Virulence factors of the family Legionellaceae

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Legionnaires' Disease

1977 • 1,687 citations

Legionnaires' Disease

1977 • 1,199 citations

Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae.

1980 • 979 citations

The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes.

1983 • 704 citations

Legionnaires' Disease Bacterium (Legionella pneumophila) Multiplies Intracellularly in Human Monocytes

1980 • 648 citations

Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes.

1983 • 644 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

Classification of the Legionnaires' Disease Bacterium: Legionella pneumophila, genus novum, species nova, of the Family Legionellaceae, familia nova

1979 • 393 citations

Legionella pneumophila inhibits acidification of its phagosome in human monocytes.

1984 • 384 citations

Catalase, superoxide dismutase, and virulence of Staphylococcus aureus. In vitro and in vivo studies with emphasis on staphylococcal--leukocyte interaction.

1975 • 324 citations

Phagocytosis of the legionnaires' disease bacterium (legionella pneumophila) occurs by a novel mechanism: Engulfment within a Pseudopod coil

1984 • 317 citations

Molecular cloning and overexpression of the human FK506-binding protein FKBP

1990 • 316 citations

Current views on the relationships between amoebae, legionellae and man.

1986 • 298 citations

Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors.

1987 • 287 citations

A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection

1989 • 254 citations

Interaction between the legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone.

1984 • 252 citations

Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes

1985 • 229 citations

Isolation of protozoa from water associated with a legionellosis outbreak and demonstration of intracellular multiplication of Legionella pneumophila

1986 • 226 citations

The pathology of the legionella pneumonias

1981 • 214 citations

DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity

1989 • 212 citations

Proliferation of Legionella pneumophila as an intracellular parasite of the ciliated protozoan Tetrahymena pyriformis

1984 • 208 citations

Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J mice

1988 • 189 citations

Legionella Pneumonia in the United States: The Distribution of Serogroups and Species Causing Human Illness

1984 • 176 citations

Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of Legionella pneumophila.

1986 • 173 citations

Interaction of the legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes but does not inhibit intracellular multiplication.

1981 • 169 citations

Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes.

1987 • 169 citations

Identification and characterization of a zinc metalloprotease associated with invasion by the fish pathogen Vibrio anguillarum

1990 • 167 citations

Cellular fatty acid composition of isolates from Legionnaires disease

1977 • 163 citations

Interaction of the legionnaires' disease bacterium (legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclearleukocytes, antibody, and complement

1981 • 162 citations

Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding

1990 • 160 citations

Activated human monocytes inhibit the intracellular multiplication of legionnaires' disease bacteria

1981 • 159 citations

Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes.

1990 • 157 citations

A Mutation in the mip Gene Results in an Attenuation of Legionella pneumophila Virulence

1990 • 155 citations

The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.

1985 • 155 citations

Cocultivation of Legionella pneumophila and free-living amoebae

1982 • 150 citations

Interactions between Naegleria fowleri and Legionella pneumophila

1985 • 148 citations

Association of shower use with Legionnaires' disease. Possible role of amoebae

1990 • 148 citations

Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.

1986 • 148 citations

Opportunistic Lung Infection Due to “Pittsburgh Pneumonia Agent”

1979 • 146 citations

Phagocyte Strategy vs. Microbial Tactics

1980 • 144 citations

Legionella micdadei species nova: Classification of a third species ofLegionella associated with human pneumonia

1980 • 134 citations

Protective Effects of Tumor Necrosis Factor in Experimental Legionella pneumophila Infections of Mice via Activation of PMN Function

1988 • 133 citations

Interaction ofL. pneumophilaand a free living amoeba (Acanthamoeba palestinensis)

1983 • 132 citations

Cell-mediated Immunity in Legionnaires' Disease

1983 • 127 citations

Growth of Legionella pneumophila in a human macrophage-like (U937) cell line

1988 • 126 citations

"Endotoxicity" of the Legionnaires' Disease Bacterium

1979 • 125 citations

Production of superoxide and hydrogen peroxide in medium used to culture Legionella pneumophila: catalytic decomposition by charcoal

1983 • 119 citations

Susceptibility of Legionella pneumophila to chlorine in tap water

1983 • 114 citations

Phosphorylation of tubulin by a calmodulin-dependent protein kinase.

1986 • 110 citations

Polymorphonuclear Neutrophils: An Effective Antimicrobial Force

1989 • 110 citations

Multiplication of Legionella spp. in tap water containing Hartmannella vermiformis

1991 • 109 citations

A comparison of virulence of two strains ofLegionella pneumophilabased on experimental aerosol infection of guinea-pigs

1985 • 102 citations

Leishmanial phosphatase blocks neutrophil O-2 production.

1984 • 102 citations

Legionella pneumophila htpAB heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen in L. pneumophila-infected HeLa cells

1990 • 102 citations

Treatment of alveolar macrophages with cytochalasin D inhibits uptake and subsequent growth of Legionella pneumophila

1986 • 101 citations

Characterization of Leishmania donovani acid phosphatases.

1985 • 98 citations

Monoclonal antibodies demonstrate that superoxide dismutase contributes to protection of Nocardia asteroides within the intact host

1990 • 98 citations

Phosphorylation of alpha-tubulin carboxyl-terminal tyrosine prevents its incorporation into microtubules.

1987 • 97 citations

The HL-60 model for the interaction of human macrophages with the Legionnaires' disease bacterium.

1990 • 95 citations

Virulence of a Legionella anisa strain associated with Pontiac fever: an evaluation using protozoan, cell culture, and guinea pig models

1990 • 95 citations

Activation of the neutrophil by calcium-mobilizing ligands. I. A chemotactic peptide and the lectin concanavalin A stimulate superoxide anion generation but elicit different calcium movements and phosphoinositide remodeling.

1988 • 89 citations

Identification of mip-like genes in the genus Legionella

1990 • 88 citations

Opportunistic Pneumonia

1979 • 85 citations

The pathology of Legionnaires' disease. Fourteen fatal cases from the 1977 outbreak in Vermont.

1978 • 84 citations

Cloning and temperature-dependent expression in Escherichia coli of a Legionella pneumophila gene coding for a genus-common 60-kilodalton antigen

1989 • 83 citations

Purification of Legionella pneumophila major outer membrane protein and demonstration that it is a porin

1985 • 82 citations

Properties of an acid phosphatase from Legionella micdadei which blocks superoxide anion production by human neutrophils

1985 • 81 citations

Vaccination with the major secretory protein of Legionella pneumophila induces cell-mediated and protective immunity in a guinea pig model of Legionnaires' disease.

1989 • 81 citations

The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing

1990 • 81 citations

MECHANISMS OF BACTERIAL VIRULENCE

1985 • 79 citations

Lack of Enhanced Oxygen Consumption by Polymorphonuclear Leukocytes on Phagocytosis of Virulent Salmonella typhi

1972 • 78 citations

Chlamydia trachomatis contains a protein similar to the Legionella pneumophila mip gene product

1991 • 77 citations

Isolation and characterization of the cytoplasmic and outer membranes of the Legionnaires' disease bacterium (Legionella pneumophila).

1985 • 77 citations

Serogroup specificity of Legionella pneumophila is related to lipopolysaccharide characteristics

1986 • 77 citations

Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase

1990 • 76 citations

Identification of a cytotoxin produced by Legionella pneumophila

1980 • 76 citations

Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes

1988 • 75 citations

The Kinetics of Early Inflammatory Events During Experimental Pneumonia Due to Legionella pneumophila in Guinea Pigs

1983 • 75 citations

Characterization of a Legionella pneumophila extracellular protease exhibiting hemolytic and cytotoxic activities

1989 • 75 citations

Purification and characterization of an extracellular protease of Legionella pneumophila

1986 • 74 citations

Importance of serratia protease in the pathogenesis of experimental Serratia marcescens pneumonia

1983 • 73 citations

Ultrastructure of Lung in Legionnaires' Disease

1979 • 73 citations

Genetics and molecular pathogenesis of Legionella pneumophila, an intracellular parasite of macrophages.

1989 • 71 citations

Adhesion, Penetration and Intracellular Replication of Legionella pneumophila: an in vitro Model of Pathogenesis

1985 • 71 citations

Determination of catalase, peroxidase, and superoxide dismutase within the genus Legionella

1984 • 70 citations

Induction of Interferon-Gamma and Tumor Necrosis Factor by Legionella pneumophila: Augmentation of Human Neutrophil Bactericidal Activity

1989 • 67 citations

Production of Superoxide by Phagocytic Leukocytes: A Paradigm for Stimulus-Response Phenomena

1986 • 67 citations

Cytolytic activity of human peripheral blood leukocytes against Legionella pneumophila-infected monocytes: characterization of the effector cell and augmentation by interleukin 2.

1987 • 65 citations

Electron microscopic examination of the inflammatory response to Legionella pneumophila in guinea pigs.

1982 • 65 citations

The identification of distinct protein kinases and phosphatases in the prokaryote Salmonella typhimurium.

1981 • 64 citations

Characterization of the selective inhibition of growth of virulent Legionella pneumophila by supplemented Mueller-Hinton medium

1989 • 63 citations

Dihydroxy and monohydroxy fatty acids in Legionella pneumophila

1981 • 63 citations

Pertussis toxin as a probe of neutrophil activation.

1986 • 62 citations

Interaction of Legionella micdadei with human monocytes

1984 • 62 citations

Multiplication of Legionella pneumophila Philadelphia-1 in cultured peritoneal macrophages and its correlation to susceptibility of animals

1986 • 61 citations

Separation of Legionella pneumophila Proteases and Purification of a Protease Which Produces Lesions Like Those of Legionnaires" Disease in Guinea Pig Lung

1986 • 61 citations

Isolation and characterization of the Legionella pneumophila outer membrane

1984 • 61 citations

Engulfment of the Philadelphia strain of Legionella pneumophila within pseudopod coils in human phagocytes. Comparison with other Legionella strains and species.

1989 • 61 citations

Exotoxin activity associated with the Legionnaires disease bacterium

1979 • 61 citations

Protein phosphorylation in Escherichia coli and purification of a protein kinase.

1984 • 60 citations

Infections Caused by Legionella micdadei and Legionella pneumophila among Renal Transplant Recipients

1984 • 59 citations

Interaction of primate alveolar macrophages and Legionella pneumophila.

1984 • 59 citations

The Effects of Legionella pneumophila Toxin on Oxidative Processes and Bacterial Killing of Human Polymorphonuclear Leukocytes

1982 • 59 citations

Serospecific antigens of Legionella pneumophila

1986 • 57 citations

Effectiveness of immunization with single and multi-component vaccines prepared from a common antigen (OEP), protease and elastase toxoids of Pseudomonas aeruginosa on protection against hemorrhagic pneumonia in mink due to P. aeruginosa.

1978 • 57 citations

Comparison of the Vibrio cholerae hemagglutinin/protease and the Pseudomonas aeruginosa elastase

1990 • 56 citations

Cytolytic and Phospholipase C Activity in Legionella Species

1985 • 56 citations

In vitro responses of guinea pig peritoneal macrophages to Legionella pneumophila

1981 • 56 citations

Pulmonary damage caused by a protease from Legionella pneumophila.

1986 • 55 citations

Partial purification and properties of isocitrate dehydrogenase kinase/phosphatase from Escherichia coli ML308

1984 • 53 citations

Proteolytic action of Legionella pneumophila on human serum proteins

1980 • 53 citations

An immunoprotective molecule, the major secretory protein of Legionella pneumophila, is not a virulence factor in a guinea pig model of Legionnaires' disease.

1990 • 52 citations

Legionnaires' pneumonia after aerosol exposure in guinea pigs and rats.

1982 • 52 citations

Con-A-stimulated superoxide production by granulocytes: reversible activation of NADPH oxidase

1982 • 51 citations

Legionnaires' pneumonia after intratracheal inoculation of guinea pigs and rats.

1982 • 51 citations

Cellular Lipids of the Legionnaires' Disease Bacterium

1979 • 50 citations

Ultrastructure of the Agent of Legionnaires’ Disease in the Human Lung

1979 • 49 citations

Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systems.

1982 • 48 citations

Enzymatic profile of Legionella pneumophilia

1981 • 48 citations

Extracellular enzymes of Legionella pneumophila

1981 • 46 citations

In Vitro Production of an Extracellular Protease by Legionella pneumophila

1981 • 46 citations

A live avirulent mutant Legionella pneumophila vaccine induces protective immunity against lethal aerosol challenge.

1989 • 46 citations

In vitro interaction between normal cynolmolgus monkey alveolar macrophages and Legionnaires disease bacteria

1979 • 46 citations

Susceptibility of Pittsburgh pneumonia agent (Legionella micdadei) and other newly recognized members of the genus Legionella to nineteen antimicrobial agents

1981 • 46 citations

Nucleotide sequence analysis of the Legionella micdadei mip gene, encoding a 30-kilodalton analog of the Legionella pneumophila Mip protein

1991 • 46 citations

Disulfide-bonded outer membrane proteins in the genus Legionella

1985 • 43 citations

Histopathology of experimental Legionnaires' disease in guinea pigs, rhesus monkeys and marmosets

1983 • 42 citations

The relationship between the serogroup antigen and lipopolysaccharide ofLegionella pneumophila

1986 • 42 citations

Immunocytochemical demonstration of the association between Legionella pneumophila, its tissue‐destructive protease, and pulmonary lesions in experimental Legionnaires' disease

1987 • 42 citations

Vaccination with the major secretory protein of Legionella induces humoral and cell-mediated immune responses and protective immunity across different serogroups of Legionella pneumophila and different species of Legionella.

1991 • 41 citations

Legionella adelaidensis, a new species isolated from cooling tower water

1991 • 40 citations

Hydrolysis of phosphoproteins and inositol phosphates by cell surface phosphatase of Leishmania donovani

1986 • 39 citations

Pathologic Findings in Guinea Pigs Inoculated lntraperitoneally with the Legionnaires' Disease Bacterium

1979 • 39 citations

Ultrastructure of pulmonary alveoli and macrophages in experimental Legionnaires' disease

1983 • 36 citations

Endogenous protein phosphorylation inEscherichia coli extracts

1982 • 36 citations

Nucleotide sequence of htpB, the Legionella pneumophila gene encoding the 58-kilodalton (kDa) common antigen, formerly designated the 60-kDa common antigen

1990 • 34 citations

Genetic, immunological, and cytotoxic comparisons of Legionella proteolytic activities

1989 • 33 citations

Outer membrane proteins from Legionella pneumophila serogroups and other Legionella species

1986 • 33 citations

In vivo Production of a Tissue-destructive Protease by Legionella pneumophila in the Lungs of Experimentally Infected Guinea-pigs

1988 • 33 citations

The Contribution of Human Neutrophils and Serum to Host Defense Against Legionella micdadei

1983 • 33 citations

Effect of Oxygen-Dependent Antimicrobial Systems on Legionella pneumophila

1983 • 33 citations

The ultrastructural morphologic features of Pittsburgh pneumonia agent.

1980 • 33 citations

Electrophoretic and serological characterization of the lipopolysaccharides of Legionella pneumophila

1986 • 32 citations

Legionella pneumophila inhibits protein synthesis in Chinese hamster ovary cells

1991 • 32 citations

A cyclic nucleotide-independent protein kinase in Leishmania donovani

1986 • 32 citations

Occurrence of dialkyl ether phospholipids in Stigmatella aurantiaca DW4

1983 • 30 citations

Virulence associated ingestion of Legionella pneumophila by HeLa cells

1987 • 30 citations

Characterization of a suppressor cell-activating factor (SCAF) released by adherent cells treated with M. tuberculosis.

1983 • 30 citations

Legionella micdadei phosphatase catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate in human neutrophils

1988 • 30 citations

Defective Triggering of Polymorphonuclear Leukocyte Oxidative Metabolism By Legionella pneumophila Toxin

1985 • 29 citations

Pathogenesis of Acute Legionnaires’ Disease Pneumonia: Immunofluorescent Microscopic Study

1980 • 27 citations

Enzymatic activities of Legionella pneumophila and Legionella-like organisms

1982 • 27 citations

A Phospholipase C from the Dallas 1E Strain of Legionella pneumophila Serogroup 5: Purification and Characterization of Conditions for Optimal Activity with an Artificial Substrate

1988 • 27 citations

Distribution, expression, and long-range mapping of legiolysin gene (lly)-specific DNA sequences in legionellae

1991 • 27 citations

Changes in cyclic amp-dependent protein kinase activity in Tetrahymena pyriformis during the growth cycle

1975 • 26 citations

Antimicrobial therapy of experimental Legionella micdadei pneumonia in guinea pigs

1985 • 24 citations

Antibodies isolated by using cloned surface antigens recognize antigenically related components of Legionella pneumophila and other Legionella species.

1986 • 22 citations

Demonstration of extracellular chymotrypsin-like activity from various Legionella species

1982 • 22 citations

Serum bactericidal activity against Legionella pneumophila

1985 • 22 citations

Identification of protein antigens of Legionella pneumophila serogroup 1

1985 • 22 citations

Bactericidal activity of antibiotics against Legionella micdadei (Pittsburgh pneumonia agent)

1982 • 22 citations

The effect of oxygen-dependent antimicrobial systems on strains ofLegionella pneumophilaof different virulence

1986 • 21 citations

Opsonization of Legionella pneumophila in human serum: key roles for specific antibodies and the classical complement pathway.

1985 • 20 citations

Ingestion of Legionella micdadei inhibits human neutrophil function

1990 • 19 citations

Role of the alveolar macrophage in host defense and immunity to Legionella micdadei pneumonia in the guinea pig

1987 • 19 citations

Macrophage Toxicity and Complement Sensitivity of Virulent and Avirulent Strains of Legionella pneumophila

1988 • 19 citations

Demonstration of Two Protein Kinases in Extracts of Legionella micdadei

1988 • 18 citations

Inactivation of Human -1-Antitrypsin by a Tissue-destructive Protease of Legionella pneumophila

1988 • 18 citations

Interactions of virulent and avirulent Legionella pneumophila with human polymorphonuclear leukocytes

1988 • 18 citations

Phagocytosis and Intracellular Biology of Legionella Pneumophila

1988 • 18 citations

Inhibition of polymorphonuclear leukocyte function by Legionella pneumophila exoproducts

1990 • 17 citations

Membrane Proteins of Legionellaceae I. Membrane Proteins of Different Strains and Serogroups of Legionella pneumophila

1985 • 17 citations

Neutrophil oxidative metabolism after exposure to bacterial phospholipase C.

1989 • 17 citations

Inhibition of human natural killer cell activity byLegionella pneumophila protease

1989 • 16 citations

Effects of polymorphonuclear leucocyte depletion on the pathogenesis of experimental Legionnaires' disease.

1988 • 14 citations

A rapid method for purification of homogenous Legionella pneumophila cytotoxic protease using fast protein liquid chromatography

1989 • 14 citations

Legionella micdadei protein kinase catalyzes phosphorylation of tubulin and phosphatidylinositol

1989 • 13 citations

Interactions of Virulent and Avirulent Legionella pneumophila With Human Monocytes

1990 • 13 citations

Patterns of extracellular proline-specific endopeptidases in Legionella and Flavobacterium spp. demonstrated by use of chromogenic peptides

1983 • 10 citations

A protease fromLegionella pneumophilawith cytotoxic and dermal ulcerative activity

1986 • 10 citations

Proteinases of Legionella: Phenylalanineaminopeptidase of L. pneumophila

1986 • 9 citations

Leukocyte stimulation: receptor, membrane, and metabolic events. Introduction and summary.

1986 • 8 citations

Opsonic requirements for phagocytosis of Legionella micdadei by polymorphonuclear leukocytes

1985 • 8 citations

The phosphorylation of isocitrate dehydrogenase in Escherichia coli

1982 • 6 citations

Legiolysin, a New Hemolysin from L. pneumophila

1991 • 5 citations

Characteristics of the cytolysin of Legionella pneumophila

1988 • 5 citations

Production of Extracellular Hemolytic Cytotoxin byLegionella bozemanii

1984 • 3 citations

An update on Legionnaires' disease and pneumonias caused by "new" Legionella-like bacteria.

1982 • 2 citations

[Cytolysin as an immunoserological marker of Legionella pneumophila].

1988 • 1 citations