Inflammation and the pathogenesis of diabetic nephropathy

Multifactorial Intervention and Cardiovascular Disease in Patients with Type 2 Diabetes

2003 • 4,328 citations

Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes

2008 • 3,390 citations

Type 2 diabetes as an inflammatory disease

2011 • 3,173 citations

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

2005 • 3,163 citations

Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study

1999 • 973 citations

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

2011 • 949 citations

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody indb/dbdiabetic mice

2000 • 907 citations

Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat

1993 • 688 citations

Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications

2011 • 454 citations

Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis

2011 • 438 citations

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

2000 • 425 citations

MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy

2008 • 397 citations

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

2010 • 380 citations

NF- B activation and overexpression of regulated genes in human diabetic nephropathy

2004 • 369 citations

Low Production Capacity of Interleukin-10 Associates With the Metabolic Syndrome and Type 2 Diabetes

2002 • 345 citations

NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy

2005 • 343 citations

Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy

2011 • 341 citations

Effects of NADPH oxidase inhibitor in diabetic nephropathy

2005 • 297 citations

Renoprotective role of the vitamin D receptor in diabetic nephropathy

2007 • 296 citations

Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

2003 • 293 citations

Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy

2008 • 289 citations

IL-17 Immunity in Human Type 1 Diabetes

2010 • 288 citations

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase

2008 • 285 citations

Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells

2009 • 279 citations

Role of High Glucose-Induced Nuclear Factor-κB Activation in Monocyte Chemoattractant Protein-1 Expression by Mesangial Cells

2002 • 269 citations

Intercellular Adhesion Molecule-1 Deficiency Is Protective against Nephropathy in Type 2 Diabetic db/db Mice

2005 • 267 citations

Identification and immune regulation of 25-hydroxyvitamin D-1-α-hydroxylase in murine macrophages

2000 • 265 citations

Possible role of tumor necrosis factor and interleukin-1 in the development of diabetic nephropathy

1991 • 262 citations

Elevated levels of interleukin-18 and tumor necrosis factor-α in serum of patients with type 2 diabetes mellitus: Relationship with diabetic nephropathy

2003 • 258 citations

Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients

2003 • 254 citations

Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase

2010 • 220 citations

Serum Interleukin-18 Levels Are Associated With Nephropathy and Atherosclerosis in Japanese Patients With Type 2 Diabetes

2005 • 214 citations

Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy

2007 • 213 citations

Role of the JAK/STAT signaling pathway in diabetic nephropathy

2006 • 208 citations

Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation

2006 • 201 citations

Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy

2011 • 199 citations

PPAR-γ agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-β

2008 • 194 citations

PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice

2006 • 192 citations

Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kB

1999 • 190 citations

Increased Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Diabetic Rat Glomeruli: Glomerular Hyperfiltration Is a Potential Mechanism of ICAM-1 Upregulation

1997 • 187 citations

Leptin and Renal Fibrosis

2006 • 185 citations

The role of TNF-α in diabetic nephropathy: Pathogenic and therapeutic implications

2006 • 184 citations

Pathogenic perspectives for the role of inflammation in diabetic nephropathy

2009 • 183 citations

ACE Inhibitors Improve Diabetic Nephropathy Through Suppression of Renal MCP-1

2003 • 179 citations

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

2010 • 176 citations

The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats

2003 • 175 citations

Advanced Glycation End-Products Induce Tubular CTGF via TGF-β–Independent Smad3 Signaling

2009 • 174 citations

Expression of VCAM-1 in the Normal and Diseased Kidney

1991 • 173 citations

1,25-Dihydroxyvitamin D3 targeting of NF-κB suppresses high glucose-induced MCP-1 expression in mesangial cells

2007 • 169 citations

Inhibition of the JAK/STAT Signaling Pathway Prevents the High Glucose-Induced Increase in TGF-β and Fibronectin Synthesis in Mesangial Cells

2002 • 165 citations

Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy

2011 • 165 citations

Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney

1999 • 162 citations

Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy

2007 • 162 citations

Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes

2009 • 162 citations

Transcription factors in the pathogenesis of diabetic nephropathy

2009 • 159 citations

Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats

1999 • 154 citations

In Situ Hybridization of Interleukin 6 in Diabetic Nephropathy

1995 • 152 citations

Plasma concentrations of VCAM‐1 and ICAM‐1 are elevated in patients with Type 1 diabetes mellitus with microalbuminuria and overt nephropathy

2000 • 152 citations

Urinary and renal interstitial concentrations of TNF-α increase prior to the rise in albuminuria in diabetic rats

2003 • 151 citations

Interleukin-1 receptor antagonist allele (ILIRN*2) associated with nephropathy in diabetes mellitus

1996 • 150 citations

Interactions between Angiotensin II and NF-κB–Dependent Pathways in Modulating Macrophage Infiltration in Experimental Diabetic Nephropathy

2004 • 147 citations

Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy

2008 • 141 citations

High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-ϰB-dependent

2000 • 139 citations

Urinary levels of monocyte chemoattractant protein‐1 (MCP‐1) and interleukin‐8 (IL‐8), and renal injuries in patients with type 2 diabetic nephropathy

2002 • 139 citations

Interactions between Renin Angiotensin System and Advanced Glycation in the Kidney

2005 • 136 citations

Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy

2011 • 136 citations

Accelerated Diabetic Nephropathy in Mice Lacking the Peroxisome Proliferator–Activated Receptor α

2006 • 134 citations

Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36–3′PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice

2008 • 132 citations

Elevated Concentrations of Soluble E-Selectin and Vascular Cell Adhesion Molecule-1 in NIDDM: Effect of intensive insulin treatment

1998 • 130 citations

Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats

2008 • 130 citations

Serum Adiponectin Is Increased in Type 1 Diabetic Patients With Nephropathy

2005 • 130 citations

Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy

2012 • 128 citations

Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes

2010 • 127 citations

Expression and Function of Peroxisome Proliferator–Activated Receptor-γ in Mesangial Cells

2001 • 125 citations

Usefulness of a Highly Sensitive Urinary and Serum IL-6 Assay in Patients with Diabetic Nephropathy

2000 • 124 citations

Role of the renin angiotensin system in diabetic nephropathy

2010 • 117 citations

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes

2011 • 112 citations

Peripheral Total and Differential Leukocyte Count in Diabetic Nephropathy

2005 • 112 citations

Endothelial dysfunction in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin

2008 • 111 citations

Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy

2009 • 110 citations

CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice

2010 • 110 citations

Dual Blockade of the Homeostatic Chemokine CXCL12 and the Proinflammatory Chemokine CCL2 Has Additive Protective Effects on Diabetic Kidney Disease

2011 • 107 citations

Effect of TNF-α inhibition on urinary albumin excretion in experimental diabetic rats

2007 • 105 citations

Proteinuric Nephropathy in Acquired and Congenital Generalized Lipodystrophy: Baseline Characteristics and Course during Recombinant Leptin Therapy

2004 • 104 citations

1,25-Dihydroxyvitamin D₃suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-κB pathway

2009 • 102 citations

Interactions Between Advanced Glycation End-Products (AGE) and their Receptors in the Development and Progression of Diabetic Nephropathy – are these Receptors Valid Therapeutic Targets

2009 • 100 citations

Thiazolidinediones Ameliorate Diabetic Nephropathy via Cell Cycle–Dependent Mechanisms

2006 • 98 citations

Posttranslational, Reversible O-Glycosylation Is Stimulated by High Glucose and Mediates Plasminogen Activator Inhibitor-1 Gene Expression and Sp1 Transcriptional Activity in Glomerular Mesangial Cells

2005 • 97 citations

Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes

2007 • 96 citations

Role of T Cells in Type 2 Diabetic Nephropathy

2011 • 91 citations

The Role of Interstitial Macrophages in Nephropathy of Type 2 Diabetic db/db Mice

2007 • 90 citations

Circulating cellular adhesion molecules ICAM-1, VCAM-1, P- and E-selectin in the prediction of cardiovascular disease in diabetes mellitus

2002 • 89 citations

Ultrastructural changes of extracellular matrices in diabetic nephropathy revealed by high resolution scanning and immunoelectron microscopy.

1993 • 88 citations

Serum C-reactive protein and leptin as predictors of kidney disease progression in the Modification of Diet in Renal Disease Study

2002 • 85 citations

Phenotypic Modulation of the Mesangium Reflected by Contractile Proteins in Diabetes

1996 • 84 citations

Aberrant cytokines/chemokines production correlate with proteinuria in patients with overt diabetic nephropathy

2010 • 82 citations

The Role of Toll-Like Receptors in Diabetes-Induced Inflammation: Implications for Vascular Complications

2012 • 81 citations

High serum TNF-α level in Type 2 diabetic patients with microangiopathy is associated with eNOS down-regulation and apoptosis in endothelial cells

2005 • 80 citations

Peroxisome proliferator-activated receptor γ1 (PPARγ1) expresses in rat mesangial cells and PPARγ agonists modulate its differentiation

2000 • 78 citations

Fenofibrate attenuates tubulointerstitial fibrosis and inflammation through suppression of nuclear factor-κB and transforming growth factor-β1/Smad3 in diabetic nephropathy

2010 • 74 citations

Serum total and high molecular weight adiponectin levels are correlated with the severity of diabetic retinopathy and nephropathy

2007 • 73 citations

Activation of Peroxisome Proliferator–Activated Receptor δ Inhibits Streptozotocin-Induced Diabetic Nephropathy Through Anti-Inflammatory Mechanisms in Mice

2011 • 71 citations

Interleukin-18 contributes more closely to the progression of diabetic nephropathy than other diabetic complications

2010 • 68 citations

Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate–activated protein kinase activation

2010 • 67 citations

Improvement of inflammatory responses associated with NF-κB pathway in kidneys from diabetic rats

2008 • 67 citations

Effect of pioglitazone and rosiglitazone on mediators of endothelial dysfunction, markers of angiogenesis and inflammatory cytokines in type-2 diabetes

2008 • 66 citations

Peroxisome Proliferator-Activated Receptor-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>γ</mml:mi></mml:math>(PPAR-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E2"><mml:mi>γ</mml:mi></mml:math>) Agonists Attenuate the Profibrotic Response Induced by TGF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E3"><mml:mi>β</mml:mi></mml:math>1 in Renal Interstitial Fibroblasts

2007 • 62 citations

Assignment of human ?-galactosidase-A gene to 3p21.33 by fluorescence in situ hybridization

1993 • 60 citations

Increased Expression of Toll-Like Receptor 2 in Rat Diabetic Nephropathy

2010 • 59 citations

Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy

2004 • 57 citations

The low dose combination of fenofibrate and rosiglitazone halts the progression of diabetes-induced experimental nephropathy

2010 • 56 citations

MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells

2008 • 55 citations

Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells

2006 • 54 citations

High levels of circulating interleukin-10 in diabetic nephropathy patients.

2005 • 54 citations

Are PPAR alpha agonists a rational therapeutic strategy for preventing abnormalities of the diabetic kidney?

2012 • 53 citations

Structural damage in diabetic nephropathy is associated with TNF-α system activity

2011 • 51 citations

Elevated serum leptin concentrations in type 2 diabetic patients with microalbuminuria and macroalbuminuria

1999 • 51 citations

Study of the role of interleukin-6 and highly sensitive C-reactive protein in diabetic nephropathy in type 1 diabetic patients.

2012 • 50 citations

Expression of ICAM-1 on glomeruli is associated with progression of diabetic nephropathy in a genetically obese diabetic rat, Wistar fatty

1996 • 50 citations

LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat

2008 • 50 citations

Fractalkine and Its Receptor, CX3CR1, Upregulation in Streptozotocin-Induced Diabetic Kidneys

2004 • 46 citations

Advanced glycation end products‐induced apoptosis attenuated by PPARδ activation and epigallocatechin gallate through NF‐κB pathway in human embryonic kidney cells and human mesangial cells

2010 • 46 citations

CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms

2005 • 45 citations

High glucose induction of DNA-binding activity of the transcription factor NFκB in patients with diabetic nephropathy

2008 • 44 citations

The activation of NF-κB and AP-1 in peripheral blood mononuclear cells isolated from patients with diabetic nephropathy

2008 • 43 citations

Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy

2005 • 42 citations

Cilostazol Ameliorates Nephropathy in Type 1 Diabetic Rats Involving Improvement in Oxidative Stress and Regulation of TGF-β and NF-κB

2010 • 41 citations

Therapeutic Potential of Aleglitazar, a New Dual PPAR-α/γ Agonist

2010 • 40 citations

Role of oxidative stress and inflammation in the origin of Type 2 diabetes – a paradigm shift

2004 • 39 citations

Increased serum levels of interleukin-18 in patients with diabetic nephropathy.

2004 • 39 citations

Adiponectin is positively associated with insulin resistance in subjects with type 2 diabetic nephropathy and effects of angiotensin II type 1 receptor blocker losartan

2009 • 39 citations

Serum Leptin Levels in Young Females with Insulin-Dependent Diabetes and the Relationship to Hyperandrogenicity and Microalbuminuria

1998 • 38 citations

The MCP-1/CCR2 axis in podocytes is involved in apoptosis induced by diabetic conditions

2011 • 38 citations

Activation of PKC-β_Iin glomerular mesangial cells is associated with specific NF-κB subunit translocation

2001 • 35 citations

Effect of Combination Therapy with Angiotensin Receptor Blocker and 1,25-Dihydroxyvitamin D&lt;sub&gt;3&lt;/sub&gt; in Type 2 Diabetic Nephropathy in KK-A&lt;sup&gt;y&lt;/sup&gt;/Ta Mice

2010 • 34 citations

KIOM‐79, an Inhibitor of AGEs–Protein Cross‐linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats

2009 • 31 citations

Intensive insulin therapy decreases urinary MCP‐1 and ICAM‐1 excretions in incipient diabetic nephropathy

2009 • 30 citations

Increased plasma adiponectin closely associates with vascular endothelial dysfunction in type 2 diabetic patients with diabetic nephropathy

2010 • 30 citations

Rosiglitazone protects diabetic rats against kidney disease through the suppression of renal moncyte chemoattractant protein-1 expression

2008 • 29 citations

The Relationship Between Plasma Leptin Levels and Chronic Complication in Patients with Type 2 Diabetes Mellitus

2010 • 26 citations

Rosiglitazone Ameliorates Diabetic Nephropathy by Inhibiting Reactive Oxygen Species and Its Downstream-Signaling Pathways

2007 • 21 citations

Nuclear Hormone Receptors as Therapeutic Targets

2011 • 20 citations

Fluvastatin inhibits activation of JAK and STAT proteins in diabetic rat glomeruli and mesangial cells under high glucose conditions

2007 • 20 citations

Vitamin D compounds and diabetic nephropathy

2012 • 20 citations

Advanced glycation end-product induces fractalkine gene upregulation in normal rat glomeruli

2005 • 17 citations

Change in the Amount of Body Fat and IL-6 Levels is Related to Altered Insulin Sensitivity in Type 1 Diabetes Patients with or without Diabetic Nephropathy

2011 • 16 citations

Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy

2003 • 16 citations

Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol

2010 • 15 citations

Renoprotective effect of rosiglitazone through the suppression of renal intercellular adhesion molecule-1 expression in streptozotocin-induced diabetic rats

2008 • 14 citations

Tissue-Specific Induction of E-Selectin in Glomeruli Is Augmented following Diabetes mellitus

2001 • 14 citations

Association of interleukin‐18 promoter polymorphism and atherosclerotic diseases in Chinese patients with diabetic nephropathy

2009 • 10 citations

RT-PCR analysis of the expression of POMC and its processing enzyme PC1 in amphibian melanotropes

2006 • 9 citations

Hydrochloride pioglitazone decreases urinary monocyte chemoattractant protein-1 excretion in type 2 diabetics

2010 • 7 citations

Serum leptin changes during weight loss in obese diabetic subjects with and without microalbuminuria.

2001 • 7 citations

Renoprotective effects of clarithromycin via reduction of urinary MCP-1 levels in type 2 diabetic patients

2010 • 6 citations