Role of T Cells in Type 2 Diabetic Nephropathy

Inflammation and metabolic disorders

2006 • 8,000 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,744 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,391 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome

2000 • 2,363 citations

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

2009 • 2,065 citations

Diabetic Nephropathy: Diagnosis, Prevention, and Treatment

2005 • 1,717 citations

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

2002 • 1,510 citations

Interleukin-17 and Type 17 Helper T Cells

2009 • 1,343 citations

Normalization of obesity-associated insulin resistance through immunotherapy

2009 • 1,263 citations

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

1997 • 1,246 citations

Endothelial Dysfunction

2004 • 1,080 citations

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

2011 • 978 citations

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

2011 • 949 citations

The Role of Advanced Glycation End Products in Progression and Complications of Diabetes

2008 • 939 citations

The Role of Inflammatory Cytokines in Diabetic Nephropathy

2008 • 867 citations

Mouse Models of Diabetic Nephropathy

2009 • 865 citations

End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions

1999 • 796 citations

Association between C-reactive protein and features of the metabolic syndrome: a population-based study.

2000 • 684 citations

T-lymphocyte Infiltration in Visceral Adipose Tissue

2008 • 656 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity

2007 • 638 citations

The pathogenesis of diabetic nephropathy

2008 • 601 citations

Nephropathy in Patients with Type 2 Diabetes

2002 • 592 citations

Pathogenetic Mechanisms of Diabetic Nephropathy

2005 • 558 citations

Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration

2007 • 550 citations

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

2009 • 545 citations

Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and progressive renal injury

2003 • 518 citations

Chemokines, Chemokine Receptors, and Renal Disease

2000 • 492 citations

Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice

2005 • 421 citations

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

2010 • 380 citations

Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy

2001 • 378 citations

Advanced glycation end products and the kidney

2005 • 375 citations

Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes

2000 • 372 citations

Leukocyte Recruitment and Vascular Injury in Diabetic Nephropathy

2006 • 352 citations

New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology

2004 • 345 citations

Low Production Capacity of Interleukin-10 Associates With the Metabolic Syndrome and Type 2 Diabetes

2002 • 345 citations

Macrophage accumulation in human progressive diabetic nephropathy

2006 • 291 citations

IL-17 Immunity in Human Type 1 Diabetes

2010 • 288 citations

Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells

2009 • 279 citations

The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease

2009 • 275 citations

Role of High Glucose-Induced Nuclear Factor-κB Activation in Monocyte Chemoattractant Protein-1 Expression by Mesangial Cells

2002 • 269 citations

Intercellular Adhesion Molecule-1 Deficiency Is Protective against Nephropathy in Type 2 Diabetic db/db Mice

2005 • 267 citations

Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy

2000 • 266 citations

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue

2008 • 266 citations

Chemokines in Renal Injury

2011 • 245 citations

Mammalian Target of Rapamycin Pathway Blockade Slows Progression of Diabetic Kidney Disease in Rats

2006 • 239 citations

Macrophages in Renal Disease

2011 • 235 citations

Interleukin-10: Biology, Role in Inflammation and Autoimmunity

1997 • 226 citations

Role of inflammation in diabetic complications

2005 • 221 citations

Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes

2003 • 199 citations

Mouse models of diabetic nephropathy

2011 • 199 citations

Increased Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Diabetic Rat Glomeruli: Glomerular Hyperfiltration Is a Potential Mechanism of ICAM-1 Upregulation

1997 • 187 citations

Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy

2003 • 187 citations

The role of TNF-α in diabetic nephropathy: Pathogenic and therapeutic implications

2006 • 184 citations

Pathogenic perspectives for the role of inflammation in diabetic nephropathy

2009 • 183 citations

Inflammation and diabetic nephropathy

2006 • 178 citations

Deficiency of Endothelial Nitric-Oxide Synthase Confers Susceptibility to Diabetic Nephropathy in Nephropathy-Resistant Inbred Mice

2007 • 174 citations

Rapamycin Prevents Early Steps of the Development of Diabetic Nephropathy in Rats

2007 • 170 citations

Spironolactone Prevents Diabetic Nephropathy through an Anti-Inflammatory Mechanism in Type 2 Diabetic Rats

2006 • 168 citations

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

2009 • 158 citations

Elevated Glucose and Diabetes Promote Interleukin-12 Cytokine Gene Expression in Mouse Macrophages

2006 • 157 citations

Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice

2005 • 157 citations

Diabetes and nephropathy

2003 • 148 citations

Regulation of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor-1 by IFN-gamma, tumor necrosis factor-alpha, IgG aggregates, and cAMP in mouse mesangial cells.

1993 • 147 citations

Interactions between Angiotensin II and NF-κB–Dependent Pathways in Modulating Macrophage Infiltration in Experimental Diabetic Nephropathy

2004 • 147 citations

State of the union between metabolism and the immune system in type 2 diabetes

2011 • 146 citations

Molecular Mechanisms of Diabetic Nephropathy and Its Therapeutic Intervention

2007 • 145 citations

ROLE OF MACROPHAGES IN COMPLICATIONS OF TYPE 2 DIABETES

2007 • 134 citations

Recent insights into diabetic renal injury from thedb/dbmouse model of type 2 diabetic nephropathy

2010 • 129 citations

Macrophages and Diabetic Nephropathy

2010 • 127 citations

Advanced glycosylation endproduct-specific receptors on human and rat T-lymphocytes mediate synthesis of interferon gamma: role in tissue remodeling.

1993 • 125 citations

Expression of Functional CCR and CXCR Chemokine Receptors in Podocytes

2002 • 122 citations

Endothelial dysfunction in diabetic nephropathy: state of the art and potential significance for non-diabetic renal disease

2004 • 120 citations

Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy

2007 • 115 citations

Making sense of regulatory T cell suppressive function

2011 • 113 citations

Role of MKK3–p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice

2008 • 107 citations

Diabetic Nephropathy in Type 2 Diabetes Prevention and Patient Management

2003 • 105 citations

Regulatory T cells in rheumatoid arthritis.

2005 • 100 citations

Potential New Therapeutic Agents for Diabetic Kidney Disease

2010 • 98 citations

Protective Effects of Angiotensin II Interruption: Evidence for Antiinflammatory Actions

2005 • 93 citations

Interleukin-1β stimulates human renal fibroblast proliferation and matrix protein production by means of a transforming growth factor-β-dependent mechanism

2002 • 91 citations

Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice

2009 • 90 citations

Effect of retinoic acid in experimental diabetic nephropathy

2004 • 89 citations

Gene transfer of RANTES elicits autoimmune renal injury in MRL-Faslpr mice

1998 • 86 citations

Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy

2010 • 84 citations

Association and Interaction of the IL4R, IL4, and IL13 Loci with Type 1 Diabetes among Filipinos

2003 • 84 citations

Aberrant cytokines/chemokines production correlate with proteinuria in patients with overt diabetic nephropathy

2010 • 82 citations

Eicosapentaenoic acid ameliorates diabetic nephropathy of type 2 diabetic KKAy/Ta mice: Involvement of MCP-1 suppression and decreased ERK1/2 and p38 phosphorylation

2005 • 81 citations

Lymphocytes promote albuminuria, but not renal dysfunction or histological damage in a mouse model of diabetic renal injury

2010 • 70 citations

Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases?

2009 • 63 citations

Juxtaglomerular apparatus T-cell infiltration affects glomerular structure in Type 1 diabetic patients

2004 • 61 citations

Association of interleukin (IL)-4 intron-3 and IL-6 −174 G/C gene polymorphism with susceptibility to end-stage renal disease

2007 • 60 citations

Role of TSC–mTOR pathway in diabetic nephropathy

2008 • 60 citations

Proteinuria and Activated T-Lymphocytes in Diabetic Nephropathy

1988 • 54 citations

High levels of circulating interleukin-10 in diabetic nephropathy patients.

2005 • 54 citations

Expression of ICAM-1 on glomeruli is associated with progression of diabetic nephropathy in a genetically obese diabetic rat, Wistar fatty

1996 • 50 citations

Correlation of enhanced thrombospondin-1 expression, TGF- signalling and proteinuria in human type-2 diabetic nephropathy

2008 • 47 citations

CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms

2005 • 45 citations

Interleukin‐10–592C/A, –819C/T and –1082A/G promoter variants affect the susceptibility to nephropathy in Tunisian type 2 diabetes (T2DM) patients

2008 • 45 citations

Aberrant Expression of Soluble Co-stimulatory Molecules and Adhesion Molecules in Type 2 Diabetic Patients with Nephropathy

2007 • 36 citations

Predictive value of interleukin‐10 promoter genotypes and haplotypes in determining the susceptibility to nephropathy in type 2 diabetes patients

2008 • 34 citations

Increased secretion of TGF‐β1 by peripheral blood mononuclear cells from patients with Type 1 diabetes mellitus with diabetic nephropathy

2001 • 28 citations

[Role of CD4+CD25+Foxp3+ regulatory T cells in type 2 diabetic nephropathy].

2009 • 23 citations

T-cell regulation in murine and human autoimmune diabetes: the role of TH1 and TH2 cells.

1997 • 22 citations

Attenuation of mouse mesangial cell contractility by high glucose and mannitol: Involvement of protein kinase C and focal adhesion kinase

2004 • 20 citations

The frequency of Th2 type cells increases with time on peritoneal dialysis in patients with diabetic nephropathy.

1999 • 20 citations

Immunosuppression for diabetic glomerular disease?

2003 • 8 citations

Attenuation of Mouse Mesangial Cell Contractility by High Glucose and Mannitol: Involvement of Protein Kinase C and Focal Adhesion Kinase

2004 • 6 citations

Deleted Work

1955 • 0 citations