneumophila Mutants Unable to Replicate in Macrophages

1996 • 70 citations

Analysis of the Intracellular Fate of Legionella pneumophila Mutants^a

1996 • 69 citations

Roles for tumor necrosis factor alpha and nitric oxide in resistance of rat alveolar macrophages to Legionella pneumophila

1996 • 67 citations

Characterization of the selective inhibition of growth of virulent Legionella pneumophila by supplemented Mueller-Hinton medium

1989 • 63 citations

Interaction of Legionella micdadei with human monocytes

1984 • 62 citations

Engulfment of the Philadelphia strain of Legionella pneumophila within pseudopod coils in human phagocytes. Comparison with other Legionella strains and species.

1989 • 61 citations

Pneumonia Due to the Pittsburgh Pneumonia Agent

1983 • 56 citations

Purified 60-kilodalton Legionella protein antigen with Legionella-specific and nonspecific epitopes

1987 • 55 citations

Legionnaires' disease: the pore macrophage and the legion of terror within

1998 • 51 citations

Cytotoxicity of extracellular Legionella pneumophila

1994 • 51 citations

Engulfment of the Philadelphia strain of Legionella pneumophila within pseudopod coils in human phagocytes

1989 • 49 citations

Classification of the legionellae.

1987 • 45 citations

Hypoexpression of major histocompatibility complex molecules on Legionella pneumophila phagosomes and phagolysosomes

1993 • 44 citations

Characterization of a Legionella micdadei mip mutant

1995 • 43 citations

A Comparative Study of Legionella micdadei and Other Nosocomial Acquired Pneumonia

1984 • 41 citations

Infection of macrophage-like cells by Legionella species that have not been associated with disease

1996 • 39 citations

Legionella species as hospital-acquired respiratory pathogens.

1987 • 34 citations

The Legionella pneumophila hel locus encodes intracellularly induced homologs of heavy-metal ion transporters of Alcaligenes spp

1996 • 30 citations

[Pittsburgh pneumonia agent].

1980 • 24 citations

Ingestion of Legionella micdadei inhibits human neutrophil function

1990 • 19 citations

Role of the alveolar macrophage in host defense and immunity to Legionella micdadei pneumonia in the guinea pig

1987 • 19 citations

Cloning and expression of the Legionella micdadei "common antigen" in Escherichia coli.

1989 • 17 citations

Identification of Virulence Determinants in Pathogenic Mycobacteria

1998 • 14 citations

Properties of the genus Tatlockia. Differentiation of Tatlockia (Legionella) maceachernii and micdadei from each other and from other legionellae

1993 • 14 citations

Cloning and expression of the Legionella micdadei“common antigen” in Escherichia coli

1989 • 10 citations

The Legionella micdadei flagellin: Expression in Escherichia coli K 12 and DNA sequence of the gene

1995 • 6 citations