DNA‐replication Fidelity, Mismatch Repair and Genome Instability in Cancer Cells

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

1994 • 559 citations

CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY

1993 • 558 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

1995 • 521 citations

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

1994 • 506 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Mismatch Repair, Genetic Stability, and Cancer

1994 • 429 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

1990 • 408 citations

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

1995 • 403 citations

Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource

1985 • 402 citations

MSH2 deficient mice are viable and susceptible to lymphoid tumours

1995 • 378 citations

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

1995 • 362 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli

1995 • 353 citations

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.

1994 • 332 citations

Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli

1995 • 332 citations

Identification of mismatch repair genes and their role in the development of cancer

1995 • 319 citations

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

1995 • 314 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

Mismatch repair: mechanisms and relationship to cancer susceptibility

1995 • 307 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines.

1995 • 301 citations

Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.

1993 • 300 citations

Microsatellite instability in inherited and sporadic neoplasms

1995 • 257 citations

Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs.

1994 • 251 citations

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

1995 • 239 citations

FRAMESHIFT MUTATION: DETERMINANTS OF SPECIFICITY

1990 • 238 citations

Preferential DNA secondary structure mutagenesis in the lagging strand of replication in E. coli

1991 • 230 citations

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

1993 • 224 citations

Repair of DNA heteroduplexes containing small heterologous sequences in Escherichia coli.

1992 • 215 citations

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 203 citations

Requirement of the Yeast RTH1 5′ to 3′ Exonuclease for the Stability of Simple Repetitive DNA

1995 • 195 citations

Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots

1993 • 180 citations

Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli.

1996 • 174 citations

Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas

1995 • 171 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

Binding of Mismatched Microsatellite DNA Sequences by the Human MSH2 Protein

1994 • 166 citations

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.

1995 • 147 citations

Genetic instability in human ovarian cancer cell lines.

1994 • 134 citations

Genetic steps in colorectal cancer

1994 • 132 citations

Mechanisms of transcription-repair coupling and mutation frequency decline

1994 • 131 citations

DNA Loop Repair by Human Cell Extracts

1994 • 125 citations

Reduced Frameshift Fidelity and Processivity of HIV-1 Reverse Transcriptase Mutants Containing Alanine Substitutions in Helix H of the Thumb Subdomain

1995 • 121 citations

Exonucleolytic Proofreading during Replication of Repetitive DNA

1996 • 111 citations

Greater Susceptibility to Mutations in Lagging Strand of DNA Replication in Escherichia coli than in Leading Strand

1993 • 108 citations

Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit.

1994 • 108 citations

Purified human MSH2 protein binds to DNA containing mismatched nucleotides.

1994 • 90 citations

The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities.

1992 • 89 citations

A hPMS2 Mutant Cell Line Is Defective in Strand-specific Mismatch Repair

1995 • 89 citations

Molecular analysis of mutations in mutator colorectal carcinoma cell lines

1995 • 86 citations

Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells.

1995 • 80 citations

Transcription-repair coupling and mutation frequency decline

1993 • 74 citations

Cloning, Characterization and Chromosomal Assignment of the Human Genes Homologous to Yeast PMS1, a Member of Mismatch Repair Genes

1994 • 69 citations

DNA replication: enzymology and mechanisms

1994 • 68 citations

Exonucleolytic proofreading of leading and lagging strand DNA replication errors.

1991 • 57 citations

Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity.

1995 • 53 citations

Repair of heteroduplex DNA molecules with multibase loops in Escherichia coli

1993 • 51 citations

Recombinagenic processing of UV-light photoproducts in nonreplicating phage DNA by the Escherichia coli methyl-directed mismatch repair system.

1991 • 48 citations

Frameshift fidelity during replication of double-stranded DNA in HeLa cell extracts

1993 • 40 citations

Relative probability of mutagenic translesion synthesis on the leading and lagging strands during replication of UV-irradiated DNA in a human cell extract

1993 • 36 citations

Mispair-, site-, and strand-specific error rates during simian virus 40 origin-dependent replication in vitro with excess deoxythymidine triphosphate.

1994 • 35 citations

Identification of two initiator elements in the bidirectional promoter of the human dihydrofolate reductase and mismatch repair protein 1 genes

1994 • 34 citations

Frequency and Fidelity of Translesion Synthesis of Site-specific N-2-Acetylaminofluorene Adducts during DNA Replication in a Human Cell Extract

1995 • 27 citations

Mismatch Repair and Genetic Stability in Human Cells

1993 • 25 citations

Design of a selectable reporter for the detection of mutations in mammalian simple repeat sequences

1995 • 18 citations