Significance of multiple mutations in cancer

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli

1976 • 1,572 citations

Rate of depurination of native deoxyribonucleic acid

1972 • 1,488 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

The causes and prevention of cancer.

1995 • 1,326 citations

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1991 • 1,125 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1998 • 985 citations

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

1994 • 748 citations

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.

1989 • 733 citations

Heat-induced deamination of cytosine residues in deoxyribonucleic acid

1974 • 725 citations

hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum

1999 • 724 citations

Role of mutator alleles in adaptive evolution

1997 • 697 citations

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

1997 • 543 citations

Mitotic forces control a cell-cycle checkpoint

1995 • 535 citations

Errors in DNA replication as a basis of malignant changes.

1974 • 527 citations

UmuD′ ₂ C is an error-prone DNA polymerase, Escherichia coli pol V

1999 • 524 citations

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1998 • 498 citations

DNA MISMATCH CORRECTION

1987 • 427 citations

Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

1999 • 425 citations

Genetic instability of cancer cells is proportional to their degree of aneuploidy

1998 • 378 citations

hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.

1999 • 374 citations

Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage.

1984 • 365 citations

Proliferation of mutators in A cell population

1997 • 342 citations

The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation.

1986 • 301 citations

Genetic analysis of benign, low-grade, and high-grade ovarian tumors.

1995 • 299 citations

Nature's chemicals and synthetic chemicals: comparative toxicology.

1990 • 275 citations

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

1996 • 266 citations

The Mutation Rate and Cancer

1998 • 258 citations

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.

1992 • 253 citations

Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.

1989 • 251 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2

1999 • 233 citations

Induction of microsatellite instability by oxidative DNA damage

1998 • 227 citations

Cancer of the microsatellite mutator phenotype.

1996 • 226 citations

Characterization of MAD2B and Other Mitotic Spindle Checkpoint Genes

1999 • 215 citations

DNA‐replication Fidelity, Mismatch Repair and Genome Instability in Cancer Cells

1996 • 209 citations

Biochemical basis of SOS-induced mutagenesis in Escherichia coli : Reconstitution of in vitro lesion bypass dependent on the UmuD′ ₂ C mutagenic complex and RecA protein

1998 • 202 citations

Endogenous carcinogenesis: molecular oncology into the twenty-first century--presidential address.

1989 • 189 citations

Mutations in the Essential Spindle Checkpoint Gene bub1 Cause Chromosome Missegregation and Fail to Block Apoptosis in Drosophila

1999 • 189 citations

Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole

1993 • 174 citations

p21^Waf1/Cip1 Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption

1999 • 171 citations

p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.

1998 • 168 citations

DNA polymerases alpha, delta, and epsilon: three distinct enzymes from HeLa cells.

1990 • 160 citations

Genome-wide search for loss of heterozygosity shows extensive genetic diversity of human breast carcinomas.

1997 • 157 citations

DNA polymerase expression differences in selected human tumors and cell lines

1999 • 131 citations

Requirement of DNA Polymerase Activity of Yeast Rad30 Protein for Its Biological Function

1999 • 105 citations

Specific Binding of Human MSH2·MSH6 Mismatch-Repair Protein Heterodimers to DNA Incorporating Thymine- or Uracil-containing UV Light Photoproducts Opposite Mismatched Bases

1999 • 102 citations

Mammalian DNA polymerase beta can substitute for DNA polymerase I during DNA replication in Escherichia coli.

1992 • 99 citations

Conditional Mutator Phenotypes in hMSH2-Deficient Tumor Cell Lines

1997 • 99 citations

Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state

1996 • 94 citations

Overexpression of DNA polymerase β: a genomic instability enhancer process

1999 • 76 citations

Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines

1999 • 67 citations

Errors in DNA synthesis: A source of spontaneous mutations

1990 • 63 citations

A DNA polymerase alpha pause site is a hot spot for nucleotide misinsertion.

1992 • 47 citations

SOS mutagenesis

1993 • 38 citations

Human breast cancer cells contain an error-prone DNA replication apparatus.

1998 • 31 citations

Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae

1996 • 28 citations

Production of active mouse DNA polymerase β in bacteria

1995 • 25 citations

Mutations in the Essential Spindle Checkpoint Gene bub1 Cause Chromosome Missegregation and Fail to Block Apoptosis in Drosophila

1999 • 17 citations