Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36–3′PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

1990 • 9,690 citations

In vitro selection of RNA molecules that bind specific ligands

1990 • 9,093 citations

Global and societal implications of the diabetes epidemic

2001 • 5,825 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 • 3,607 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

5'-Triphosphate RNA Is the Ligand for RIG-I

2006 • 2,329 citations

Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

2005 • 1,196 citations

End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions

1999 • 796 citations

Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and progressive renal injury

2003 • 518 citations

RANTES and Monocyte Chemoattractant Protein–1 (MCP-1) Play an Important Role in the Inflammatory Phase of Crescentic Nephritis, but Only MCP-1 Is Involved in Crescent Formation and Interstitial Fibrosis

1997 • 498 citations

Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice

2005 • 421 citations

Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy

2006 • 398 citations

Mirror-image RNA that binds D-adenosine

1996 • 378 citations

Leukocyte Recruitment and Vascular Injury in Diabetic Nephropathy

2006 • 352 citations

Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance

2004 • 323 citations

The Role of Macrophages in Diabetic Glomerulosclerosis

1993 • 312 citations

Advanced Glycation End Product-induced Apoptosis and Overexpression of Vascular Endothelial Growth Factor and Monocyte Chemoattractant Protein-1 in Human-cultured Mesangial Cells

2002 • 308 citations

The Effect of Ruboxistaurin on Nephropathy in Type 2 Diabetes

2005 • 293 citations

Acute-Phase Markers of Inflammation and Glomerular Structure in Patients with Type 2 Diabetes

2005 • 286 citations

The Pathogenesis of Chronic Renal Failure in Diabetic Nephropathy

1991 • 284 citations

Intercellular Adhesion Molecule-1 Deficiency Is Protective against Nephropathy in Type 2 Diabetic db/db Mice

2005 • 267 citations

Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus

2003 • 237 citations

Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice

2006 • 237 citations

Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes

2003 • 199 citations

Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys.

2000 • 197 citations

Spiegelmer Inhibition of CCL2/MCP-1 Ameliorates Lupus Nephritis in MRL-(Fas)lpr Mice

2007 • 176 citations

In vivo properties of an anti-GnRH Spiegelmer: An example of an oligonucleotide-based therapeutic substance class

2002 • 174 citations

Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy

2002 • 173 citations

Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice

2003 • 153 citations

Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation

2003 • 152 citations

Urinary levels of monocyte chemoattractant protein‐1 (MCP‐1) and interleukin‐8 (IL‐8), and renal injuries in patients with type 2 diabetic nephropathy

2002 • 139 citations

Inhibition of ghrelin actionin vitroandin vivoby an RNA-Spiegelmer

2004 • 135 citations

Monocyte chemoattractant protein-1 mediates monocyte/macrophage influx in anti-thymocyte antibody-induced glomerulonephritis

1997 • 123 citations

Monocyte chemoattractant protein 1 mediates glomerular macrophage infiltration in anti-GBM Ab GN

1996 • 113 citations

Laser microdissection and gene expression analysis on formaldehyde-fixed archival tissue

2002 • 113 citations

Suppression of anti-glomerular basement membrane nephritis by administration of anti-monocyte chemoattractant protein-1 antibody in WKY rats.

1997 • 109 citations

Delayed Chemokine Receptor 1 Blockade Prolongs Survival in Collagen 4A3–Deficient Mice with Alport Disease

2005 • 104 citations

Signs of Nephropathy May Occur Early in Young Adults With Diabetes Despite Modern Diabetes Management

2003 • 104 citations

Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-β

1999 • 102 citations

A High Glucose Concentration Stimulates the Expression of Monocyte Chemotactic Peptide 1 in Human Mesangial Cells

1998 • 100 citations

The Role of Interstitial Macrophages in Nephropathy of Type 2 Diabetic db/db Mice

2007 • 90 citations

Methotrexate Prevents Renal Injury in Experimental Diabetic Rats via Anti-Inflammatory Actions

2005 • 89 citations

Protein Kinase Cβ Inhibition Attenuates Osteopontin Expression, Macrophage Recruitment, and Tubulointerstitial Injury in Advanced Experimental Diabetic Nephropathy

2005 • 89 citations

Regulation of RANTES and ICAM-1 expression in murine mesangial cells.

1997 • 55 citations

An <scp>l</scp> -RNA-based aquaretic agent that inhibits vasopressin in vivo

2006 • 53 citations

Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients

2006 • 46 citations

The role of inflammation as a pathogenic factor in the development of renal disease in diabetes

2005 • 45 citations

Macrophage heterogeneity in renal inflammation

2003 • 20 citations

Immunosuppression for diabetic glomerular disease?

2003 • 8 citations