Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy

A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation

1999 • 14,690 citations

Global and societal implications of the diabetes epidemic

2001 • 5,825 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

TLR4 links innate immunity and fatty acid–induced insulin resistance

2006 • 3,422 citations

New Equations to Estimate GFR in Children with CKD

2009 • 3,261 citations

Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy

1997 • 1,775 citations

Inferences, questions and possibilities in Toll-like receptor signalling

2004 • 1,458 citations

The Role of Inflammatory Cytokines in Diabetic Nephropathy

2008 • 867 citations

TLR4 activation mediates kidney ischemia/reperfusion injury

2007 • 796 citations

HMGB1: Endogenous Danger Signaling

2008 • 738 citations

The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?

1999 • 623 citations

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

2007 • 551 citations

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

2005 • 544 citations

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

2010 • 542 citations

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

2010 • 494 citations

Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice

2005 • 421 citations

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes

2008 • 409 citations

MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy

2008 • 397 citations

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

2008 • 370 citations

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

2009 • 327 citations

HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

2010 • 322 citations

Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy

2005 • 282 citations

TLR2 Is Constitutively Expressed within the Kidney and Participates in Ischemic Renal Injury through Both MyD88-Dependent and -Independent Pathways

2007 • 267 citations

Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo

2003 • 264 citations

Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice

2006 • 237 citations

Role of Toll-Like Receptor 4 in Endotoxin-Induced Acute Renal Failure

2004 • 237 citations

Viral Double-Stranded RNA Aggravates Lupus Nephritis through Toll-Like Receptor 3 on Glomerular Mesangial Cells and Antigen-Presenting Cells

2005 • 215 citations

Production and cytokine-mediated regulation of monocyte chemoattractant protein-1 by human proximal tubular epithelial cells

1995 • 200 citations

Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

2010 • 198 citations

MCP-1 Induces Inflammatory Activation of Human Tubular Epithelial Cells

2002 • 187 citations

Role of Inflammation in Diabetic Nephropathy

2008 • 183 citations

Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model

2007 • 174 citations

Discovery and Development of Toll-Like Receptor 4 (TLR4) Antagonists: A New Paradigm for Treating Sepsis and Other Diseases

2008 • 174 citations

Rapid fluorescence-based measurement of neutrophil migration in vitro

1998 • 160 citations

Relevance of Toll-like receptor-4 polymorphisms in renal transplantation

2005 • 159 citations

Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes

2009 • 156 citations

Clinical and Histological Correlations of Decline in Renal Function in Diabetic Patients With Proteinuria

1994 • 149 citations

Blocking of Responses to Endotoxin by E5564 in Healthy Volunteers with Experimental Endotoxemia

2003 • 149 citations

TLR4 Promotes Fibrosis but Attenuates Tubular Damage in Progressive Renal Injury

2010 • 147 citations

Toll-Like Receptor-7 Modulates Immune Complex Glomerulonephritis

2005 • 128 citations

Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury

2010 • 124 citations

Involvement of PKCα/β in TLR4 and TLR2 dependent activation of NF-κB

2004 • 118 citations

Toll-Like Receptor 4 Ligation on Intrinsic Renal Cells Contributes to the Induction of Antibody-Mediated Glomerulonephritis via CXCL1 and CXCL2

2007 • 103 citations

Ligands to Nucleic Acid–Specific Toll-Like Receptors and the Onset of Lupus Nephritis

2006 • 99 citations

Angiotensin II Upregulates Toll-Like Receptor 4 on Mesangial Cells

2006 • 86 citations

Activation of Tubular Epithelial Cells in Diabetic Nephropathy and the Role of the Peroxisome Proliferator–Activated Receptor-γ Agonist

2006 • 74 citations

Bradykinin and high glucose promote renal tubular inflammation

2009 • 69 citations

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

2010 • 61 citations

Increased Expression of Toll-Like Receptor 2 in Rat Diabetic Nephropathy

2010 • 59 citations

Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy of transgenic (mRen-2)27 rats

2002 • 58 citations

Candesartan attenuates Angiotensin II-induced mesangial cell apoptosis via TLR4/MyD88 pathway

2009 • 56 citations

Toll-Like Receptor 2 Agonists Exacerbate Accelerated Nephrotoxic Nephritis

2006 • 51 citations

Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling

2006 • 47 citations

Amelioration of diabetic tubulointerstitial damage in liver-type fatty acid-binding protein transgenic mice

2008 • 43 citations

Differential Regulation of <i>Toll-Like Receptor 4</i> Gene Expression in Renal Cells by Angiotensin II: Dependency on AP1 and PU.1 Transcriptional Sites

2007 • 39 citations

Tubular atrophy, interstitial fibrosis, and inflammation in type 2 diabetic db/db mice. An accelerated model of advanced diabetic nephropathy.

2007 • 38 citations

Association of genetic polymorphisms in the IL12-IFNG pathway with susceptibility to and prognosis of pulmonary tuberculosis in a Chinese population

2010 • 33 citations

Enhanced inflammatory responses to toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin

2010 • 28 citations

Renoprotection by Rosiglitazone in Accelerated Type 2 Diabetic Nephropathy: Role of STAT1 Inhibition and Nephrin Restoration

2010 • 27 citations

Additive renoprotective effects of B2-kinin receptor blocker and PPAR-γ agonist in uninephrectomized db/db mice

2011 • 23 citations

Angiotensin receptor blockers in chronic renal disease: the promise of a bright clinical future.

1999 • 19 citations

[Effect of spironolactone on the expression of Toll-like receptor 4 in renal tubular epithelia cells exposed to high glucose].

2010 • 9 citations